Article(id=1309634311620490040, tenantId=1146029695717560320, journalId=1227999776411738115, issueId=1309634291257143967, articleNumber=null, orderNo=null, doi=10.12048/j.issn.1674-229X.2026.06.003, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1759161600000, receivedDateStr=2025-09-30, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1790170751718, onlineDateStr=2026-09-23, pubDate=1782316800000, pubDateStr=2026-06-25, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1790170751718, onlineIssueDateStr=2026-09-23, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1790170751718, creator=13701087609, updateTime=1790170751718, updator=13701087609, issue=Issue{id=1309634291257143967, tenantId=1146029695717560320, journalId=1227999776411738115, year='2026', volume='36', issue='6', pageStart='401', pageEnd='480', issueExtLink='null', onlineDate='null', pubDate='1782316800000', pubDateStr='2026-06-25', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1790170746864, creator='13701087609', updateTime=1790218948815, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1309836464964337802, tenantId=1146029695717560320, journalId=1227999776411738115, issueId=1309634291257143967, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1309836464964337803, tenantId=1146029695717560320, journalId=1227999776411738115, issueId=1309634291257143967, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=416, endPage=420, ext={EN=ArticleExt(id=1309634311792456505, articleId=1309634311620490040, tenantId=1146029695717560320, journalId=1227999776411738115, language=EN, title=Study on Acute and Long-term Toxicity of Chuanxiong Broken-wall Decoction Pieces to SD Rats, columnId=null, journalTitle=Pharmacy Today, columnName=null, runingTitle=null, highlight=null, articleAbstract=
OBJECTIVE

To explore the effects of Chuanxiong broken-wall decoction pieces (CXBDP) on acute and long-term toxicity in SD rats, and compare them with traditional Chuanxiong decoction pieces (CXDP), so as to provide more data support for clinical medication.

METHODS

Acute toxicity: SD rats were given a single oral dose of CXBDP 10.08 g·kg-1 and CXDP 10.08 g·kg-1, and then observed for 2 weeks.Long-term toxicity: SD rats were orally given CXBDP 0.54, 1.35, 3.78 g·kg-1, CXDP 0.54, 3.78 g·kg-1 for 4 weeks, and then allowed to recover for 4 weeks after drug withdrawal. The effects of CXBDP and CXDP on rats' clinical observation, body weight, food intake, hematology, blood biochemistry, organ weight, organ coefficient and histopathological indicators were investigated.

RESULTS

Acute toxicity: no obvious toxic reactions was observed after single oral administration of CXBDP 10.08 g·kg-1 (maximum dose) and CXDP 10.08 g·kg-1. Long-term toxicity: no obvious toxic reactions was observed in SD rats after continuous oral administration of CXBDP (0.54, 1.35, and 3.78 g·kg-1) and CXDP (0.54 and 3.78 g·kg-1) for 4 weeks, as well as during the 4-week recovery period after drug withdrawal.

CONCLUSION

There were no statistically significant difference in safety between CXBDP and traditional CXDP in SD rats.

, authors=Shaohua WU1, Lu LIU1, Wen DENG2, Xialing LEI1, Weixuan CHEN2, Qianliang ZHANG2, Jianmin GUO1, Wei YANG1, *, authorsList=Shaohua WU, Lu LIU, Wen DENG, Xialing LEI, Weixuan CHEN, Qianliang ZHANG, Jianmin GUO, Wei YANG, authorCompany=null, correspAuthors=Wei YANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1309634312060891962, articleId=1309634311620490040, tenantId=1146029695717560320, journalId=1227999776411738115, language=CN, title=川芎破壁饮片对SD大鼠急性毒性和长期毒性试验研究, columnId=1228268589086606089, journalTitle=今日药学, columnName=论著, runingTitle=null, highlight=null, articleAbstract=
目的

探究川芎破壁饮片(CXBDP)对SD大鼠急性和长期毒性的影响,并与传统川芎饮片(CXDP)比较,为临床用药提供更多数据支持。

方法

急毒:单次口服给予SD大鼠CXBDP 10.08 g·kg-1和CXDP 10.08 g·kg-1后观察2周;长毒:口服给予SD大鼠CXBDP 0.54、1.35、3.78 g·kg-1,CXDP 0.54、3.78 g·kg-1 4周,停药恢复4周,考察CXBDP和CXDP对大鼠临床观察、体质量、摄食量、血液学、血液生化学、脏器重量和脏器系数以及组织病理学等指标的影响。

结果

急毒:单次口服给予大鼠CXBDP 10.08 g·kg-1(最大给药量)和CXDP 10.08 g·kg-1后,未见明显毒性反应;长毒:连续口服给予CXBDP 0.54、1.35、3.78 g·kg-1,CXDP 0.54、3.78 g·kg-1 4周后,均未见明显毒性反应。

结论

CXBDP与传统CXDP对SD大鼠的安全性差异无统计学意义。

, authors=吴少华1, 柳璐1, 邓雯2, 雷夏凌1, 陈炜旋2, 张前亮2, 郭健敏1, 杨威1, *, authorsList=吴少华, 柳璐, 邓雯, 雷夏凌, 陈炜旋, 张前亮, 郭健敏, 杨威, authorCompany=null, correspAuthors=杨威, authorNote=

吴少华,研究方向:药物毒理研究

, correspAuthorsNote=

*

杨威,教授级高级工程师,博士生导师,研究方向:药物药理毒理研究,E-mail:
, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=8Lu9m7iPD1IMTuanEzmcmw==, magXml=qoN7p9k5Oj4MXbZQaSbV/Q==, pdfUrl=null, pdf=lxupU36fsybP7WDQYU6f8w==, pdfFileSize=3454236, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=KvSH6GYqSJC0wB2mC0TNeQ==, mapNumber=null, fund=null)}, authors=[Author(id=1309634312446767938, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1309634312518071108, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, authorId=1309634312446767938, language=EN, stringName=Shaohua WU, firstName=Shaohua, middleName=null, lastName=WU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.Guangzhou Bay Area Institute of Biomedicine, Guangdong Lewwin Pharmaceutical Research Institute Co., Ltd., Guangdong Provincial Key Laboratory of Drug Non-Clinical Evaluation and Research, TCM Non-clinic Evaluation Branch of National Engineering Research Center for Modernization of Traditional Chinese Medicine, Guangdong Engineering Research Center for Innovative Drug Evaluation and Research, Guangzhou, Guangdong 510990, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1309634312589374277, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, authorId=1309634312446767938, language=CN, stringName=吴少华, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.广州湾区生物医药研究院,广东莱恩医药研究院有限公司,广东省药物非临床评价与研究重点实验室,国家中药现代化工程技术研究中心中药非临床评价分中心,广东省创新药物评价与研究工程技术研究中心,广东 广州 510990, bio={"content":"

