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Article(id=1309634644086186237, tenantId=1146029695717560320, journalId=1227999776411738115, issueId=1309634614356968036, articleNumber=null, orderNo=null, doi=10.12048/j.issn.1674-229X.2026.03.011, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1744560000000, receivedDateStr=2025-04-14, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1790170830985, onlineDateStr=2026-09-23, pubDate=1774368000000, pubDateStr=2026-03-25, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1790170830985, onlineIssueDateStr=2026-09-23, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1790170830985, creator=13701087609, updateTime=1790170830985, updator=13701087609, issue=Issue{id=1309634614356968036, tenantId=1146029695717560320, journalId=1227999776411738115, year='2026', volume='36', issue='3', pageStart='161', pageEnd='240', issueExtLink='null', onlineDate='null', pubDate='1774368000000', pubDateStr='2026-03-25', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1790170823897, creator='13701087609', updateTime=1790219059643, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1309836929789682362, tenantId=1146029695717560320, journalId=1227999776411738115, issueId=1309634614356968036, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1309836929789682363, tenantId=1146029695717560320, journalId=1227999776411738115, issueId=1309634614356968036, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=224, endPage=228, ext={EN=ArticleExt(id=1309634644908269823, articleId=1309634644086186237, tenantId=1146029695717560320, journalId=1227999776411738115, language=EN, title=Efficacy of Sintilimab and Bevacizumab Combined with HAIC in the Treatment of Late-stage Hepatocellular Carcinoma and Their Impact on Macrophages, columnId=null, journalTitle=Pharmacy Today, columnName=null, runingTitle=null, highlight=null, articleAbstract=
OBJECTIVE

To evaluate the efficacy of sintilimab plus bevacizumab combined with hepatic arterial infusion chemotherapy (HAIC) for advanced hepatocellular carcinoma (HCC) and explore their effects of this combined regimen on macrophage function and phenotype.

METHODS

Patients with advanced HCC admitted to a hospital from September 2022 to May 2024 were prospectively selected and randomly divided into a control group and an observation group, with 50 cases in each group.The control group received HAIC alone, while the observation group received HAIC combined with sintilimab and bevacizumab. The differences in short-term clinical efficacy, functional indices, and adverse reactions between the two groups were compared.A 6-month follow-up was conducted on patients in both groups after the end of treatment to evaluate long-term efficacy.

RESULTS

After treatment, the observation group exhibited higher disease control rate (DCR), objective response rate (ORR), median progression-free survival (PFS), mean overall survival (OS), macrophage count, proportion of anti-tumor phenotype (M1 type) macrophages, and counts of CD3+, CD4+, and CD8+ T lymphocytes compared to the control group (all P < 0.05). The observation group also showed lower levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBIL), proportion of immunosuppressive phenotype (M2 type) macrophages, and interleukin-6 (all P < 0.05). The incidence of adverse reactions was lower in the observation group, though the difference was not statistically significant (all P > 0.05).

CONCLUSION

The combination of sintilimab and bevacizumab with HAIC in the treatment of advanced hepatocellular carcinoma can effectively improve short-term and long-term clinical efficacy, improve liver function, regulate macrophage function and phenotype, and enhance the cellular immune function of patients.

, authors=Chunhua HUANG1, Yuping LI2, Jinlong LI1, Lin LI1, Jingke ZENG1, Jianmin YE1, Xiaohuan LAI1, Guanlin ZHOU1, Changhong LIU1, *, authorsList=Chunhua HUANG, Yuping LI, Jinlong LI, Lin LI, Jingke ZENG, Jianmin YE, Xiaohuan LAI, Guanlin ZHOU, Changhong LIU, authorCompany=null, correspAuthors=Changhong LIU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1309634645440946432, articleId=1309634644086186237, tenantId=1146029695717560320, journalId=1227999776411738115, language=CN, title=信迪利单抗及贝伐珠单抗联合HAIC治疗晚期肝癌的疗效及其对巨噬细胞的影响研究, columnId=1228268588277105398, journalTitle=今日药学, columnName=临床药学, runingTitle=null, highlight=null, articleAbstract=
目的

