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Article(id=1309634302216860383, tenantId=1146029695717560320, journalId=1227999776411738115, issueId=1309634291257143967, articleNumber=null, orderNo=null, doi=10.12048/j.issn.1674-229X.2026.06.002, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1761062400000, receivedDateStr=2025-10-22, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1790170749477, onlineDateStr=2026-09-23, pubDate=1782316800000, pubDateStr=2026-06-25, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1790170749477, onlineIssueDateStr=2026-09-23, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1790170749477, creator=13701087609, updateTime=1790170749477, updator=13701087609, issue=Issue{id=1309634291257143967, tenantId=1146029695717560320, journalId=1227999776411738115, year='2026', volume='36', issue='6', pageStart='401', pageEnd='480', issueExtLink='null', onlineDate='null', pubDate='1782316800000', pubDateStr='2026-06-25', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1790170746864, creator='13701087609', updateTime=1790218948815, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1309836464964337802, tenantId=1146029695717560320, journalId=1227999776411738115, issueId=1309634291257143967, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1309836464964337803, tenantId=1146029695717560320, journalId=1227999776411738115, issueId=1309634291257143967, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=409, endPage=415, ext={EN=ArticleExt(id=1309634302376243936, articleId=1309634302216860383, tenantId=1146029695717560320, journalId=1227999776411738115, language=EN, title=Study on Enhancing Immunity and Improving Gastrointestinal Effect of the Water Extract of Ficus hirta, columnId=null, journalTitle=Pharmacy Today, columnName=null, runingTitle=null, highlight=null, articleAbstract=
OBJECTIVE

To explore the pharmacological effects of water extract of Ficus hirta on enhancing immunity and improving gastrointestinal function.

METHODS

Sixty healthy male Kunming (KM) mice, weighing 18-22 g, were randomly divided into 6 groups: normal group, model group, positive (Thymus-intestinal peptide) group, low-, medium-, and high-dose groups of the test drug, with 10 mice in each group. Except for the normal group, the other groups were given intraperitoneal injection of cyclophosphamide combined with 5-fluorouracil to prepare mice models of immunosuppression and gastrointestinal dysfunction. The normal and model groups were given distilled water, and the positive group and the test drug groups were given the corresponding drugs for 7 consecutive days. The intestinal charcoal transit rate, blood cell count, serum inflammatory cytokines and immune protein levels of the mice were detected, and the pathological damage of intestinal and spleen tissues was observed, and pathological injury of intestinal and spleen tissues were observed.

RESULTS

Compared with the model group, the water extract of Ficus hirta significantly significantly increased the levels of IgA, IgE, IgM, IL-2, and IFN-γ in the plasma supernatant of mice and increased the spleen index, increased the intestinal charcoal transit rate and the number of red blood cells in the blood of mice, and alleviated the pathological injury degree of intestinal and spleen tissues of mice, and to some extent alleviated the immunosuppression induced by cyclophosphamide combined with 5-Fu in mice induced by cyclophosphamide combined with 5-Fu in mice.

CONCLUSION

This study confirmed that the water extract of Ficus hirta has a promoting effect on enhancing immunity and improving gastrointestinal peristalsis, and provides data reference for the development and utilization of Ficus hirta resources.

, authors=Yulan WU1, Yingui LI2, 3, ling ZHANG3, Canhong WANG2, 3, authorsList=Yulan WU, Yingui LI, ling ZHANG, Canhong WANG, authorCompany=null, correspAuthors=ling ZHANG, Canhong WANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1309634302703399649, articleId=1309634302216860383, tenantId=1146029695717560320, journalId=1227999776411738115, language=CN, title=五指毛桃水提物提高免疫和改善胃肠道作用研究, columnId=1228268589086606089, journalTitle=今日药学, columnName=论著, runingTitle=null, highlight=null, articleAbstract=
目的

探究五指毛桃水提取物提高免疫和改善胃肠道药效作用。

方法

采用健康的雄性昆明（KM）小鼠60只，体质量18~22 g，随机分为6组，正常组、模型组、阳性（胸腺肠肽）组、受试药物低、中和高剂量组，每组10只。除正常组外，其余组腹腔注射环磷酰5-氟尿嘧啶（5-fluorouracil, 5-Fu），制备小鼠免疫抑制和胃肠道功能紊乱模型。正常和模型组给予蒸馏水，阳性组和受试药物组给予相应药物处理，连续7 d。处理小鼠，计算小鼠的肠炭末推进率、计数红细胞，检测血清中炎性细胞因子和免疫蛋白水平，观察肠和脾脏组织病理损伤情况。

