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Article(id=1309634306906092299, tenantId=1146029695717560320, journalId=1227999776411738115, issueId=1309634291257143967, articleNumber=null, orderNo=null, doi=10.12048/j.issn.1674-229X.2026.06.009, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1760889600000, receivedDateStr=2025-10-20, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1790170750594, onlineDateStr=2026-09-23, pubDate=1782316800000, pubDateStr=2026-06-25, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1790170750594, onlineIssueDateStr=2026-09-23, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1790170750594, creator=13701087609, updateTime=1790170750594, updator=13701087609, issue=Issue{id=1309634291257143967, tenantId=1146029695717560320, journalId=1227999776411738115, year='2026', volume='36', issue='6', pageStart='401', pageEnd='480', issueExtLink='null', onlineDate='null', pubDate='1782316800000', pubDateStr='2026-06-25', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1790170746864, creator='13701087609', updateTime=1790218948815, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1309836464964337802, tenantId=1146029695717560320, journalId=1227999776411738115, issueId=1309634291257143967, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1309836464964337803, tenantId=1146029695717560320, journalId=1227999776411738115, issueId=1309634291257143967, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=456, endPage=461, ext={EN=ArticleExt(id=1309634307107418892, articleId=1309634306906092299, tenantId=1146029695717560320, journalId=1227999776411738115, language=EN, title=Analysis of Serum Concentration Monitoring of Oxcarbazepine and Levetiracetam in the Neurology Department of a Hospital, columnId=null, journalTitle=Pharmacy Today, columnName=null, runingTitle=null, highlight=null, articleAbstract=
OBJECTIVE

To provide reference for guiding individualized medication in epilepsy patients by retrospectively analyzing the therapeutic drug monitoring (TDM) of new antiseizure medications in the neurology department of a hospital.

METHODS

Clinical data were collected from outpatients and inpatients in the neurology department (including pediatric neurology, neurology, and neurosurgery) of the hospital from January 2022 to August 2024, who underwent blood concentration monitoring of two new antiseizure medications, namely oxcarbazepine (OXC) and levetiracetam (LEV). The data included gender, age, antiseizure medication regimens, blood concentration measurements, clinical efficacy, and adverse drug reactions (ADRs). Statistical analysis was performed to compare whether there were differences in blood concentration levels among different age groups, genders, and combination therapies, as well as whether differences existed in clinical efficacy and ADR incidence across different blood concentration ranges.

RESULTS

Among the 414 TDM records, 206 cases were for OXC and 208 cases for LEV. Blood concentrations within the reference range were observed in 114 cases (69.9%) for OXC and 86 cases (41.35%) for LEV. A statistically significant difference in LEV blood concentrations was found among different age groups (P<0.05). The total incidence of ADRs in the OXC group (13.11%) was higher than that in the LEV group (0.27%), and ADR incidence in both groups was significantly correlated with blood concentration (P<0.05). However, no significant differences in blood concentrations were observed based on gender or combination therapy for either OXC or LEV (P>0.05). Additionally, no significant differences in clinical efficacy were found among different blood concentration groups (P>0.05).

CONCLUSION

Although the two new antiseizure medications, OXC and LEV, didn't show a significant positive correlation between blood concentration and clinical efficacy in the TDM process, their drug exposure levels are closely associated with the risk of ADRs. Blood concentration monitoring can provide valuable guidance for rational clinical drug use, ensuring safe and effective treatment for patients.

, authors=Huirong DENG1, Ziyi CHEN2, Qifa CHENG1, Jie TIAN2, Huili CHANG1, authorsList=Huirong DENG, Ziyi CHEN, Qifa CHENG, Jie TIAN, Huili CHANG, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1309634307409408781, articleId=1309634306906092299, tenantId=1146029695717560320, journalId=1227999776411738115, language=CN, title=某院神经科奥卡西平与左乙拉西坦血药浓度监测分析, columnId=1228268588277105398, journalTitle=今日药学, columnName=临床药学, runingTitle=null, highlight=null, articleAbstract=
目的

通过回顾性分析某院神经科两种新型抗癫痫发作药物治疗药物监测（therapeutic drug monitoring, TDM）情况，为指导癫痫患者个体化用药提供参考。