评估信迪利单抗及贝伐珠单抗联合肝动脉灌注化疗（HAIC）治疗晚期肝细胞癌（HCC）的疗效，并探讨其对巨噬细胞功能及表型的影响。

方法

前瞻性选取2022年9月~2024年5月某院收治的晚期HCC患者，随机分为对照组和观察组，各50例。对照组予以单一HAIC治疗，观察组在对照组基础上联合信迪利单抗及贝伐珠单抗治疗。比较两组近期临床疗效、功能指标及不良反应的差异。对两组患者于疗程结束后行6个月的随访，以评估远期疗效。

结果

治疗后，观察组的疾病控制率、客观缓解率、平均无进展生存期、平均总生存期、巨噬细胞数量及抗肿瘤表型（M1型）比例、CD3+、CD4+及CD8+的T淋巴细胞数量均高于对照组（均P < 0.05）；观察组谷丙转氨酶、谷草转氨酶、总胆红素、巨噬细胞免疫抑制表型（M2型）比例及白细胞介素-6水平均低于对照组（均P < 0.05）；不良反应发生率低于对照组（P > 0.05）。

结论

信迪利单抗及贝伐珠单抗联合HAIC治疗晚期HCC，能够有效提高近远期临床疗效，改善肝功能，调节巨噬细胞功能及表型，增强患者的细胞免疫功能。

, authors=黄春华1, 李育平2, 李金垄1, 李林1, 曾敬科1, 叶建敏1, 赖小欢1, 周观林1, 刘长虹1, *, authorsList=黄春华, 李育平, 李金垄, 李林, 曾敬科, 叶建敏, 赖小欢, 周观林, 刘长虹, authorCompany=null, correspAuthors=刘长虹, authorNote=

黄春华，主治医师，研究方向：肝癌治疗

, correspAuthorsNote=

*

刘长虹，主治医师，研究方向：肝癌治疗，E-mail:
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信迪利单抗及贝伐珠单抗联合HAIC治疗晚期肝癌的疗效及其对巨噬细胞的影响研究
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黄春华 1 , 李育平 2 , 李金垄 1 , 李林 1 , 曾敬科 1 , 叶建敏 1 , 赖小欢 1 , 周观林 1 , 刘长虹 1, *
今日药学 | 临床药学 2026,36(3): 224-228
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今日药学 |临床药学 2026 , 36 (3) : 224 -228
信迪利单抗及贝伐珠单抗联合HAIC治疗晚期肝癌的疗效及其对巨噬细胞的影响研究
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黄春华1, 李育平2, 李金垄1, 李林1, 曾敬科1, 叶建敏1, 赖小欢1, 周观林1, 刘长虹1, *
作者信息
  • 1．江西省赣州市第五人民医院，赣州市肝病研究所，江西 赣州 341000
  • 2．赣州市全南县人民医院，江西 赣州 341800
通讯作者:

*

刘长虹，主治医师，研究方向：肝癌治疗，E-mail:
作者简介:

黄春华，主治医师，研究方向：肝癌治疗

Efficacy of Sintilimab and Bevacizumab Combined with HAIC in the Treatment of Late-stage Hepatocellular Carcinoma and Their Impact on Macrophages
Chunhua HUANG1, Yuping LI2, Jinlong LI1, Lin LI1, Jingke ZENG1, Jianmin YE1, Xiaohuan LAI1, Guanlin ZHOU1, Changhong LIU1, *
Affiliations
  • 1.Ganzhou Fifth People's Hospital Ganzhou Liver Disease Research Institute, Ganzhou, Jiangxi 341000, China
  • 2.Quannan County People's Hospital in Ganzhou City, Ganzhou, Jiangxi 341800, China
出版时间: 2026-03-25 doi: 10.12048/j.issn.1674-229X.2026.03.011
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摘要
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目的

评估信迪利单抗及贝伐珠单抗联合肝动脉灌注化疗（HAIC）治疗晚期肝细胞癌（HCC）的疗效，并探讨其对巨噬细胞功能及表型的影响。

方法

前瞻性选取2022年9月~2024年5月某院收治的晚期HCC患者，随机分为对照组和观察组，各50例。对照组予以单一HAIC治疗，观察组在对照组基础上联合信迪利单抗及贝伐珠单抗治疗。比较两组近期临床疗效、功能指标及不良反应的差异。对两组患者于疗程结束后行6个月的随访，以评估远期疗效。

