今日药学

基于多指标定量、化学计量学及灰色关联度分析的不同产地凌霄花综合质量评价

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褚书豪 ¹ , 王晓波 ² , 汪小彩 ¹^,^*

今日药学 | 论著 2026,36(4): 270-275

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今日药学 |论著 2026 , 36 (4) : 270 -275

基于多指标定量、化学计量学及灰色关联度分析的不同产地凌霄花综合质量评价

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褚书豪¹, 王晓波², 汪小彩¹^,^*

作者信息

^1．河南中医药大学第三附属医院药学部，河南郑州 450008

^2．河南中医药大学药学院，河南郑州 450046

通讯作者:

汪小彩，主管药师，研究方向：药物质量评价及医院药学，E-mail: nawz86@163.com

作者简介:

褚书豪，主管中药师，研究方向：中药学

Comprehensive Quality Evaluation of Campsis Flos From Different Origins Based on Multi-Index Quantification, Chemometrics and Grey Relational Analysis

Shuhao CHU¹, Xiaobo WANG², Xiaocai WANG¹^,^*

Affiliations

^1.Department of Pharmacy, Third Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan 450008, China

^2.School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, Henan 450046, China

出版时间: 2026-04-25 doi: 10.12048/j.issn.1674-229X.2026.04.004

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摘要

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目的

基于凌霄花中多指标含量，探究凌霄花质量差异要素，并综合评价不同产地凌霄花质量。

方法

采集江苏、浙江等产地18批凌霄花，以凌霄花中毛蕊花糖苷、异麦角甾苷、芹菜素、木犀草素、槲皮素、鼠李柠檬素、山楂酸、常春藤皂苷元、齐墩果酸、熊果酸、水溶性浸出物、总灰分和酸不溶性灰分含量为质量评价指标，借助统计学方法，对不同产地凌霄花药材之间的差异进行表征。结合化学计量学和灰色关联度分析法2种数学模型对13个质量评价指标进行统计分析，获得不同产地凌霄花质量排名信息。

结果

不同产地凌霄花中13个指标含量存在一定的波动，建立的多指标定量方法准确可行。质量评估模型结果显示，18批凌霄花按产地分为3组，齐墩果酸、熊果酸、槲皮素和毛蕊花糖苷是影响凌霄花药材质量的主要要素，以江苏产地的凌霄花质量较优。

结论

不同产地凌霄花中多指标含量存在差异，建立的质量评估方法可对不同产地凌霄花进行区分，并特异性识别差异性成分，为凌霄花的质量评价提供参考。

关键词

凌霄花 / 高效液相色谱法 / 灰色关联度分析法 / PCA / OPLS-DA / 综合评价

Abstract

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OBJECTIVE

To investigate the elements of quality difference in Campsis flos based on multi-index content, and to comprehensively evaluate the quality of Campsis flos from different producing areas based on multi-index content.

METHODS

Eighteen batches of Campsis flos were collected from Jiangsu, Zhejiang and other producing areas. The contents of verbascoside, isoacteoside, apigenin, luteolin, quercetin, rhamnocitrin, maslinic acid, hederagenin, oleanolic acid, ursolic acid, water-soluble extract, total ash and acid-insoluble ash in Campsis flos were used as quality evaluation indexes, the differences from different producing areas were analyzed and characterized by statistical methods. 13 quality evaluation indexes were statistically analyzed by two mathematical models of chemometrics and grey relational analysis (GRA), and the ranking information of the quality of Campsis flos from different producing areas was obtained.

RESULTS

There were some fluctuations in the contents of 13 indexes in Campsis flos from different producing areas, and the established multi-index quantitative method was accurate and feasible. The results of quality evaluation model showed that 18 batches of Campsis flos were divided into three groups according to the origins. Oleanolic acid, ursolic acid, quercetin and verbascoside were the main factors affecting the quality of Campsis flos. The quality of Campsis flos from Jiangsu was better.

CONCLUSION

There are differences in the content of multiple indexes in Campsis flos from different origin. The established quality evaluation method can distinguish Campsis flos from different origins, and specifically identify the different components, so as to provide reference for the quality evaluation of Campsis flos (including those from different producing areas).

Key words

Campsis flos / HPLC / GRA / PCA / OPLS-DA / comprehensive evaluation

引用本文

褚书豪, 王晓波, 汪小彩. 基于多指标定量、化学计量学及灰色关联度分析的不同产地凌霄花综合质量评价. 今日药学, 2026 , 36 (4) : 270 -275 . DOI: 10.12048/j.issn.1674-229X.2026.04.004

Shuhao CHU, Xiaobo WANG, Xiaocai WANG. Comprehensive Quality Evaluation of Campsis Flos From Different Origins Based on Multi-Index Quantification, Chemometrics and Grey Relational Analysis[J]. Pharmacy Today, 2026 , 36 (4) : 270 -275 . DOI: 10.12048/j.issn.1674-229X.2026.04.004

基金

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河南省高等学校重点科研指导计划项目(20B550007)

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2026年第36卷第4期

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文章信息

doi: 10.12048/j.issn.1674-229X.2026.04.004

接收时间：2025-07-23
首发时间：2026-09-23
出版时间：2026-04-25

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出版历史

收稿日期：2025-07-23

基金

河南省高等学校重点科研指导计划项目(20B550007)

作者信息

^1．河南中医药大学第三附属医院药学部，河南郑州 450008

^2．河南中医药大学药学院，河南郑州 450046

通讯作者:

汪小彩，主管药师，研究方向：药物质量评价及医院药学，E-mail: nawz86@163.com

参考文献

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https://castjournals.cast.org.cn/joweb/jryx/CN/10.12048/j.issn.1674-229X.2026.04.004

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2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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