Article(id=1228268592337187514, tenantId=1146029695717560320, journalId=1227999776411738115, issueId=1228268587459216114, articleNumber=null, orderNo=null, doi=10.12048/j.issn.1674-229X.2025.08.014, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1728662400000, receivedDateStr=2024-10-12, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1770771652540, onlineDateStr=2026-02-11, pubDate=1756051200000, pubDateStr=2025-08-25, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1770771652540, onlineIssueDateStr=2026-02-11, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1770771652540, creator=13701087609, updateTime=1770771652540, updator=13701087609, issue=Issue{id=1228268587459216114, tenantId=1146029695717560320, journalId=1227999776411738115, year='2025', volume='35', issue='8', pageStart='561', pageEnd='640', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=1, specialIssue=null, createTime=1770771651377, creator=13701087609, updateTime=1770795163631, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1228367205105075039, tenantId=1146029695717560320, journalId=1227999776411738115, issueId=1228268587459216114, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1228367205105075040, tenantId=1146029695717560320, journalId=1227999776411738115, issueId=1228268587459216114, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=634, endPage=640, ext={EN=ArticleExt(id=1228268592551097023, articleId=1228268592337187514, tenantId=1146029695717560320, journalId=1227999776411738115, language=EN, title=Research Progress on Anti-tumor Effects of Nanoformulations of Active Ingredients of Traditional Chinese Medicine, columnId=null, journalTitle=Pharmacy Today, columnName=null, runingTitle=null, highlight=null, articleAbstract=

Malignant tumors are among the primary diseases threatening public health in China, and traditional Chinese medicine has been proven to be an important means of cancer prevention and treatment. However, the strong hydrophobicity, poor stability, low bioavailability, and short half-life of active ingredients of traditional Chinese medicine limit their clinical use. Nanoformulations, as an innovative type of formulation, offer unique advantages in targeted delivery, controlled release, and combination therapy. The combination of nanoformulations with active ingredients of traditional Chinese medicine can improve their bioavailability and biological activity. This article reviews the characteristics and applications of active ingredients of TCM and their nanoformulations in recent years, aiming to provide scientific basis and reference for the development of novel anti-tumor drugs derived from traditional Chinese medicine.

, correspAuthors=Chen ZHU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, authorCompany=null, fund=null, authors=null, authorsList=Shiheng WU, Chen ZHU), CN=ArticleExt(id=1228268593641616096, articleId=1228268592337187514, tenantId=1146029695717560320, journalId=1227999776411738115, language=CN, title=中药活性成分纳米制剂抗肿瘤的研究进展, columnId=1228268593092162252, journalTitle=今日药学, columnName=药学进展, runingTitle=null, highlight=null, articleAbstract=

恶性肿瘤是威胁我国居民健康的主要疾病之一，中医药在肿瘤防治中发挥着重要作用。然而中药活性成分的理化特性，如疏水性强、稳定性差、生物利用度低以及半衰期短等，限制了其临床使用。纳米制剂作为一种新型制剂，在靶向递送、控释和多药联用等方面具有独特的优势。纳米制剂与中药活性成分结合，可提高其生物利用度和生物活性。本文综述了近年来中药活性成分及其纳米制剂的作用特点和应用，以期为新型中药抗肿瘤药物的研发提供科学依据和参考。

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伍世恒，副主任药师，研究方向：药事管理、中药质量控制与评价和药物制剂

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伍世恒，副主任药师，研究方向：药事管理、中药质量控制与评价和药物制剂

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Int J Med Sci, 2019, 16(1): 33-42., articleTitle=Complete disaggregation of mcf-7-derived breast tumour spheroids with very low concentrations of alpha-mangostin loaded in CD44 thioaptamer-tagged nanoparticles, refAbstract=null)], funds=[Fund(id=1228268597231940455, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1228268592337187514, awardId=2022A1515012583, language=CN, fundingSource=广东省基础与应用基础研究基金项目(2022A1515012583), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1228268593993937648, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1228268592337187514, xref=null, ext=[AuthorCompanyExt(id=1228268594002326258, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1228268592337187514, companyId=1228268593993937648, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Pharmacy, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510120, China), AuthorCompanyExt(id=1228268594010714867, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1228268592337187514, companyId=1228268593993937648, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=广州中医药大学第二附属医院药学部，广东　广州　510120)])], figs=[ArticleFig(id=1228268596728623944, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1228268592337187514, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=

