Article(id=1309634779117609594, tenantId=1146029695717560320, journalId=1227999776411738115, issueId=1309634747681304819, articleNumber=null, orderNo=null, doi=10.12048/j.issn.1674-229X.2026.01.011, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1742400000000, receivedDateStr=2025-03-20, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1790170863179, onlineDateStr=2026-09-23, pubDate=1769270400000, pubDateStr=2026-01-25, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1790170863179, onlineIssueDateStr=2026-09-23, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1790170863179, creator=13701087609, updateTime=1790170863179, updator=13701087609, issue=Issue{id=1309634747681304819, tenantId=1146029695717560320, journalId=1227999776411738115, year='2026', volume='36', issue='1', pageStart='1', pageEnd='80', issueExtLink='null', onlineDate='null', pubDate='1769270400000', pubDateStr='2026-01-25', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1790170855683, creator='13701087609', updateTime=1790219109143, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1309837137445482891, tenantId=1146029695717560320, journalId=1227999776411738115, issueId=1309634747681304819, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1309837137445482892, tenantId=1146029695717560320, journalId=1227999776411738115, issueId=1309634747681304819, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=59, endPage=66, ext={EN=ArticleExt(id=1309634779281187453, articleId=1309634779117609594, tenantId=1146029695717560320, journalId=1227999776411738115, language=EN, title=Pharmacological Properties of 18β-Glycyrrhetinic Acid and Its Research Progress in Skin Diseases, columnId=null, journalTitle=Pharmacy Today, columnName=null, runingTitle=null, highlight=null, articleAbstract=

18β-Glycyrrhetinic Acid, a naturally occurring active compound extracted from licorice, has recently garnered significant attention in the field of dermatological research. The pathophysiology of skin diseases is often highly complex, involving pathological processes such as inflammatory responses, oxidative stress, and cellular damage, which can severely impact patients' quality of life. Despite the availability of various treatment options, some medications are hampered by significant side effects or insufficient efficacy, highlighting the need for the development of safe and effective natural natural drugs. 18β-Glycyrrhetinic Acid stands out due to its remarkable pharmacological properties, including anti-inflammatory, antioxidant, wound-healing, and antitumor effects. Its ability to alleviate or improve symptoms of skin diseases through multiple mechanisms has led to widespread recognition of its biological activity and therapeutic potential. This review aims to summarize the research advancements on 18β-Glycyrrhetinic Acid in skin diseases, analyze its mechanisms of action, and discuss its clinical clinical prospects, thereby providing a scientific basis for future investigations and applications.

, authors=Ying XIE1, Hankun CHEN2, Ying LIN3, Wei ZHU1, *, authorsList=Ying XIE, Hankun CHEN, Ying LIN, Wei ZHU, authorCompany=null, correspAuthors=Wei ZHU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1309634779562205822, articleId=1309634779117609594, tenantId=1146029695717560320, journalId=1227999776411738115, language=CN, title=18β-甘草次酸的药理特性及在皮肤疾病中的研究进展, columnId=1228268593092162252, journalTitle=今日药学, columnName=药学进展, runingTitle=null, highlight=null, articleAbstract=

18β-甘草次酸(18β-Glycyrrhetinic Acid)是一种从甘草中提取的天然活性化合物,近期在皮肤相关疾病研究中备受关注。皮肤疾病的发病机制复杂,常伴随炎症反应、氧化应激及细胞损伤等病理过程,严重影响患者生活质量。尽管现有治疗手段丰富,但部分药物因副作用大或疗效有限而无法满足临床需求,开发安全高效的天然药物已成为研究热点。18β-甘草次酸具有显著的抗炎、抗氧化、促进伤口愈合和抗肿瘤等药理作用,能够通过多种机制改善皮肤疾病的症状,其生物活性及治疗潜力得到广泛认可。本文旨在综述18β-甘草次酸在皮肤疾病中的研究进展,分析其作用机制和临床应用前景,为未来的研究和应用提供科学依据。

, authors=谢英1, 陈汉坤2, 林颖3, 朱伟1, *, authorsList=谢英, 陈汉坤, 林颖, 朱伟, authorCompany=null, correspAuthors=朱伟, authorNote=

谢英,博士,研究方向:中药物质基础研究

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*

朱伟,研究员,研究方向:中药物质基础研究,E-mail:
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谢英,博士,研究方向:中药物质基础研究

