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Article(id=1309634562423087784, tenantId=1146029695717560320, journalId=1227999776411738115, issueId=1309634546845442540, articleNumber=null, orderNo=null, doi=10.12048/j.issn.1674-229X.2026.05.006, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1757865600000, receivedDateStr=2025-09-15, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1790170811514, onlineDateStr=2026-09-23, pubDate=1779638400000, pubDateStr=2026-05-25, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1790170811514, onlineIssueDateStr=2026-09-23, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1790170811514, creator=13701087609, updateTime=1790170811514, updator=13701087609, issue=Issue{id=1309634546845442540, tenantId=1146029695717560320, journalId=1227999776411738115, year='2026', volume='36', issue='5', pageStart='321', pageEnd='400', issueExtLink='null', onlineDate='null', pubDate='1779638400000', pubDateStr='2026-05-25', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1790170807800, creator='13701087609', updateTime=1790218979984, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1309836595717570703, tenantId=1146029695717560320, journalId=1227999776411738115, issueId=1309634546845442540, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1309836595717570704, tenantId=1146029695717560320, journalId=1227999776411738115, issueId=1309634546845442540, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=355, endPage=363, ext={EN=ArticleExt(id=1309634562607637161, articleId=1309634562423087784, tenantId=1146029695717560320, journalId=1227999776411738115, language=EN, title=Investigation Into Gastrointestinal System Adverse Events Triggered by Cephalosporin Drugs: Insights From the FAERS Database, columnId=null, journalTitle=Pharmacy Today, columnName=null, runingTitle=null, highlight=null, articleAbstract=
OBJECTIVE

Based on the US FDA Adverse Event Reporting System (FAERS), this study comprehensively evaluated the adverse reaction characteristics of cephalosporins on the gastrointestinal system, and analyzed the risk heterogeneity among different drug varieties and the influence of patients' baseline characteristics.

METHODS

The data from the FAERS database from 1994 to 2024 were extracted, and disproportionality analysis combined with Bayesian method was used to mine the correlation signals between cephalosporins and gastrointestinal adverse events.

RESULTS

A total of 54.249 6 million adverse event reports were included, and 793 gastrointestinal system adverse events related to signal-positive cephalosporins were screened out.The signal intensity of cefdinir [ROR=2.69 (2.52-2.88)] was significantly higher than that of other drugs. The Bayesian method verified the association of high-risk events, such as the megacolon signal of cefixime [EBGM=75.21 (95%CI:23.54)]. The risk of signal-negative cephalosporin was low, and very few had a certain intensity of PT signal values.

CONCLUSION

This study analyzed the risk of gastrointestinal adverse reactions associated with the use of different types of cephalosporins. Among them, cefdinir had the highest risk of gastrointestinal-related adverse events (AEs), while non-oral signal-negative ceped drugs.

, authors=Fangyu SONG1, 2, Keqin FAN1, 2, Liangjing XIA3, Yuehui ZHANG2, Haizhu ZHANG1, Liangming ZHANG2, Tong CHEN4, Jiaqi SUN1, Zijun YAN2, 4, *, authorsList=Fangyu SONG, Keqin FAN, Liangjing XIA, Yuehui ZHANG, Haizhu ZHANG, Liangming ZHANG, Tong CHEN, Jiaqi SUN, Zijun YAN, authorCompany=null, correspAuthors=Zijun YAN, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1309634562867684010, articleId=1309634562423087784, tenantId=1146029695717560320, journalId=1227999776411738115, language=CN, title=基于FAERS数据库的头孢菌素类药物胃肠系统不良事件信号挖掘与分析, columnId=1228268589086606089, journalTitle=今日药学, columnName=论著, runingTitle=null, highlight=null, articleAbstract=
目的

基于美国FDA不良事件报告系统（FAERS），全面评估头孢类药物在胃肠系统的不良反应特征，分析不同药物品种间的风险异质性及患者基线特征等因素的影响。

方法

提取FAERS数据库中1994~2024年数据，结合比例失衡分析与贝叶斯方法，挖掘头孢类药物与胃肠系统不良事件的关联信号。

结果

共纳入5 424.96万例不良事件报告，并筛选出793例与信号阳性头孢类药物相关的胃肠系统事件。其中头孢地尼的信号强度［ROR=2.69（2.52~2.88）］显著高于其他药物；贝叶斯方法验证了高风险事件的关联性，如头孢克肟的巨结肠信号［EBGM=75.21（23.54）］。阴性信号头孢类药物的风险均较低，极个别的具有一定强度的PT信号值。

