Article(id=1309634311620490040, tenantId=1146029695717560320, journalId=1227999776411738115, issueId=1309634291257143967, articleNumber=null, orderNo=null, doi=10.12048/j.issn.1674-229X.2026.06.003, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1759161600000, receivedDateStr=2025-09-30, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1790170751718, onlineDateStr=2026-09-23, pubDate=1782316800000, pubDateStr=2026-06-25, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1790170751718, onlineIssueDateStr=2026-09-23, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1790170751718, creator=13701087609, updateTime=1790170751718, updator=13701087609, issue=Issue{id=1309634291257143967, tenantId=1146029695717560320, journalId=1227999776411738115, year='2026', volume='36', issue='6', pageStart='401', pageEnd='480', issueExtLink='null', onlineDate='null', pubDate='1782316800000', pubDateStr='2026-06-25', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1790170746864, creator='13701087609', updateTime=1790218948815, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1309836464964337802, tenantId=1146029695717560320, journalId=1227999776411738115, issueId=1309634291257143967, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1309836464964337803, tenantId=1146029695717560320, journalId=1227999776411738115, issueId=1309634291257143967, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=416, endPage=420, ext={EN=ArticleExt(id=1309634311792456505, articleId=1309634311620490040, tenantId=1146029695717560320, journalId=1227999776411738115, language=EN, title=Study on Acute and Long-term Toxicity of
Chuanxiong Broken-wall Decoction Pieces to SD Rats, columnId=null, journalTitle=Pharmacy Today, columnName=null, runingTitle=null, highlight=null, articleAbstract=
OBJECTIVE To explore the effects of Chuanxiong broken-wall decoction pieces (CXBDP) on acute and long-term toxicity in SD rats, and compare them with traditional Chuanxiong decoction pieces (CXDP), so as to provide more data support for clinical medication.
METHODS Acute toxicity: SD rats were given a single oral dose of CXBDP 10.08 g·kg-1 and CXDP 10.08 g·kg-1, and then observed for 2 weeks.Long-term toxicity: SD rats were orally given CXBDP 0.54, 1.35, 3.78 g·kg-1, CXDP 0.54, 3.78 g·kg-1 for 4 weeks, and then allowed to recover for 4 weeks after drug withdrawal. The effects of CXBDP and CXDP on rats' clinical observation, body weight, food intake, hematology, blood biochemistry, organ weight, organ coefficient and histopathological indicators were investigated.
RESULTS Acute toxicity: no obvious toxic reactions was observed after single oral administration of CXBDP 10.08 g·kg-1 (maximum dose) and CXDP 10.08 g·kg-1. Long-term toxicity: no obvious toxic reactions was observed in SD rats after continuous oral administration of CXBDP (0.54, 1.35, and 3.78 g·kg-1) and CXDP (0.54 and 3.78 g·kg-1) for 4 weeks, as well as during the 4-week recovery period after drug withdrawal.
CONCLUSION There were no statistically significant difference in safety between CXBDP and traditional CXDP in SD rats.