吴少华,研究方向:药物毒理研究

"}, bioImg=null, bioContent=

吴少华,研究方向:药物毒理研究

, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1309634312258024251, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, xref=1., ext=[AuthorCompanyExt(id=1309634312266412860, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, companyId=1309634312258024251, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.Guangzhou Bay Area Institute of Biomedicine, Guangdong Lewwin Pharmaceutical Research Institute Co., Ltd., Guangdong Provincial Key Laboratory of Drug Non-Clinical Evaluation and Research, TCM Non-clinic Evaluation Branch of National Engineering Research Center for Modernization of Traditional Chinese Medicine, Guangdong Engineering Research Center for Innovative Drug Evaluation and Research, Guangzhou, Guangdong 510990, China), AuthorCompanyExt(id=1309634312274801469, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, companyId=1309634312258024251, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.广州湾区生物医药研究院,广东莱恩医药研究院有限公司,广东省药物非临床评价与研究重点实验室,国家中药现代化工程技术研究中心中药非临床评价分中心,广东省创新药物评价与研究工程技术研究中心,广东 广州 510990)])]), Author(id=1309634312673260359, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1309634312744563529, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, authorId=1309634312673260359, language=EN, stringName=Lu LIU, firstName=Lu, middleName=null, lastName=LIU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.Guangzhou Bay Area Institute of Biomedicine, Guangdong Lewwin Pharmaceutical Research Institute Co., Ltd., Guangdong Provincial Key Laboratory of Drug Non-Clinical Evaluation and Research, TCM Non-clinic Evaluation Branch of National Engineering Research Center for Modernization of Traditional Chinese Medicine, Guangdong Engineering Research Center for Innovative Drug Evaluation and Research, Guangzhou, Guangdong 510990, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1309634312824255306, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, authorId=1309634312673260359, language=CN, stringName=柳璐, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.广州湾区生物医药研究院,广东莱恩医药研究院有限公司,广东省药物非临床评价与研究重点实验室,国家中药现代化工程技术研究中心中药非临床评价分中心,广东省创新药物评价与研究工程技术研究中心,广东 广州 510990, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1309634312258024251, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, xref=1., ext=[AuthorCompanyExt(id=1309634312266412860, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, companyId=1309634312258024251, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.Guangzhou Bay Area Institute of Biomedicine, Guangdong Lewwin Pharmaceutical Research Institute Co., Ltd., Guangdong Provincial Key Laboratory of Drug Non-Clinical Evaluation and Research, TCM Non-clinic Evaluation Branch of National Engineering Research Center for Modernization of Traditional Chinese Medicine, Guangdong Engineering Research Center for Innovative Drug Evaluation and Research, Guangzhou, Guangdong 510990, China), AuthorCompanyExt(id=1309634312274801469, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, companyId=1309634312258024251, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.广州湾区生物医药研究院,广东莱恩医药研究院有限公司,广东省药物非临床评价与研究重点实验室,国家中药现代化工程技术研究中心中药非临床评价分中心,广东省创新药物评价与研究工程技术研究中心,广东 广州 510990)])]), Author(id=1309634312891364172, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1309634312971055950, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, authorId=1309634312891364172, language=EN, stringName=Wen DENG, firstName=Wen, middleName=null, lastName=DENG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=2, address=2.Zhongshan Zhongzhi Pharmaceutical Group Co., Ltd., National Enterprise Technology Center Chinese Medicine Broken-walled Pieces Joint Engineering Research Center, Zhongshan, Guangdong 528437, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1309634313046553423, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, authorId=1309634312891364172, language=CN, stringName=邓雯, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=2, address=2.中山市中智药业集团有限公司,国家企业技术中心中药破壁饮片国家地方联合工程研究中心,广东 中山 528437, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1309634312358687550, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, xref=2., ext=[AuthorCompanyExt(id=1309634312362881855, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, companyId=1309634312358687550, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2.Zhongshan Zhongzhi Pharmaceutical Group Co., Ltd., National Enterprise Technology Center Chinese Medicine Broken-walled Pieces Joint Engineering Research Center, Zhongshan, Guangdong 528437, China), AuthorCompanyExt(id=1309634312371270464, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, companyId=1309634312358687550, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2.中山市中智药业集团有限公司,国家企业技术中心中药破壁饮片国家地方联合工程研究中心,广东 中山 528437)])]), Author(id=1309634313105273681, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1309634313184965459, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, authorId=1309634313105273681, language=EN, stringName=Xialing LEI, firstName=Xialing, middleName=null, lastName=LEI, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.Guangzhou Bay Area Institute of Biomedicine, Guangdong Lewwin Pharmaceutical Research Institute Co., Ltd., Guangdong Provincial Key Laboratory of Drug Non-Clinical Evaluation and Research, TCM Non-clinic Evaluation Branch of National Engineering Research Center for Modernization of Traditional Chinese Medicine, Guangdong Engineering Research Center for Innovative Drug Evaluation and Research, Guangzhou, Guangdong 510990, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1309634313247880020, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, authorId=1309634313105273681, language=CN, stringName=雷夏凌, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.广州湾区生物医药研究院,广东莱恩医药研究院有限公司,广东省药物非临床评价与研究重点实验室,国家中药现代化工程技术研究中心中药非临床评价分中心,广东省创新药物评价与研究工程技术研究中心,广东 广州 510990, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1309634312258024251, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, xref=1., ext=[AuthorCompanyExt(id=1309634312266412860, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, companyId=1309634312258024251, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.Guangzhou Bay Area Institute of Biomedicine, Guangdong Lewwin Pharmaceutical Research Institute Co., Ltd., Guangdong Provincial Key Laboratory of Drug Non-Clinical Evaluation and Research, TCM Non-clinic Evaluation Branch of National Engineering Research Center for Modernization of Traditional Chinese Medicine, Guangdong Engineering Research Center for Innovative Drug Evaluation and Research, Guangzhou, Guangdong 510990, China), AuthorCompanyExt(id=1309634312274801469, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, companyId=1309634312258024251, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.