结果

与模型组相比，五指毛桃水提物显著升高小鼠血浆上清中IgA、IgE、IgM、IL-2、IFN-γ水平及脾脏指数，提高小鼠肠炭末推进率和血液红细胞数目，减轻小鼠肠组织和脾脏组织的病理损伤程度，一定程度上缓解环磷酰胺联合5-Fu所致的小鼠免疫功能低下。

结论

本研究证实，五指毛桃水提物对提高免疫和改善胃肠道蠕动有促进作用，为五指毛桃资源的开发利用提供数据参考。

, authors=吴玉兰1, 李银桂2, 3, 张玲3, *, 王灿红2, 3, *, authorsList=吴玉兰, 李银桂, 张玲, 王灿红, authorCompany=null, correspAuthors=张玲, 王灿红, authorNote=

吴玉兰，在读硕士研究生，研究方向：中药药效作用机理研究

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共同通信作者
张玲，博士，教授，硕士生导师，研究方向：食品保鲜、食品加工技术、农业废弃物资源化利用，E-mail:
王灿红，硕士，助理研究员，研究方向：中药、天然药物药效活性评价、作用机理研究及产品开发，E-mail:
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五指毛桃水提物提高免疫和改善胃肠道作用研究
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吴玉兰 1 , 李银桂 2, 3 , 张玲 3, * , 王灿红 2, 3, *
今日药学 | 论著 2026,36(6): 409-415
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今日药学 |论著 2026 , 36 (6) : 409 -415
五指毛桃水提物提高免疫和改善胃肠道作用研究
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吴玉兰1, 李银桂2, 3, 张玲3, * , 王灿红2, 3, *
作者信息
  • 1．海南医科大学，海南省热带药用植物研究开发重点实验室，海南 海口 571199
  • 2．岭南现代农业科学与技术广东省实验室茂名分中心，广东 茂名 525099
  • 3．广东石油化工学院，广东省绿色农产品加工与智能装备重点实验室，广东 茂名 525099
通讯作者:
共同通信作者
张玲，博士，教授，硕士生导师，研究方向：食品保鲜、食品加工技术、农业废弃物资源化利用，E-mail:
王灿红，硕士，助理研究员，研究方向：中药、天然药物药效活性评价、作用机理研究及产品开发，E-mail:
作者简介:

吴玉兰，在读硕士研究生，研究方向：中药药效作用机理研究

Study on Enhancing Immunity and Improving Gastrointestinal Effect of the Water Extract of Ficus hirta
Yulan WU1, Yingui LI2, 3, ling ZHANG3 , Canhong WANG2, 3
Affiliations
  • 1.Hainan Medical University, Hainan Provincial Key Laboratory for Research and Development of Tropical Herbs, Haikou, Hainan 571199, China
  • 2.Maoming Branch of Guangdong Laboratory for Lingnan Modern Agriculture, Maoming, Guangdong 525099, China
  • 3.Guangdong Key Laboratory of Green Agricultural Products Processing and Intelligent Equipment, Guangdong University of Petrochemical Technology, Maoming, Guangdong 525099, China
出版时间: 2026-06-25 doi: 10.12048/j.issn.1674-229X.2026.06.002
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摘要
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目的

探究五指毛桃水提取物提高免疫和改善胃肠道药效作用。

方法

采用健康的雄性昆明（KM）小鼠60只，体质量18~22 g，随机分为6组，正常组、模型组、阳性（胸腺肠肽）组、受试药物低、中和高剂量组，每组10只。除正常组外，其余组腹腔注射环磷酰5-氟尿嘧啶（5-fluorouracil, 5-Fu），制备小鼠免疫抑制和胃肠道功能紊乱模型。正常和模型组给予蒸馏水，阳性组和受试药物组给予相应药物处理，连续7 d。处理小鼠，计算小鼠的肠炭末推进率、计数红细胞，检测血清中炎性细胞因子和免疫蛋白水平，观察肠和脾脏组织病理损伤情况。

