Article(id=1242130874242761269, tenantId=1146029695717560320, journalId=1146031591421210625, issueId=1242130862028947957, articleNumber=null, orderNo=null, doi=10.3981/j.issn.1000-7857.2013.26.011, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1372348800000, receivedDateStr=2013-06-28, revisedDate=1373817600000, revisedDateStr=2013-07-15, acceptedDate=null, acceptedDateStr=null, onlineDate=1379433600000, onlineDateStr=2013-09-18, pubDate=1379433600000, pubDateStr=2013-09-18, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1379433600000, onlineIssueDateStr=2013-09-18, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1774076678092, creator=sys-migrate, updateTime=1774076678092, updator=sys-migrate, issue=Issue{id=1242130862028947957, tenantId=1146029695717560320, journalId=1146031591421210625, year='2013', volume='31', issue='26', pageStart='3', pageEnd='96', issueExtLink='null', onlineDate='null', pubDate='1379433600000', pubDateStr='2013-09-18', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=3, issueType=-1, specialIssue=null, createTime=1774076675180, creator='sys-migrate', updateTime=1774076675180, updator='sys-migrate', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=64, endPage=67, ext={EN=ArticleExt(id=1242130878109913110, articleId=1242130874242761269, tenantId=1146029695717560320, journalId=1146031591421210625, language=EN, title=Relationship Between the Signal Transduction Pathway and the Disorder of Neuro-endocrine-immunity Network in Abnormal Savda Hilit, columnId=1242116080374710456, journalTitle=Science & Technology Review, columnName=Articles, runingTitle=null, highlight=null, articleAbstract=In order to study the relationship between the signal transduction pathway and the disorder of the neuro-endocrine-immunity network in abnormal Savda Hilit, the blood samples of the abnormal Savda Hilit group and the non-abnormal Savda Hilit group (abnormal Kan Hilit, abnormal Belhem Hilit, abnormal Safra Hilit) were collected. After separating the white blood cell and extracting the RNA, the Affymetrix gene expression microarray technology was applied to detect the gene expression of the two groups. Then the differentially expressed genes were selected and a bioinformatic analysis was made by using the CapitalBio Molecule Annotation System (MAS) to find the genes related to the signal transduction pathway. The result of chip shows that 75 genes are up-regulated in the abnormal Savda Hilit group comparing with the non-abnormal Savda Hilit group. The bioinformatic analysis shows that 12 genes are concentrated in the signal transduction pathways of the biological process, involved in the MAPK, Toll-like receptor, the Wnt signal transduction pathway. These findings indicate that the abnormal activation of the MAPK, Toll-like receptor, the Wnt signal transduction pathway may be related to the disorder of the neuro-endocrine-immunity network in the abnormal Savda Hilit group., authors=HUANG Jingjing¹, LI Chunyan¹, YUNUSI Kurexi¹, YUNUSI Ayiguli², MAIMAITI Palidan¹, WUBU Nuerbiya³, LIU Wenxian⁴, UFUER Hamulati⁴, authorsList=HUANG Jingjing;LI Chunyan;YUNUSI Kurexi;YUNUSI Ayiguli;MAIMAITI Palidan;WUBU Nuerbiya;LIU Wenxian;UFUER Hamulati, authorCompany=1. Basic College, Xinjiang Medical University, Urumqi 830011, China;2. Pharmacy, the Second Affiliated Hospital, Xinjiang Medical University, Urumqi 830063, China;3. Urumqi Center for Disease Control and Prevention, Urumqi 830002, China;4. Uyghur Medical College, Xinjiang Medical University, Urumqi 830011, China, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=JX4yv9b7uDwolkAQ75Tz1w==, pdfFileSize=882134, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1242130877287829520, articleId=1242130874242761269, tenantId=1146029695717560320, journalId=1146031591421210625, language=CN, title=信号转导通路与异常黑胆质证NEI网络功能紊乱的关系, columnId=1146540929516700224, journalTitle=科技导报, columnName=研究论文, runingTitle=null, highlight=null, articleAbstract=为探讨信号转导通路与异常黑胆质证神经-内分泌-免疫(NEI)网络功能紊乱的关系,采用基因芯片技术检测异常黑胆质证与非异常黑胆质(异常血液质、异常黏液质、异常胆液质)证白细胞结构基因表达水平,筛选差异表达基因,利用生物信息学技术分析差异表达基因参与的相关信号转导通路。芯片结果提示,与非异常黑胆质证相比,异常黑胆质证白细胞中有75个结构基因表达上调,生物信息学分析显示差异表达基因中富集到信号转导生物学过程的基因有12个,这些基因主要涉及MAPK、Toll样受体和Wnt信号转导通路等。由此可见,MAPK、Toll样受体、Wnt信号转导通路在异常黑胆质证患者体内存在异常激活现象,这可能与异常黑胆质证神经-内分泌-免疫网络功能紊乱密切相关。, authors=黄静静¹, 李春燕¹, 库热西·玉努斯¹, 阿衣古丽·玉努斯², 帕丽旦·麦麦提¹, 努尔比亚·吾布³, 刘文先⁴, 哈木拉提·吾甫尔⁴, authorsList=黄静静;李春燕;库热西·玉努斯;阿衣古丽·玉努斯;帕丽旦·麦麦提;努尔比亚·吾布;刘文先;哈木拉提·吾甫尔, authorCompany=1. 新疆医科大学基础医学院, 乌鲁木齐 830011;2. 新疆医科大学第二附属医院药剂科, 乌鲁木齐 830063;3. 乌鲁木齐市疾病预防控制中心, 乌鲁木齐 830002;4. 新疆医科大学维吾尔医学院, 乌鲁木齐 830011, correspAuthors=null, authorNote=null, correspAuthorsNote=哈木拉提·吾甫尔,教授,研究方向为复杂性疾病的中维西医研究,电子信箱:halmurat@263.net, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=QCYomhPru5UvmmUmaeX0Jg==, pdfFileSize=882134, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, 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