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Article(id=1291753232976597701, tenantId=1146029695717560320, journalId=1291416913693474840, issueId=1291753151179280707, articleNumber=PA20260408_66PgCQzi, orderNo=null, doi=10.3969/j.issn.1671-7856.2026.06.012, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1756569600000, receivedDateStr=2025-08-31, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785907570356, onlineDateStr=2026-08-05, pubDate=1774800000000, pubDateStr=2026-03-30, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785907570355, onlineIssueDateStr=2026-08-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785907570355, creator=admin, updateTime=1785907570355, updator=admin, issue=Issue{id=1291753151179280707, tenantId=1146029695717560320, journalId=1291416913693474840, year='2026', volume='36', issue='6', pageStart='1', pageEnd='144', issueExtLink='null', onlineDate='null', pubDate='1774800000000', pubDateStr='2026-03-30', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=1, specialIssue=null, createTime=1785907550854, creator='ztmeta', updateTime=1786331902788, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1293533012289941791, tenantId=1146029695717560320, journalId=1291416913693474840, issueId=1291753151179280707, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1293533012289941792, tenantId=1146029695717560320, journalId=1291416913693474840, issueId=1291753151179280707, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=122, endPage=133, ext={EN=ArticleExt(id=1291753236432704199, articleId=1291753232976597701, tenantId=1146029695717560320, journalId=1291416913693474840, language=EN, title=Research advances in the impact of nitric oxide on the blood-brain barrier, columnId=1292760404241969391, journalTitle=Chinese Journal of Comparative Medicine, columnName=Research Progress, runingTitle=null, highlight=null, articleAbstract=

The blood-brain barrier (BBB) plays a critical role in maintaining brain homeostasis. BBB dysfunction is closely associated with various neurodegenerative diseases and acute brain injuries, which impair brain defense mechanisms and can exacerbate the progression of pathological conditions. Nitric oxide (NO), an important biological signaling molecule, exerts a wide range of effects on the central nervous system, influencing both physiological and pathological states. This review summarizes the production and metabolism of NO and their effects on BBB permeability, followed by an introduction to the role of NO in pathological conditions such as cerebral ischemia-reperfusion injury, neurodegenerative diseases, and brain tumors. NO regulates BBB integrity through the regulation of tight junction proteins and vascular endothelial growth factor receptor 2 (VEGFR2). The review also delves into the potential of NO as a therapeutic target in drug delivery and gene therapy, and explores its potential to enhance drug penetration across the BBB. These explorations provide novel perspectives for future therapeutic strategies.

, authors=Jingyi XIN1, 2, 3, Meiwen YANG1, 2, 4, Fenfang HONG5, *, Shulong YANG1, 2, 3, *, authorsList=Jingyi XIN, Meiwen YANG, Fenfang HONG, Shulong YANG, authorCompany=null, correspAuthors=Fenfang HONG, Shulong YANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291753236357206726, articleId=1291753232976597701, tenantId=1146029695717560320, journalId=1291416913693474840, language=CN, title=一氧化氮对血脑屏障的影响研究进展, columnId=1292760404409741552, journalTitle=中国比较医学杂志, columnName=研究进展, runingTitle=null, highlight=null, articleAbstract=

血脑屏障（BBB）在维持脑稳态方面发挥重要作用，其功能障碍与多种神经退行性疾病以及急性脑损伤密切相关，不仅影响大脑的防御机制，还可能加剧病理状态的进展。一氧化氮（NO）作为一种重要的生物信号分子，在中枢神经系统中作用广泛，其影响不仅局限于生理状态，还包括多种病理状态的调节作用。本文综述了NO的生成与代谢及其对BBB通透性的影响，分别介绍NO在脑缺血再灌注损伤、神经退行性疾病及脑肿瘤等病理条件中的作用，并着重强调NO通过紧密连接蛋白、血管内皮生长因子受体2（VEGFR2）等对BBB完整性的调节。进一步探讨NO作为治疗靶点在药物递送和基因治疗中的潜力以及NO在增强药物跨越BBB方面的可能性，为未来相关治疗策略提供了新思路。

