Article(id=1309634757877657931, tenantId=1146029695717560320, journalId=1227999776411738115, issueId=1309634747681304819, articleNumber=null, orderNo=null, doi=10.12048/j.issn.1674-229X.2026.01.009, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1737302400000, receivedDateStr=2025-01-20, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1790170858115, onlineDateStr=2026-09-23, pubDate=1769270400000, pubDateStr=2026-01-25, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1790170858115, onlineIssueDateStr=2026-09-23, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1790170858115, creator=13701087609, updateTime=1790170858115, updator=13701087609, issue=Issue{id=1309634747681304819, tenantId=1146029695717560320, journalId=1227999776411738115, year='2026', volume='36', issue='1', pageStart='1', pageEnd='80', issueExtLink='null', onlineDate='null', pubDate='1769270400000', pubDateStr='2026-01-25', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1790170855683, creator='13701087609', updateTime=1790219109143, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1309837137445482891, tenantId=1146029695717560320, journalId=1227999776411738115, issueId=1309634747681304819, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1309837137445482892, tenantId=1146029695717560320, journalId=1227999776411738115, issueId=1309634747681304819, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=49, endPage=52, ext={EN=ArticleExt(id=1309634758146093388, articleId=1309634757877657931, tenantId=1146029695717560320, journalId=1227999776411738115, language=EN, title=Relationship Between Serum Olanzapine Concentration and Metabolic Parameters in Patients: The Effect of Valproic Acid, columnId=null, journalTitle=Pharmacy Today, columnName=null, runingTitle=null, highlight=null, articleAbstract=
OBJECTIVE To investigate a potential relationship between metabolic parameters and steady-state serum concentration of olanzapine (OLA) in patients treated with OLA combined with or without VAL in patients with mental disorders.
METHODS A retrospective analysis was performed on 225 inpatients with mental disorders who received OLA monotherapy or OLA-VAL combination therapy. The serum concentration of OLA was measured, and fasting blood samples were analyzed for insulin, glucose, total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), and uric acid (UA). The effects of OLA serum concentration, with or without VAL, on the aforementioned parameters and the correlation with these parameters were investigated.
RESULTS VAL co-administration decreased OLA concentration and C/D ratio by 19.57% (P < 0.01) and 32.76%(P < 0.001), respectively.Patients taking OLA combined with VAL had higher weight (4.83%, P <0.01), BMI (4.07%, P < 0.05) and UA level (8.96%, P < 0.05), but lower glucose level (13.83%, P < 0.05), than those taking OLA alone. VAL co-administration had no significant effect on the levels of TC, HDL-c, LDL-c, TG and INS.The serum OLA concentration was negatively correlated with body weight in the OLA-VAL combination group (r =-0.199, P < 0.05), and there exists no correlation with other metabolic parameters.
CONCLUSION There is no correlation between the serum OLA concentration and glycolipid metabolic parameters in the OLA monotherapy group, however, a negative correlation is found between serum OLA concentration and body weight in the OLA-VAL combination group; meanwhile, significantly higher body weight, BMI and UA levels are observed in this group.
, authors=Shuhua DENG
1, Yongfeng LIU
2, Huanshan XIE
3, Jinqing HU
1, Chang QIU
1, Haoyang LU
1, Meixia LUO
1, Xiaojia NI
1, Dewei SHANG
1, Yuguan WEN
1, *, authorsList=Shuhua DENG, Yongfeng LIU, Huanshan XIE, Jinqing HU, Chang QIU, Haoyang LU, Meixia LUO, Xiaojia NI, Dewei SHANG, Yuguan WEN, authorCompany=null, correspAuthors=Yuguan WEN, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1309634758397751629, articleId=1309634757877657931, tenantId=1146029695717560320, journalId=1227999776411738115, language=CN, title=奥氮平血药浓度与精神障碍患者糖脂代谢指标的相关性研究：丙戊酸因素的影响, columnId=1228268588277105398, journalTitle=今日药学, columnName=临床药学, runingTitle=null, highlight=null, articleAbstract=
目的 探讨精神障碍患者联用与不联用丙戊酸（VAL）时，奥氮平（OLA）稳态血清浓度与糖脂代谢指标相关性。
方法 回顾性分析225例接受OLA或OLA合并VAL治疗的精神障碍住院患者。测定血清中OLA的浓度、空腹血中胰岛素（INS）、葡萄糖（GLU）、总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-c）、低密度脂蛋白胆固醇（LDL-c）及尿酸（UA）水平，探讨联用及不联用丙戊酸时，奥氮平浓度与上述代谢指标的相关性及对上述指标的影响。
结果 联用丙戊酸显著降低奥氮平浓度及C/D比值，分别降低19.57%（P < 0.01）及32.76%（P < 0.001），联用并丙戊酸显著增加患者体重、BMI及尿酸水平，分别为4.83%（P < 0.01）、4.07%（P < 0.05）及8.96%（P < 0.05），但空腹血糖水平偏低13.83%（P < 0.05），两组差异有统计学意义，奥氮平联用丙戊酸对TC、HDL-c、LDL-c、TG及INS水平无影响。联用丙戊酸组的奥氮平血药浓度与患者体重呈负相关，与其他指标不存在相关性。
结论 单独服用奥氮平浓度与患者糖脂代谢指标无相关性，但服用奥氮平联合丙戊酸的患者，其奥氮平浓度与体重存在负相关性，且体重及尿酸水平偏高。
, authors=邓书华
1, 刘永峰
2, 谢焕山
3, 胡晋卿
1, 邱畅
1, 卢浩扬
1, 罗美霞
1, 倪晓佳
1, 尚德为
1, 温预关
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3.the Third People's Hospital of Zhuhai, Zhuhai, Guangdong 519000, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1309634801712333798, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634757877657931, authorId=1309634801548755939, language=CN, stringName=谢焕山, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
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3．珠海市第三人民医院，广东 珠海 519000, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1309634800986719189, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634757877657931, xref=3., ext=[AuthorCompanyExt(id=1309634800990913494, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634757877657931, companyId=1309634800986719189, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
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1.the Affiliated Brain Hospital, Guangzhou Medical University, Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, Guangzhou Medical University, Guangzhou, Guangdong 510370, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1309634801905271787, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634757877657931, authorId=1309634801771054056, language=CN, stringName=胡晋卿, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
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1．广州医科大学附属脑科医院，广东省神经科学疾病研究重点实验室、神经致病基因和离子通道教育部重点实验室，广东 广州 510370, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1309634799225111503, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634757877657931, xref=1., ext=[AuthorCompanyExt(id=1309634799233500112, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634757877657931, companyId=1309634799225111503, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
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1．广州医科大学附属脑科医院，广东省神经科学疾病研究重点实验室、神经致病基因和离子通道教育部重点实验室，广东 广州 510370)])]), Author(id=1309634801972380653, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634757877657931, orderNo=4, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1309634802056266735, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634757877657931, authorId=1309634801972380653, language=EN, stringName=Chang QIU, firstName=Chang, middleName=null, lastName=QIU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
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1．广州医科大学附属脑科医院，广东省神经科学疾病研究重点实验室、神经致病基因和离子通道教育部重点实验室，广东 广州 510370)])]), Author(id=1309634802169512946, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634757877657931, orderNo=5, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1309634802253399028, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634757877657931, authorId=1309634802169512946, language=EN, stringName=Haoyang LU, firstName=Haoyang, middleName=null, lastName=LU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
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