Article(id=1292765509355860967, tenantId=1146029695717560320, journalId=1291416979304972313, issueId=1291824268032110598, articleNumber=null, orderNo=null, doi=10.3969/j.issn.1005-4847.2026.03.005, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1740326400000, receivedDateStr=2025-02-24, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1786148915851, onlineDateStr=2026-08-08, pubDate=1774800000000, pubDateStr=2026-03-30, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1786148915851, onlineIssueDateStr=2026-08-08, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1786148915851, creator=13701087609, updateTime=1786148915851, updator=13701087609, issue=Issue{id=1291824268032110598, tenantId=1146029695717560320, journalId=1291416979304972313, year='2026', volume='34', issue='3', pageStart='313', pageEnd='468', issueExtLink='null', onlineDate='null', pubDate='1774800000000', pubDateStr='2026-03-30', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=1, specialIssue=null, createTime=1785924506432, creator='ztmeta', updateTime=1786331936953, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1293533155567366441, tenantId=1146029695717560320, journalId=1291416979304972313, issueId=1291824268032110598, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1293533155567366442, tenantId=1146029695717560320, journalId=1291416979304972313, issueId=1291824268032110598, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=362, endPage=370, ext={EN=ArticleExt(id=1292765509552993256, articleId=1292765509355860967, tenantId=1146029695717560320, journalId=1291416979304972313, language=EN, title=Comparison of microbiota in Chinese hamsters and golden hamsters based on 16S rDNA sequencing, columnId=null, journalTitle=Acta Laboratorium Animalis Scientia Sinica, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective To compare the composition and diversity of lung and gut microbiota between Chinese and golden hamsters using 16S rDNA sequencing, to provide a new perspective for understanding their applications in human disease research.
Methods SPF-grade Chinese hamsters and golden hamsters (6 males and 6 females per group) aged 6 ~ 8 weeks were selected. Bronchoalveolar lavage fluid, small intestinal contents, and large intestinal contents were collected under sterile conditions. Species annotation and α-diversity and β-diversity analyses were performed using 16S rDNA sequencing. Linear discriminant analysis effect size (LEfSe) analysis was employed to identify potential biomarkers.
Results The α-diversity of the lung and small intestinal microbiota was significantly higher in golden hamsters (especially males) than in Chinese hamsters (P < 0.05), while the diversity of the large intestinal microbiota was significantly higher in Chinese hamsters (P < 0.05). Regarding β-diversity, the composition of the lung, small intestinal, and large intestinal microbiota differed significantly between the two types of hamsters (P < 0.01). LEfSe analysis revealed differential occurrence of the phylum Firmicutes in the lung microbiota in golden hamsters, and differential occurrence of the phyla Bacteroidota (females) and Proteobacteria (males) in Chinese hamsters. Regarding the small intestinal and large intestinal microbiota, Firmicutes and Bacteroidota were differential phyla in Chinese and golden hamsters, respectively.
Conclusions The composition and diversity of the lung and gut microbiota differed significantly between Chinese and golden hamsters, which may be related to their distinct applications in human disease research. This study provides a new perspective for understanding the applications of these two types of hamsters in human disease research and lays a theoretical foundation for future efforts to improve their health status and their value as experimental models by modulating their microbiota.
, authors=Kaihui LIU, Yaxi GUO, Xiaopeng DU, Zhaohua WANG, Hua ZHU
*, authorsList=Kaihui LIU, Yaxi GUO, Xiaopeng DU, Zhaohua WANG, Hua ZHU, authorCompany=null, correspAuthors=Hua ZHU, authorNote=null, correspAuthorsNote=
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目的 本研究旨在通过16S rDNA测序技术比较中国地鼠和金黄地鼠肺部与肠道微生物群落的组成和多样性差异，为理解它们在人类疾病研究中的应用提供新的视角。
方法 选取6 ~ 8周龄的SPF级中国地鼠和金黄地鼠各12只（雌雄各半），在无菌条件下采集肺泡灌洗液、小肠内容物和大肠内容物样本。通过16S rDNA测序技术进行物种注释和多样性分析，包括α多样性和β多样性分析，并使用线性判别分析（linear discriminant analysis effect size, LEfSe）识别潜在的生物标志物。
结果 多样性分析，金黄地鼠（尤其是雄性）的肺部和小肠微生物群落多样性显著高于中国地鼠（P < 0.05），中国地鼠的大肠微生物群落的多样性显著高于金黄地鼠（P < 0.05）。β多样性分析，两种地鼠在肺部、小肠和大肠的微生物群落组成上均存在显著性差异（P < 0.01）。LEfSe分析，在肺部微生物群落中，金黄地鼠的差异物种是厚壁菌门（Firmicutes），中国地鼠差异物种是拟杆菌门（Bacteroidota）（雌性）和变形菌门（Proteobacteria）（雄性）；在小肠和大肠微生物群中，中国地鼠的差异物种是厚壁菌门（Firmicutes），金黄地鼠的差异物种是拟杆菌门（Bacteroidota）。
结论 中国地鼠和金黄地鼠在肺部和肠道微生物群落的组成和多样性上存在显著性差异，这些差异可能与它们在人类疾病研究中的不同应用领域相关。本研究为理解这两种地鼠在人类疾病研究中的应用提供了新的视角，并为未来通过调节微生物群落提升它们的健康水平及其作为实验模型的价值提供了理论基础。
, authors=刘凯慧, 郭亚茜, 杜晓鹏, 王昭华, 朱华
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