Article(id=1309634553875100636, tenantId=1146029695717560320, journalId=1227999776411738115, issueId=1309634546845442540, articleNumber=null, orderNo=null, doi=10.12048/j.issn.1674-229X.2026.05.009, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1772985600000, receivedDateStr=2026-03-09, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1790170809477, onlineDateStr=2026-09-23, pubDate=1779638400000, pubDateStr=2026-05-25, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1790170809477, onlineIssueDateStr=2026-09-23, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1790170809477, creator=13701087609, updateTime=1790170809477, updator=13701087609, issue=Issue{id=1309634546845442540, tenantId=1146029695717560320, journalId=1227999776411738115, year='2026', volume='36', issue='5', pageStart='321', pageEnd='400', issueExtLink='null', onlineDate='null', pubDate='1779638400000', pubDateStr='2026-05-25', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1790170807800, creator='13701087609', updateTime=1790218979984, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1309836595717570703, tenantId=1146029695717560320, journalId=1227999776411738115, issueId=1309634546845442540, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1309836595717570704, tenantId=1146029695717560320, journalId=1227999776411738115, issueId=1309634546845442540, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=376, endPage=381, ext={EN=ArticleExt(id=1309634554042872797, articleId=1309634553875100636, tenantId=1146029695717560320, journalId=1227999776411738115, language=EN, title=Analysis of the Rationality and Safety of Clinical Application of PD-1 Anti-tumor Drugs Before and After Clinical Pharmacist Intervention, columnId=null, journalTitle=Pharmacy Today, columnName=null, runingTitle=null, highlight=null, articleAbstract=
OBJECTIVE

To analyze the rationality and safety of clinical use of PD-1 inhibitors as novel antitumor drugs, providing guidance for their standardized and safe clinical application.

METHODS

This study randomly selected inpatient medical records from April to June 2024 (before clinical pharmacist intervention) as the control group, and records from July 2024 to June 2025 (after intervention) as the intervention group. The rationality and safety of PD-1 inhibitor use were analyzed, with each 3-month period constituting a cycle. Results from each cycle were compared with those of the preceding cycle. Statistical analysis was performed to compare the rationality and safety of PD-1 inhibitor use between the first, second, third, and fourth intervention cycles and the pre-intervention cycle.

RESULTS

Post-intervention improvements were observed in prescription qualified rate, proportion of off-label use rate, and number of adverse drug reaction reports for PD-1 inhibitors. For prescription compliance and expanded clinical use indicators, the differences between the first, second, third, and fourth intervention cycles versus the pre-intervention cycle showed statistical significance (P<0.05).

CONCLUSION

Clinical pharmacist intervention enhances the rationality and standardization of PD-1 inhibitor use in clinical practice, facilitates timely identification of new or severe adverse reactions, and enables appropriate treatment measures, thereby reducing patient mortality, prolonging survival time, and reducing patients'medical costs.

, authors=Zhongshun OUa, Xuemin LIUb, *, Mingjian CHENGa, Qingshang ZHANGa, Bang CAIb, Xiaofeng ZHUa, authorsList=Zhongshun OU, Xuemin LIU, Mingjian CHENG, Qingshang ZHANG, Bang CAI, Xiaofeng ZHU, authorCompany=null, correspAuthors=Xuemin LIU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1309634554265170910, articleId=1309634553875100636, tenantId=1146029695717560320, journalId=1227999776411738115, language=CN, title=临床药师干预前后对PD-1类抗肿瘤药物临床应用合理性与安全性分析, columnId=1228268588277105398, journalTitle=今日药学, columnName=临床药学, runingTitle=null, highlight=null, articleAbstract=
目的

通过对PD-1类新型抗肿瘤药物的临床用药合理性和安全性进行分析,为临床安全并规范应用PD-1类药物提供指导。

方法

本研究随机选取临床药师未干预前2024年4~6月的住院病历作为对照组,临床药师干预后的2024年7月~2025年6月的住院病历作为干预组,通过对PD-1合理性和安全性进行分析,每3个月作为1个循环周期。将每1周期结果与实施前1周期的结果进行比较,将临床药师干预实施第1周期、第2周期、第3周期、第4周期与实施前1周期的PD-1类抗肿瘤药物使用合理性与安全性进行统计分析比较。

结果

干预后PD-1类新型抗肿瘤药物处方合格率、拓展性临床使用比例、药品不良反应报告数量都得到改善,其中处方合格率、拓展性临床使用比例2个指标,实施干预后第1周期、第2周期、第3周期、第4周期与实施前1周期的比较差异均有统计学意义(P<0.05)。

结论

临床药师干预有助于提高PD-1类抗肿瘤药物临床应用的合理性和规范性,及时发现新的或严重的不良反应,并采取相应救治措施,可降低患者死亡率,提高患者生存时间,减轻患者就医成本。

, authors=欧忠顺a, 刘学敏b, *, 成明建a, 张庆尚a, 蔡邦b, 祝小凤a, authorsList=欧忠顺, 刘学敏, 成明建, 张庆尚, 蔡邦, 祝小凤, authorCompany=null, correspAuthors=刘学敏, authorNote=

欧忠顺,副主任药师,研究方向:药事管理、临床药学

, correspAuthorsNote=

*

刘学敏,副主任医师,研究方向:肿瘤学,E-mail:
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欧忠顺,副主任药师,研究方向:药事管理、临床药学

