Article(id=1291753223421973113, tenantId=1146029695717560320, journalId=1291416913693474840, issueId=1291753151179280707, articleNumber=PA20260408_BVNaOuUN, orderNo=null, doi=10.3969/j.issn.1671-7856.2026.06.010, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1755014400000, receivedDateStr=2025-08-13, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785907568078, onlineDateStr=2026-08-05, pubDate=1774800000000, pubDateStr=2026-03-30, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785907568078, onlineIssueDateStr=2026-08-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785907568078, creator=admin, updateTime=1785907568078, updator=admin, issue=Issue{id=1291753151179280707, tenantId=1146029695717560320, journalId=1291416913693474840, year='2026', volume='36', issue='6', pageStart='1', pageEnd='144', issueExtLink='null', onlineDate='null', pubDate='1774800000000', pubDateStr='2026-03-30', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=1, specialIssue=null, createTime=1785907550854, creator='ztmeta', updateTime=1786331902788, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1293533012289941791, tenantId=1146029695717560320, journalId=1291416913693474840, issueId=1291753151179280707, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1293533012289941792, tenantId=1146029695717560320, journalId=1291416913693474840, issueId=1291753151179280707, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=102, endPage=113, ext={EN=ArticleExt(id=1291753224223085179, articleId=1291753223421973113, tenantId=1146029695717560320, journalId=1291416913693474840, language=EN, title=Research progress on intervention strategies for the blood-brain barrier, columnId=1292760404241969391, journalTitle=Chinese Journal of Comparative Medicine, columnName=Research Progress, runingTitle=null, highlight=null, articleAbstract=

The blood-brain barrier (BBB) is a dynamic interface for selective molecular trafficking between blood and brain parenchyma, playing a pivotal role in maintaining central nervous system homeostasis. Recent investigations have uncovered intricate regulatory networks governing BBB function, involving dynamic intercellular tight junction remodeling, signaling cascade activation, and multicomponent interactions within the neurovascular unit. This review systematically integrates current mechanistic understanding of BBB regulation and provides a critical evaluation of emerging interventional strategies, including nanotechnology-based drug delivery systems, gene editing, and traditional Chinese medicine formula interventions, with emphasis on their translational potential in the future. By integrating bench-to-bedside perspectives, this work aims to provide novel theoretical frameworks for developing precision therapies targeting BBB dysfunction in neurological disorders.

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血脑屏障（BBB）是介于血液和脑组织之间的对物质通过有选择性阻碍作用的动态界面，对维持中枢神经系统（CNS）内环境稳定起着关键作用。近年来，研究发现BBB的调节机制涉及多种因素，包括细胞间紧密连接的动态变化、信号通路的激活、神经血管单元的相互作用等。本文综述了现阶段BBB的多种临床干预措施，包括药物治疗、基因治疗、中医药干预等及其未来可能的发展，以期为神经系统疾病的治疗提供新的思路和理论依据。

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毛旭清（1989—），女，硕士，讲师，研究方向：针灸治疗脑病的基础及临床研究。E-mail: 1286791450@qq.com

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毛旭清（1989—），女，硕士，讲师，研究方向：针灸治疗脑病的基础及临床研究。E-mail: 1286791450@qq.com

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