Article(id=1292765521016025153, tenantId=1146029695717560320, journalId=1291416979304972313, issueId=1291824268032110598, articleNumber=null, orderNo=null, doi=10.3969/j.issn.1005-4847.2026.03.010, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1751040000000, receivedDateStr=2025-06-28, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1786148918631, onlineDateStr=2026-08-08, pubDate=1774800000000, pubDateStr=2026-03-30, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1786148918631, onlineIssueDateStr=2026-08-08, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1786148918631, creator=13701087609, updateTime=1786148918631, updator=13701087609, issue=Issue{id=1291824268032110598, tenantId=1146029695717560320, journalId=1291416979304972313, year='2026', volume='34', issue='3', pageStart='313', pageEnd='468', issueExtLink='null', onlineDate='null', pubDate='1774800000000', pubDateStr='2026-03-30', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=1, specialIssue=null, createTime=1785924506432, creator='ztmeta', updateTime=1786331936953, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1293533155567366441, tenantId=1146029695717560320, journalId=1291416979304972313, issueId=1291824268032110598, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1293533155567366442, tenantId=1146029695717560320, journalId=1291416979304972313, issueId=1291824268032110598, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=424, endPage=431, ext={EN=ArticleExt(id=1292765521179603010, articleId=1292765521016025153, tenantId=1146029695717560320, journalId=1291416979304972313, language=EN, title=Research progress on the establishment of septic mouse models and evaluation of immunosuppressive status, columnId=null, journalTitle=Acta Laboratorium Animalis Scientia Sinica, columnName=null, runingTitle=null, highlight=null, articleAbstract=

Sepsis is a life-threatening condition associated with high mortality rates in clinical settings. The subsequent immunosuppressive state is strongly correlated with adverse patient outcomes. Establishing robust animal models is therefore essential for elucidating the pathophysiological mechanisms of sepsis-induced immunosuppression and developing therapeutic interventions. Current models, however, are predominantly employed in sepsis hyperinflammation studies, while their utilization specifically for the immunosuppression phase remains limited. In addition, standardized assessment criteria for immunosuppression are lacking across different investigations. Commonly employed models include cecal ligation and puncture (CLP) and lipopolysaccharide (LPS) administration. Although cecal ligation and puncture effectively recapitulates the clinical pathology, it suffers from significant outcome variability. Conversely, although lipopolysaccharide administration is technically straightforward, its artificial nature fails to replicate the polymicrobial pathogenesis of natural infection. Quantitative analysis of immune cell populations, cytokine profiles, and immune organ status provides a reliable assessment of immunosuppression severity in animal models. By synthesizing recent literature, this review consolidates the method ologies and assessment parameters for establishing immunosuppressive sepsis models. By critically evaluating the strengths and limitations of each approach, the review aims to establish a standardized experimental framework for the future development of optimized sepsis models.

, authors=Changqi LI¹, Xinyang LI¹, Bo CHEN^{1, 2, *}, Jingyu ZHANG¹, Jingwen WANG¹, Xiaobing KUANG³, Ningcen LI¹, Liyuan FU³, Peihong MA³, authorsList=Changqi LI, Xinyang LI, Bo CHEN, Jingyu ZHANG, Jingwen WANG, Xiaobing KUANG, Ningcen LI, Liyuan FU, Peihong MA, authorCompany=null, correspAuthors=Bo CHEN, authorNote=null, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1292765521829720131, articleId=1292765521016025153, tenantId=1146029695717560320, journalId=1291416979304972313, language=CN, title=脓毒症小鼠模型制备及免疫抑制状态评价的研究进展, columnId=1292765517996122928, journalTitle=中国实验动物学报, columnName=研究进展, runingTitle=null, highlight=null, articleAbstract=

脓毒症是临床中死亡率较高的危重疾病，后期的免疫抑制状态与患者不良预后密切相关。建立可靠的动物模型对于深入剖析脓毒症免疫抑制的机制及治疗策略至关重要。目前，现有模型多用于脓毒症过度炎症的研究，在脓毒症免疫抑制的相关研究中使用较少，并且相关研究的评估标准也不尽相同。盲肠结扎穿孔（CLP）和脂多糖（LPS）注射是常用模型，其中CLP能较好模拟临床病理过程，但模型稳定性较差；LPS操作简单，但与实际感染存在差异。对于动物模型免疫抑制程度，可通过检测免疫细胞数量、细胞因子水平及免疫器官等指标进行有效地评估。本文通过系统查阅分析近年文献，总结脓毒症动物模型免疫抑制状态的构建方法与评估指标，分析不同模型的优缺点，以期为脓毒症模型设计提供前期实验依据。

, authors=李昌奇¹, 李昕洋¹, 陈波^{1, 2, *}, 张靖宇¹, 王婧文¹, 匡小冰³, 李柠岑¹, 傅丽媛³, 马培宏³, authorsList=李昌奇, 李昕洋, 陈波, 张靖宇, 王婧文, 匡小冰, 李柠岑, 傅丽媛, 马培宏, authorCompany=null, correspAuthors=陈波, authorNote=, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=0r/dNMXxqq78ceDusGtYoQ==, magXml=bKji5QrIv98GVX7rOIoBlg==, pdfUrl=null, pdf=Do1NMdypvipn0DmymKtm2g==, pdfFileSize=877728, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=1Tgp6P97uwKNL2AFKygJEw==, mapNumber=null, fund=null)}, authors=[Author(id=1292769802502824382, tenantId=1146029695717560320, journalId=1291416979304972313, articleId=1292765521016025153, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=17713040363@163.com, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1292769802578321856, tenantId=1146029695717560320, journalId=1291416979304972313, articleId=1292765521016025153, authorId=1292769802502824382, language=EN, stringName=Changqi LI, firstName=Changqi, middleName=null, lastName=LI, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=^1.School of Acupuncture-Moxibustion and Tuina, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1292769802658013633, tenantId=1146029695717560320, journalId=1291416979304972313, articleId=1292765521016025153, authorId=1292769802502824382, language=CN, stringName=李昌奇, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=^1．天津中医药大学针灸推拿学院，天津　301617, bio={"content":"

李昌奇，男，在读硕士研究生，研究方向：针刺的作用机理。Email：17713040363@163.com

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李昌奇，男，在读硕士研究生，研究方向：针刺的作用机理。Email：17713040363@163.com

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