Article(id=1292765527382978695, tenantId=1146029695717560320, journalId=1291416979304972313, issueId=1291824268032110598, articleNumber=null, orderNo=null, doi=10.3969/j.issn.1005-4847.2026.03.013, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1744041600000, receivedDateStr=2025-04-08, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1786148920150, onlineDateStr=2026-08-08, pubDate=1774800000000, pubDateStr=2026-03-30, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1786148920150, onlineIssueDateStr=2026-08-08, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1786148920150, creator=13701087609, updateTime=1786148920150, updator=13701087609, issue=Issue{id=1291824268032110598, tenantId=1146029695717560320, journalId=1291416979304972313, year='2026', volume='34', issue='3', pageStart='313', pageEnd='468', issueExtLink='null', onlineDate='null', pubDate='1774800000000', pubDateStr='2026-03-30', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=1, specialIssue=null, createTime=1785924506432, creator='ztmeta', updateTime=1786331936953, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1293533155567366441, tenantId=1146029695717560320, journalId=1291416979304972313, issueId=1291824268032110598, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1293533155567366442, tenantId=1146029695717560320, journalId=1291416979304972313, issueId=1291824268032110598, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=451, endPage=458, ext={EN=ArticleExt(id=1292765529152974984, articleId=1292765527382978695, tenantId=1146029695717560320, journalId=1291416979304972313, language=EN, title=Development strategies for animal models of anticipatory nausea and vomiting, columnId=null, journalTitle=Acta Laboratorium Animalis Scientia Sinica, columnName=null, runingTitle=null, highlight=null, articleAbstract=

Anticipatory nausea and vomiting (ANV) is a learned form of nausea and vomiting that occurs when chemotherapy-induced nausea and vomiting are inadequately controlled. Patients often develop nausea and vomiting prior to subsequent chemotherapy sessions, a phenomenon termed ANV, with the severity correlating positively with the patient's anxiety and depression levels. Although approximately 20% ~ 30% of patients develop ANV by the fourth chemotherapy cycle, current treatment options for ANV remain limited, highlighting the need to elucidate its pathogenesis, explore effective therapies, and develop novel pharmacological agents. The establishment of ANV animal models plays an indispensable role in this process; however, no ideal preclinical model has yet fully and accurately replicated all features of ANV onset and progression observed in chemotherapy patients. This article systematically reviews recent advances in method ologies for establishing ANV animal models, including the selection of experimental species, common emetic agents, and protocols for modeling ANV in rats using lithium chloride. The review aims to provide references to aid the design of more precise animal models and to offer a foundation for further investigations into ANV mechanisms and potential drug development.

, authors=Yuelian WANG, Ke JIANG, Mengting DONG, Xinyue ZHOU, Jiayu SHENG^*, authorsList=Yuelian WANG, Ke JIANG, Mengting DONG, Xinyue ZHOU, Jiayu SHENG, authorCompany=null, correspAuthors=Jiayu SHENG, authorNote=null, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1292765529371078793, articleId=1292765527382978695, tenantId=1146029695717560320, journalId=1291416979304972313, language=CN, title=预期性恶心呕吐动物模型的构建策略, columnId=1292765517996122928, journalTitle=中国实验动物学报, columnName=研究进展, runingTitle=null, highlight=null, articleAbstract=

预期性恶心呕吐是一种习得性恶心呕吐，当化疗引起的恶心呕吐没有得到有效的控制时，患者往往会在下一次化疗前即出现恶心呕吐称为预期性恶心呕吐，其恶心呕吐的程度与患者焦虑抑郁程度呈正相关，约有20% ~ 30%的患者在第4个化疗周期会出现预期性恶心呕吐。然而，目前针对预期性恶心呕吐的治疗手段有限，因此深入探究预期性恶心呕吐的发病机制、探寻有效的治疗方法以及开发新型药物已成为当务之急。在这一过程中，预期性恶心呕吐动物模型的建立发挥着不可或缺的关键作用。但目前尚无一种理想的预期性动物模型能够全面、准确地复刻化疗患者预期性恶心呕吐的发生与发展的所有特征。本文系统梳理了近年来预期性恶心呕吐动物模型建立方法的研究进展，详细综述了常见实验动物、常见致吐剂以及使用氯化锂致吐剂建立大鼠预期性恶心呕吐动物模型的方法，旨在为未来设计出更为精准的动物模型提供参考，并为进一步探索其发病机制以及潜在药物治疗提供一定的基础。

, authors=王月莲, 江科, 董梦婷, 周鑫玥, 盛佳钰^*, authorsList=王月莲, 江科, 董梦婷, 周鑫玥, 盛佳钰, authorCompany=null, correspAuthors=盛佳钰, authorNote=, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=17dbvuyzCz0Q9g/mydNC3A==, magXml=vzoOH7Q1p47QTZCCx08L2g==, pdfUrl=null, pdf=2v5SEBvx28oVOKebY77ECg==, pdfFileSize=865337, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=2/xiULJ/rX8kv3asywY6Kg==, mapNumber=null, fund=null)}, authors=[Author(id=1292769842550042646, tenantId=1146029695717560320, journalId=1291416979304972313, articleId=1292765527382978695, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=wangyuelian2001@163.com, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1292769842629734424, tenantId=1146029695717560320, journalId=1291416979304972313, articleId=1292765527382978695, authorId=1292769842550042646, language=EN, stringName=Yuelian WANG, firstName=Yuelian, middleName=null, lastName=WANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Yueyang Hospital of Integrated Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1292769842747174937, tenantId=1146029695717560320, journalId=1291416979304972313, articleId=1292765527382978695, authorId=1292769842550042646, language=CN, stringName=王月莲, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=上海中医药大学附属岳阳中西医结合医院，上海　200437, bio={"content":"

王月莲，女，在读硕士研究生，研究方向：中医药防治乳腺恶性肿瘤。Email：wangyuelian2001@163.com

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王月莲，女，在读硕士研究生，研究方向：中医药防治乳腺恶性肿瘤。Email：wangyuelian2001@163.com

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