结论

本研究分析了使用不同类型的头孢类药物而发生的胃肠道系统不良反应的风险，其中头孢地尼胃肠系统相关不良反应（adverse event, AE）发生风险最高，非口服阴性信号头孢类药物AE发生风险较低，临床需依据已知风险优化用药，以平衡疗效与安全性。

, authors=宋方宇1, 2, 范科琴1, 2, 夏靓婧3, 张月辉2, 张海珠1, 张良明2, 陈彤4, 孙佳琪1, 晏子俊2, 4, *, authorsList=宋方宇, 范科琴, 夏靓婧, 张月辉, 张海珠, 张良明, 陈彤, 孙佳琪, 晏子俊, authorCompany=null, correspAuthors=晏子俊, authorNote=

宋方宇，在读硕士

, correspAuthorsNote=

*

晏子俊，博士，副主任药师、副教授，研究生导师，E-mail:
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基于FAERS数据库的头孢菌素类药物胃肠系统不良事件信号挖掘与分析
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宋方宇 1, 2 , 范科琴 1, 2 , 夏靓婧 3 , 张月辉 2 , 张海珠 1 , 张良明 2 , 陈彤 4 , 孙佳琪 1 , 晏子俊 2, 4, *
今日药学 | 论著 2026,36(5): 355-363
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今日药学 |论著 2026 , 36 (5) : 355 -363
基于FAERS数据库的头孢菌素类药物胃肠系统不良事件信号挖掘与分析
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宋方宇1, 2, 范科琴1, 2, 夏靓婧3, 张月辉2, 张海珠1, 张良明2, 陈彤4, 孙佳琪1, 晏子俊2, 4, *
作者信息
  • 1．大理大学药学院，云南 大理 671000
  • 2．攀枝花市中心医院药学部，四川 攀枝花 617067
  • 3．香港浸会大学中医学院，香港 999077
  • 4．昆明医科大学药学院暨云南省天然药物药理重点实验室，云南 昆明 650500
通讯作者:

*

晏子俊，博士，副主任药师、副教授，研究生导师，E-mail:
作者简介:

宋方宇，在读硕士

Investigation Into Gastrointestinal System Adverse Events Triggered by Cephalosporin Drugs: Insights From the FAERS Database
Fangyu SONG1, 2, Keqin FAN1, 2, Liangjing XIA3, Yuehui ZHANG2, Haizhu ZHANG1, Liangming ZHANG2, Tong CHEN4, Jiaqi SUN1, Zijun YAN2, 4, *
Affiliations
  • 1.School of Pharmacy, Dali University, Dali, Yunnan 671000, China
  • 2.Department of Pharmacy, Panzhihua Central Hospital, Panzhihua, Sichuan 617067, China
  • 3.College of Chinese Medicine, Hong Kong Baptist University, Hong Kong 999077, China
  • 4.School of Pharmaceutical Sciences and Yunnan Key Laboratory of Pharmacology for natural Products, Kunming Medical University, Kunming, Yunnan 650500, China
出版时间: 2026-05-25 doi: 10.12048/j.issn.1674-229X.2026.05.006
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摘要
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目的

基于美国FDA不良事件报告系统（FAERS），全面评估头孢类药物在胃肠系统的不良反应特征，分析不同药物品种间的风险异质性及患者基线特征等因素的影响。

方法

提取FAERS数据库中1994~2024年数据，结合比例失衡分析与贝叶斯方法，挖掘头孢类药物与胃肠系统不良事件的关联信号。

结果

共纳入5 424.96万例不良事件报告，并筛选出793例与信号阳性头孢类药物相关的胃肠系统事件。其中头孢地尼的信号强度［ROR=2.69（2.52~2.88）］显著高于其他药物；贝叶斯方法验证了高风险事件的关联性，如头孢克肟的巨结肠信号［EBGM=75.21（23.54）］。阴性信号头孢类药物的风险均较低，极个别的具有一定强度的PT信号值。

结论

本研究分析了使用不同类型的头孢类药物而发生的胃肠道系统不良反应的风险，其中头孢地尼胃肠系统相关不良反应（adverse event, AE）发生风险最高，非口服阴性信号头孢类药物AE发生风险较低，临床需依据已知风险优化用药，以平衡疗效与安全性。

头孢类药物  /  FAERS  /  信号挖掘  /  胃肠系统疾病  /  不良反应
OBJECTIVE

Based on the US FDA Adverse Event Reporting System (FAERS), this study comprehensively evaluated the adverse reaction characteristics of cephalosporins on the gastrointestinal system, and analyzed the risk heterogeneity among different drug varieties and the influence of patients' baseline characteristics.

