Article(id=1321826816705282114, tenantId=1146029695717560320, journalId=1227999776411738115, issueId=1321826809193288569, articleNumber=null, orderNo=null, doi=10.12048/j.issn.1674-229X.2026.07.006, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1762790400000, receivedDateStr=2025-11-11, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1793077671457, onlineDateStr=2026-10-27, pubDate=1784908800000, pubDateStr=2026-07-25, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793077671457, onlineIssueDateStr=2026-10-27, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793077671457, creator=13701087609, updateTime=1793077671457, updator=13701087609, issue=Issue{id=1321826809193288569, tenantId=1146029695717560320, journalId=1227999776411738115, year='2026', volume='36', issue='7', pageStart='481', pageEnd='560', issueExtLink='null', onlineDate='null', pubDate='1784908800000', pubDateStr='2026-07-25', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=1, specialIssue=null, createTime=1793077669666, creator='13701087609', updateTime=1793077915753, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1321827841440858287, tenantId=1146029695717560320, journalId=1227999776411738115, issueId=1321826809193288569, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1321827841440858288, tenantId=1146029695717560320, journalId=1227999776411738115, issueId=1321826809193288569, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=523, endPage=529, ext={EN=ArticleExt(id=1321826816894025795, articleId=1321826816705282114, tenantId=1146029695717560320, journalId=1227999776411738115, language=EN, title=Pharmacovigilance Analysis of Tetracycline Use in Children Based on the FAERS Database, columnId=null, journalTitle=Pharmacy Today, columnName=null, runingTitle=null, highlight=null, articleAbstract=
OBJECTIVE To mine and analyze adverse drug event (ADE) signals associated with the use of three tetracycline antibiotics (doxycycline，minocycline，and tigecycline) in children，providing evidence for the safe use of tetracyclines in pediatric populations.
METHODS ADE reports of doxycycline，minocycline，and tigecycline in children from Q1 2004 to Q2 2025 were extracted from the FDA Adverse Event Reporting System (FAERS) database. Data mining and analysis were performed using the Reporting Odds Ratio (ROR) method and the Bayesian Confidence Propagation Neural Network (BCPNN).
RESULTS A total of 1 653 pediatric ADE reports were identified，involving doxycycline (664 reports)，minocycline (926 reports)，and tigecycline (63 reports). Significant signals were detected across 19 important System Organ Classes (SOCs). In children under 2 years old，only doxycycline was found to be associated with adverse reactions，primarily affecting the Blood/Lymphatic System，Metabolism/Nutrition，and Injury/Poisoning categories. In the 2-7 years age group，doxycycline-related events concentrated in Nervous System and Eye disorders，while tigecycline-related events concentrated in Gastrointestinal System disorders. For children aged 8-17 years old，signals were detected for all three drugs: doxycycline was primarily associated with Psychiatric and Gastrointestinal disorders; minocycline was mainly associated with nervous system，eye，and skin and subcutaneous tissue disorders. Tigecycline was primarily associated with injury and poisoning.
CONCLUSION Adverse drug reactions (ADRs) of the three tetracyclines are varied across different pediatric age groups. Doxycycline is associated is neurological damage，Horner syndrome，and psychiatric adverse reactions. Minocycline will induce long-term autoimmune disorders，increasing the risk of type 1 diabetes. Tigecycline is found to induce unlabeled hypertriglyceridemia not stated in the drug labeling，necessitating enhanced lipid monitoring during clinical use.
, authors=Yani ZHAO, Minyi LV, Shaojie DENG, Danyi FAN, Lina WANG, Hong CHANG
*, authorsList=Yani ZHAO, Minyi LV, Shaojie DENG, Danyi FAN, Lina WANG, Hong CHANG, authorCompany=null, correspAuthors=Hong CHANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1321826817250541636, articleId=1321826816705282114, tenantId=1146029695717560320, journalId=1227999776411738115, language=CN, title=基于FAERS数据库对儿童使用四环素类药物警戒分析, columnId=1228268589086606089, journalTitle=今日药学, columnName=论著, runingTitle=null, highlight=null, articleAbstract=
目的 挖掘与分析儿童使用3种四环素类药物（多西环素、米诺环素、替加环素）不良事件（ADE）信号，为该类药物在儿童群体中的安全使用提供参考依据。
方法 检索美国FDA不良事件报告系统（FAERS）数据库中2004年第一季度至2025年第二季度儿童使用多西环素、米诺环素及替加环素的ADE报告，采用报告比值比法（ROR）和贝叶斯置信区间递进神经网络法（BCPNN）进行数据挖掘与分析。
结果 共检出1 653例儿童ADE报告，其中多西环素664例、米诺环素926例、替加环素63例。确定19个重要系统器官分类（SOC）信号。<2岁仅发现多西环素相关不良反应，主要为血液/淋巴系统、代谢营养及损伤/中毒类；2~7岁多西环素集中于神经系统和眼部疾病，替加环素集中于胃肠系统；8~17岁三药均有信号，多西环素以精神病和胃肠疾病为主，米诺环素以神经、眼部及皮肤疾病为主，替加环素以损伤/中毒为主。
结论 不同的未成年年龄段中，3种四环素类药物的药物不良反应表现出一定的差异，多西环素易导致神经损伤、霍纳综合征及精神类不良反应；米诺环素可能诱发长期自身免疫紊乱，进而增加Ⅰ型糖尿病的风险；替加环素可引起说明书未列明的高甘油三酯血症，临床使用时需加强血脂监测。
, authors=赵雅妮, 吕敏仪, 邓少洁, 樊丹怡, 王黎娜, 常宏
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