Article(id=1309634654936850754, tenantId=1146029695717560320, journalId=1227999776411738115, issueId=1309634614356968036, articleNumber=null, orderNo=null, doi=10.12048/j.issn.1674-229X.2026.03.012, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1744300800000, receivedDateStr=2025-04-11, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1790170833571, onlineDateStr=2026-09-23, pubDate=1774368000000, pubDateStr=2026-03-25, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1790170833571, onlineIssueDateStr=2026-09-23, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1790170833571, creator=13701087609, updateTime=1790170833571, updator=13701087609, issue=Issue{id=1309634614356968036, tenantId=1146029695717560320, journalId=1227999776411738115, year='2026', volume='36', issue='3', pageStart='161', pageEnd='240', issueExtLink='null', onlineDate='null', pubDate='1774368000000', pubDateStr='2026-03-25', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1790170823897, creator='13701087609', updateTime=1790219059643, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1309836929789682362, tenantId=1146029695717560320, journalId=1227999776411738115, issueId=1309634614356968036, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1309836929789682363, tenantId=1146029695717560320, journalId=1227999776411738115, issueId=1309634614356968036, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=229, endPage=236, ext={EN=ArticleExt(id=1309634655696019779, articleId=1309634654936850754, tenantId=1146029695717560320, journalId=1227999776411738115, language=EN, title=A Case Analysis of A Patient with Non-squamous NSCLC Harboring EGFR Mutation and PD-L1 Expression, columnId=null, journalTitle=Pharmacy Today, columnName=null, runingTitle=null, highlight=null, articleAbstract=
OBJECTIVE To investigate the initial and subsequent treatment strategies for NSCLC with concurrent EGFR mutations and PD-L1 expression, and to summarize the diagnostic and therapeutic approaches so as to provide references for treatment decisions for such patients.
METHODS The treatment plan of a patient with NSCLC harboring EGFR mutations and PD-L1 expression was analyzed.
RESULTS The patient was diagnosed with adenocarcinoma of the right lung with EGFR mutations and expression of PD-L1.The initial treatment plan was osimertinib combined with pemetrexed and carboplatin, and the patient ultimately achieved a progression-free survival (PFS) of 39 months from September 2020 to December 2023. On December 27, 2023, re-examination revealed chronic disease progression, and the regimen was adjusted to osimertinib combined with bevacizumab. On March 12, 2024, the patient experienced disease progression, with no significant changes in genetic testing. Chemotherapy was considered for reinitiation, and we selected the treatment regimen of "pemetrexed + carboplatin + sintilimab + anlotinib". After one cycle, a follow-up CT scan demonstrated a partial response (PR), and PR was maintained after the second cycle.
CONCLUSION This study reports a case of advanced NSCLC with EGFR mutations and PD-L1 expression. In the treatment of this patient, an individualized diagnosis and treatment plan was formulated through literature review and relevant genetic testing. By combining immunotherapy, chemotherapy and anti-angiogenic drugs, the patient's disease was effectiveI resistance are complex and vary based on individual patient differences and tumor locations. After disease progression, re-genetic testing may clarify the resistance mechanisms and guide clinical treatment to achieve better efficacy and precision treatment.
, authors=Ning YANG
1a, Dexi GUO
1b, Ya GUO
1b, 2, Baorong LU
1b, 3, Juan ZHOU
1a, Ning WAN
1b, 2, Chen YANG
1b, *, authorsList=Ning YANG, Dexi GUO, Ya GUO, Baorong LU, Juan ZHOU, Ning WAN, Chen YANG, authorCompany=null, correspAuthors=Chen YANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1309634656123838788, articleId=1309634654936850754, tenantId=1146029695717560320, journalId=1227999776411738115, language=CN, title=1例EGFR突变合并PD-L1表达非鳞状NSCLC患者的病例分析, columnId=1228268588277105398, journalTitle=今日药学, columnName=临床药学, runingTitle=null, highlight=null, articleAbstract=
目的 探讨EGFR突变合并PD-L1表达NSCLC的初始及后续治疗方案，总结诊疗思路，以期为该类患者的治疗决策提供参考。
方法 对1例EGFR突变合并PD-L1表达NSCLC患者的治疗方案进行分析。
结果 患者诊断为右肺腺癌合并EGFR突变和PD-L1表达，初始治疗方案为奥希替尼联合培美曲塞和卡铂，患者最终获得了自2020年9月~2023年12月长达39个月的PFS（无进展生存时间）。2023年12月27日复查评估慢性进展，方案调整为奥希替尼联合贝伐珠单抗。2024年3月12日患者出现疾病进展，基因检测无明显变化，考虑重启化疗，本次进展后，选择“培美曲塞+卡铂+信迪利单抗+安罗替尼”治疗方案，1个周期后复查CT达到PR（部分缓解），C2程后持续PR。
结论 本研究报道了EGFR突变并PD-L1表达晚期NSCLC的病例。在该名患者的治疗中，通过文献复习及相关基因检测，制定了个体化诊疗方案，联合免疫、化疗以及抗血管生成药物，使患者疾病得到有效控制，并且疗效显著。TKI耐药的机制复杂，且根据患者的个体差异和肿瘤部位的不同而有所差别，在患者出现进展后可以通过再次进行基因检测明确耐药机制后指导临床治疗可获得更好的疗效，达到精准化治疗。
, authors=杨宁
1a, 郭德喜
1b, 郭娅
1b, 2, 卢葆荣
1b, 3, 周娟
1a, 万宁
1b, 2, 杨晨
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a.Department of Oncology, General Hospital of Southern Theater Command, Guangzhou, Guangdong 510010, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1309634658430706005, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634654936850754, authorId=1309634658246156626, language=CN, stringName=杨宁, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
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1a．中国人民解放军南部战区总医院，肿瘤科，广东 广州 510010, bio={"content":"