, authors=Shaohua WU
1, Lu LIU
1, Wen DENG
2, Xialing LEI
1, Weixuan CHEN
2, Qianliang ZHANG
2, Jianmin GUO
1, Wei YANG
1, *, authorsList=Shaohua WU, Lu LIU, Wen DENG, Xialing LEI, Weixuan CHEN, Qianliang ZHANG, Jianmin GUO, Wei YANG, authorCompany=null, correspAuthors=Wei YANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1309634312060891962, articleId=1309634311620490040, tenantId=1146029695717560320, journalId=1227999776411738115, language=CN, title=川芎破壁饮片对SD大鼠急性毒性和长期毒性试验研究, columnId=1228268589086606089, journalTitle=今日药学, columnName=论著, runingTitle=null, highlight=null, articleAbstract=
目的 探究川芎破壁饮片(CXBDP)对SD大鼠急性和长期毒性的影响,并与传统川芎饮片(CXDP)比较,为临床用药提供更多数据支持。
方法 急毒:单次口服给予SD大鼠CXBDP 10.08 g·kg-1和CXDP 10.08 g·kg-1后观察2周;长毒:口服给予SD大鼠CXBDP 0.54、1.35、3.78 g·kg-1,CXDP 0.54、3.78 g·kg-1 4周,停药恢复4周,考察CXBDP和CXDP对大鼠临床观察、体质量、摄食量、血液学、血液生化学、脏器重量和脏器系数以及组织病理学等指标的影响。
结果 急毒:单次口服给予大鼠CXBDP 10.08 g·kg-1(最大给药量)和CXDP 10.08 g·kg-1后,未见明显毒性反应;长毒:连续口服给予CXBDP 0.54、1.35、3.78 g·kg-1,CXDP 0.54、3.78 g·kg-1 4周后,均未见明显毒性反应。
结论 CXBDP与传统CXDP对SD大鼠的安全性差异无统计学意义。
, authors=吴少华
1, 柳璐
1, 邓雯
2, 雷夏凌
1, 陈炜旋
2, 张前亮
2, 郭健敏
1, 杨威
1, *, authorsList=吴少华, 柳璐, 邓雯, 雷夏凌, 陈炜旋, 张前亮, 郭健敏, 杨威, authorCompany=null, correspAuthors=杨威, authorNote=
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1.Guangzhou Bay Area Institute of Biomedicine, Guangdong Lewwin Pharmaceutical Research Institute Co., Ltd., Guangdong Provincial Key Laboratory of Drug Non-Clinical Evaluation and Research, TCM Non-clinic Evaluation Branch of National Engineering Research Center for Modernization of Traditional Chinese Medicine, Guangdong Engineering Research Center for Innovative Drug Evaluation and Research, Guangzhou, Guangdong 510990, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1309634312589374277, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, authorId=1309634312446767938, language=CN, stringName=吴少华, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
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1.广州湾区生物医药研究院,广东莱恩医药研究院有限公司,广东省药物非临床评价与研究重点实验室,国家中药现代化工程技术研究中心中药非临床评价分中心,广东省创新药物评价与研究工程技术研究中心,广东 广州 510990)])]), Author(id=1309634312673260359, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1309634312744563529, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, authorId=1309634312673260359, language=EN, stringName=Lu LIU, firstName=Lu, middleName=null, lastName=LIU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
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1.Guangzhou Bay Area Institute of Biomedicine, Guangdong Lewwin Pharmaceutical Research Institute Co., Ltd., Guangdong Provincial Key Laboratory of Drug Non-Clinical Evaluation and Research, TCM Non-clinic Evaluation Branch of National Engineering Research Center for Modernization of Traditional Chinese Medicine, Guangdong Engineering Research Center for Innovative Drug Evaluation and Research, Guangzhou, Guangdong 510990, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1309634312824255306, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, authorId=1309634312673260359, language=CN, stringName=柳璐, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
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1.广州湾区生物医药研究院,广东莱恩医药研究院有限公司,广东省药物非临床评价与研究重点实验室,国家中药现代化工程技术研究中心中药非临床评价分中心,广东省创新药物评价与研究工程技术研究中心,广东 广州 510990, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1309634312258024251, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, xref=1., ext=[AuthorCompanyExt(id=1309634312266412860, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, companyId=1309634312258024251, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1.Guangzhou Bay Area Institute of Biomedicine, Guangdong Lewwin Pharmaceutical Research Institute Co., Ltd., Guangdong Provincial Key Laboratory of Drug Non-Clinical Evaluation and Research, TCM Non-clinic Evaluation Branch of National Engineering Research Center for Modernization of Traditional Chinese Medicine, Guangdong Engineering Research Center for Innovative Drug Evaluation and Research, Guangzhou, Guangdong 510990, China), AuthorCompanyExt(id=1309634312274801469, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, companyId=1309634312258024251, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1.广州湾区生物医药研究院,广东莱恩医药研究院有限公司,广东省药物非临床评价与研究重点实验室,国家中药现代化工程技术研究中心中药非临床评价分中心,广东省创新药物评价与研究工程技术研究中心,广东 广州 510990)])]), Author(id=1309634312891364172, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1309634312971055950, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, authorId=1309634312891364172, language=EN, stringName=Wen DENG, firstName=Wen, middleName=null, lastName=DENG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
