今日药学

黄芪桂枝五物汤治疗奥沙利铂相关神经毒性临床观察研究

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曹燕青 ^a , 陈英 ^b^,^*

今日药学 | 临床药学 2026,36(6): 462-466

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今日药学 |临床药学 2026 , 36 (6) : 462 -466

黄芪桂枝五物汤治疗奥沙利铂相关神经毒性临床观察研究

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曹燕青^a, 陈英^b^,^*

作者信息

^a．广东药科大学附属第一医院，肿瘤科，广东广州 510080

^b．广东药科大学附属第一医院，超声科，广东广州 510080

通讯作者:

陈英，主治医师，研究方向：常见恶性肿瘤超声诊断、肌骨、浅表组织及心脏超声，E-mail: chenyingjx.2010@163.com

作者简介:

曹燕青，主治医师，研究方向：肿瘤放化综合治疗

Clinical Observational Study on Huangqi Guizhi Wuwu Decoction Treating the Neuropathy Caused by Oxaliplatin in Colorectal Cancer

Yanqing CAO^a, Ying CHEN^b^,^*

Affiliations

^a.Department of Oncology, the First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, Guangdong 510080, China

^b.Department of Ultrasonography, the First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, Guangdong 510080, China

出版时间: 2026-06-25 doi: 10.12048/j.issn.1674-229X.2026.06.010

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摘要

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目的

探讨在接受奥沙利铂辅助化疗的结直肠癌患者中，黄芪桂枝五物汤对奥沙利铂相关外周神经毒性的治疗疗效。

方法

纳入2022年3月~2024年12月在某院接受mFOLFOX6辅助化疗的结直肠癌患者共42例，对照组（21例）仅接受化疗，试验组（21例）在化疗的同时配合服用黄芪桂枝五物汤4个周期。采用CTCAE V4.0标准评估奥沙利铂相关外周神经毒性，主要研究终点为3级及以上外周神经毒性的发生率。

结果

试验组和对照组3级及以上感觉异常发生率分别为23.8% vs． 57.1%（P=0.03）；3级及以上外周感觉神经障碍发生率分别为19.1% vs． 47.6%（P=0.04），差异具有统计学意义。

结论

化疗期间同步服用黄芪桂枝五物汤能有效防治奥沙利铂的感觉异常和外周感觉神经障碍。

关键词

结直肠癌 / 奥沙利铂 / 外周神经毒性 / 黄芪桂枝五物汤

Abstract

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OBJECTIVE

To explore the therapeutic effect of Huangqi Guizhi Wuwu decoction on oxaliplatin-related peripheral neurotoxicity in patients with colorectal cancer receiving adjuvant chemotherapy.

METHODS

A total of 42 colorectal cancer patients who received mFOLFOX6 adjuvant chemotherapy in a hospital from March 2022 to December 2024 were enrolled in this study. They were randomly divided into two groups (n=21 each). The control group was treated with chemotherapy alone, while the experimental group received Huangqi Guizhi Wuwu decoction for 4 cycles concurrently with chemotherapy. The CTCAE V4.0 standard was used to evaluate oxaliplatin-related peripheral neurotoxicity, and the primary study endpoint was the incidence of grade 3 and above peripheral neurotoxicity.

RESULTS

The incidences of grade 3 or higher peripheral paresthesia in the experimental group and the control group were 23.8% vs. 57.1% (P=0.03). The incidences of grade 3 and above peripheral sensory neuropathy were 19.1% vs. 47.6% (P=0.04), with statistically significant differences observed between the two groups.

CONCLUSION

Taking Huangqi Guizhi Wuwu decoction simultaneously during chemotherapy can effectively prevent and treat oxaliplatin-induced peripheral paresthesia and peripheral sensory neuropathy.

Key words

colorectal cancer / oxaliplatin / peripheral neurotoxicity / Huangqi Guizhi Wuwu decoction

引用本文

曹燕青, 陈英. 黄芪桂枝五物汤治疗奥沙利铂相关神经毒性临床观察研究. 今日药学, 2026 , 36 (6) : 462 -466 . DOI: 10.12048/j.issn.1674-229X.2026.06.010

Yanqing CAO, Ying CHEN. Clinical Observational Study on Huangqi Guizhi Wuwu Decoction Treating the Neuropathy Caused by Oxaliplatin in Colorectal Cancer[J]. Pharmacy Today, 2026 , 36 (6) : 462 -466 . DOI: 10.12048/j.issn.1674-229X.2026.06.010

基金

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广东省中医药局科研项目(20221224)
广东省医学科学技术研究基金(B2022050)
广东省中医药局科研项目(20252022)

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2026年第36卷第6期

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文章信息

doi: 10.12048/j.issn.1674-229X.2026.06.010

接收时间：2025-05-09
首发时间：2026-09-23
出版时间：2026-06-25

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收稿日期：2025-05-09

基金

广东省中医药局科研项目(20221224)

广东省医学科学技术研究基金(B2022050)

广东省中医药局科研项目(20252022)

作者信息

^a．广东药科大学附属第一医院，肿瘤科，广东广州 510080

^b．广东药科大学附属第一医院，超声科，广东广州 510080

通讯作者:

陈英，主治医师，研究方向：常见恶性肿瘤超声诊断、肌骨、浅表组织及心脏超声，E-mail: chenyingjx.2010@163.com

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https://castjournals.cast.org.cn/joweb/jryx/CN/10.12048/j.issn.1674-229X.2026.06.010

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2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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