Article(id=1309634582815793991, tenantId=1146029695717560320, journalId=1227999776411738115, issueId=1309634582362809158, articleNumber=null, orderNo=null, doi=10.12048/j.issn.1674-229X.2026.04.002, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1750780800000, receivedDateStr=2025-06-25, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1790170816377, onlineDateStr=2026-09-23, pubDate=1777046400000, pubDateStr=2026-04-25, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1790170816377, onlineIssueDateStr=2026-09-23, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1790170816377, creator=13701087609, updateTime=1790170816377, updator=13701087609, issue=Issue{id=1309634582362809158, tenantId=1146029695717560320, journalId=1227999776411738115, year='2026', volume='36', issue='4', pageStart='241', pageEnd='320', issueExtLink='null', onlineDate='null', pubDate='1777046400000', pubDateStr='2026-04-25', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1790170816268, creator='13701087609', updateTime=1790219015105, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1309836742979576497, tenantId=1146029695717560320, journalId=1227999776411738115, issueId=1309634582362809158, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1309836742979576498, tenantId=1146029695717560320, journalId=1227999776411738115, issueId=1309634582362809158, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=254, endPage=262, ext={EN=ArticleExt(id=1309634582979371848, articleId=1309634582815793991, tenantId=1146029695717560320, journalId=1227999776411738115, language=EN, title=JP-1366 for Injection Treats Hemorrhagic Gastric Ulcer by Inhibiting Gastric Acid Secretion, columnId=null, journalTitle=Pharmacy Today, columnName=null, runingTitle=null, highlight=null, articleAbstract=
OBJECTIVE To evaluate the inhibitory effect of JP-1366 for injection on gastric acid secretion and its therapeutic effect on hemorrhagic gastric ulcer.
METHODS The histamine-induced gastric acid secretion model in rats was used, and the animals were given JP-1366 for injection by a single intravenous injection to evaluate the inhibitory effect of the test substance on gastric acid secretion in these rats. In the water-immersion restraint-induced hemorrhagic gastric ulcer rat model and aspirin-induced hemorrhagic gastric ulcer rat model, animals were given a single intravenous injection of JP-1366 for injection. The therapeutic effect of the test substance on hemorrhagic gastric ulcer in rats was evaluated by detecting the pH value of gastric juice, gastric bleeding spots, area of hemorrhagic lesions, and inhibition rate on hemorrhagic lesions.
RESULTS In the histamine induced rat gastric acid secretion model, JP-1366 for injection at different doses significantly increased the pH of gastric juice in the model rats, reduce the volume, concentration, and total acidity of gastric juice, and exhibit a dose-response relationship in terms of acid inhibition. The acid inhibition effect is better than that of omeprazole sodium. In the water immersion restraint induced and aspirin induced rat hemorrhagic gastric ulcer model, injection of JP-1366 can increase the pH of gastric juice, inhibit bleeding in the gastric glands and ameliorate mucosal erosion of gastric tissues at different doses. The ulcer inhibition rate shows a good dose-response, and the effect of improving gastric hemorrhagic lesions in the model rats is better than that of omeprazole sodium. At the same dose (1 mg·kg-1), the degree of improvement in gastric hemorrhagic lesions by injection of JP-1366 and fumarate vonosine is basically equivalent.
CONCLUSION JP-1366 for injection treats hemorrhagic gastric ulcers by inhibiting gastric acid secretion, and its effects in inhibiting gastric acid and improving gastric hemorrhagic lesions are superior to those of omeprazole sodium. At the same dose, the improvement of bleeding lesions is equivalent to that of vonoprazan fumarate.
, authors=Lu YANG
1, Guannan MA
2, Yuying PANG
2, Jiang WANG
1, Liping ZHOU
1, Dandan HUANG
2, Hongdan CHEN
1, Long FU
1, 2, authorsList=Lu YANG, Guannan MA, Yuying PANG, Jiang WANG, Liping ZHOU, Dandan HUANG, Hongdan CHEN, Long FU, authorCompany=null, correspAuthors=Hongdan CHEN, Long FU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1309634583306527561, articleId=1309634582815793991, tenantId=1146029695717560320, journalId=1227999776411738115, language=CN, title=注射用JP-1366通过抑制胃酸分泌治疗出血性胃溃疡, columnId=1228268589086606089, journalTitle=今日药学, columnName=论著, runingTitle=null, highlight=null, articleAbstract=
目的 评价注射用JP-1366对胃酸分泌的抑制作用以及对出血性胃溃疡的治疗作用。
方法 采用组胺诱导大鼠胃酸分泌模型，动物单次静脉注射给予注射用JP-1366，评价受试物对大鼠胃酸分泌的抑制作用。采用水浸拘束诱导大鼠出血性胃溃疡模型和阿司匹林诱导大鼠出血性胃溃疡模型，动物单次静脉注射给予注射用JP-1366，通过检测胃液pH值、胃部出血点、出血性病灶面积及对出血性病灶的抑制率，评价受试物对大鼠出血性胃溃疡的治疗作用。
结果 在组胺诱导大鼠胃酸分泌模型中，注射用JP-1366在不同剂量下均可升高模型大鼠胃液pH，降低胃液体积、胃酸浓度和胃液总酸度，抑酸作用呈现出良好的量-效关系，抑酸效果优于奥美拉唑钠。水浸拘束法诱导大鼠出血性胃溃疡模型和阿司匹林诱导大鼠出血性胃溃疡模型中，注射用JP-1366在不同剂量下均可升高模型大鼠胃液pH、抑制大鼠胃腺部出血、改善胃组织黏膜糜烂，溃疡抑制率呈现出良好的量-效关系，改善模型大鼠胃部出血性病灶的效果优于奥美拉唑钠，同等剂量下（1 mg·kg-1），注射用JP-1366与富马酸伏诺拉生对模型大鼠胃部出血性病灶的改善程度基本等效。
结论 注射用JP-1366通过抑制胃酸分泌治疗出血性胃溃疡，抑制胃酸和改善胃部出血性病灶效果优于奥美拉唑钠，同剂量下，对出血性病灶的改善程度优于富马酸伏诺拉生。
, authors=杨璐
1, 马冠男
2, 庞语盈
2, 王江
1, 周丽平
1, 黄丹丹
2, 谌红丹
1, *, 付龙
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