Article(id=1309634566776775418, tenantId=1146029695717560320, journalId=1227999776411738115, issueId=1309634546845442540, articleNumber=null, orderNo=null, doi=10.12048/j.issn.1674-229X.2026.05.010, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1755705600000, receivedDateStr=2025-08-21, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1790170812553, onlineDateStr=2026-09-23, pubDate=1779638400000, pubDateStr=2026-05-25, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1790170812553, onlineIssueDateStr=2026-09-23, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1790170812553, creator=13701087609, updateTime=1790170812553, updator=13701087609, issue=Issue{id=1309634546845442540, tenantId=1146029695717560320, journalId=1227999776411738115, year='2026', volume='36', issue='5', pageStart='321', pageEnd='400', issueExtLink='null', onlineDate='null', pubDate='1779638400000', pubDateStr='2026-05-25', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1790170807800, creator='13701087609', updateTime=1790218979984, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1309836595717570703, tenantId=1146029695717560320, journalId=1227999776411738115, issueId=1309634546845442540, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1309836595717570704, tenantId=1146029695717560320, journalId=1227999776411738115, issueId=1309634546845442540, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=382, endPage=386, ext={EN=ArticleExt(id=1309634566919381755, articleId=1309634566776775418, tenantId=1146029695717560320, journalId=1227999776411738115, language=EN, title=Efficacy Analysis of PD-1 Monoclonal Antibody in the Treatment of Colorectal Cancer with MSI-H and
Kras Mutation, columnId=null, journalTitle=Pharmacy Today, columnName=null, runingTitle=null, highlight=null, articleAbstract=
OBJECTIVE To study the efficacy of PD-1 monoclonal antibody in treating microsatellite instability-high (MSI-H) colorectal cancer with different Kras gene point mutations.
METHODS Clinical data of patients with confirmed MSI-H colorectal cancer combined with Kras mutations were collected. Patients were divided into four groups based on different Kras mutation types: A146T, G12C, G12D, and G12V. Treatment efficacy was evaluated using the RECIST 1.1 criteria. Event-free survival (EFS) was calculated with the first administration of PD-1 monoclonal antibody as the starting point for survival time. The detection results of tumor markers (CEA, CA19-9, and CA72-4) were compared before and after treatment. The incidence of adverse reactions during treatment across groups was statistically analyzed.
RESULTS The ORR (overall response rate) was highest in the G12V group (33.33%), followed by the G12D group (25.00%), the G12C group (20.00%), and the A146T group (12.50%). The DCR (disease control rate) was highest in the A146T group (100%), followed by the G12D group (91.66%), the G12V group (86.66%), the G12C group (70.00%), no statistically significant differences in ORR and DCR were observed among all groups (P>0.05). The average EFS duration was 19.25±12.19 months in the G12V group, 17.60±10.46 months in the A146T group, 15.36±9.32 months in the G12C group, and 12.15±7.36 months in the G12D group, with no significant differences among the groups (P>0.05). The median EFS duration was 15.12 months in the G12V group, 12.76 months in the A146T group, 10.65 months in the G12C group, and 10.20 months in the G12D group. In the G12V group, the levels of CEA and CA19-9 decreased significantly after treatment (P<0.05). During treatment, patients experienced immune-related adverse reactions such as rash, thyroid dysfunction, elevated transaminases, immune-related pneumonia, colitis, and peripheral neuritis, but no statistically significant differences in the incidence rates were found among the groups (P>0.05).
CONCLUSION PD-1 monoclonal antibody showed better efficacy in patients with MSI-H colorectal cancer combined with Kras G12V mutation.
, authors=Yanyu LI, Qing LIU, Hongbing HUANG, Tao LIU, Jie ZHOU
*, authorsList=Yanyu LI, Qing LIU, Hongbing HUANG, Tao LIU, Jie ZHOU, authorCompany=null, correspAuthors=Jie ZHOU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1309634567271703292, articleId=1309634566776775418, tenantId=1146029695717560320, journalId=1227999776411738115, language=CN, title=PD-1单抗治疗MSI-H合并
Kras基因突变型结直肠癌的疗效分析, columnId=1228268588277105398, journalTitle=今日药学, columnName=临床药学, runingTitle=null, highlight=null, articleAbstract=
目的 研究PD-1单抗在微卫星高度不稳定（Microsatellite instability-high, MSI-H）结直肠癌中对Kras基因不同点突变类型的疗效。
方法 收集确诊MSI-H合并Kras基因突变结直肠癌患者的临床资料，按不同的Kras基因突变类型分为A146T组、G12C组、G12D组、G12V组4个组别。以Recist 1.1为标准评价药物的疗效。以患者首次接受PD-1单抗治疗为生存时间起点计算无事件生存期（EFS）。对比用药前后CEA、CA19-9和CA72-4等肿瘤标志物的检测结果。统计分析用药过程中各组出现不良反应的发生率。
结果 ORR高低依次为G12V组（33.33%）、G12D组（25.00%）、G12C组（20.00%）、A146T组（12.5%），DCR高低依次为A146T组（100%）、G12D组（91.66%）、G12V组（86.66%）、G12C组（70.00%）、，各组ORR和DCR均差异未见统计学意义（P> 0.05）。平均EFS时长依次为G12V（19.25±12.19）个月、A146T（17.60±10.46）个月、G12C（15.36±9.32）个月、G12D（12.15±7.36）个月，各组差异未见统计学意义（P>0.05）。中位EFS时长依次为G12V组15.12个月、A146T组12.76个月、G12C组10.65个月、G12D组10.20个月。G12V组用药后CEA和CA19-9水平显著降低（P<0.05）。治疗过程中，患者出现了皮疹、甲状腺功能异常、转氨酶升高、免疫性肺炎、结肠炎、外周神经炎等免疫相关性不良反应，但各组发生率差异无统计学意义（P>0.05）。
结论 PD-1单抗对MSI-H合并Kras G12V突变的结直肠癌各项疗效指标较好。
, authors=李燕瑜, 刘庆, 黄红兵, 刘韬, 周捷
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