杨宁，硕士研究生，研究方向：肿瘤的临床治疗
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杨宁，硕士研究生，研究方向：肿瘤的临床治疗
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b.Department of Clinical Pharmacy, General Hospital of Southern Theater Command, Guangzhou, Guangdong 510010, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1309634658741084506, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634654936850754, authorId=1309634658510397783, language=CN, stringName=郭德喜, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
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1b．中国人民解放军南部战区总医院，临床药学科，广东 广州 510010, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1309634656379691336, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634654936850754, xref=b., ext=[AuthorCompanyExt(id=1309634656388079945, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634654936850754, companyId=1309634656379691336, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
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1b, 2, address=
b.Department of Clinical Pharmacy, General Hospital of Southern Theater Command, Guangzhou, Guangdong 510010, China
2.School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong 510515, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1309634658938216800, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634654936850754, authorId=1309634658812387676, language=CN, stringName=郭娅, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1b, 2, address=
1b．中国人民解放军南部战区总医院，临床药学科，广东 广州 510010
2．南方医科大学药学院，广东 广州 510515, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1309634656379691336, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634654936850754, xref=b., ext=[AuthorCompanyExt(id=1309634656388079945, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634654936850754, companyId=1309634656379691336, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
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2.School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong 510515, China), AuthorCompanyExt(id=1309634656471966029, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634654936850754, companyId=1309634656459383115, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
2．南方医科大学药学院，广东 广州 510515)])]), Author(id=1309634659034685794, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634654936850754, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1309634659114377573, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634654936850754, authorId=1309634659034685794, language=EN, stringName=Baorong LU, firstName=Baorong, middleName=null, lastName=LU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1b, 3, address=
b.Department of Clinical Pharmacy, General Hospital of Southern Theater Command, Guangzhou, Guangdong 510010, China
3.College of Pharmacy, Jinan University, Guangzhou, Guangdong 511436, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1309634659189875046, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634654936850754, authorId=1309634659034685794, language=CN, stringName=卢葆荣, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1b, 3, address=
1b．中国人民解放军南部战区总医院，临床药学科，广东 广州 510010
3．暨南大学药学院，广东 广州 511436, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1309634656379691336, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634654936850754, xref=b., ext=[AuthorCompanyExt(id=1309634656388079945, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634654936850754, companyId=1309634656379691336, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
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1a, address=
a.Department of Oncology, General Hospital of Southern Theater Command, Guangzhou, Guangdong 510010, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1309634659470893419, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634654936850754, authorId=1309634659248595304, language=CN, stringName=周娟, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1a, address=
1a．中国人民解放军南部战区总医院，肿瘤科，广东 广州 510010, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1309634656308388165, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634654936850754, xref=a., ext=[AuthorCompanyExt(id=1309634656312582470, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634654936850754, companyId=1309634656308388165, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
a.Department of Oncology, General Hospital of Southern Theater Command, Guangzhou, Guangdong 510010, China), AuthorCompanyExt(id=1309634656320971079, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634654936850754, companyId=1309634656308388165, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
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1b, 2, address=
b.Department of Clinical Pharmacy, General Hospital of Southern Theater Command, Guangzhou, Guangdong 510010, China
2.School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong 510515, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1309634659672220017, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309634654936850754, authorId=1309634659529613677, language=CN, stringName=万宁, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
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