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欧忠顺,副主任药师,研究方向:药事管理、临床药学

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临床药师干预前后对PD-1类抗肿瘤药物临床应用合理性与安全性分析
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欧忠顺 a , 刘学敏 b, * , 成明建 a , 张庆尚 a , 蔡邦 b , 祝小凤 a
今日药学 | 临床药学 2026,36(5): 376-381
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今日药学 |临床药学 2026 , 36 (5) : 376 -381
临床药师干预前后对PD-1类抗肿瘤药物临床应用合理性与安全性分析
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欧忠顺a, 刘学敏b, * , 成明建a, 张庆尚a, 蔡邦b, 祝小凤a
作者信息
  • a.云浮市人民医院,药学部,广东 云浮 527300
  • b.云浮市人民医院,肿瘤科,广东 云浮 527300
通讯作者:

*

刘学敏,副主任医师,研究方向:肿瘤学,E-mail:
作者简介:

欧忠顺,副主任药师,研究方向:药事管理、临床药学

Analysis of the Rationality and Safety of Clinical Application of PD-1 Anti-tumor Drugs Before and After Clinical Pharmacist Intervention
Zhongshun OUa, Xuemin LIUb, * , Mingjian CHENGa, Qingshang ZHANGa, Bang CAIb, Xiaofeng ZHUa
Affiliations
  • a.Department of Pharmacy, Yunfu, Guangdong 527300, China
  • b.Oncology Department, Yunfu People's Hospital, Yunfu, Guangdong 527300, China
出版时间: 2026-05-25 doi: 10.12048/j.issn.1674-229X.2026.05.009
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目的

通过对PD-1类新型抗肿瘤药物的临床用药合理性和安全性进行分析,为临床安全并规范应用PD-1类药物提供指导。

方法

本研究随机选取临床药师未干预前2024年4~6月的住院病历作为对照组,临床药师干预后的2024年7月~2025年6月的住院病历作为干预组,通过对PD-1合理性和安全性进行分析,每3个月作为1个循环周期。将每1周期结果与实施前1周期的结果进行比较,将临床药师干预实施第1周期、第2周期、第3周期、第4周期与实施前1周期的PD-1类抗肿瘤药物使用合理性与安全性进行统计分析比较。

结果

干预后PD-1类新型抗肿瘤药物处方合格率、拓展性临床使用比例、药品不良反应报告数量都得到改善,其中处方合格率、拓展性临床使用比例2个指标,实施干预后第1周期、第2周期、第3周期、第4周期与实施前1周期的比较差异均有统计学意义(P<0.05)。

结论

临床药师干预有助于提高PD-1类抗肿瘤药物临床应用的合理性和规范性,及时发现新的或严重的不良反应,并采取相应救治措施,可降低患者死亡率,提高患者生存时间,减轻患者就医成本。

临床药师  /  干预  /  PD-1类抗肿瘤药物  /  合理性  /  安全性
OBJECTIVE

To analyze the rationality and safety of clinical use of PD-1 inhibitors as novel antitumor drugs, providing guidance for their standardized and safe clinical application.

METHODS

This study randomly selected inpatient medical records from April to June 2024 (before clinical pharmacist intervention) as the control group, and records from July 2024 to June 2025 (after intervention) as the intervention group. The rationality and safety of PD-1 inhibitor use were analyzed, with each 3-month period constituting a cycle. Results from each cycle were compared with those of the preceding cycle. Statistical analysis was performed to compare the rationality and safety of PD-1 inhibitor use between the first, second, third, and fourth intervention cycles and the pre-intervention cycle.

RESULTS

Post-intervention improvements were observed in prescription qualified rate, proportion of off-label use rate, and number of adverse drug reaction reports for PD-1 inhibitors. For prescription compliance and expanded clinical use indicators, the differences between the first, second, third, and fourth intervention cycles versus the pre-intervention cycle showed statistical significance (P<0.05).

CONCLUSION

Clinical pharmacist intervention enhances the rationality and standardization of PD-1 inhibitor use in clinical practice, facilitates timely identification of new or severe adverse reactions, and enables appropriate treatment measures, thereby reducing patient mortality, prolonging survival time, and reducing patients'medical costs.

clinical pharmacist  /  intervention  /  PD-1 inhibitors  /  rationality  /  safety
欧忠顺, 刘学敏, 成明建, 张庆尚, 蔡邦, 祝小凤. 临床药师干预前后对PD-1类抗肿瘤药物临床应用合理性与安全性分析. 今日药学, 2026 , 36 (5) : 376 -381 . DOI: 10.12048/j.issn.1674-229X.2026.05.009
Zhongshun OU, Xuemin LIU, Mingjian CHENG, Qingshang ZHANG, Bang CAI, Xiaofeng ZHU. Analysis of the Rationality and Safety of Clinical Application of PD-1 Anti-tumor Drugs Before and After Clinical Pharmacist Intervention[J]. Pharmacy Today, 2026 , 36 (5) : 376 -381 . DOI: 10.12048/j.issn.1674-229X.2026.05.009
  • 广东省医学科研基金(B2024232)
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doi: 10.12048/j.issn.1674-229X.2026.05.009
  • 接收时间:2026-03-09
  • 首发时间:2026-09-23
  • 出版时间:2026-05-25
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  • 收稿日期:2026-03-09
基金
广东省医学科研基金(B2024232)
作者信息
    a.云浮市人民医院,药学部,广东 云浮 527300
    b.云浮市人民医院,肿瘤科,广东 云浮 527300

通讯作者:

*

刘学敏,副主任医师,研究方向:肿瘤学,E-mail:
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https://castjournals.cast.org.cn/joweb/jryx/CN/10.12048/j.issn.1674-229X.2026.05.009
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2种不同金属材料的力学参数
科
Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)
属
Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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