Article(id=1242128632668291863, tenantId=1146029695717560320, journalId=1146031591421210625, issueId=1242128626758521850, articleNumber=null, orderNo=null, doi=10.3981/j.issn.1000-7857.2012.08.002, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1325001600000, receivedDateStr=2011-12-28, revisedDate=1330358400000, revisedDateStr=2012-02-28, acceptedDate=null, acceptedDateStr=null, onlineDate=1332000000000, onlineDateStr=2012-03-18, pubDate=1332000000000, pubDateStr=2012-03-18, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1332000000000, onlineIssueDateStr=2012-03-18, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1774076143659, creator=sys-migrate, updateTime=1774076143659, updator=sys-migrate, issue=Issue{id=1242128626758521850, tenantId=1146029695717560320, journalId=1146031591421210625, year='2012', volume='30', issue='8', pageStart='3', pageEnd='95', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=3, issueType=-1, specialIssue=null, createTime=1774076142250, creator=sys-migrate, updateTime=1774076142250, updator=sys-migrate, preIssue=null, nextIssue=null, ext=null, issueFiles=null}, startPage=25, endPage=29, ext={EN=ArticleExt(id=1242128635885326369, articleId=1242128632668291863, tenantId=1146029695717560320, journalId=1146031591421210625, language=EN, title=Serum Metabonomics Research on Shenxu-tanyu Syndrome Type 2 Diabetes Mellitus Based on NMR, columnId=1242116080374710456, journalTitle=Science & Technology Review, columnName=Articles, runingTitle=null, highlight=null, articleAbstract=To explore the metabolic variation and pathogenesis of type 2 diabetes mellitus of Shenxu-tanyu syndrome in Traditional Chinese Medicine (TCM) by using Nuclear Magnetic Resonance (NMR). Serum samples from 33 cases of Shenxu-tanyu syndrome type 2 diabetes mellitus patients and 50 cases of healthy people are detected and described with 1H-NMR based metabonomics, and than the data is analyzed by Orthogonal Partial Least Squares-Discriminant Analysis (OPLS-DA). The results show that comparing with the healthy people, the various kinds of amino acids of Shenxu-tanyu syndrome type 2 diabetes mellitus patients are markedly lower, including isoleucine, leucine, valine, alanine, glutamate, histidine, tyrosine, phenylalanine, and 1-methylhistidine, the differences are statistically significant (P<0.05). In addition, lactate, citrate, creatine and creatinine are also markedly lower (P<0.05). However, the α-glucose and β-glucose are increased comparing with the health people (P<0.05). It is concluded that the metabolites of shenxu-tanyu syndrome type 2 diabetics are significantly different from healthy people, their tricarboxylic acid cycle and glycolysis are inhibited, protein is metabolic disorder, and branched chain amino acid is metabolic boost., correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=IY+xaItXSxTEvreLwEC3Pw==, pdfFileSize=1302542, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, authorCompany=1. College of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi 830054, China;2. College of Pharmacy, Xinjiang Medical University, Urumqi 830054, China, fund=null, authors=YOU Li¹, MAMTIMIN Batur², UPUR Halmurat², authorsList=YOU Li;MAMTIMIN Batur;UPUR Halmurat), CN=ArticleExt(id=1242128634937410338, articleId=1242128632668291863, tenantId=1146029695717560320, journalId=1146031591421210625, language=CN, title=基于核磁共振的肾虚痰瘀型2型糖尿病患者血清代谢组学研究, columnId=1146540929516700224, journalTitle=科技导报, columnName=研究论文, runingTitle=null, highlight=null, articleAbstract=利用核磁共振技术(Nuclear Magnetic Resonance,NMR)探讨肾虚痰瘀型2型糖尿病患者的血清代谢变化及发生机制。对33例肾虚痰瘀型2型糖尿病患者和50例健康人血清进行核磁共振氢谱检测,通过分段积分后运用正交偏最小二乘判别(OPLS-DA)分析所采集的图谱。结果显示,肾虚痰瘀型2型糖尿病患者与健康人相比血清中多种氨基酸显著降低,包括异亮氨酸、亮氨酸、缬氨酸、丙氨酸、谷氨酸、组氨酸、酪氨酸、苯丙氨酸、1-甲基组氨酸,差异有统计学意义(P<0.05)。此外,乳酸、柠檬酸、肌酸及肌酸酐也较健康人显著降低,差异有统计学意义(P<0.05)。同时,肾虚痰瘀型2型糖尿病患者血清中α-葡萄糖及β-葡萄糖较健康人增加,差异有统计学意义(P<0.05)。由此得出结论,肾虚痰瘀型2型糖尿病患者代谢成分与健康人存在显著差异,肾虚痰瘀型2型糖尿病患者体内的三羧酸循环及糖酵解途径被抑制,蛋白质代谢异常,支链氨基酸代谢增强。, correspAuthors=null, authorNote=null, correspAuthorsNote=哈木拉提·吾甫尔(中国科协所属全国学会个人会员登记号:S253002398M),教授,研究方向为新疆重大疾病的中维医干预,电子信箱:halmurat@263.net, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=f6ldtTi2oJ9pm9ZfiA/yCQ==, pdfFileSize=1302542, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, authorCompany=1. 新疆医科大学中医学院,乌鲁木齐 830054;2. 新疆医科大学药学院,乌鲁木齐 830054, fund=null, authors=尤丽¹, 巴吐尔·买买提明², 哈木拉提·吾甫尔², authorsList=尤丽;巴吐尔·买买提明;哈木拉提·吾甫尔)}, authors=null, keywords=[Keyword(id=1242128634576700190, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242128632668291863, language=CN, orderNo=1, keyword=肾虚痰瘀), Keyword(id=1242128634652197663, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242128632668291863, language=CN, orderNo=1, keyword=2型糖尿病), 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