Article(id=1309634754778063287, tenantId=1146029695717560320, journalId=1227999776411738115, issueId=1309634747681304819, articleNumber=null, orderNo=null, doi=10.12048/j.issn.1674-229X.2026.01.005, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1757260800000, receivedDateStr=2025-09-08, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1790170857375, onlineDateStr=2026-09-23, pubDate=1769270400000, pubDateStr=2026-01-25, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1790170857375, onlineIssueDateStr=2026-09-23, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1790170857375, creator=13701087609, updateTime=1790170857375, updator=13701087609, issue=Issue{id=1309634747681304819, tenantId=1146029695717560320, journalId=1227999776411738115, year='2026', volume='36', issue='1', pageStart='1', pageEnd='80', issueExtLink='null', onlineDate='null', pubDate='1769270400000', pubDateStr='2026-01-25', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1790170855683, creator='13701087609', updateTime=1790219109143, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1309837137445482891, tenantId=1146029695717560320, journalId=1227999776411738115, issueId=1309634747681304819, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1309837137445482892, tenantId=1146029695717560320, journalId=1227999776411738115, issueId=1309634747681304819, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=19, endPage=23, ext={EN=ArticleExt(id=1309634756594196920, articleId=1309634754778063287, tenantId=1146029695717560320, journalId=1227999776411738115, language=EN, title=The Fingerprint Chromatogram and Content Determination Method of Aquilaria Sinensis were Constructed Based on GC-MS, columnId=null, journalTitle=Pharmacy Today, columnName=null, runingTitle=null, highlight=null, articleAbstract=
OBJECTIVE

To establish a quality control method for Aquilaria sinensis and provide a basis for improving its quality standards.

METHODS

A fingerprint identification method for Aquilaria sinensis was established. The contents of 4-phenyl-2-butanone, 4-methoxyphenyl-2-butanone, and Nootkatone in Aquilaria sinensis were determined by GC-MS.

RESULTS

Reference fingerprint for Aquilaria sinensis was established. The similarity among 25 batches of samples ranged from 0.718 to 0.994. In the content determination, 4-phenyl-2-butanone, 4-methoxyphenyl-2-butanone, and Nootkatone showed good linear relationships within the concentration ranges of 0.14-11.58, 0.27-21.56, 0.65-52.14 µg·mL-1, respectively.The average recovery rates of the three components were 92.5% (n=9), 92.1% (n=9), and 90.2% (n=9).

CONCLUSION

The fingerprint chromatogram and the content determination methods of the three components established in this studyt can be used for multi-index quality evaluation of Aquilaria sinensis.

, authors=Lihai TANG, Weiwen LIN*, Yichun CHEN, Chenglong YI, authorsList=Lihai TANG, Weiwen LIN, Yichun CHEN, Chenglong YI, authorCompany=null, correspAuthors=Weiwen LIN, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1309634756883603897, articleId=1309634754778063287, tenantId=1146029695717560320, journalId=1227999776411738115, language=CN, title=基于GC-MS法构建莞香的指纹图谱和含量测定方法, columnId=1228268589086606089, journalTitle=今日药学, columnName=论著, runingTitle=null, highlight=null, articleAbstract=
目的

建立莞香的质量控制方法,为其质量标准提高提供依据。

方法

建立莞香指纹图谱鉴别方法,采用GC-MS法测定莞香中对4-苯基-2-丁酮、4-甲氧苯基-2-丁酮、诺卡酮含量。

结果

建立了莞香的对照指纹图谱,25批样品相似度为0.718 ~0.994。含量测定中4-苯基-2-丁酮、4-甲氧苯基-2-丁酮、诺卡酮分别在0.14 ~ 11.58、0.27 ~ 21.56和0.65 ~ 52.14 µg·mL-1浓度范围内线性关系良好;3个成分平均回收率分别为92.5%(n=9)、92.1%(n=9)、90.2%(n=9)。

结论

本实验建立的指纹图谱和3种成分的含量测定方法,可用于莞香的多指标质量评价。

, authors=唐立海, 林蔚文*, 陈奕纯, 易承龙, authorsList=唐立海, 林蔚文, 陈奕纯, 易承龙, authorCompany=null, correspAuthors=林蔚文, authorNote=

唐立海,博士,研究方向:中药检验

, correspAuthorsNote=

*

林蔚文,主管药师,研究方向:中药检验,E-mail:
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唐立海,博士,研究方向:中药检验

