Article(id=1242132071318106291, tenantId=1146029695717560320, journalId=1146031591421210625, issueId=1242132062942077861, articleNumber=null, orderNo=5, doi=10.3981/j.issn.1000-7857.2014.16.003, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1392307200000, receivedDateStr=2014-02-14, revisedDate=1396195200000, revisedDateStr=2014-03-31, acceptedDate=null, acceptedDateStr=null, onlineDate=1402718363390, onlineDateStr=2014-06-14, pubDate=1402156800000, pubDateStr=2014-06-08, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1402718363390, onlineIssueDateStr=2014-06-14, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1774076963495, creator=sys-migrate, updateTime=1774076963495, updator=sys-migrate, issue=Issue{id=1242132062942077861, tenantId=1146029695717560320, journalId=1146031591421210625, year='2014', volume='32', issue='16', pageStart='1', pageEnd='95', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=3, issueType=-1, specialIssue=null, createTime=1774076961500, creator=sys-migrate, updateTime=1774076961500, updator=sys-migrate, preIssue=null, nextIssue=null, ext=null, issueFiles=null}, startPage=24, endPage=28, ext={EN=ArticleExt(id=1242132073696273336, articleId=1242132071318106291, tenantId=1146029695717560320, journalId=1146031591421210625, language=EN, title=Comparative Study of Stasis-Phlegm and Abnormal Savda Syndrome Asthma Patients Based on NMR, columnId=1242116080374710456, journalTitle=Science & Technology Review, columnName=Articles, runingTitle=null, highlight=null, articleAbstract=To investigate the plasma samples from asthma patients with phlegm-stasis or abnormal Savda syndrome with NMR spectroscopy and to analyze their metabolic varieties, characteristics and reciprocity, fifty healthy volunteers who were confirmed by medical examination and 162 asthma patients were enrolled. The asthma patients were divided into the abnormal Savda syndrome group and the phlegm-stasis syndrome group according to the theory of traditional Uyghur medicine and the theory of traditional Chinese medicine, respectively. There were 80 cases in the abnormal Savda syndrome group and 82 in the phlegm-stasis group. Plasma samples were obtained by centrifugation of blood samples from all the individuals in the morning before breakfast, and were immediately stored at -80℃ until use for NMR spectroscopy. ¹H NMR spectra were analyzed using the orthogonal projection to latent structure with the discriminative analysis (OPLS-DA) method with unit variance scaling. The discriminative significance of metabolites was determined by the Pearson's product-moment correlation coefficient. The results showed that compared to the control group, the asthma patients with phlegm-stasis had low concentrations of isoleucine, leucine, valine, lactate, alanine, glycoprotein, citrate, tyrosine, phenylalanine and 1-methylhistidine (P<0.05); the asthma patients with abnormal Savda syndrome had low concentrations of isoleucine, leucine, valine, lactate, alanine, glycoprotein, glutamine, creatine, creatinine, citrate, tyrosine, phenylalanine and 1-methylhistidine, α-glucose and β-glucose (P<0.05). The