Article(id=1292765517702521646, tenantId=1146029695717560320, journalId=1291416979304972313, issueId=1291824268032110598, articleNumber=null, orderNo=null, doi=10.3969/j.issn.1005-4847.2026.03.012, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1743609600000, receivedDateStr=2025-04-03, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1786148917841, onlineDateStr=2026-08-08, pubDate=1774800000000, pubDateStr=2026-03-30, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1786148917841, onlineIssueDateStr=2026-08-08, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1786148917841, creator=13701087609, updateTime=1786148917841, updator=13701087609, issue=Issue{id=1291824268032110598, tenantId=1146029695717560320, journalId=1291416979304972313, year='2026', volume='34', issue='3', pageStart='313', pageEnd='468', issueExtLink='null', onlineDate='null', pubDate='1774800000000', pubDateStr='2026-03-30', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=1, specialIssue=null, createTime=1785924506432, creator='ztmeta', updateTime=1786331936953, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1293533155567366441, tenantId=1146029695717560320, journalId=1291416979304972313, issueId=1291824268032110598, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1293533155567366442, tenantId=1146029695717560320, journalId=1291416979304972313, issueId=1291824268032110598, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=442, endPage=450, ext={EN=ArticleExt(id=1292765517887071023, articleId=1292765517702521646, tenantId=1146029695717560320, journalId=1291416979304972313, language=EN, title=Research progress on animal models of comorbid chronic obstructive pulmonary disease and pulmonary interstitial fibrosis, columnId=null, journalTitle=Acta Laboratorium Animalis Scientia Sinica, columnName=null, runingTitle=null, highlight=null, articleAbstract=

Chronic obstructive pulmonary disease (COPD) and pulmonary interstitial fibrosis (PIF) are chronic pulmonary diseases that severely impair lung function. COPD combined with PIF (COPD-PIF) exacerbates lung-tissue damage, accelerates disease progression, and significantly worsens patient prognosis. However, the exact pathogenesis of COPD-PIF remains unclear, and effective treatment options are still lacking. Animal models have recently played a crucial role in elucidating the pathological mechanisms of COPD-PIF and facilitating new drug development. Current COPD models are primarily established by single-factor induction (such as cigarette smoke exposure or lipopolysaccharide injection) or multi-factor combination method, while PIF models mainly rely on bleomycin induction. The administration route (e. g., intratracheal instillation, aerosol inhalation, or intravenous injection) affects the stability and reproducibility of these models. Although various COPD-PIF animal models have been developed and utilized for research, challenges remain in establishing a standardized and reliable model that fully mimics human disease characteristics. Additionally, although the order in which COPD and PIF are induced may influence the pathological manifestations, there is no consensus in current studies. Further investigations into the pathogenesis of COPD-PIF and the identification of effective therapeutic strategies require more research focusing on optimizing modeling techniques, improving model stability and reproducibility, and developing animal models that better reflect the clinical characteristics of COPD-PIF. These efforts will contribute to advancing fundamental research and facilitating new drug development in this field.

, authors=Yu JIANG¹, Yu DING¹, Jianjian YU², Lina FU², Chengsen CAI², Jun WANG^{2, *}, authorsList=Yu JIANG, Yu DING, Jianjian YU, Lina FU, Chengsen CAI, Jun WANG, authorCompany=null, correspAuthors=Jun WANG, authorNote=null, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1292765518298112817, articleId=1292765517702521646, tenantId=1146029695717560320, journalId=1291416979304972313, language=CN, title=慢性阻塞性肺疾病合并肺间质纤维化动物模型的研究进展, columnId=1292765517996122928, journalTitle=中国实验动物学报, columnName=研究进展, runingTitle=null, highlight=null, articleAbstract=

慢性阻塞性肺疾病（COPD）和肺间质纤维化（PIF）是两种严重影响肺功能的慢性肺部疾病。COPD合并PIF（COPD-PIF）可导致肺组织损伤进一步加重，加速病情进展，并显著影响患者预后。然而，COPD-PIF的具体发病机制尚未完全阐明，且目前尚无有效的治疗手段。近年来，动物模型在COPD-PIF的病理机制研究及新药开发中发挥了重要作用。现有COPD模型的构建方法主要包括单因素诱导（如香烟烟雾暴露、脂多糖注射）和多因素联合诱导，而PIF模型则主要依赖博来霉素诱导，不同给药方式（如气管内滴注、雾化吸入、尾静脉注射）对模型的稳定性和重复性具有重要影响。尽管已有一定类型的COPD-PIF动物模型被用于研究，但仍存在模型建立方法不完善、稳定性不足及难以全面模拟人类疾病特征的问题。此外，COPD与PIF的发生顺序可能影响模型的病理表现，这在现有研究中尚未达成一致。为更好地研究COPD-PIF的病理机制及筛选有效治疗策略，未来应进一步优化造模方法，提高模型的稳定性和可重复性，探索更符合COPD-PIF临床特征的动物模型，从而推动该领域的基础研究和新药开发。

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姜雨，女，在读硕士研究生，研究方向：中医药防治呼吸系统疾病及急危重症。Email：17861173907@163.com

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姜雨，女，在读硕士研究生，研究方向：中医药防治呼吸系统疾病及急危重症。Email：17861173907@163.com

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