广州湾区生物医药研究院,广东莱恩医药研究院有限公司,广东省药物非临床评价与研究重点实验室,国家中药现代化工程技术研究中心中药非临床评价分中心,广东省创新药物评价与研究工程技术研究中心,广东 广州 510990)])]), Author(id=1309634313403069270, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, orderNo=4, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1309634313478566744, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, authorId=1309634313403069270, language=EN, stringName=Weixuan CHEN, firstName=Weixuan, middleName=null, lastName=CHEN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=2, address=2.Zhongshan Zhongzhi Pharmaceutical Group Co., Ltd., National Enterprise Technology Center Chinese Medicine Broken-walled Pieces Joint Engineering Research Center, Zhongshan, Guangdong 528437, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1309634313809916761, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, authorId=1309634313403069270, language=CN, stringName=陈炜旋, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=2, address=2.中山市中智药业集团有限公司,国家企业技术中心中药破壁饮片国家地方联合工程研究中心,广东 中山 528437, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1309634312358687550, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, xref=2., ext=[AuthorCompanyExt(id=1309634312362881855, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, companyId=1309634312358687550, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2.Zhongshan Zhongzhi Pharmaceutical Group Co., Ltd., National Enterprise Technology Center Chinese Medicine Broken-walled Pieces Joint Engineering Research Center, Zhongshan, Guangdong 528437, China), AuthorCompanyExt(id=1309634312371270464, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, companyId=1309634312358687550, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2.中山市中智药业集团有限公司,国家企业技术中心中药破壁饮片国家地方联合工程研究中心,广东 中山 528437)])]), Author(id=1309634315244368731, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, orderNo=5, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1309634315496026973, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, authorId=1309634315244368731, language=EN, stringName=Qianliang ZHANG, firstName=Qianliang, middleName=null, lastName=ZHANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=2, address=2.Zhongshan Zhongzhi Pharmaceutical Group Co., Ltd., National Enterprise Technology Center Chinese Medicine Broken-walled Pieces Joint Engineering Research Center, Zhongshan, Guangdong 528437, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1309634315563135838, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, authorId=1309634315244368731, language=CN, stringName=张前亮, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=2, address=2.中山市中智药业集团有限公司,国家企业技术中心中药破壁饮片国家地方联合工程研究中心,广东 中山 528437, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1309634312358687550, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, xref=2., ext=[AuthorCompanyExt(id=1309634312362881855, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, companyId=1309634312358687550, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2.Zhongshan Zhongzhi Pharmaceutical Group Co., Ltd., National Enterprise Technology Center Chinese Medicine Broken-walled Pieces Joint Engineering Research Center, Zhongshan, Guangdong 528437, China), AuthorCompanyExt(id=1309634312371270464, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, companyId=1309634312358687550, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2.中山市中智药业集团有限公司,国家企业技术中心中药破壁饮片国家地方联合工程研究中心,广东 中山 528437)])]), Author(id=1309634315634439008, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, orderNo=6, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1309634315911263074, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, authorId=1309634315634439008, language=EN, stringName=Jianmin GUO, firstName=Jianmin, middleName=null, lastName=GUO, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.Guangzhou Bay Area Institute of Biomedicine, Guangdong Lewwin Pharmaceutical Research Institute Co., Ltd., Guangdong Provincial Key Laboratory of Drug Non-Clinical Evaluation and Research, TCM Non-clinic Evaluation Branch of National Engineering Research Center for Modernization of Traditional Chinese Medicine, Guangdong Engineering Research Center for Innovative Drug Evaluation and Research, Guangzhou, Guangdong 510990, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1309634315978371939, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, authorId=1309634315634439008, language=CN, stringName=郭健敏, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.广州湾区生物医药研究院,广东莱恩医药研究院有限公司,广东省药物非临床评价与研究重点实验室,国家中药现代化工程技术研究中心中药非临床评价分中心,广东省创新药物评价与研究工程技术研究中心,广东 广州 510990, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1309634312258024251, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, xref=1., ext=[AuthorCompanyExt(id=1309634312266412860, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, companyId=1309634312258024251, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.Guangzhou Bay Area Institute of Biomedicine, Guangdong Lewwin Pharmaceutical Research Institute Co., Ltd., Guangdong Provincial Key Laboratory of Drug Non-Clinical Evaluation and Research, TCM Non-clinic Evaluation Branch of National Engineering Research Center for Modernization of Traditional Chinese Medicine, Guangdong Engineering Research Center for Innovative Drug Evaluation and Research, Guangzhou, Guangdong 510990, China), AuthorCompanyExt(id=1309634312274801469, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, companyId=1309634312258024251, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.广州湾区生物医药研究院,广东莱恩医药研究院有限公司,广东省药物非临床评价与研究重点实验室,国家中药现代化工程技术研究中心中药非临床评价分中心,广东省创新药物评价与研究工程技术研究中心,广东 广州 510990)])]), Author(id=1309634316041286501, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, orderNo=7, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=yangwei0719@163.com, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1309634316112589671, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, authorId=1309634316041286501, language=EN, stringName=Wei YANG, firstName=Wei, middleName=null, lastName=YANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, *, address=1.Guangzhou Bay Area Institute of Biomedicine, Guangdong Lewwin Pharmaceutical Research Institute Co., Ltd., Guangdong Provincial Key Laboratory of Drug Non-Clinical Evaluation and Research, TCM Non-clinic Evaluation Branch of National Engineering Research Center for Modernization of Traditional Chinese Medicine, Guangdong Engineering Research Center for Innovative Drug Evaluation and Research, Guangzhou, Guangdong 510990, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1309634316330693480, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, authorId=1309634316041286501, language=CN, stringName=杨威, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, *, address=1.