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Article(id=1309634297921888586, tenantId=1146029695717560320, journalId=1227999776411738115, issueId=1309634291257143967, articleNumber=null, orderNo=null, doi=10.12048/j.issn.1674-229X.2026.06.005, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1768924800000, receivedDateStr=2026-01-21, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1790170748453, onlineDateStr=2026-09-23, pubDate=1782316800000, pubDateStr=2026-06-25, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1790170748453, onlineIssueDateStr=2026-09-23, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1790170748453, creator=13701087609, updateTime=1790170748453, updator=13701087609, issue=Issue{id=1309634291257143967, tenantId=1146029695717560320, journalId=1227999776411738115, year='2026', volume='36', issue='6', pageStart='401', pageEnd='480', issueExtLink='null', onlineDate='null', pubDate='1782316800000', pubDateStr='2026-06-25', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1790170746864, creator='13701087609', updateTime=1790218948815, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1309836464964337802, tenantId=1146029695717560320, journalId=1227999776411738115, issueId=1309634291257143967, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1309836464964337803, tenantId=1146029695717560320, journalId=1227999776411738115, issueId=1309634291257143967, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=428, endPage=433, ext={EN=ArticleExt(id=1309634298131603787, articleId=1309634297921888586, tenantId=1146029695717560320, journalId=1227999776411738115, language=EN, title=Preparation and Preliminary Evaluation of Berberine Hydrochloride-Loaded Dual-Network Hydrogels, columnId=null, journalTitle=Pharmacy Today, columnName=null, runingTitle=null, highlight=null, articleAbstract=
OBJECTIVE

To develop a dual-crosslinked hydrogel loaded with berberine hydrochloride and to evaluate its physicochemical properties and drug release behavior.

METHODS

Soluble silk fibroin with high resolubility rate was prepared by autoclaving combined with freeze-drying. A stable silk fibroin-tannic acid hydrogel matrix was established by optimizing the concentration and ratio of silk fibroin to tannic acid. Glucono-δ-lactone (GDL) was then introduced to modulate the gelation process, thereby constructing a silk fibroin-tannic acid/sodium alginate-Ca2+ dual-crosslinked hydrogel dual-crosslinked hydrogel loaded with berberine hydrochloride. The in vitro drug release profiles were investigated in buffers at different pH values.

RESULTS

The optimal mass concentrations of silk fibroin and tannic acid were 4% and 0.25%, respectively, under which a stable hydrogel was formed. When 0.32 g of GDL was added, the dual-crosslinked hydrogel formed rapidly and maintained color stability at different temperatures. The hydrogel exhibited injectability, and the release rate of its loaded berberine hydrochloride was significantly faster at pH 7.4 than at pH 5.5.

CONCLUSION

The as-prepared berberine hydrochloride-loaded dual-crosslinked hydrogel possesses both injectability and pH responsiveness, the developed hydrogel can provide a scientific basis for the development of localized drug delivery systems and novel dressings for chronic wounds.

, authors=Baojie WANG1, 2, Nan JIANG3, Junying ZENG3, Yuqin QIU3, Weiwei ZENG1, *, authorsList=Baojie WANG, Nan JIANG, Junying ZENG, Yuqin QIU, Weiwei ZENG, authorCompany=null, correspAuthors=Weiwei ZENG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1309634298546839884, articleId=1309634297921888586, tenantId=1146029695717560320, journalId=1227999776411738115, language=CN, title=盐酸小檗碱双交联水凝胶的制备及其性能初步评价, columnId=1228268589086606089, journalTitle=今日药学, columnName=论著, runingTitle=null, highlight=null, articleAbstract=
目的

构建负载盐酸小檗碱的双交联水凝胶体系，并评价其理化特性与释药行为。

方法

采用热压灭菌联合冷冻干燥法制备高复溶率的可溶性丝素蛋白。通过优化丝素蛋白与单宁酸浓度及配比，确立稳定的丝素蛋白-单宁酸水凝胶基质；进一步引入葡萄糖酸-δ-内酯（GDL）调控凝胶化过程，构建丝素蛋白-单宁酸/海藻酸钠-钙离子双交联水凝胶，并载入盐酸小檗碱。随后，分别在不同pH的缓冲液中考察其体外释药特性。

结果

丝素蛋白与单宁酸的最佳质量浓度分别为4%与0.25%时凝胶形成稳定。当GDL添加量为0.32 g时，双交联水凝胶可快速形成并在不同温度下保持色泽稳定。该水凝胶具备可注射性，并且其负载的盐酸小檗碱在pH 7.4下的释放速率显著快于在pH 5.5下。

结论

所制备的盐酸小檗碱双交联水凝胶兼具可注射性与pH敏感性，可为慢性创面局部递药系统及新型水凝胶敷料的开发提供依据。

, authors=王报捷1, 2, 江南3, 曾君颖3, 邱玉琴3, 曾位位1, *, authorsList=王报捷, 江南, 曾君颖, 邱玉琴, 曾位位, authorCompany=null, correspAuthors=曾位位, authorNote=

王报捷，在读硕士研究生

, correspAuthorsNote=

*

曾位位，主任药师，研究方向：药物新剂型，E-mail:
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盐酸小檗碱双交联水凝胶的制备及其性能初步评价
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王报捷 1, 2 , 江南 3 , 曾君颖 3 , 邱玉琴 3 , 曾位位 1, *
今日药学 | 论著 2026,36(6): 428-433
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今日药学 |论著 2026 , 36 (6) : 428 -433
盐酸小檗碱双交联水凝胶的制备及其性能初步评价
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王报捷1, 2, 江南3, 曾君颖3, 邱玉琴3, 曾位位1, *
作者信息
  • 1．汕头大学医学院，广东 汕头 515041
  • 2．深圳市龙岗区第三人民医院，广东 深圳 518112
  • 3．广东药科大学药学院，广东 广州 510006
通讯作者:

*

曾位位，主任药师，研究方向：药物新剂型，E-mail:
作者简介:

王报捷，在读硕士研究生

Preparation and Preliminary Evaluation of Berberine Hydrochloride-Loaded Dual-Network Hydrogels
Baojie WANG1, 2, Nan JIANG3, Junying ZENG3, Yuqin QIU3, Weiwei ZENG1, *
Affiliations
  • 1.Shantou University Medical College, Shantou, Guangdong 515041, China
  • 2.The Third People's Hospital of Longgang District Shenzhen, Gangdong 518112, China
  • 3.School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006, China
出版时间: 2026-06-25 doi: 10.12048/j.issn.1674-229X.2026.06.005
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摘要
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目的

构建负载盐酸小檗碱的双交联水凝胶体系，并评价其理化特性与释药行为。

方法

采用热压灭菌联合冷冻干燥法制备高复溶率的可溶性丝素蛋白。通过优化丝素蛋白与单宁酸浓度及配比，确立稳定的丝素蛋白-单宁酸水凝胶基质；进一步引入葡萄糖酸-δ-内酯（GDL）调控凝胶化过程，构建丝素蛋白-单宁酸/海藻酸钠-钙离子双交联水凝胶，并载入盐酸小檗碱。随后，分别在不同pH的缓冲液中考察其体外释药特性。

结果

丝素蛋白与单宁酸的最佳质量浓度分别为4%与0.25%时凝胶形成稳定。当GDL添加量为0.32 g时，双交联水凝胶可快速形成并在不同温度下保持色泽稳定。该水凝胶具备可注射性，并且其负载的盐酸小檗碱在pH 7.4下的释放速率显著快于在pH 5.5下。

结论

所制备的盐酸小檗碱双交联水凝胶兼具可注射性与pH敏感性，可为慢性创面局部递药系统及新型水凝胶敷料的开发提供依据。

盐酸小檗碱  /  丝素蛋白  /  双交联水凝胶  /  pH响应性
OBJECTIVE

To develop a dual-crosslinked hydrogel loaded with berberine hydrochloride and to evaluate its physicochemical properties and drug release behavior.

METHODS

Soluble silk fibroin with high resolubility rate was prepared by autoclaving combined with freeze-drying. A stable silk fibroin-tannic acid hydrogel matrix was established by optimizing the concentration and ratio of silk fibroin to tannic acid. Glucono-δ-lactone (GDL) was then introduced to modulate the gelation process, thereby constructing a silk fibroin-tannic acid/sodium alginate-Ca2+ dual-crosslinked hydrogel dual-crosslinked hydrogel loaded with berberine hydrochloride. The in vitro drug release profiles were investigated in buffers at different pH values.

RESULTS

The optimal mass concentrations of silk fibroin and tannic acid were 4% and 0.25%, respectively, under which a stable hydrogel was formed. When 0.32 g of GDL was added, the dual-crosslinked hydrogel formed rapidly and maintained color stability at different temperatures. The hydrogel exhibited injectability, and the release rate of its loaded berberine hydrochloride was significantly faster at pH 7.4 than at pH 5.5.

CONCLUSION

The as-prepared berberine hydrochloride-loaded dual-crosslinked hydrogel possesses both injectability and pH responsiveness, the developed hydrogel can provide a scientific basis for the development of localized drug delivery systems and novel dressings for chronic wounds.

berberine hydrochloride  /  silk fibroin  /  dual-crosslinked hydrogel  /  pH responsiveness
王报捷, 江南, 曾君颖, 邱玉琴, 曾位位. 盐酸小檗碱双交联水凝胶的制备及其性能初步评价. 今日药学, 2026 , 36 (6) : 428 -433 . DOI: 10.12048/j.issn.1674-229X.2026.06.005
Baojie WANG, Nan JIANG, Junying ZENG, Yuqin QIU, Weiwei ZENG. Preparation and Preliminary Evaluation of Berberine Hydrochloride-Loaded Dual-Network Hydrogels[J]. Pharmacy Today, 2026 , 36 (6) : 428 -433 . DOI: 10.12048/j.issn.1674-229X.2026.06.005
基金
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  • 2024年度国家级大学生创新创业训练计划(202410573006)
  • 深圳市龙岗区科技创新专项资金医疗卫生科技计划项目(LGWJ2023-117)
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2026年第36卷第6期
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doi: 10.12048/j.issn.1674-229X.2026.06.005
  • 接收时间：2026-01-21
  • 首发时间：2026-09-23
  • 出版时间：2026-06-25
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  • 收稿日期：2026-01-21
基金
2024年度国家级大学生创新创业训练计划(202410573006)
深圳市龙岗区科技创新专项资金医疗卫生科技计划项目(LGWJ2023-117)
作者信息
    1．汕头大学医学院，广东 汕头 515041
    2．深圳市龙岗区第三人民医院，广东 深圳 518112
    3．广东药科大学药学院，广东 广州 510006

通讯作者:

*

曾位位，主任药师，研究方向：药物新剂型，E-mail:
参考文献
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https://castjournals.cast.org.cn/joweb/jryx/CN/10.12048/j.issn.1674-229X.2026.06.005
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2种不同金属材料的力学参数
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Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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