方法

收集该院2022年1月~2024年8月神经科（小儿神经专科、神经内科、神经外科）门诊和住院监测过新型抗癫痫发作药物奥卡西平（OXC）、左乙拉西坦（LEV）血药浓度的患者临床资料，包括性别、年龄、抗癫痫药物治疗方案、血药浓度检测数据、临床治疗效果及药品不良反应等，比较不同年龄段、性别分组以及联合用药情况下的血药浓度监测数值差异是否存在统计学意义，不同血药浓度临床疗效及药品不良反应发生率是否有差异。

结果

414例次TDM数据中，OXC 206例次，LEV 208例次；血药浓度在参考范围内分别为114例次（69.9%）和86例次（41.35%）；不同年龄段患者LEV血药浓度差异有统计学意义（P<0.05）；OXC组总不良反应发生率（13.11%）高于LEV组（0.27%），且两组的不良反应发生率均与血药浓度相关（P<0.05）。而性别、是否联合用药对OXC及LEV组血药浓度的结果差异无统计学意义（P>0.05）；不同血药浓度组临床疗效差异无统计学意义（P>0.05）。

结论

OXC与LEV两种新型抗癫痫发作药物虽在血药浓度监测中未呈现显著正相关疗效特征，但其药物暴露水平与不良反应的发生风险存在密切联系，血药浓度监测可为临床合理用药提供参考，保障患者用药安全、有效。

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邓惠容，副主任药师，研究方向：临床药学，E-mail:

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某院神经科奥卡西平与左乙拉西坦血药浓度监测分析
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邓惠容 1 , 陈子毅 2 , 成其发 1 , 田婕 2 , 常惠礼 1
今日药学 | 临床药学 2026,36(6): 456-461
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今日药学 |临床药学 2026 , 36 (6) : 456 -461
某院神经科奥卡西平与左乙拉西坦血药浓度监测分析
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journalId=1227999776411738115, articleId=1309634306906092299, authorId=1309634308600591145, language=EN, stringName=Huili CHANG, firstName=Huili, middleName=null, lastName=CHANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.Department of Pharmacy, the Affiliated Qingyuan Hospital, Guangzhou Medical University, Qingyuan People's Hospital, Qingyuan, Guangdong 511518, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1309634308747391788, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634306906092299, authorId=1309634308600591145, language=CN, stringName=常惠礼, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1．广州医科大学附属清远医院（清远市人民医院）药学部，广东 清远 511518, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, 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邓惠容1 , 陈子毅2, 成其发1, 田婕2, 常惠礼1
作者信息
  • 1．广州医科大学附属清远医院（清远市人民医院）药学部，广东 清远 511518
  • 2．广州医科大学药学院，广东 广州 511436
作者简介:

邓惠容，副主任药师，研究方向：临床药学，E-mail:

Analysis of Serum Concentration Monitoring of Oxcarbazepine and Levetiracetam in the Neurology Department of a Hospital
Huirong DENG1 , Ziyi CHEN2, Qifa CHENG1, Jie TIAN2, Huili CHANG1
Affiliations
  • 1.Department of Pharmacy, the Affiliated Qingyuan Hospital, Guangzhou Medical University, Qingyuan People's Hospital, Qingyuan, Guangdong 511518, China
  • 2.School of Pharmacy, Guangzhou Medical University, Guangzhou, Guangdong 511436, China
出版时间: 2026-06-25 doi: 10.12048/j.issn.1674-229X.2026.06.009
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摘要
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目的

通过回顾性分析某院神经科两种新型抗癫痫发作药物治疗药物监测（therapeutic drug monitoring, TDM）情况，为指导癫痫患者个体化用药提供参考。

方法

收集该院2022年1月~2024年8月神经科（小儿神经专科、神经内科、神经外科）门诊和住院监测过新型抗癫痫发作药物奥卡西平（OXC）、左乙拉西坦（LEV）血药浓度的患者临床资料，包括性别、年龄、抗癫痫药物治疗方案、血药浓度检测数据、临床治疗效果及药品不良反应等，比较不同年龄段、性别分组以及联合用药情况下的血药浓度监测数值差异是否存在统计学意义，不同血药浓度临床疗效及药品不良反应发生率是否有差异。

