Article(id=1309635231376834908, tenantId=1146029695717560320, journalId=1227999776411738115, issueId=1309635220643607372, articleNumber=null, orderNo=null, doi=10.12048/j.issn.1674-229X.2026.02.011, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1743955200000, receivedDateStr=2025-04-07, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1790170971006, onlineDateStr=2026-09-23, pubDate=1771948800000, pubDateStr=2026-02-25, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1790170971006, onlineIssueDateStr=2026-09-23, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1790170971006, creator=13701087609, updateTime=1790170971006, updator=13701087609, issue=Issue{id=1309635220643607372, tenantId=1146029695717560320, journalId=1227999776411738115, year='2026', volume='36', issue='2', pageStart='81', pageEnd='160', issueExtLink='null', onlineDate='null', pubDate='1771948800000', pubDateStr='2026-02-25', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1790170968446, creator='13701087609', updateTime=1790219084169, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1309837032671772868, tenantId=1146029695717560320, journalId=1227999776411738115, issueId=1309635220643607372, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1309837032671772869, tenantId=1146029695717560320, journalId=1227999776411738115, issueId=1309635220643607372, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=147, endPage=153, ext={EN=ArticleExt(id=1309635231594938717, articleId=1309635231376834908, tenantId=1146029695717560320, journalId=1227999776411738115, language=EN, title=Clinical Research Progress of Semaglutide, columnId=null, journalTitle=Pharmacy Today, columnName=null, runingTitle=null, highlight=null, articleAbstract=

Semaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, is widely used to treat diabetes mellitus, obesity, and cardiovascular diseases. By activating the GLP-1 receptor, semaglutide enhances insulin secretion and inhibits glucagon release, effectively lowering blood glucose levels. Additionally, semaglutide has multiple beneficial effects, including weight loss and improvement of cardiovascular diseases, and has demonstrated potential in treating conditions such as non-alcoholic fatty liver disease and polycystic ovary syndrome. Semaglutide exhibits significant efficacy in patients with type 2 diabetes mellitus and high safety profile when used in combination with other medications in these patients, underscoring its broad clinical applicability. This article aims to review the mechanisms of action of semaglutide and its clinical research progress in the treatment of diabetes mellitus, cardiovascular diseases, and obesity, exploring its clinical application potential and future prospects.

, authors=Yikai CHEN^1a, Zhiqi LUO^1b, Wenjiao WU², Siyu ZENG², Zhongze LI², Hongai WANG^{2, *}, authorsList=Yikai CHEN, Zhiqi LUO, Wenjiao WU, Siyu ZENG, Zhongze LI, Hongai WANG, authorCompany=null, correspAuthors=Hongai WANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1309635232031146334, articleId=1309635231376834908, tenantId=1146029695717560320, journalId=1227999776411738115, language=CN, title=司美格鲁肽的临床应用与研究现状, columnId=1228268593092162252, journalTitle=今日药学, columnName=药学进展, runingTitle=null, highlight=null, articleAbstract=

司美格鲁肽（Semaglutide）作为一种胰高血糖素样肽-1（glucagon-like peptide-1, GLP-1）受体激动剂，广泛用于治疗糖尿病、肥胖症及心血管疾病。通过激活GLP-1受体，增强胰岛素分泌，抑制胰高糖素分泌，从而有效降低血糖。此外，司美格鲁肽还具有减重、改善心血管疾病等多重作用，在非酒精性脂肪性肝病和多囊卵巢综合征等疾病中也显示出潜力。司美格鲁肽对2型糖尿病患者疗效显著，在临床上与其他药物联合使用时安全性高，具有较广泛的应用前景。本文旨在综述司美格鲁肽的作用机制及其在糖尿病、心血管疾病、肥胖症治疗等的临床研究进展，探索司美格鲁肽的临床应用潜力及未来前景。

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