Article(id=1317870237312205389, tenantId=1146029695717560320, journalId=1316781486805975183, issueId=1317870111650861922, articleNumber=null, orderNo=null, doi=10.7502/j.issn.1674-3962.202504025, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1745424000000, receivedDateStr=2025-04-24, revisedDate=1757433600000, revisedDateStr=2025-09-10, acceptedDate=null, acceptedDateStr=null, onlineDate=1792134349420, onlineDateStr=2026-10-16, pubDate=1792425600000, pubDateStr=2026-10-20, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792134349420, onlineIssueDateStr=2026-10-16, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792134349420, creator=13701087609, updateTime=1792134349420, updator=13701087609, issue=Issue{id=1317870111650861922, tenantId=1146029695717560320, journalId=1316781486805975183, year='2026', volume='45', issue='10', pageStart='973', pageEnd='1112', issueExtLink='null', onlineDate='null', pubDate='1792425600000', pubDateStr='2026-10-20', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=1, specialIssue=null, createTime=1792134319460, creator='13701087609', updateTime=1792134412817, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1317870503340131086, tenantId=1146029695717560320, journalId=1316781486805975183, issueId=1317870111650861922, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1317870503340131087, tenantId=1146029695717560320, journalId=1316781486805975183, issueId=1317870111650861922, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1026, endPage=1038, ext={EN=ArticleExt(id=1317870237496754766, articleId=1317870237312205389, tenantId=1146029695717560320, journalId=1316781486805975183, language=EN, title=Progress in the Application of Inorganic Sonosensitizers in Tumor Sonodynamic Therapy, columnId=1317870128553907155, journalTitle=Materials China, columnName=Comprehensive Review, runingTitle=null, highlight=null, articleAbstract=

As an emerging non-invasive tumor treatment technique, sonodynamic therapy (SDT) uses ultrasound to stimulate the generation of reactive oxygen species to kill cancer cells. It has attracted much attention due to its excellent tissue penetration, efficient therapeutic effect and low toxicity side effect. In recent years, the development of efficient and low toxicity sonosensitizers have become a research hotspot in this field. Inorganic sonosensitizers have shown great potential in the field of SDT due to their excellent stability, controllable physicochemical properties, multifunctional integration ability and tumor targeting ability. This review systematically summarizes the evolution of inorganic sonosensitizers and divides them into three generations: the first generation improves performance by optimizing material structure, the second generation focuses on regulating the tumor microenvironment to enhance SDT efficacy, and the third generation achieves synergistic therapy by regulating immune response. Finally, this review discusses the challenges currently faced by inorganic sonosensitizers and looks forward to future development directions.

, authors=Yali YANG¹, Jihu NIE², Nailin YANG², Shumin SUN², Liang CHENG², authorsList=Yali YANG, Jihu NIE, Nailin YANG, Shumin SUN, Liang CHENG, authorCompany=null, correspAuthors=Liang CHENG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1317870237916185169, articleId=1317870237312205389, tenantId=1146029695717560320, journalId=1316781486805975183, language=CN, title=无机声敏剂在肿瘤声动力疗法中的研究进展, columnId=1317870128792982485, journalTitle=中国材料进展, columnName=综合评述, runingTitle=null, highlight=null, articleAbstract=

声动力疗法（SDT）作为一种新兴的非侵入性肿瘤治疗技术，通过超声激发声敏剂产生活性氧来杀伤癌细胞，因其优异的组织穿透性、高治疗效应和低毒副作用而备受关注。近年来开发高效低毒声敏剂已成为该领域的研究热点。无机声敏剂因具有优异的稳定性、可控的理化性质、多功能整合能力及肿瘤靶向性，在SDT领域展现出巨大潜力。系统总结了无机声敏剂的演进历程，将它划分为3代：第一代通过优化材料结构提升性能，第二代聚焦肿瘤微环境调控以增强SDT疗效，第三代则通过调节免疫反应实现协同治疗。最后，探讨了当前无机声敏剂面临的挑战并展望其未来发展方向。

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杨亚丽，女，1985年生，硕士研究生

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杨亚丽，女，1985年生，硕士研究生

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程亮：男，1983年生，苏州大学功能纳米与软物质研究院教授、博士生导师。教育部青年长江学者和江苏省杰青项目获得者。中国生物材料学会纳米生物材料分会委员。近年来从材料科学研究出发，在纳米生物医学等领域从事多学科交叉研究，在Nature Communications，Science Advances，National Science Review，Cell Biomaterials，Advanced Materials，Journal of the American Chemical Society等国内外重要学术期刊发表SCI论文300余篇。2025年入选全球前0.05%顶尖学者；2017~2025连续9年入选“全球高被引科学家名单”（Highly Cited Researchers）（材料）和中国高被引学者。

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程亮：男，1983年生，苏州大学功能纳米与软物质研究院教授、博士生导师。教育部青年长江学者和江苏省杰青项目获得者。中国生物材料学会纳米生物材料分会委员。近年来从材料科学研究出发，在纳米生物医学等领域从事多学科交叉研究，在Nature Communications，Science Advances，National Science Review，Cell Biomaterials，Advanced Materials，Journal of the American Chemical Society等国内外重要学术期刊发表SCI论文300余篇。2025年入选全球前0.05%顶尖学者；2017~2025连续9年入选“全球高被引科学家名单”（Highly Cited Researchers）（材料）和中国高被引学者。

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