Article(id=1309635221516017901, tenantId=1146029695717560320, journalId=1227999776411738115, issueId=1309635220643607372, articleNumber=null, orderNo=null, doi=10.12048/j.issn.1674-229X.2026.02.004, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1749398400000, receivedDateStr=2025-06-09, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1790170968655, onlineDateStr=2026-09-23, pubDate=1771948800000, pubDateStr=2026-02-25, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1790170968655, onlineIssueDateStr=2026-09-23, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1790170968655, creator=13701087609, updateTime=1790170968655, updator=13701087609, issue=Issue{id=1309635220643607372, tenantId=1146029695717560320, journalId=1227999776411738115, year='2026', volume='36', issue='2', pageStart='81', pageEnd='160', issueExtLink='null', onlineDate='null', pubDate='1771948800000', pubDateStr='2026-02-25', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1790170968446, creator='13701087609', updateTime=1790219084169, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1309837032671772868, tenantId=1146029695717560320, journalId=1227999776411738115, issueId=1309635220643607372, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1309837032671772869, tenantId=1146029695717560320, journalId=1227999776411738115, issueId=1309635220643607372, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=105, endPage=112, ext={EN=ArticleExt(id=1309635221667012846, articleId=1309635221516017901, tenantId=1146029695717560320, journalId=1227999776411738115, language=EN, title=Quality Difference Evaluation of Actinidiae chinensis radix based on Multi-index Quantification, Chemometrics and Weighted TOPSIS Model, columnId=null, journalTitle=Pharmacy Today, columnName=null, runingTitle=null, highlight=null, articleAbstract=
OBJECTIVE To establish a method for the simultaneous determination of catechin, epicatechin, isoquercitrin, quercetin, madecassic acid, asiatic acid, corosolic acid, oleanolic acid, ursolic acid, β-sitosterol, ethanol-soluble extractive, total ash and acid-insoluble ash in Actinidiae chinensis Radix (Radix Actinidiae Chinensis, Tengligen), and explore the application of chemometrics and weighted TOPSIS in the quality evaluation of Actinidiae chinensis radix.
METHODS An HPLC method was adopted with acetonitrile-0.2% phosphoric acid solution as the mobile phase under gradient elution.The detection wavelengths were set at 280 nm and 210 nm. Chemometric analysis (principal component analysis (PCA) and orthogonal partial least squares-discriminant analysis (OPLS-DA)) was performed on the multi-index content results, and a weighted TOPSIS model was established to comprehensively evaluate the overall quality of Actinidiae chinensis radix.
RESULTS The methodological validation results of the external standard method for HPLC simultaneous determination were consistent with the requirements of the Chinese Pharmacopoeia (ChP). The results of chemometrics analysis showed that 18 batches of Actinidiae chinensis radix were clustered into three categories, and epicatechin, β-sitosterol, asiatic acid, ursolic acid, quercetin and catechin were the main potential quality markers affecting the quality of Actinidiae chinensis radix.The Euclidean closeness degree (Ci) of the weighted TOPSIS method ranged from 0.143 8 to 0.763 4, indicating a certain degree of batch-to-batch variation in Actinidiae chinensis radix.
CONCLUSION The multi-index quantitative evaluation method combined with chemometrics and weighted TOPSIS method of Actinidiae chinensis radix is efficient and accurate, with good repeatability and stability, which can be used for the quality evaluation of Actinidiae chinensis radix.
, authors=Tian LIANG
1a, 2, Yuan LIU
1a, 2, Qingmei HU
3, Tian WANG
1b, 2, Min ZHAO
1a, 2, *, authorsList=Tian LIANG, Yuan LIU, Qingmei HU, Tian WANG, Min ZHAO, authorCompany=null, correspAuthors=Min ZHAO, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1309635221964808431, articleId=1309635221516017901, tenantId=1146029695717560320, journalId=1227999776411738115, language=CN, title=基于多指标定量、化学计量学及加权TOPSIS分析的不同产地藤梨根质量差异评价, columnId=1228268589086606089, journalTitle=今日药学, columnName=论著, runingTitle=null, highlight=null, articleAbstract=
目的 建立同时测定藤梨根中儿茶素、表儿茶素、异槲皮苷、槲皮素、羟基积雪草酸、积雪草酸、科罗索酸、齐墩果酸、熊果酸、β-谷甾醇、醇溶性浸出物、总灰分和酸不溶性灰分含量的方法，探索化学计量学和加权TOPSIS模型在藤梨根质量评价中的应用。
方法 采用HPLC法，以乙腈-0.2%磷酸为流动相，梯度洗脱；检测波长分别为280 nm和210 nm；对多指标含量结果进行PCA、OPLS-DA分析，同时建立加权TOPSIS模型，综合评价藤梨根的整体质量。
结果 外标法方法学验证结果均符合中国药典要求。化学计量学分析结果显示18批藤梨根聚为3类，提示表儿茶素、β-谷甾醇、积雪草酸、熊果酸、槲皮素和儿茶素是影响藤梨根产品质量的主要潜在标志物。加权TOPSIS法的最优解的欧氏贴近度（Ci）为0.143 8 ~ 0.763 4，藤梨根存在一定批间差异。
结论 多指标定量结合化学计量学及加权TOPSIS法的藤梨根质量评价方法高效准确，重复性和稳定性良好，可用于藤梨根的质量评价。
, authors=梁田
1a, 2, 刘源
1a, 2, 胡庆梅
3, 王田
1b, 2, 赵敏
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1a.Department of Pharmacy, The First People's Hospital of Shangqiu, Shangqiu, Henan 476100, China
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1a.Department of Pharmacy, The First People's Hospital of Shangqiu, Shangqiu, Henan 476100, China
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1a．商丘市第一人民医院，药学部，河南 商丘 476100
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3.School of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi 330004, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1309635223055327500, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309635221516017901, authorId=1309635222921109769, language=CN, stringName=胡庆梅, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
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1b, 2, address=
1b.Department of Digestive Medicine, The First People's Hospital of Shangqiu, Shangqiu, Henan 476100, China
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1b, 2, address=
1b．商丘市第一人民医院，消化内科，河南 商丘 476100
2．徐州医科大学商丘临床学院，河南 商丘 476100, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1309635222283575539, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309635221516017901, xref=1b., ext=[AuthorCompanyExt(id=1309635222291964148, tenantId=1146029695717560320, journalId=1227999776411738115, articleId=1309635221516017901, companyId=1309635222283575539, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
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1a, 2, *, address=
1a.Department of Pharmacy, The First People's Hospital of Shangqiu, Shangqiu, Henan 476100, China
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1a．商丘市第一人民医院，药学部，河南 商丘 476100
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