, authors=辛靖怡1, 2, 3, 杨美雯1, 2, 4, 洪芬芳5, *, 杨树龙1, 2, 3, *, authorsList=辛靖怡, 杨美雯, 洪芬芳, 杨树龙, authorCompany=null, correspAuthors=洪芬芳, 杨树龙, authorNote=

*

辛靖怡（2005—），女，本科，研究方向：心脑血管心理学。E-mail:

, correspAuthorsNote=
洪芬芳（1974—），女，高级实验师，研究方向：炎症药理学。E-mail:
杨树龙（1966—），男，教授，博士生导师，研究方向：心脑血管生理学与炎症药理学。E-mail:
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2．抚州市慢性病研究技术创新中心，江西 抚州　344100
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辛靖怡（2005—），女，本科，研究方向：心脑血管心理学。E-mail:

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2．抚州市慢性病研究技术创新中心，江西 抚州　344100
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一氧化氮对血脑屏障的影响研究进展
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辛靖怡 1, 2, 3 , 杨美雯 1, 2, 4 , 洪芬芳 5, * , 杨树龙 1, 2, 3, *
中国比较医学杂志 | 研究进展 2026,36(6): 122-133
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中国比较医学杂志 |研究进展 2026 , 36 (6) : 122 -133
一氧化氮对血脑屏障的影响研究进展
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辛靖怡1, 2, 3 , 杨美雯1, 2, 4, 洪芬芳5, * , 杨树龙1, 2, 3, *
作者信息
  • 1．南昌大学抚州医学院慢性病研究重点实验室，江西 抚州　344100
  • 2．抚州市慢性病研究技术创新中心，江西 抚州　344100
  • 3．南昌大学抚州医学院生理学教研室，江西 抚州　344100
  • 4．南昌大学抚州医学院外科学教研室，江西 抚州　344100
  • 5．南昌大学基础医学院病原生物学实验中心，南昌　330031
通讯作者:
洪芬芳（1974—），女，高级实验师，研究方向：炎症药理学。E-mail:
杨树龙（1966—），男，教授，博士生导师，研究方向：心脑血管生理学与炎症药理学。E-mail:
作者简介:

*

辛靖怡（2005—），女，本科，研究方向：心脑血管心理学。E-mail:

Research advances in the impact of nitric oxide on the blood-brain barrier
Jingyi XIN1, 2, 3 , Meiwen YANG1, 2, 4, Fenfang HONG5, * , Shulong YANG1, 2, 3, *
Affiliations
  • 1.Key Research Laboratory of Chronic Disease, Fuzhou Medical College of Nanchang University, Fuzhou 344100, China
  • 2.Technology Innovation Center of Chronic Disease Research in Fuzhou City, Fuzhou Science and Technology Bureau, Fuzhou 344100
  • 3.Department of Physiology, Fuzhou Medical College of Nanchang University, Fuzhou 344100
  • 4.Department of Surgery, Fuzhou Medical College of Nanchang University, Fuzhou 344100
  • 5.Experimental Center of Pathogen Biology, Basic College of Medicine, Nanchang University, Nanchang 330031
出版时间: 2026-03-30 doi: 10.3969/j.issn.1671-7856.2026.06.012
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摘要
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血脑屏障（BBB）在维持脑稳态方面发挥重要作用，其功能障碍与多种神经退行性疾病以及急性脑损伤密切相关，不仅影响大脑的防御机制，还可能加剧病理状态的进展。一氧化氮（NO）作为一种重要的生物信号分子，在中枢神经系统中作用广泛，其影响不仅局限于生理状态，还包括多种病理状态的调节作用。本文综述了NO的生成与代谢及其对BBB通透性的影响，分别介绍NO在脑缺血再灌注损伤、神经退行性疾病及脑肿瘤等病理条件中的作用，并着重强调NO通过紧密连接蛋白、血管内皮生长因子受体2（VEGFR2）等对BBB完整性的调节。进一步探讨NO作为治疗靶点在药物递送和基因治疗中的潜力以及NO在增强药物跨越BBB方面的可能性，为未来相关治疗策略提供了新思路。