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唐立海,博士,研究方向:中药检验

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基于GC-MS法构建莞香的指纹图谱和含量测定方法
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唐立海 , 林蔚文 * , 陈奕纯 , 易承龙
今日药学 | 论著 2026,36(1): 19-23
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今日药学 |论著 2026 , 36 (1) : 19 -23
基于GC-MS法构建莞香的指纹图谱和含量测定方法
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唐立海, 林蔚文* , 陈奕纯, 易承龙
作者信息
  • 东莞市食品药品检验所,广东 东莞 523808
通讯作者:

*

林蔚文,主管药师,研究方向:中药检验,E-mail:
作者简介:

唐立海,博士,研究方向:中药检验

The Fingerprint Chromatogram and Content Determination Method of Aquilaria Sinensis were Constructed Based on GC-MS
Lihai TANG, Weiwen LIN* , Yichun CHEN, Chenglong YI
Affiliations
  • Dongguan Institute for Food and Drug Control, Dongguan, Guandong 523808, China
出版时间: 2026-01-25 doi: 10.12048/j.issn.1674-229X.2026.01.005
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目的

建立莞香的质量控制方法,为其质量标准提高提供依据。

方法

建立莞香指纹图谱鉴别方法,采用GC-MS法测定莞香中对4-苯基-2-丁酮、4-甲氧苯基-2-丁酮、诺卡酮含量。

结果

建立了莞香的对照指纹图谱,25批样品相似度为0.718 ~0.994。含量测定中4-苯基-2-丁酮、4-甲氧苯基-2-丁酮、诺卡酮分别在0.14 ~ 11.58、0.27 ~ 21.56和0.65 ~ 52.14 µg·mL-1浓度范围内线性关系良好;3个成分平均回收率分别为92.5%(n=9)、92.1%(n=9)、90.2%(n=9)。

结论

本实验建立的指纹图谱和3种成分的含量测定方法,可用于莞香的多指标质量评价。

莞香  /  指纹图谱  /  4-苯基-2-丁酮  /  4-甲氧苯基-2-丁酮  /  诺卡酮
OBJECTIVE

To establish a quality control method for Aquilaria sinensis and provide a basis for improving its quality standards.

METHODS

A fingerprint identification method for Aquilaria sinensis was established. The contents of 4-phenyl-2-butanone, 4-methoxyphenyl-2-butanone, and Nootkatone in Aquilaria sinensis were determined by GC-MS.

RESULTS

Reference fingerprint for Aquilaria sinensis was established. The similarity among 25 batches of samples ranged from 0.718 to 0.994. In the content determination, 4-phenyl-2-butanone, 4-methoxyphenyl-2-butanone, and Nootkatone showed good linear relationships within the concentration ranges of 0.14-11.58, 0.27-21.56, 0.65-52.14 µg·mL-1, respectively.The average recovery rates of the three components were 92.5% (n=9), 92.1% (n=9), and 90.2% (n=9).

CONCLUSION

The fingerprint chromatogram and the content determination methods of the three components established in this studyt can be used for multi-index quality evaluation of Aquilaria sinensis.

Aquilaria sinensis  /  fingerprint chromatogram  /  4-phenyl-2-butanone  /  4-methoxyphenyl-2-butanone  /  nootkatone
唐立海, 林蔚文, 陈奕纯, 易承龙. 基于GC-MS法构建莞香的指纹图谱和含量测定方法. 今日药学, 2026 , 36 (1) : 19 -23 . DOI: 10.12048/j.issn.1674-229X.2026.01.005
Lihai TANG, Weiwen LIN, Yichun CHEN, Chenglong YI. The Fingerprint Chromatogram and Content Determination Method of Aquilaria Sinensis were Constructed Based on GC-MS[J]. Pharmacy Today, 2026 , 36 (1) : 19 -23 . DOI: 10.12048/j.issn.1674-229X.2026.01.005
  • 东莞市社会发展科技项目(20211800904852)
  • 广东省药品监督管理局科技创新项目(2021ZDB05)
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文章信息
doi: 10.12048/j.issn.1674-229X.2026.01.005
  • 接收时间:2025-09-08
  • 首发时间:2026-09-23
  • 出版时间:2026-01-25
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出版历史
  • 收稿日期:2025-09-08
基金
东莞市社会发展科技项目(20211800904852)
广东省药品监督管理局科技创新项目(2021ZDB05)
作者信息
    东莞市食品药品检验所,广东 东莞 523808

通讯作者:

*

林蔚文,主管药师,研究方向:中药检验,E-mail:
参考文献
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https://castjournals.cast.org.cn/joweb/jryx/CN/10.12048/j.issn.1674-229X.2026.01.005
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2种不同金属材料的力学参数
科
Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)
属
Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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