广州湾区生物医药研究院,广东莱恩医药研究院有限公司,广东省药物非临床评价与研究重点实验室,国家中药现代化工程技术研究中心中药非临床评价分中心,广东省创新药物评价与研究工程技术研究中心,广东 广州 510990, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1309634312258024251, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, xref=1., ext=[AuthorCompanyExt(id=1309634312266412860, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, companyId=1309634312258024251, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.Guangzhou Bay Area Institute of Biomedicine, Guangdong Lewwin Pharmaceutical Research Institute Co., Ltd., Guangdong Provincial Key Laboratory of Drug Non-Clinical Evaluation and Research, TCM Non-clinic Evaluation Branch of National Engineering Research Center for Modernization of Traditional Chinese Medicine, Guangdong Engineering Research Center for Innovative Drug Evaluation and Research, Guangzhou, Guangdong 510990, China), AuthorCompanyExt(id=1309634312274801469, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, companyId=1309634312258024251, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.广州湾区生物医药研究院,广东莱恩医药研究院有限公司,广东省药物非临床评价与研究重点实验室,国家中药现代化工程技术研究中心中药非临床评价分中心,广东省创新药物评价与研究工程技术研究中心,广东 广州 510990)])])], keywords=[Keyword(id=1309634316422968169, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, language=EN, orderNo=1, keyword=Chuanxiong broken-wall decoction pieces), Keyword(id=1309634316485882730, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, language=EN, orderNo=2, keyword=Chuanxiong decoction pieces), Keyword(id=1309634316565574507, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, language=EN, orderNo=3, keyword=SD rats), Keyword(id=1309634316754318188, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, language=EN, orderNo=4, keyword=acute toxicity), Keyword(id=1309634316817232749, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, language=EN, orderNo=5, keyword=long-term toxicity), Keyword(id=1309634316871758702, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, language=CN, orderNo=1, keyword=川芎破壁饮片), Keyword(id=1309634316938867567, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, language=CN, orderNo=2, keyword=川芎饮片), Keyword(id=1309634316997587824, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, language=CN, orderNo=3, keyword=SD大鼠), Keyword(id=1309634317161165681, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, language=CN, orderNo=4, keyword=急性毒性), Keyword(id=1309634317215691634, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, language=CN, orderNo=5, keyword=长期毒性)], refs=null, funds=[Fund(id=1309634317316354931, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, awardId=2023B1212070029, language=CN, fundingSource=广东省药物非临床评价与研究重点实验室(2023B1212070029), fundOrder=null, country=null), Fund(id=1309634317572207476, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, awardId=2021TY060021, language=CN, fundingSource=广东省重大人才工程项目(2021TY060021), fundOrder=null, country=null), Fund(id=1309634317639316341, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, awardId=SQ2024RA3E000198, language=CN, fundingSource=国家科技创业领军人才(SQ2024RA3E000198), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1309634312258024251, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, xref=1., ext=[AuthorCompanyExt(id=1309634312266412860, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, companyId=1309634312258024251, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.Guangzhou Bay Area Institute of Biomedicine, Guangdong Lewwin Pharmaceutical Research Institute Co., Ltd., Guangdong Provincial Key Laboratory of Drug Non-Clinical Evaluation and Research, TCM Non-clinic Evaluation Branch of National Engineering Research Center for Modernization of Traditional Chinese Medicine, Guangdong Engineering Research Center for Innovative Drug Evaluation and Research, Guangzhou, Guangdong 510990, China), AuthorCompanyExt(id=1309634312274801469, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, companyId=1309634312258024251, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.广州湾区生物医药研究院,广东莱恩医药研究院有限公司,广东省药物非临床评价与研究重点实验室,国家中药现代化工程技术研究中心中药非临床评价分中心,广东省创新药物评价与研究工程技术研究中心,广东 广州 510990)]), AuthorCompany(id=1309634312358687550, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, xref=2., ext=[AuthorCompanyExt(id=1309634312362881855, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, companyId=1309634312358687550, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2.Zhongshan Zhongzhi Pharmaceutical Group Co., Ltd., National Enterprise Technology Center Chinese Medicine Broken-walled Pieces Joint Engineering Research Center, Zhongshan, Guangdong 528437, China), AuthorCompanyExt(id=1309634312371270464, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, companyId=1309634312358687550, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2.中山市中智药业集团有限公司,国家企业技术中心中药破壁饮片国家地方联合工程研究中心,广东 中山 528437)])], figs=null, attaches=null, journal=Journal(id=1227999522736037889, delFlag=0, nameCn=今日药学, nameEn=Pharmacy Today, nameHistory1=null, nameHistory2=null, issn=1674-229X, eissn=null, cn=44-1650/R, coden=null, periodic=0, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=FY3TxpBvpOUMSCZYZYfGWg==, journalPrice=null, startedYear=null, abbrevIsoEn=Pharmacy Today, journalRemark=null, publicationField=null, createdTime=1770707501354, updatedTime=1788949008280, createdBy=18614031015, updatedBy=13041195026, firstLetterCn=J, firstLetterEn=J, subjectCode=Medical and Pharmaceutical Sciences, subjectName=null, subjectCodeEn=Medical and Pharmaceutical Sciences, subjectNameEn=null, picCn=FY3TxpBvpOUMSCZYZYfGWg==, picEn=NQ3glGuPq+e1P2N68+hOuA==, jcr=null, cjcr=null, exts=[JournalExt(id=1304509948906467610, language=CN, name=今日药学, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788949008442, updatedTime=1788949008442, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://yaxu.cbpt.cnki.net/index.aspx?t=1, submissionEditorUrl=https://yaxu.cbpt.cnki.net/index.aspx?t=3, submissionReviewUrl=https://yaxu.cbpt.cnki.net/index.aspx?t=2, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""}), JournalExt(id=1304509948973576475, language=EN, name=Pharmacy Today, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788949008458, updatedTime=1788949008458, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://yaxu.cbpt.cnki.net/index.aspx?t=1, submissionEditorUrl=https://yaxu.cbpt.cnki.net/index.aspx?t=3, submissionReviewUrl=https://yaxu.cbpt.cnki.net/index.aspx?t=2, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""})], databaseList=null, tenantJournalId=1227999776411738115, websiteList=[Website(id=1228000871989047931, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1227999776411738115, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/jryx/CN, language=CN, createTime=1770707823035, createBy=18614031015, updateTime=1770708039065, updateBy=18614031015, name=今日药学-中文, tplId=1146099689490845704, title=今日药学, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1228002007718490824, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1228000871989047931, code=articleTextType, value=kx, createTime=1770708093814, updateTime=1770708093814, creator=18614031015, updator=18614031015), WebsiteProps(id=1228002007697519301, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1228000871989047931, code=banner, value=null, createTime=1770708093809, updateTime=1770708093809, creator