血脑屏障  /  一氧化氮合酶  /  血管内皮细胞  /  紧密连接蛋白

The blood-brain barrier (BBB) plays a critical role in maintaining brain homeostasis. BBB dysfunction is closely associated with various neurodegenerative diseases and acute brain injuries, which impair brain defense mechanisms and can exacerbate the progression of pathological conditions. Nitric oxide (NO), an important biological signaling molecule, exerts a wide range of effects on the central nervous system, influencing both physiological and pathological states. This review summarizes the production and metabolism of NO and their effects on BBB permeability, followed by an introduction to the role of NO in pathological conditions such as cerebral ischemia-reperfusion injury, neurodegenerative diseases, and brain tumors. NO regulates BBB integrity through the regulation of tight junction proteins and vascular endothelial growth factor receptor 2 (VEGFR2). The review also delves into the potential of NO as a therapeutic target in drug delivery and gene therapy, and explores its potential to enhance drug penetration across the BBB. These explorations provide novel perspectives for future therapeutic strategies.

blood-brain barrier  /  nitric oxide synthase  /  endothelial cells  /  tight junction proteins
辛靖怡, 杨美雯, 洪芬芳, 杨树龙. 一氧化氮对血脑屏障的影响研究进展. 中国比较医学杂志, 2026 , 36 (6) : 122 -133 . DOI: 10.3969/j.issn.1671-7856.2026.06.012
Jingyi XIN, Meiwen YANG, Fenfang HONG, Shulong YANG. Research advances in the impact of nitric oxide on the blood-brain barrier[J]. Chinese Journal of Comparative Medicine, 2026 , 36 (6) : 122 -133 . DOI: 10.3969/j.issn.1671-7856.2026.06.012
基金
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  • 国家自然科学基金(82360880)
  • 江西省自然科学基金(20232ACB206057; 20212BAB206092)
  • 江西省教育厅科技研究重点项目(GJJ218104)
  • 江西省高等学校教学改革研究课题(JXJG-22-130-1)
  • 南昌大学抚州医学院校级重点项目(fykj202301)
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2026年第36卷第6期
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doi: 10.3969/j.issn.1671-7856.2026.06.012
  • 接收时间：2025-08-31
  • 首发时间：2026-08-05
  • 出版时间：2026-03-30
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  • 收稿日期：2025-08-31
基金
国家自然科学基金(82360880)
江西省自然科学基金(20232ACB206057; 20212BAB206092)
江西省教育厅科技研究重点项目(GJJ218104)
江西省高等学校教学改革研究课题(JXJG-22-130-1)
南昌大学抚州医学院校级重点项目(fykj202301)
作者信息
    1．南昌大学抚州医学院慢性病研究重点实验室，江西 抚州　344100
    2．抚州市慢性病研究技术创新中心，江西 抚州　344100
    3．南昌大学抚州医学院生理学教研室，江西 抚州　344100
    4．南昌大学抚州医学院外科学教研室，江西 抚州　344100
    5．南昌大学基础医学院病原生物学实验中心，南昌　330031

通讯作者:

洪芬芳（1974—），女，高级实验师，研究方向：炎症药理学。E-mail:
杨树龙（1966—），男，教授，博士生导师，研究方向：心脑血管生理学与炎症药理学。E-mail:
参考文献
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https://castjournals.cast.org.cn/joweb/zgbjyxzz/CN/10.3969/j.issn.1671-7856.2026.06.012
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2种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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