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谢英,博士,研究方向:中药物质基础研究

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18β-甘草次酸的药理特性及在皮肤疾病中的研究进展
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谢英 1 , 陈汉坤 2 , 林颖 3 , 朱伟 1, *
今日药学 | 药学进展 2026,36(1): 59-66
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今日药学 |药学进展 2026 , 36 (1) : 59 -66
18β-甘草次酸的药理特性及在皮肤疾病中的研究进展
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谢英1, 陈汉坤2, 林颖3, 朱伟1, *
作者信息
  • 1.广州中医药大学第二临床医学院,广东 广州 510006
  • 2.广州青岚生物科技有限公司,广东 广州 515000
  • 3.广东省中医院,广东 广州 510006
通讯作者:

*

朱伟,研究员,研究方向:中药物质基础研究,E-mail:
作者简介:

谢英,博士,研究方向:中药物质基础研究

Pharmacological Properties of 18β-Glycyrrhetinic Acid and Its Research Progress in Skin Diseases
Ying XIE1, Hankun CHEN2, Ying LIN3, Wei ZHU1, *
Affiliations
  • 1.The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510006, China
  • 2.Guangzhou Qinglan Biotechnology Co., Ltd., Guangzhou, Guangdong 515000, China
  • 3.Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou, Guangdong 510006, China
出版时间: 2026-01-25 doi: 10.12048/j.issn.1674-229X.2026.01.011
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18β-甘草次酸(18β-Glycyrrhetinic Acid)是一种从甘草中提取的天然活性化合物,近期在皮肤相关疾病研究中备受关注。皮肤疾病的发病机制复杂,常伴随炎症反应、氧化应激及细胞损伤等病理过程,严重影响患者生活质量。尽管现有治疗手段丰富,但部分药物因副作用大或疗效有限而无法满足临床需求,开发安全高效的天然药物已成为研究热点。18β-甘草次酸具有显著的抗炎、抗氧化、促进伤口愈合和抗肿瘤等药理作用,能够通过多种机制改善皮肤疾病的症状,其生物活性及治疗潜力得到广泛认可。本文旨在综述18β-甘草次酸在皮肤疾病中的研究进展,分析其作用机制和临床应用前景,为未来的研究和应用提供科学依据。

18β-甘草次酸  /  皮肤疾病  /  药理作用  /  抗炎  /  抗氧化

18β-Glycyrrhetinic Acid, a naturally occurring active compound extracted from licorice, has recently garnered significant attention in the field of dermatological research. The pathophysiology of skin diseases is often highly complex, involving pathological processes such as inflammatory responses, oxidative stress, and cellular damage, which can severely impact patients' quality of life. Despite the availability of various treatment options, some medications are hampered by significant side effects or insufficient efficacy, highlighting the need for the development of safe and effective natural natural drugs. 18β-Glycyrrhetinic Acid stands out due to its remarkable pharmacological properties, including anti-inflammatory, antioxidant, wound-healing, and antitumor effects. Its ability to alleviate or improve symptoms of skin diseases through multiple mechanisms has led to widespread recognition of its biological activity and therapeutic potential. This review aims to summarize the research advancements on 18β-Glycyrrhetinic Acid in skin diseases, analyze its mechanisms of action, and discuss its clinical clinical prospects, thereby providing a scientific basis for future investigations and applications.

18β-Glycyrrhetinic Acid  /  skin diseases  /  pharmacological effects  /  anti-inflammatory  /  antioxidant
谢英, 陈汉坤, 林颖, 朱伟. 18β-甘草次酸的药理特性及在皮肤疾病中的研究进展. 今日药学, 2026 , 36 (1) : 59 -66 . DOI: 10.12048/j.issn.1674-229X.2026.01.011
Ying XIE, Hankun CHEN, Ying LIN, Wei ZHU. Pharmacological Properties of 18β-Glycyrrhetinic Acid and Its Research Progress in Skin Diseases[J]. Pharmacy Today, 2026 , 36 (1) : 59 -66 . DOI: 10.12048/j.issn.1674-229X.2026.01.011
  • 广东省中医药局中医药科研项目(20241142)
  • 广东省中医院中医药科学技术研究专项(YN2023MS23; YN2023MS44)
  • 广东省中医院拔尖人才项目(BJ2022YL08)
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2026年第36卷第1期
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doi: 10.12048/j.issn.1674-229X.2026.01.011
  • 接收时间:2025-03-20
  • 首发时间:2026-09-23
  • 出版时间:2026-01-25
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  • 收稿日期:2025-03-20
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广东省中医药局中医药科研项目(20241142)
广东省中医院中医药科学技术研究专项(YN2023MS23; YN2023MS44)
广东省中医院拔尖人才项目(BJ2022YL08)
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    1.广州中医药大学第二临床医学院,广东 广州 510006
    2.广州青岚生物科技有限公司,广东 广州 515000
    3.广东省中医院,广东 广州 510006

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朱伟,研究员,研究方向:中药物质基础研究,E-mail:
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2种不同金属材料的力学参数
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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