结果

与模型组相比，五指毛桃水提物显著升高小鼠血浆上清中IgA、IgE、IgM、IL-2、IFN-γ水平及脾脏指数，提高小鼠肠炭末推进率和血液红细胞数目，减轻小鼠肠组织和脾脏组织的病理损伤程度，一定程度上缓解环磷酰胺联合5-Fu所致的小鼠免疫功能低下。

结论

本研究证实，五指毛桃水提物对提高免疫和改善胃肠道蠕动有促进作用，为五指毛桃资源的开发利用提供数据参考。

五指毛桃  /  水取物  /  提高免疫  /  肠道蠕动
OBJECTIVE

To explore the pharmacological effects of water extract of Ficus hirta on enhancing immunity and improving gastrointestinal function.

METHODS

Sixty healthy male Kunming (KM) mice, weighing 18-22 g, were randomly divided into 6 groups: normal group, model group, positive (Thymus-intestinal peptide) group, low-, medium-, and high-dose groups of the test drug, with 10 mice in each group. Except for the normal group, the other groups were given intraperitoneal injection of cyclophosphamide combined with 5-fluorouracil to prepare mice models of immunosuppression and gastrointestinal dysfunction. The normal and model groups were given distilled water, and the positive group and the test drug groups were given the corresponding drugs for 7 consecutive days. The intestinal charcoal transit rate, blood cell count, serum inflammatory cytokines and immune protein levels of the mice were detected, and the pathological damage of intestinal and spleen tissues was observed, and pathological injury of intestinal and spleen tissues were observed.

RESULTS

Compared with the model group, the water extract of Ficus hirta significantly significantly increased the levels of IgA, IgE, IgM, IL-2, and IFN-γ in the plasma supernatant of mice and increased the spleen index, increased the intestinal charcoal transit rate and the number of red blood cells in the blood of mice, and alleviated the pathological injury degree of intestinal and spleen tissues of mice, and to some extent alleviated the immunosuppression induced by cyclophosphamide combined with 5-Fu in mice induced by cyclophosphamide combined with 5-Fu in mice.

CONCLUSION

This study confirmed that the water extract of Ficus hirta has a promoting effect on enhancing immunity and improving gastrointestinal peristalsis, and provides data reference for the development and utilization of Ficus hirta resources.

Ficus hirta  /  water extract  /  immunity enhancement  /  intestinal peristalsis
吴玉兰, 李银桂, 张玲, 王灿红. 五指毛桃水提物提高免疫和改善胃肠道作用研究. 今日药学, 2026 , 36 (6) : 409 -415 . DOI: 10.12048/j.issn.1674-229X.2026.06.002
Yulan WU, Yingui LI, ling ZHANG, Canhong WANG. Study on Enhancing Immunity and Improving Gastrointestinal Effect of the Water Extract of Ficus hirta[J]. Pharmacy Today, 2026 , 36 (6) : 409 -415 . DOI: 10.12048/j.issn.1674-229X.2026.06.002
基金
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  • 国家自然科学基金(82204657)
  • 茂名市科技计划项目(2022S032; 2023S001007)
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doi: 10.12048/j.issn.1674-229X.2026.06.002
  • 接收时间：2025-10-22
  • 首发时间：2026-09-23
  • 出版时间：2026-06-25
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出版历史
  • 收稿日期：2025-10-22
基金
国家自然科学基金(82204657)
茂名市科技计划项目(2022S032; 2023S001007)
作者信息
    1．海南医科大学，海南省热带药用植物研究开发重点实验室，海南 海口 571199
    2．岭南现代农业科学与技术广东省实验室茂名分中心，广东 茂名 525099
    3．广东石油化工学院，广东省绿色农产品加工与智能装备重点实验室，广东 茂名 525099

通讯作者:

共同通信作者
张玲，博士，教授，硕士生导师，研究方向：食品保鲜、食品加工技术、农业废弃物资源化利用，E-mail:
王灿红，硕士，助理研究员，研究方向：中药、天然药物药效活性评价、作用机理研究及产品开发，E-mail:
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https://castjournals.cast.org.cn/joweb/jryx/CN/10.12048/j.issn.1674-229X.2026.06.002
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2种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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