=18614031015, updator=18614031015), WebsiteProps(id=1228002007747850955, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1228000871989047931, code=grayFlag, value=0, createTime=1770708093821, updateTime=1770708093821, creator=18614031015, updator=18614031015), WebsiteProps(id=1228002007693324996, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1228000871989047931, code=logo, value=https://castjournals.cast.org.cn/joweb/jryx/CN/file/pic?fileId=NhSjHI8Rs1pxX20zcTmDlg==, createTime=1770708093808, updateTime=1770708093808, creator=18614031015, updator=18614031015), WebsiteProps(id=1228002007764628173, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1228000871989047931, code=minRunFlag, value=0, createTime=1770708093825, updateTime=1770708093825, creator=18614031015, updator=18614031015), WebsiteProps(id=1228002007714296519, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1228000871989047931, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/jryx/CN/file/pic, createTime=1770708093813, updateTime=1770708093813, creator=18614031015, updator=18614031015), WebsiteProps(id=1228002007756239564, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1228000871989047931, code=silenceFlag, value=0, createTime=1770708093823, updateTime=1770708093823, creator=18614031015, updator=18614031015), WebsiteProps(id=1228002007705907910, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1228000871989047931, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1770708093811, updateTime=1770708093811, creator=18614031015, updator=18614031015), WebsiteProps(id=1228002007731073737, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1228000871989047931, code=themeColor, value=null, createTime=1770708093817, updateTime=1770708093817, creator=18614031015, updator=18614031015), WebsiteProps(id=1228002007739462346, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1228000871989047931, code=themeStyle, value=null, createTime=1770708093819, updateTime=1770708093819, creator=18614031015, updator=18614031015)]), Website(id=1228000872060351101, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1227999776411738115, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/jryx/EN, language=EN, createTime=1770707823052, createBy=18614031015, updateTime=1770708061891, updateBy=18614031015, name=今日药学-英文, tplId=1146101810881728533, title=Pharmacy Today, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1228002043235857106, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1228000872060351101, code=articleTextType, value=kx, createTime=1770708102282, updateTime=1770708102282, creator=18614031015, updator=18614031015), WebsiteProps(id=1228002043210691279, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1228000872060351101, code=banner, value=null, createTime=1770708102276, updateTime=1770708102276, creator=18614031015, updator=18614031015), WebsiteProps(id=1228002043261022933, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1228000872060351101, code=grayFlag, value=0, createTime=1770708102288, updateTime=1770708102288, creator=18614031015, updator=18614031015), WebsiteProps(id=1228002043202302670, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1228000872060351101, code=logo, value=https://castjournals.cast.org.cn/joweb/jryx/EN/file/pic?fileId=NhSjHI8Rs1pxX20zcTmDlg==, createTime=1770708102274, updateTime=1770708102274, creator=18614031015, updator=18614031015), WebsiteProps(id=1228002043277800151, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1228000872060351101, code=minRunFlag, value=0, createTime=1770708102292, updateTime=1770708102292, creator=18614031015, updator=18614031015), WebsiteProps(id=1228002043227468497, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1228000872060351101, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/jryx/EN/file/pic, createTime=1770708102280, updateTime=1770708102280, creator=18614031015, updator=18614031015), WebsiteProps(id=1228002043269411542, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1228000872060351101, code=silenceFlag, value=0, createTime=1770708102290, updateTime=1770708102290, creator=18614031015, updator=18614031015), WebsiteProps(id=1228002043219079888, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1228000872060351101, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1770708102278, updateTime=1770708102278, creator=18614031015, updator=18614031015), WebsiteProps(id=1228002043248440019, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1228000872060351101, code=themeColor, value=null, createTime=1770708102285, updateTime=1770708102285, creator=18614031015, updator=18614031015), WebsiteProps(id=1228002043252634324, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1228000872060351101, code=themeStyle, value=null, createTime=1770708102286, updateTime=1770708102286, creator=18614031015, updator=18614031015)])], journalTitle=今日药学, weixinUrl=null, journalUrl=https://yaxu.cbpt.cnki.net/, iacademicId=null, status=1, seqNo=null, journalTitleEn=Pharmacy Today, journalPhotoCn=FY3TxpBvpOUMSCZYZYfGWg==, journalPhotoEn=NQ3glGuPq+e1P2N68+hOuA==, journalFirstLetter=J, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/jryx/CN/10.12048/j.issn.1674-229X.2026.06.003, detailUrlEn=https://castjournals.cast.org.cn/joweb/jryx/EN/10.12048/j.issn.1674-229X.2026.06.003, pdfUrlCn=https://castjournals.cast.org.cn/joweb/jryx/CN/PDF/10.12048/j.issn.1674-229X.2026.06.003, pdfUrlEn=https://castjournals.cast.org.cn/joweb/jryx/EN/PDF/10.12048/j.issn.1674-229X.2026.06.003, aliStartDate=0, aliEndDate=0, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=0, orderTime=1782316800000, fullTextJson=null, articleText=null, reference=null)
收藏切换
川芎破壁饮片对SD大鼠急性毒性和长期毒性试验研究
收藏切换
PDF下载
吴少华 1 , 柳璐 1 , 邓雯 2 , 雷夏凌 1 , 陈炜旋 2 , 张前亮 2 , 郭健敏 1 , 杨威 1, *
今日药学 | 论著 2026,36(6): 416-420
收起
收藏切换
今日药学 |论著 2026 , 36 (6) : 416 -420
川芎破壁饮片对SD大鼠急性毒性和长期毒性试验研究
全屏
[Author(id=1309634312446767938, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1309634312518071108, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, authorId=1309634312446767938, language=EN, stringName=Shaohua WU, firstName=Shaohua, middleName=null, lastName=WU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.Guangzhou Bay Area Institute of Biomedicine, Guangdong Lewwin Pharmaceutical Research Institute Co., Ltd., Guangdong Provincial Key Laboratory of Drug Non-Clinical Evaluation and Research, TCM Non-clinic Evaluation Branch of National Engineering Research Center for Modernization of Traditional Chinese Medicine, Guangdong Engineering Research Center for Innovative Drug Evaluation and Research, Guangzhou, Guangdong 510990, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1309634312589374277, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, authorId=1309634312446767938, language=CN, stringName=吴少华, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.广州湾区生物医药研究院,广东莱恩医药研究院有限公司,广东省药物非临床评价与研究重点实验室,国家中药现代化工程技术研究中心中药非临床评价分中心,广东省创新药物评价与研究工程技术研究中心,广东 广州 510990, bio={"content":"