结果

414例次TDM数据中，OXC 206例次，LEV 208例次；血药浓度在参考范围内分别为114例次（69.9%）和86例次（41.35%）；不同年龄段患者LEV血药浓度差异有统计学意义（P<0.05）；OXC组总不良反应发生率（13.11%）高于LEV组（0.27%），且两组的不良反应发生率均与血药浓度相关（P<0.05）。而性别、是否联合用药对OXC及LEV组血药浓度的结果差异无统计学意义（P>0.05）；不同血药浓度组临床疗效差异无统计学意义（P>0.05）。

结论

OXC与LEV两种新型抗癫痫发作药物虽在血药浓度监测中未呈现显著正相关疗效特征，但其药物暴露水平与不良反应的发生风险存在密切联系，血药浓度监测可为临床合理用药提供参考，保障患者用药安全、有效。

抗癫痫发作药物  /  奥卡西平  /  左乙拉西坦  /  血药浓度  /  治疗药物监测
OBJECTIVE

To provide reference for guiding individualized medication in epilepsy patients by retrospectively analyzing the therapeutic drug monitoring (TDM) of new antiseizure medications in the neurology department of a hospital.

METHODS

Clinical data were collected from outpatients and inpatients in the neurology department (including pediatric neurology, neurology, and neurosurgery) of the hospital from January 2022 to August 2024, who underwent blood concentration monitoring of two new antiseizure medications, namely oxcarbazepine (OXC) and levetiracetam (LEV). The data included gender, age, antiseizure medication regimens, blood concentration measurements, clinical efficacy, and adverse drug reactions (ADRs). Statistical analysis was performed to compare whether there were differences in blood concentration levels among different age groups, genders, and combination therapies, as well as whether differences existed in clinical efficacy and ADR incidence across different blood concentration ranges.

RESULTS

Among the 414 TDM records, 206 cases were for OXC and 208 cases for LEV. Blood concentrations within the reference range were observed in 114 cases (69.9%) for OXC and 86 cases (41.35%) for LEV. A statistically significant difference in LEV blood concentrations was found among different age groups (P<0.05). The total incidence of ADRs in the OXC group (13.11%) was higher than that in the LEV group (0.27%), and ADR incidence in both groups was significantly correlated with blood concentration (P<0.05). However, no significant differences in blood concentrations were observed based on gender or combination therapy for either OXC or LEV (P>0.05). Additionally, no significant differences in clinical efficacy were found among different blood concentration groups (P>0.05).

CONCLUSION

Although the two new antiseizure medications, OXC and LEV, didn't show a significant positive correlation between blood concentration and clinical efficacy in the TDM process, their drug exposure levels are closely associated with the risk of ADRs. Blood concentration monitoring can provide valuable guidance for rational clinical drug use, ensuring safe and effective treatment for patients.

antiseizure medications  /  oxcarbazepine  /  levetiracetam  /  blood concentration  /  therapeutic drug monitoring
邓惠容, 陈子毅, 成其发, 田婕, 常惠礼. 某院神经科奥卡西平与左乙拉西坦血药浓度监测分析. 今日药学, 2026 , 36 (6) : 456 -461 . DOI: 10.12048/j.issn.1674-229X.2026.06.009
Huirong DENG, Ziyi CHEN, Qifa CHENG, Jie TIAN, Huili CHANG. Analysis of Serum Concentration Monitoring of Oxcarbazepine and Levetiracetam in the Neurology Department of a Hospital[J]. Pharmacy Today, 2026 , 36 (6) : 456 -461 . DOI: 10.12048/j.issn.1674-229X.2026.06.009
基金
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  • 广东省药学会科学研究基金(2023KP84)
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doi: 10.12048/j.issn.1674-229X.2026.06.009
  • 接收时间：2025-10-20
  • 首发时间：2026-09-23
  • 出版时间：2026-06-25
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  • 收稿日期：2025-10-20
基金
广东省药学会科学研究基金(2023KP84)
作者信息
    1．广州医科大学附属清远医院（清远市人民医院）药学部，广东 清远 511518
    2．广州医科大学药学院，广东 广州 511436
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小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
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红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
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