种类	活性成分	肿瘤类型	参考文献
生物碱	长春新碱	急性淋巴细胞性白血病、乳腺癌、胃癌、弥漫大B细胞淋巴瘤	[11-13]
	胡椒碱	黑色素瘤、前列腺癌、肝癌	[14-17]
	苦参碱	卵巢癌、乳腺癌、甲状腺乳头状癌	[18-20]
	小檗碱	子宫内膜癌、卵巢癌、皮肤癌、胃癌、结直肠癌	[21-25]
	粉防己碱	卵巢癌、肝癌、黑色素瘤	[26-28]
黄酮	半枝莲黄酮	卵巢癌、肝癌	[29]
	槲皮素	乳腺癌、肺癌、宫颈癌、肝癌	[30-33]
	白花蛇舌草总黄酮	肝癌、肺癌、乳腺癌、胃癌	[34-37]
皂苷	黄芪皂苷	肝癌、肺癌	[38-40]
	人参皂苷	卵巢癌、肝癌、白血病、乳腺癌	[41-44]
	柴胡皂苷	宫颈癌、胰腺癌、肝癌	[45-47]
	三七皂苷	乳腺癌、咽鳞状细胞癌、肝癌、结直肠癌	[48-50]
多糖	灵芝多糖	肺癌、肝癌、结肠癌、宫颈癌	[51-54]
	枸杞多糖	胆囊癌、肝癌、膀胱癌	[55-57]
	黄芪多糖	结肠癌、宫颈癌、肺癌、黑色素瘤	[58-61]
	甘草多糖	肝癌、结肠癌	[62,63]

), ArticleFig(id=1228268596862841678, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1228268592337187514, language=CN, label=表1, caption=

中药活性成分抗肿瘤

, figureFileSmall=null, figureFileBig=null, tableContent=

种类	活性成分	肿瘤类型	参考文献
生物碱	长春新碱	急性淋巴细胞性白血病、乳腺癌、胃癌、弥漫大B细胞淋巴瘤	[11-13]
	胡椒碱	黑色素瘤、前列腺癌、肝癌	[14-17]
	苦参碱	卵巢癌、乳腺癌、甲状腺乳头状癌	[18-20]
	小檗碱	子宫内膜癌、卵巢癌、皮肤癌、胃癌、结直肠癌	[21-25]
	粉防己碱	卵巢癌、肝癌、黑色素瘤	[26-28]
黄酮	半枝莲黄酮	卵巢癌、肝癌	[29]
	槲皮素	乳腺癌、肺癌、宫颈癌、肝癌	[30-33]
	白花蛇舌草总黄酮	肝癌、肺癌、乳腺癌、胃癌	[34-37]
皂苷	黄芪皂苷	肝癌、肺癌	[38-40]
	人参皂苷	卵巢癌、肝癌、白血病、乳腺癌	[41-44]
	柴胡皂苷	宫颈癌、胰腺癌、肝癌	[45-47]
	三七皂苷	乳腺癌、咽鳞状细胞癌、肝癌、结直肠癌	[48-50]
多糖	灵芝多糖	肺癌、肝癌、结肠癌、宫颈癌	[51-54]
	枸杞多糖	胆囊癌、肝癌、膀胱癌	[55-57]
	黄芪多糖	结肠癌、宫颈癌、肺癌、黑色素瘤	[58-61]
	甘草多糖	肝癌、结肠癌	[62,63]

), ArticleFig(id=1228268596967699287, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1228268592337187514, language=EN, label=null, caption=null, figureFileSmall=null, figureFileBig=null, tableContent=