吴少华,研究方向:药物毒理研究

"}, bioImg=null, bioContent=

吴少华,研究方向:药物毒理研究

, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1309634312258024251, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, xref=1., ext=[AuthorCompanyExt(id=1309634312266412860, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, companyId=1309634312258024251, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.Guangzhou Bay Area Institute of Biomedicine, Guangdong Lewwin Pharmaceutical Research Institute Co., Ltd., Guangdong Provincial Key Laboratory of Drug Non-Clinical Evaluation and Research, TCM Non-clinic Evaluation Branch of National Engineering Research Center for Modernization of Traditional Chinese Medicine, Guangdong Engineering Research Center for Innovative Drug Evaluation and Research, Guangzhou, Guangdong 510990, China), AuthorCompanyExt(id=1309634312274801469, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, companyId=1309634312258024251, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.广州湾区生物医药研究院,广东莱恩医药研究院有限公司,广东省药物非临床评价与研究重点实验室,国家中药现代化工程技术研究中心中药非临床评价分中心,广东省创新药物评价与研究工程技术研究中心,广东 广州 510990)])]), Author(id=1309634312673260359, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1309634312744563529, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, authorId=1309634312673260359, language=EN, stringName=Lu LIU, firstName=Lu, middleName=null, lastName=LIU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.Guangzhou Bay Area Institute of Biomedicine, Guangdong Lewwin Pharmaceutical Research Institute Co., Ltd., Guangdong Provincial Key Laboratory of Drug Non-Clinical Evaluation and Research, TCM Non-clinic Evaluation Branch of National Engineering Research Center for Modernization of Traditional Chinese Medicine, Guangdong Engineering Research Center for Innovative Drug Evaluation and Research, Guangzhou, Guangdong 510990, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1309634312824255306, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, authorId=1309634312673260359, language=CN, stringName=柳璐, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.广州湾区生物医药研究院,广东莱恩医药研究院有限公司,广东省药物非临床评价与研究重点实验室,国家中药现代化工程技术研究中心中药非临床评价分中心,广东省创新药物评价与研究工程技术研究中心,广东 广州 510990, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1309634312258024251, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, xref=1., ext=[AuthorCompanyExt(id=1309634312266412860, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, companyId=1309634312258024251, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.Guangzhou Bay Area Institute of Biomedicine, Guangdong Lewwin Pharmaceutical Research Institute Co., Ltd., Guangdong Provincial Key Laboratory of Drug Non-Clinical Evaluation and Research, TCM Non-clinic Evaluation Branch of National Engineering Research Center for Modernization of Traditional Chinese Medicine, Guangdong Engineering Research Center for Innovative Drug Evaluation and Research, Guangzhou, Guangdong 510990, China), AuthorCompanyExt(id=1309634312274801469, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, companyId=1309634312258024251, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.广州湾区生物医药研究院,广东莱恩医药研究院有限公司,广东省药物非临床评价与研究重点实验室,国家中药现代化工程技术研究中心中药非临床评价分中心,广东省创新药物评价与研究工程技术研究中心,广东 广州 510990)])]), Author(id=1309634312891364172, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1309634312971055950, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, authorId=1309634312891364172, language=EN, stringName=Wen DENG, firstName=Wen, middleName=null, lastName=DENG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=2, address=2.Zhongshan Zhongzhi Pharmaceutical Group Co., Ltd., National Enterprise Technology Center Chinese Medicine Broken-walled Pieces Joint Engineering Research Center, Zhongshan, Guangdong 528437, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1309634313046553423, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, authorId=1309634312891364172, language=CN, stringName=邓雯, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=2, address=2.中山市中智药业集团有限公司,国家企业技术中心中药破壁饮片国家地方联合工程研究中心,广东 中山 528437, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1309634312358687550, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, xref=2., ext=[AuthorCompanyExt(id=1309634312362881855, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, companyId=1309634312358687550, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2.Zhongshan Zhongzhi Pharmaceutical Group Co., Ltd., National Enterprise Technology Center Chinese Medicine Broken-walled Pieces Joint Engineering Research Center, Zhongshan, Guangdong 528437, China), AuthorCompanyExt(id=1309634312371270464, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, companyId=1309634312358687550, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2.中山市中智药业集团有限公司,国家企业技术中心中药破壁饮片国家地方联合工程研究中心,广东 中山 528437)])]), Author(id=1309634313105273681, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1309634313184965459, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, authorId=1309634313105273681, language=EN, stringName=Xialing LEI, firstName=Xialing, middleName=null, lastName=LEI, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.Guangzhou Bay Area Institute of Biomedicine, Guangdong Lewwin Pharmaceutical Research Institute Co., Ltd., Guangdong Provincial Key Laboratory of Drug Non-Clinical Evaluation and Research, TCM Non-clinic Evaluation Branch of National Engineering Research Center for Modernization of Traditional Chinese Medicine, Guangdong Engineering Research Center for Innovative Drug Evaluation and Research, Guangzhou, Guangdong 510990, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1309634313247880020, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, authorId=1309634313105273681, language=CN, stringName=雷夏凌, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.广州湾区生物医药研究院,广东莱恩医药研究院有限公司,广东省药物非临床评价与研究重点实验室,国家中药现代化工程技术研究中心中药非临床评价分中心,广东省创新药物评价与研究工程技术研究中心,广东 广州 510990, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1309634312258024251, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, xref=1., ext=[AuthorCompanyExt(id=1309634312266412860, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, companyId=1309634312258024251, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.Guangzhou Bay Area Institute of Biomedicine, Guangdong Lewwin Pharmaceutical Research Institute Co., Ltd., Guangdong Provincial Key Laboratory of Drug Non-Clinical Evaluation and Research, TCM Non-clinic Evaluation Branch of National Engineering Research Center for Modernization of Traditional Chinese Medicine, Guangdong Engineering Research Center for Innovative Drug Evaluation and Research, Guangzhou, Guangdong 510990, China), AuthorCompanyExt(id=1309634312274801469, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, companyId=1309634312258024251, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.广州湾区生物医药研究院,广东莱恩医药研究院有限公司,广东省药物非临床评价与研究重点实验室,国家中药现代化工程技术研究中心中药非临床评价分中心,广东省创新药物评价与研究工程技术研究中心,广东 广州 510990)])]), Author(id=1309634313403069270, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, orderNo=4, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1309634313478566744, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, authorId=1309634313403069270, language=EN, stringName=Weixuan CHEN, firstName=Weixuan, middleName=null, lastName=CHEN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=2, address=2.Zhongshan Zhongzhi Pharmaceutical Group Co., Ltd., National Enterprise Technology Center Chinese Medicine Broken-walled Pieces Joint Engineering Research Center, Zhongshan, Guangdong 528437, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1309634313809916761, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, authorId=1309634313403069270, language=CN, stringName=陈炜旋, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=2, address=2.