结果

治疗后，观察组的疾病控制率、客观缓解率、平均无进展生存期、平均总生存期、巨噬细胞数量及抗肿瘤表型（M1型）比例、CD3+、CD4+及CD8+的T淋巴细胞数量均高于对照组（均P < 0.05）；观察组谷丙转氨酶、谷草转氨酶、总胆红素、巨噬细胞免疫抑制表型（M2型）比例及白细胞介素-6水平均低于对照组（均P < 0.05）；不良反应发生率低于对照组（P > 0.05）。

结论

信迪利单抗及贝伐珠单抗联合HAIC治疗晚期HCC，能够有效提高近远期临床疗效，改善肝功能，调节巨噬细胞功能及表型，增强患者的细胞免疫功能。

肝动脉灌注化疗  /  信迪利单抗  /  贝伐珠单抗  /  肝细胞癌  /  疗效  /  巨噬细胞
OBJECTIVE

To evaluate the efficacy of sintilimab plus bevacizumab combined with hepatic arterial infusion chemotherapy (HAIC) for advanced hepatocellular carcinoma (HCC) and explore their effects of this combined regimen on macrophage function and phenotype.

METHODS

Patients with advanced HCC admitted to a hospital from September 2022 to May 2024 were prospectively selected and randomly divided into a control group and an observation group, with 50 cases in each group.The control group received HAIC alone, while the observation group received HAIC combined with sintilimab and bevacizumab. The differences in short-term clinical efficacy, functional indices, and adverse reactions between the two groups were compared.A 6-month follow-up was conducted on patients in both groups after the end of treatment to evaluate long-term efficacy.

RESULTS

After treatment, the observation group exhibited higher disease control rate (DCR), objective response rate (ORR), median progression-free survival (PFS), mean overall survival (OS), macrophage count, proportion of anti-tumor phenotype (M1 type) macrophages, and counts of CD3+, CD4+, and CD8+ T lymphocytes compared to the control group (all P < 0.05). The observation group also showed lower levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBIL), proportion of immunosuppressive phenotype (M2 type) macrophages, and interleukin-6 (all P < 0.05). The incidence of adverse reactions was lower in the observation group, though the difference was not statistically significant (all P > 0.05).

CONCLUSION

The combination of sintilimab and bevacizumab with HAIC in the treatment of advanced hepatocellular carcinoma can effectively improve short-term and long-term clinical efficacy, improve liver function, regulate macrophage function and phenotype, and enhance the cellular immune function of patients.

hepatic arterial infusion chemotherapy (HAIC)  /  sintilimab  /  bevacizumab  /  hepatocellular carcinoma  /  efficacy  /  macrophages
黄春华, 李育平, 李金垄, 李林, 曾敬科, 叶建敏, 赖小欢, 周观林, 刘长虹. 信迪利单抗及贝伐珠单抗联合HAIC治疗晚期肝癌的疗效及其对巨噬细胞的影响研究. 今日药学, 2026 , 36 (3) : 224 -228 . DOI: 10.12048/j.issn.1674-229X.2026.03.011
Chunhua HUANG, Yuping LI, Jinlong LI, Lin LI, Jingke ZENG, Jianmin YE, Xiaohuan LAI, Guanlin ZHOU, Changhong LIU. Efficacy of Sintilimab and Bevacizumab Combined with HAIC in the Treatment of Late-stage Hepatocellular Carcinoma and Their Impact on Macrophages[J]. Pharmacy Today, 2026 , 36 (3) : 224 -228 . DOI: 10.12048/j.issn.1674-229X.2026.03.011
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  • 赣州市指导性科技计划项目(GZ2024ZSF309)
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doi: 10.12048/j.issn.1674-229X.2026.03.011
  • 接收时间：2025-04-14
  • 首发时间：2026-09-23
  • 出版时间：2026-03-25
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  • 收稿日期：2025-04-14
基金
赣州市指导性科技计划项目(GZ2024ZSF309)
作者信息
    1．江西省赣州市第五人民医院，赣州市肝病研究所，江西 赣州 341000
    2．赣州市全南县人民医院，江西 赣州 341800

通讯作者:

*

刘长虹，主治医师，研究方向：肝癌治疗，E-mail:
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https://castjournals.cast.org.cn/joweb/jryx/CN/10.12048/j.issn.1674-229X.2026.03.011
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2种不同金属材料的力学参数
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Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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