活性成分	纳米制剂类型	肿瘤类型	参考文献
黄芪甲苷	介孔二氧化硅纳米粒	结肠癌	[82]
当归多糖	纳米粒	乳腺癌	[83]
黄芪多糖	纳米粒	乳腺癌	[84]
南蛇藤醇	聚合物纳米粒、纳米乳剂	黑色素瘤	[85,86]
姜黄素	纳米纤维、脂质体	肺癌、结肠癌	[87,88]
喜树碱	纳米纤维	脑癌	[89]
二氢丹参酮	仿生纳米粒	肝癌	[90]
表没食子儿茶素没食子酸酯	聚合物纳米粒、纳米粒	乳腺癌、胶质母细胞瘤、黑色素瘤	[91-93]
人参皂苷	脂质体、环糊精纳米粒	神经胶质瘤、结直肠癌	[94,95]
灵芝多糖	金纳米颗粒	乳腺癌	[96]
淫羊藿素	聚合物纳米粒	肝癌、黑色素瘤	[97]
去甲斑蝥素	脂质体	肝癌	[98]
葛根素	纳米乳剂	乳腺癌	[99]
鬼臼毒素	脂质纳米粒	肺癌	[100]
槲皮素、木香内酯	聚合物胶束	结直肠癌	[101]
水飞蓟宾	脂质体、聚合纳米粒	乳腺癌	[102,103]
紫草醌	乳铁蛋白纳米颗粒、脂质体、聚合物胶束	结直肠癌、黑色素瘤	[103-106]
丹酚酸B	脂质体	乳腺癌	[107]
熊果酸	脂质体	乳腺癌、肺癌、宫颈癌、结肠癌	[108-110]
吴茱萸碱	纳米胶束、纳米粒	宫颈癌、乳腺癌、结肠癌	[111-115]
淫羊藿苷	纳米颗粒、脂质体	肝癌	[116,97]
木犀草素	纳米颗粒、纳米粒	神经胶质瘤、黑色素瘤、乳腺癌	[117-119]
α-倒捻子素	纳米胶束、聚合纳米颗粒、纳米粒	黑色素瘤、胰腺癌、乳腺癌	[120-122]

), ArticleFig(id=1228268597068362591, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1228268592337187514, language=CN, label=表2, caption=

抗肿瘤中药纳米制剂

, figureFileSmall=null, figureFileBig=null, tableContent=

活性成分	纳米制剂类型	肿瘤类型	参考文献
黄芪甲苷	介孔二氧化硅纳米粒	结肠癌	[82]
当归多糖	纳米粒	乳腺癌	[83]
黄芪多糖	纳米粒	乳腺癌	[84]
南蛇藤醇	聚合物纳米粒、纳米乳剂	黑色素瘤	[85,86]
姜黄素	纳米纤维、脂质体	肺癌、结肠癌	[87,88]
喜树碱	纳米纤维	脑癌	[89]
二氢丹参酮	仿生纳米粒	肝癌	[90]
表没食子儿茶素没食子酸酯	聚合物纳米粒、纳米粒	乳腺癌、胶质母细胞瘤、黑色素瘤	[91-93]
人参皂苷	脂质体、环糊精纳米粒	神经胶质瘤、结直肠癌	[94,95]
灵芝多糖	金纳米颗粒	乳腺癌	[96]
淫羊藿素	聚合物纳米粒	肝癌、黑色素瘤	[97]
去甲斑蝥素	脂质体	肝癌	[98]
葛根素	纳米乳剂	乳腺癌	[99]
鬼臼毒素	脂质纳米粒	肺癌	[100]
槲皮素、木香内酯	聚合物胶束	结直肠癌	[101]
水飞蓟宾	脂质体、聚合纳米粒	乳腺癌	[102,103]
紫草醌	乳铁蛋白纳米颗粒、脂质体、聚合物胶束	结直肠癌、黑色素瘤	[103-106]
丹酚酸B	脂质体	乳腺癌	[107]
熊果酸	脂质体	乳腺癌、肺癌、宫颈癌、结肠癌	[108-110]
吴茱萸碱	纳米胶束、纳米粒	宫颈癌、乳腺癌、结肠癌	[111-115]
淫羊藿苷	纳米颗粒、脂质体	肝癌	[116,97]
木犀草素	纳米颗粒、纳米粒	神经胶质瘤、黑色素瘤、乳腺癌	[117-119]
α-倒捻子素	纳米胶束、聚合纳米颗粒、纳米粒	黑色素瘤、胰腺癌、乳腺癌	[120-122]

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