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2.Zhongshan Zhongzhi Pharmaceutical Group Co., Ltd., National Enterprise Technology Center Chinese Medicine Broken-walled Pieces Joint Engineering Research Center, Zhongshan, Guangdong 528437, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1309634313046553423, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, authorId=1309634312891364172, language=CN, stringName=邓雯, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
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2.中山市中智药业集团有限公司,国家企业技术中心中药破壁饮片国家地方联合工程研究中心,广东 中山 528437, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1309634312358687550, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, xref=2., ext=[AuthorCompanyExt(id=1309634312362881855, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, companyId=1309634312358687550, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
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2.中山市中智药业集团有限公司,国家企业技术中心中药破壁饮片国家地方联合工程研究中心,广东 中山 528437)])]), Author(id=1309634313105273681, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1309634313184965459, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, authorId=1309634313105273681, language=EN, stringName=Xialing LEI, firstName=Xialing, middleName=null, lastName=LEI, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, address=
1.Guangzhou Bay Area Institute of Biomedicine, Guangdong Lewwin Pharmaceutical Research Institute Co., Ltd., Guangdong Provincial Key Laboratory of Drug Non-Clinical Evaluation and Research, TCM Non-clinic Evaluation Branch of National Engineering Research Center for Modernization of Traditional Chinese Medicine, Guangdong Engineering Research Center for Innovative Drug Evaluation and Research, Guangzhou, Guangdong 510990, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1309634313247880020, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, authorId=1309634313105273681, language=CN, stringName=雷夏凌, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
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1.广州湾区生物医药研究院,广东莱恩医药研究院有限公司,广东省药物非临床评价与研究重点实验室,国家中药现代化工程技术研究中心中药非临床评价分中心,广东省创新药物评价与研究工程技术研究中心,广东 广州 510990, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1309634312258024251, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, xref=1., ext=[AuthorCompanyExt(id=1309634312266412860, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, companyId=1309634312258024251, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1.Guangzhou Bay Area Institute of Biomedicine, Guangdong Lewwin Pharmaceutical Research Institute Co., Ltd., Guangdong Provincial Key Laboratory of Drug Non-Clinical Evaluation and Research, TCM Non-clinic Evaluation Branch of National Engineering Research Center for Modernization of Traditional Chinese Medicine, Guangdong Engineering Research Center for Innovative Drug Evaluation and Research, Guangzhou, Guangdong 510990, China), AuthorCompanyExt(id=1309634312274801469, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, companyId=1309634312258024251, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1.广州湾区生物医药研究院,广东莱恩医药研究院有限公司,广东省药物非临床评价与研究重点实验室,国家中药现代化工程技术研究中心中药非临床评价分中心,广东省创新药物评价与研究工程技术研究中心,广东 广州 510990)])]), Author(id=1309634313403069270, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, orderNo=4, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1309634313478566744, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, authorId=1309634313403069270, language=EN, stringName=Weixuan CHEN, firstName=Weixuan, middleName=null, lastName=CHEN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
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2, address=
2.中山市中智药业集团有限公司,国家企业技术中心中药破壁饮片国家地方联合工程研究中心,广东 中山 528437, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1309634312358687550, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, xref=2., ext=[AuthorCompanyExt(id=1309634312362881855, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, companyId=1309634312358687550, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
2.Zhongshan Zhongzhi Pharmaceutical Group Co., Ltd., National Enterprise Technology Center Chinese Medicine Broken-walled Pieces Joint Engineering Research Center, Zhongshan, Guangdong 528437, China), AuthorCompanyExt(id=1309634312371270464, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634311620490040, companyId=1309634312358687550, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
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