conclusion is that the asthma patients with different syndromes have very similar metabolic changes, i.e., abnormal performance for amino acid metabolism, inhibited citric acid cycle gluconeogenesis disorder and immune dysfunction., correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=XudqnfZ/+fwX3GO4IBCzAQ==, pdfFileSize=1300554, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, authorCompany=1. College of Pharmacy, Xinjiang Medical University, Urumqi 830011, China;
2. The Fourth Affiliated Hospital, Xinjiang Medical University, Urumqi 830011, China;
3. College of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi 830011, China, fund=null, authors=MAMTIMIN Batur¹, XU Weifang², LI Wei³, WU Yan³, UPUR Halmurat³, authorsList=MAMTIMIN Batur, XU Weifang, LI Wei, WU Yan, UPUR Halmurat), CN=ArticleExt(id=1242132072735781055, articleId=1242132071318106291, tenantId=1146029695717560320, journalId=1146031591421210625, language=CN, title=基于核磁共振分析支气管哮喘患者中医肾虚痰瘀证与维医异常黑胆质证共性特征, columnId=1146540929516700224, journalTitle=科技导报, columnName=研究论文, runingTitle=null, highlight=null, articleAbstract=采用核磁共振（NMR）检测技术进行哮喘肾虚痰瘀证患者与哮喘异常黑胆质证患者血浆代谢组学分析，寻找哮喘肾虚痰瘀证和异常黑胆质证代谢组学异同点，从代谢组学层面解释中医和维医辩证分型的异同点及其物质基础，描述主要的代谢变化特点，阐述2 种理论物质基础的异同点，为中医和维医等传统医学理论的现代研究提供一定的基础。收集哮喘病患者162 例和50 例健康志愿者，患者根据中医学传统理论和维吾尔医学传统理论分为肾虚痰瘀证患者和异常黑胆质证患者，收集健康志愿者和患者早餐前血液并分离血浆；对血浆样本进行核磁共振（NMR）为基础的代谢组学研究。血浆核磁共振氢谱（¹H NMR）数据采用正交偏最小二乘判别分析（OPLS-DA）结合自动规格化（UV）处理方法进行处理和分析，差异性代谢物的确定根据皮尔森相关系数显著性差异检测所确定的相关系数判断。结果显示，与健康对照组相比，哮喘病肾虚痰瘀证患者血浆中异亮氨酸、亮氨酸、缬氨酸、乳酸、丙氨酸、糖蛋白、柠檬酸、酪氨酸、苯丙氨酸和1-甲基组氨酸10 种代谢物含量明显降低，差异有统计学意义（P<0.05）；哮喘病异常黑胆质证患血浆中异亮氨酸、亮氨酸、缬氨酸、乳酸、丙氨酸、糖蛋白、谷氨酰胺、肌酸、肌酸酐、柠檬酸、酪氨酸、苯丙氨酸、1-甲基组氨酸、α-葡萄糖、β-葡萄糖和肉碱等16 种代谢物含量明显降低，差异有统计学意义（P<0.05）。由此表明，肾虚痰瘀型哮喘和异常黑胆质型哮喘有着相似的体内代谢变化机制，表现为氨基酸代谢异常、三羧酸循环被抑制、糖异生增强和免疫功能紊乱等；支气管哮喘肾虚痰瘀证和异常黑胆质都有相似的病理变化基础，体现了两证的基本一致性，是同一病理现象和过程在不同医学体系内的描述。, correspAuthors=null, authorNote=巴吐尔·买买提明，副教授，研究方向为维吾尔医学，电子信箱：batur72@163.com, correspAuthorsNote=哈木拉提·吾甫尔，教授，研究方向为新疆重大疾病的中维西医干预，电子信箱：halmurat@263.net, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=2yMI63LrP9uvajTk9mTsUA==, pdfFileSize=1300554, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, authorCompany=1. 新疆医科大学药学院, 乌鲁木齐830011;
2. 新疆医科大学附属中医医院, 乌鲁木齐830011;
3. 新疆医科大学中医学院, 乌鲁木齐830011, fund=国家自然科学基金项目（81273873）, authors=巴吐尔·买买提明¹, 徐卫芳², 李威³, 吴燕³, 哈木拉提·吾甫尔³, authorsList=巴吐尔·买买提明, 徐卫芳, 李威, 吴燕, 哈木拉提·吾甫尔)}, authors=null, keywords=[Keyword(id=1242132072291184825, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242132071318106291, language=CN, orderNo=1, keyword=肾虚痰瘀), Keyword(id=1242132072370876603, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242132071318106291, language=CN, orderNo=1, keyword=异常黑胆质), Keyword(id=1242132072500900028, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242132071318106291, language=CN, orderNo=1, keyword=传统医学), Keyword(id=1242132072584786109, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242132071318106291, language=CN, orderNo=1, keyword=代谢组学), Keyword(id=1242132073272651968, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242132071318106291, language=EN, orderNo=1, keyword=phlegm stasis), 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