中山市中智药业集团有限公司,国家企业技术中心中药破壁饮片国家地方联合工程研究中心,广东 中山 528437, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1309634312358687550, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, xref=2., ext=[AuthorCompanyExt(id=1309634312362881855, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, companyId=1309634312358687550, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2.Zhongshan Zhongzhi Pharmaceutical Group Co., Ltd., National Enterprise Technology Center Chinese Medicine Broken-walled Pieces Joint Engineering Research Center, Zhongshan, Guangdong 528437, China), AuthorCompanyExt(id=1309634312371270464, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, companyId=1309634312358687550, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2.中山市中智药业集团有限公司,国家企业技术中心中药破壁饮片国家地方联合工程研究中心,广东 中山 528437)])]), Author(id=1309634315244368731, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, orderNo=5, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1309634315496026973, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, authorId=1309634315244368731, language=EN, stringName=Qianliang ZHANG, firstName=Qianliang, middleName=null, lastName=ZHANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=2, address=2.Zhongshan Zhongzhi Pharmaceutical Group Co., Ltd., National Enterprise Technology Center Chinese Medicine Broken-walled Pieces Joint Engineering Research Center, Zhongshan, Guangdong 528437, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1309634315563135838, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, authorId=1309634315244368731, language=CN, stringName=张前亮, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=2, address=2.中山市中智药业集团有限公司,国家企业技术中心中药破壁饮片国家地方联合工程研究中心,广东 中山 528437, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1309634312358687550, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, xref=2., ext=[AuthorCompanyExt(id=1309634312362881855, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, companyId=1309634312358687550, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2.Zhongshan Zhongzhi Pharmaceutical Group Co., Ltd., National Enterprise Technology Center Chinese Medicine Broken-walled Pieces Joint Engineering Research Center, Zhongshan, Guangdong 528437, China), AuthorCompanyExt(id=1309634312371270464, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, companyId=1309634312358687550, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2.中山市中智药业集团有限公司,国家企业技术中心中药破壁饮片国家地方联合工程研究中心,广东 中山 528437)])]), Author(id=1309634315634439008, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, orderNo=6, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1309634315911263074, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, authorId=1309634315634439008, language=EN, stringName=Jianmin GUO, firstName=Jianmin, middleName=null, lastName=GUO, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.Guangzhou Bay Area Institute of Biomedicine, Guangdong Lewwin Pharmaceutical Research Institute Co., Ltd., Guangdong Provincial Key Laboratory of Drug Non-Clinical Evaluation and Research, TCM Non-clinic Evaluation Branch of National Engineering Research Center for Modernization of Traditional Chinese Medicine, Guangdong Engineering Research Center for Innovative Drug Evaluation and Research, Guangzhou, Guangdong 510990, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1309634315978371939, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, authorId=1309634315634439008, language=CN, stringName=郭健敏, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.广州湾区生物医药研究院,广东莱恩医药研究院有限公司,广东省药物非临床评价与研究重点实验室,国家中药现代化工程技术研究中心中药非临床评价分中心,广东省创新药物评价与研究工程技术研究中心,广东 广州 510990, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1309634312258024251, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, xref=1., ext=[AuthorCompanyExt(id=1309634312266412860, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, companyId=1309634312258024251, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.Guangzhou Bay Area Institute of Biomedicine, Guangdong Lewwin Pharmaceutical Research Institute Co., Ltd., Guangdong Provincial Key Laboratory of Drug Non-Clinical Evaluation and Research, TCM Non-clinic Evaluation Branch of National Engineering Research Center for Modernization of Traditional Chinese Medicine, Guangdong Engineering Research Center for Innovative Drug Evaluation and Research, Guangzhou, Guangdong 510990, China), AuthorCompanyExt(id=1309634312274801469, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, companyId=1309634312258024251, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.广州湾区生物医药研究院,广东莱恩医药研究院有限公司,广东省药物非临床评价与研究重点实验室,国家中药现代化工程技术研究中心中药非临床评价分中心,广东省创新药物评价与研究工程技术研究中心,广东 广州 510990)])]), Author(id=1309634316041286501, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, orderNo=7, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=yangwei0719@163.com, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1309634316112589671, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, authorId=1309634316041286501, language=EN, stringName=Wei YANG, firstName=Wei, middleName=null, lastName=YANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, *, address=1.Guangzhou Bay Area Institute of Biomedicine, Guangdong Lewwin Pharmaceutical Research Institute Co., Ltd., Guangdong Provincial Key Laboratory of Drug Non-Clinical Evaluation and Research, TCM Non-clinic Evaluation Branch of National Engineering Research Center for Modernization of Traditional Chinese Medicine, Guangdong Engineering Research Center for Innovative Drug Evaluation and Research, Guangzhou, Guangdong 510990, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1309634316330693480, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, authorId=1309634316041286501, language=CN, stringName=杨威, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, *, address=1.广州湾区生物医药研究院,广东莱恩医药研究院有限公司,广东省药物非临床评价与研究重点实验室,国家中药现代化工程技术研究中心中药非临床评价分中心,广东省创新药物评价与研究工程技术研究中心,广东 广州 510990, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1309634312258024251, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, xref=1., ext=[AuthorCompanyExt(id=1309634312266412860, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, companyId=1309634312258024251, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.Guangzhou Bay Area Institute of Biomedicine, Guangdong Lewwin Pharmaceutical Research Institute Co., Ltd., Guangdong Provincial Key Laboratory of Drug Non-Clinical Evaluation and Research, TCM Non-clinic Evaluation Branch of National Engineering Research Center for Modernization of Traditional Chinese Medicine, Guangdong Engineering Research Center for Innovative Drug Evaluation and Research, Guangzhou, Guangdong 510990, China), AuthorCompanyExt(id=1309634312274801469, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, companyId=1309634312258024251, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.广州湾区生物医药研究院,广东莱恩医药研究院有限公司,广东省药物非临床评价与研究重点实验室,国家中药现代化工程技术研究中心中药非临床评价分中心,广东省创新药物评价与研究工程技术研究中心,广东 广州 510990)])])]
吴少华1, 柳璐1, 邓雯2, 雷夏凌1, 陈炜旋2, 张前亮2, 郭健敏1, 杨威1, *
作者信息
  • 1.广州湾区生物医药研究院,广东莱恩医药研究院有限公司,广东省药物非临床评价与研究重点实验室,国家中药现代化工程技术研究中心中药非临床评价分中心,广东省创新药物评价与研究工程技术研究中心,广东 广州 510990
  • 2.中山市中智药业集团有限公司,国家企业技术中心中药破壁饮片国家地方联合工程研究中心,广东 中山 528437
通讯作者:

*

杨威,教授级高级工程师,博士生导师,研究方向:药物药理毒理研究,E-mail:
作者简介:

吴少华,研究方向:药物毒理研究

Study on Acute and Long-term Toxicity of Chuanxiong Broken-wall Decoction Pieces to SD Rats
Shaohua WU1, Lu LIU1, Wen DENG2, Xialing LEI1, Weixuan CHEN2, Qianliang ZHANG2, Jianmin GUO1, Wei YANG1, *
Affiliations
  • 1.Guangzhou Bay Area Institute of Biomedicine, Guangdong Lewwin Pharmaceutical Research Institute Co., Ltd., Guangdong Provincial Key Laboratory of Drug Non-Clinical Evaluation and Research, TCM Non-clinic Evaluation Branch of National Engineering Research Center for Modernization of Traditional Chinese Medicine, Guangdong Engineering Research Center for Innovative Drug Evaluation and Research, Guangzhou, Guangdong 510990, China
  • 2.Zhongshan Zhongzhi Pharmaceutical Group Co., Ltd., National Enterprise Technology Center Chinese Medicine Broken-walled Pieces Joint Engineering Research Center, Zhongshan, Guangdong 528437, China
出版时间: 2026-06-25 doi: 10.12048/j.issn.1674-229X.2026.06.003
文章导航
收藏切换
目的

探究川芎破壁饮片(CXBDP)对SD大鼠急性和长期毒性的影响,并与传统川芎饮片(CXDP)比较,为临床用药提供更多数据支持。

方法

急毒:单次口服给予SD大鼠CXBDP 10.08 g·kg-1和CXDP 10.08 g·kg-1后观察2周;长毒:口服给予SD大鼠CXBDP 0.54、1.35、3.78 g·kg-1,CXDP 0.54、3.78 g·kg-1 4周,停药恢复4周,考察CXBDP和CXDP对大鼠临床观察、体质量、摄食量、血液学、血液生化学、脏器重量和脏器系数以及组织病理学等指标的影响。

结果

急毒:单次口服给予大鼠CXBDP 10.08 g·kg-1(最大给药量)和CXDP 10.08 g·kg-1后,未见明显毒性反应;长毒:连续口服给予CXBDP 0.54、1.35、3.78 g·kg-1,CXDP 0.54、3.78 g·kg-1 4周后,均未见明显毒性反应。

结论

CXBDP与传统CXDP对SD大鼠的安全性差异无统计学意义。

川芎破壁饮片  /  川芎饮片  /  SD大鼠  /  急性毒性  /  长期毒性
OBJECTIVE

To explore the effects of Chuanxiong broken-wall decoction pieces (CXBDP) on acute and long-term toxicity in SD rats, and compare them with traditional Chuanxiong decoction pieces (CXDP), so as to provide more data support for clinical medication.

METHODS

Acute toxicity: SD rats were given a single oral dose of CXBDP 10.08 g·kg-1 and CXDP 10.08 g·kg-1, and then observed for 2 weeks.Long-term toxicity: SD rats were orally given CXBDP 0.54, 1.35, 3.78 g·kg-1, CXDP 0.54, 3.78 g·kg-1 for 4 weeks, and then allowed to recover for 4 weeks after drug withdrawal. The effects of CXBDP and CXDP on rats' clinical observation, body weight, food intake, hematology, blood biochemistry, organ weight, organ coefficient and histopathological indicators were investigated.

RESULTS

Acute toxicity: no obvious toxic reactions was observed after single oral administration of CXBDP 10.08 g·kg-1 (maximum dose) and CXDP 10.08 g·kg-1. Long-term toxicity: no obvious toxic reactions was observed in SD rats after continuous oral administration of CXBDP (0.54, 1.35, and 3.78 g·kg-1) and CXDP (0.54 and 3.78 g·kg-1) for 4 weeks, as well as during the 4-week recovery period after drug withdrawal.

CONCLUSION

There were no statistically significant difference in safety between CXBDP and traditional CXDP in SD rats.

Chuanxiong broken-wall decoction pieces  /  Chuanxiong decoction pieces  /  SD rats  /  acute toxicity  /  long-term toxicity
吴少华, 柳璐, 邓雯, 雷夏凌, 陈炜旋, 张前亮, 郭健敏, 杨威. 川芎破壁饮片对SD大鼠急性毒性和长期毒性试验研究. 今日药学, 2026 , 36 (6) : 416 -420 . DOI: 10.12048/j.issn.1674-229X.2026.06.003
Shaohua WU, Lu LIU, Wen DENG, Xialing LEI, Weixuan CHEN, Qianliang ZHANG, Jianmin GUO, Wei YANG. Study on Acute and Long-term Toxicity of Chuanxiong Broken-wall Decoction Pieces to SD Rats[J]. Pharmacy Today, 2026 , 36 (6) : 416 -420 . DOI: 10.12048/j.issn.1674-229X.2026.06.003
  • 广东省药物非临床评价与研究重点实验室(2023B1212070029)
  • 广东省重大人才工程项目(2021TY060021)
  • 国家科技创业领军人才(SQ2024RA3E000198)
参考文献 引证文献
排序方式:
2026年第36卷第6期
PDF下载
155
38
引用本文
BibTeX
文章信息
doi: 10.12048/j.issn.1674-229X.2026.06.003
  • 接收时间:2025-09-30
  • 首发时间:2026-09-23
  • 出版时间:2026-06-25
补充材料
相关文章
文章信息
作者
出版历史
  • 收稿日期:2025-09-30
基金
广东省药物非临床评价与研究重点实验室(2023B1212070029)
广东省重大人才工程项目(2021TY060021)
国家科技创业领军人才(SQ2024RA3E000198)
作者信息
    1.广州湾区生物医药研究院,广东莱恩医药研究院有限公司,广东省药物非临床评价与研究重点实验室,国家中药现代化工程技术研究中心中药非临床评价分中心,广东省创新药物评价与研究工程技术研究中心,广东 广州 510990
    2.中山市中智药业集团有限公司,国家企业技术中心中药破壁饮片国家地方联合工程研究中心,广东 中山 528437

通讯作者:

*

杨威,教授级高级工程师,博士生导师,研究方向:药物药理毒理研究,E-mail:
参考文献
分享链接
https://castjournals.cast.org.cn/joweb/jryx/CN/10.12048/j.issn.1674-229X.2026.06.003
分享至
全文二维码

扫描看全文

引用本文
BibTeX
本文的引用情况
2种不同金属材料的力学参数
科
Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)
属
Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