METHODS

The data from the FAERS database from 1994 to 2024 were extracted, and disproportionality analysis combined with Bayesian method was used to mine the correlation signals between cephalosporins and gastrointestinal adverse events.

RESULTS

A total of 54.249 6 million adverse event reports were included, and 793 gastrointestinal system adverse events related to signal-positive cephalosporins were screened out.The signal intensity of cefdinir [ROR=2.69 (2.52-2.88)] was significantly higher than that of other drugs. The Bayesian method verified the association of high-risk events, such as the megacolon signal of cefixime [EBGM=75.21 (95%CI:23.54)]. The risk of signal-negative cephalosporin was low, and very few had a certain intensity of PT signal values.

CONCLUSION

This study analyzed the risk of gastrointestinal adverse reactions associated with the use of different types of cephalosporins. Among them, cefdinir had the highest risk of gastrointestinal-related adverse events (AEs), while non-oral signal-negative ceped drugs.

cephalosporins  /  FAERS  /  signal mining  /  gastrointestinal system  /  adverse reactions
宋方宇, 范科琴, 夏靓婧, 张月辉, 张海珠, 张良明, 陈彤, 孙佳琪, 晏子俊. 基于FAERS数据库的头孢菌素类药物胃肠系统不良事件信号挖掘与分析. 今日药学, 2026 , 36 (5) : 355 -363 . DOI: 10.12048/j.issn.1674-229X.2026.05.006
Fangyu SONG, Keqin FAN, Liangjing XIA, Yuehui ZHANG, Haizhu ZHANG, Liangming ZHANG, Tong CHEN, Jiaqi SUN, Zijun YAN. Investigation Into Gastrointestinal System Adverse Events Triggered by Cephalosporin Drugs: Insights From the FAERS Database[J]. Pharmacy Today, 2026 , 36 (5) : 355 -363 . DOI: 10.12048/j.issn.1674-229X.2026.05.006
基金
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  • 国家卫生健康委研究项目(GWJJMB202510025013; YLZLXZ24G039)
  • 四川省省级科技项目(2025ZNSFSC0684)
  • 2020年云南省地方本科高校基础研究联合专项项目(202001BA070001-041)
  • 云南省天然药物药理重点实验室开放基金重点项目(YKLPNP-K2302)
  • 四川省医院协会青年药师科研专项资金项目(22009; YP2202419)
  • 四川省医学科技创新研究会专研科研课题(2025YCYM107)
  • 成都药学会药学科研项目(Cdyxky7021; Cdyxky8041)
  • 攀枝花市科学技术局项目(2024ZD-S-28)
  • 攀枝花市中心医院院内课题(202311)
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文章信息
doi: 10.12048/j.issn.1674-229X.2026.05.006
  • 接收时间：2025-09-15
  • 首发时间：2026-09-23
  • 出版时间：2026-05-25
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出版历史
  • 收稿日期：2025-09-15
基金
国家卫生健康委研究项目(GWJJMB202510025013; YLZLXZ24G039)
四川省省级科技项目(2025ZNSFSC0684)
2020年云南省地方本科高校基础研究联合专项项目(202001BA070001-041)
云南省天然药物药理重点实验室开放基金重点项目(YKLPNP-K2302)
四川省医院协会青年药师科研专项资金项目(22009; YP2202419)
四川省医学科技创新研究会专研科研课题(2025YCYM107)
成都药学会药学科研项目(Cdyxky7021; Cdyxky8041)
攀枝花市科学技术局项目(2024ZD-S-28)
攀枝花市中心医院院内课题(202311)
作者信息
    1．大理大学药学院，云南 大理 671000
    2．攀枝花市中心医院药学部，四川 攀枝花 617067
    3．香港浸会大学中医学院，香港 999077
    4．昆明医科大学药学院暨云南省天然药物药理重点实验室，云南 昆明 650500

通讯作者:

*

晏子俊，博士，副主任药师、副教授，研究生导师，E-mail:
参考文献
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https://castjournals.cast.org.cn/joweb/jryx/CN/10.12048/j.issn.1674-229X.2026.05.006
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2种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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