Article(id=1309634753096151327, tenantId=1146029695717560320, journalId=1227999776411738115, issueId=1309634747681304819, articleNumber=null, orderNo=null, doi=10.12048/j.issn.1674-229X.2026.01.008, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1742745600000, receivedDateStr=2025-03-24, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1790170856974, onlineDateStr=2026-09-23, pubDate=1769270400000, pubDateStr=2026-01-25, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1790170856974, onlineIssueDateStr=2026-09-23, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1790170856974, creator=13701087609, updateTime=1790170856974, updator=13701087609, issue=Issue{id=1309634747681304819, tenantId=1146029695717560320, journalId=1227999776411738115, year='2026', volume='36', issue='1', pageStart='1', pageEnd='80', issueExtLink='null', onlineDate='null', pubDate='1769270400000', pubDateStr='2026-01-25', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1790170855683, creator='13701087609', updateTime=1790219109143, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1309837137445482891, tenantId=1146029695717560320, journalId=1227999776411738115, issueId=1309634747681304819, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1309837137445482892, tenantId=1146029695717560320, journalId=1227999776411738115, issueId=1309634747681304819, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=41, endPage=48, ext={EN=ArticleExt(id=1309634753247146272, articleId=1309634753096151327, tenantId=1146029695717560320, journalId=1227999776411738115, language=EN, title=Comparative Effectiveness and Safety of Edaravone Dexborneol Versus Edaravone in Acute Ischemic Stroke: Meta Analysis, columnId=null, journalTitle=Pharmacy Today, columnName=null, runingTitle=null, highlight=null, articleAbstract=
OBJECTIVE To compare the efficacy and safety differences between edaravone dexborneol and edaravone in Acute ischemic stroke (AIS).
METHODS Randomized controlled trials (RCTs) of edaravone dexborneol versus edaravone in the treatment of AIS were identified by systematically searching PubMed, Embase, Cochrane Library, CNKI, VIP Database, Wanfang Data, and SinoMed. The risk of bias of included studies was assessed according to the Cochrane bias risk assessment tool, and meta-analysis was performed using R 4.4.1 and RevMan 5.3. The efficacy outcomes included changes from baseline in the National Institutes of Health Stroke Scale (NIHSS) scores, the Modified Rankin Scale (mRS) scores, the Barthel Index (BI), and clinical response rate at 14 days post-treatment. Adverse reactions occurring during treatment were considered as safety indicators.
RESULTS A total of 19 studies involving 2 885 patients were ultimately included. After 14 days of treatment, compared with the edaravone group, the edaravone dexborneol group was more effective in improving the clinical response rate [RR =1.22, 95%CI =1.13-1.33, P < 0.000 1] and the BI [MD =10.60, 95%CI =8.12-13.07, P < 0.000 1], and in reducing the NIHSS [MD =-1.92, 95%CI = -2.61-1.23, P < 0.000 1] and mRS [MD = 1.69, 95%CI = -2.49--0.90, P < 0.000 1]. In terms of safety, edaravone dexborneol group had a lower incidence of adverse reactions during the treatment period than the edaravone group [RR =0.47, 95%CI =0.33-0.69, P < 0.000 1].
CONCLUSION Edaravone dexborneol group exhibited superior efficacy and safety compared with edaravone group in the treatment of AIS.
, authors=Weidan ZHONG
1, 2, Ke ZHONG
1, Zhichao HE
1, Jianhong ZHU
1, Junyan WU
1, *, authorsList=Weidan ZHONG, Ke ZHONG, Zhichao HE, Jianhong ZHU, Junyan WU, authorCompany=null, correspAuthors=Junyan WU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1309634753561719073, articleId=1309634753096151327, tenantId=1146029695717560320, journalId=1227999776411738115, language=CN, title=依达拉奉与依达拉奉右莰醇治疗急性缺血性脑卒中的疗效与安全性比较：Meta分析, columnId=1228268588277105398, journalTitle=今日药学, columnName=临床药学, runingTitle=null, highlight=null, articleAbstract=
目的 比较依达拉奉与依达拉奉右莰醇治疗急性缺血性脑卒中（Acute ischemic stroke, AIS）的疗效及安全性差异。
方法 通过检索Pubmed、Embase、Cochrance、知网、维普、万方及SinoMed七大中英文数据库，收集依达拉奉右莰醇对比依达拉奉治疗AIS的随机对照试验（Randomized clinical trials, RCTs）。采用Cochrance风险偏倚评估工具对纳入文献进行质量评价，采用R 4.4.1和RevMan 5.3进行Meta分析。以治疗14 d后，美国国立卫生研究院卒中量表（NIHSS）评分、改良Rankin（mRS）评分、Barthel（BI）指数较基线变化以及临床有效率作为有效性结局指标；以治疗期间发生的不良反应作为安全性结局指标。
结果 共纳入19项研究，共涉及2 885例患者。在治疗14 d后，与依达拉奉组比，依达拉奉右莰醇组在提高临床有效率［RR=1.22，95%CI = 1.13 ~ 1.33，P < 0.000 1］和BI指数［MD=10.60，95%CI=8.12 ~ 13.07，P < 0.000 1］方面，在降低NIHSS评分［MD=-1.92，95%CI= -2.61 ~ -1.23，P < 0.000 1］和mRS评分［MD=-1.69，95%CI=-2.49 ~ -0.90，P < 0.000 1］方面显示出更优的疗效。安全性分析结果显示，依达拉奉右莰醇组在治疗期间不良反应发生率低于依达拉奉组［RR=0.47，95%CI=0.33 ~ 0.69，P < 0.000 1］。
结论 依达拉奉右莰醇组在治疗AIS中的疗效和安全性上均优于依达拉奉组。
, authors=钟伟丹
1, 2, 钟科
1, 何志超
1, 朱建红
1, 伍俊妍
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1.Department of Pharmacy, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong 510120, China
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