Article(id=1309634309351367084, tenantId=1146029695717560320, journalId=1227999776411738115, issueId=1309634291257143967, articleNumber=null, orderNo=null, doi=10.12048/j.issn.1674-229X.2026.06.011, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1760976000000, receivedDateStr=2025-10-21, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1790170751177, onlineDateStr=2026-09-23, pubDate=1782316800000, pubDateStr=2026-06-25, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1790170751177, onlineIssueDateStr=2026-09-23, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1790170751177, creator=13701087609, updateTime=1790170751177, updator=13701087609, issue=Issue{id=1309634291257143967, tenantId=1146029695717560320, journalId=1227999776411738115, year='2026', volume='36', issue='6', pageStart='401', pageEnd='480', issueExtLink='null', onlineDate='null', pubDate='1782316800000', pubDateStr='2026-06-25', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1790170746864, creator='13701087609', updateTime=1790218948815, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1309836464964337802, tenantId=1146029695717560320, journalId=1227999776411738115, issueId=1309634291257143967, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1309836464964337803, tenantId=1146029695717560320, journalId=1227999776411738115, issueId=1309634291257143967, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=467, endPage=473, ext={EN=ArticleExt(id=1309634311012311469, articleId=1309634309351367084, tenantId=1146029695717560320, journalId=1227999776411738115, language=EN, title=Advances in Liquid Biopsy Biomarkers for Monitoring and Evaluating the Therapeutic Response of Breast Cancer, columnId=null, journalTitle=Pharmacy Today, columnName=null, runingTitle=null, highlight=null, articleAbstract=

Breast cancer is a malignant tumor with a high incidence rate among women, and its high heterogeneity leads to great differences in therapeutic responses to treatment regimens. Early efficacy assessment of breast cancer therapy can help identify ineffective treatment regimens as soon as possible, allowing for timely adjustments in treatment strategies. This effectively avoids treatment delays and toxic damage from ineffective regimens, thereby improving patients' therapeutic benefits. Currently, the evaluation of therapeutic efficacy for breast cancer primarily relies on imaging methods to monitor changes in tumor size before and after treatment. However, monitoring such changes often requires a lengthy evaluation period, making it difficult to meet the clinical need for early efficacy assessment. Liquid biopsy is a minimally invasive detection method that analyzes tumor-derived biomarkers in body fluids, such as circulating tumor cells, circulating tumor DNA, circulating tumor microRNA, extracellular vesicles, proteins, and metabolites, to obtain pathophysiology-related information of tumors. This enables real-time monitoring of tumor status and progression, demonstrating broad application prospects in the monitoring and evaluation of tumor treatment efficacy. This review will systematically summarize the advances in liquid biopsy biomarkers for the monitoring and evaluation of breast cancer treatment efficacy, while also analyzing and discussing the challenges in their clinical translation and potential future developments in this field.

, authors=Zhihua LI^a, Yuan LI^a, Guobin QIU^b, Xixiao YANG^{a, *}, authorsList=Zhihua LI, Yuan LI, Guobin QIU, Xixiao YANG, authorCompany=null, correspAuthors=Xixiao YANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1309634311364633006, articleId=1309634309351367084, tenantId=1146029695717560320, journalId=1227999776411738115, language=CN, title=乳腺癌治疗疗效监测评估的液体活检生物标志物研究进展, columnId=1228268593092162252, journalTitle=今日药学, columnName=药学进展, runingTitle=null, highlight=null, articleAbstract=

乳腺癌是一种女性高发病率的恶性肿瘤，其高异质性导致治疗方案疗效差异大。乳腺癌治疗的早期疗效评估将有助于尽早识别无效治疗方案，及时调整治疗策略，可有效避免延误治疗和无效方案的毒性损伤，从而提高患者的治疗获益。目前，乳腺癌治疗疗效评估主要通过影像学方法监测治疗前后肿瘤大小的变化评价治疗方案的疗效。然而，监测评估治疗前后肿瘤大小变化往往需要较长的评估周期，难以满足早期疗效监测评估的临床需求。液体活检是一种微创检测方法，通过检测分析体液中循环肿瘤细胞、循环肿瘤DNA、循环肿瘤microRNA、细胞外囊泡、蛋白质、代谢物等肿瘤来源的生物标志物获得肿瘤病理生理学相关信息，实现实时肿瘤状态及进展监测，在肿瘤治疗疗效监测评估中表现出广阔应用前景。本文将系统总结液体活检生物标志物在乳腺癌治疗疗效监测评估中的研究进展，同时分析探讨其临床转化的挑战及未来该领域可能的发展方向。

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李志华，博士，主管药师，研究方向：肿瘤精准治疗

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李志华，博士，主管药师，研究方向：肿瘤精准治疗

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