Article(id=1309634570773947170, tenantId=1146029695717560320, journalId=1227999776411738115, issueId=1309634546845442540, articleNumber=null, orderNo=null, doi=10.12048/j.issn.1674-229X.2026.05.007, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1771948800000, receivedDateStr=2026-02-25, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1790170813505, onlineDateStr=2026-09-23, pubDate=1779638400000, pubDateStr=2026-05-25, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1790170813505, onlineIssueDateStr=2026-09-23, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1790170813505, creator=13701087609, updateTime=1790170813505, updator=13701087609, issue=Issue{id=1309634546845442540, tenantId=1146029695717560320, journalId=1227999776411738115, year='2026', volume='36', issue='5', pageStart='321', pageEnd='400', issueExtLink='null', onlineDate='null', pubDate='1779638400000', pubDateStr='2026-05-25', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1790170807800, creator='13701087609', updateTime=1790218979984, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1309836595717570703, tenantId=1146029695717560320, journalId=1227999776411738115, issueId=1309634546845442540, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1309836595717570704, tenantId=1146029695717560320, journalId=1227999776411738115, issueId=1309634546845442540, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=364, endPage=368, ext={EN=ArticleExt(id=1309634570920747811, articleId=1309634570773947170, tenantId=1146029695717560320, journalId=1227999776411738115, language=EN, title=Analysis of Clinical Trials Registration Status of Asthma Drugs in China, columnId=null, journalTitle=Pharmacy Today, columnName=null, runingTitle=null, highlight=null, articleAbstract=
OBJECTIVE To explore the characteristics and development trends of asthma drug clinical trials in China, and to provide references for promoting the research of new asthma drugs.
METHODS Using "asthma" as the keyword, we searched the Chinese Clinical Trial Registry and Information Disclosure Platform. Data regarding clinical trials of asthma drugs registered from January 2013 to December 2025 were collected, and statistical analyses were performed on registration time, geographic information, investigational drugs and other relevant information.
RESULTS A total of 663 clinical trials of asthma drugs were included in this study. Over the past decade, the number of clinical trials of asthma drugs has shown an upward trend. In terms of trial phases, bioequivalence trials accounted for the largest proportion (n=398, 60.03%). Regarding the categories of investigational drugs, there were 527 chemical drugs, 110 biological agents, and 26 traditional Chinese medicines/natural medicines. The geographical distribution of clinical trial sites was generally characterized by a concentration in eastern China and a scarcity in central and western regions. Regarding pharmacological mechanisms, glucocorticoids were the most widely studied drug category (n=131, 19.76%), while there were 105 biotargeted drugs (15.84%). Among them, domestic innovative drugs have been growing rapidly in recent years.
CONCLUSION Significant progress has been made in clinical trials of asthma drugs in China, particularly with the rapid development of biotargeted drugs. However, problems such as uneven regional distribution of clinical trials and low proportion of innovative drugs still exist. It is necessary to strengthen policy support, optimize the allocation of regional medical and pharmaceutical resources, and continuously promote the research and development of asthma drugs and the advancement of related clinical trials.
, authors=Xixi ZHAO, Yang TAO, Hong ZHANG, Zengqing MA
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目的 探讨我国哮喘药物临床试验的特点和发展趋势，为推动哮喘新药研究提供参考。
方法 以“哮喘”为关键词，对中国“药物临床试验登记与信息公示平台”进行检索，收集2013年1月~2025年12月注册的哮喘药物临床试验信息，对注册时间、地理信息、试验药物等信息进行统计分析。
结果 本研究共纳入663项哮喘药物临床试验。近10年来，哮喘药物临床试验注册数量呈上升趋势。在试验分期方面，生物等效性试验数量最多（n=398，60.03%）。在试验药物类型方面，化学药物共527项，生物制剂110项、中药/天然药物26项。临床试验注册地点总体呈东部多、中西部少的特征。药理作用方面，糖皮质激素类药物是研究最多的类型（n=131，19.76%），另有105项生物靶向药物（15.84%），其中国产创新药物近年来呈现快速增长趋势。
结论 中国哮喘药物临床试验取得了很大进展，其中生物靶向药物发展迅速，但仍存在临床试验地区分布不均、创新药物占比较低等问题，应加大政策支持、完善区域医药配置，推动哮喘药物的研发和临床试验的发展。
, authors=赵茜茜, 陶洋, 张红, 马曾庆
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