Article(id=1291753227238789782, tenantId=1146029695717560320, journalId=1291416913693474840, issueId=1291753151179280707, articleNumber=PA20260408_hep9C2f9, orderNo=null, doi=10.3969/j.issn.1671-7856.2026.06.011, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1756137600000, receivedDateStr=2025-08-26, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785907568988, onlineDateStr=2026-08-05, pubDate=1774800000000, pubDateStr=2026-03-30, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785907568987, onlineIssueDateStr=2026-08-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785907568987, creator=admin, updateTime=1785907568987, updator=admin, issue=Issue{id=1291753151179280707, tenantId=1146029695717560320, journalId=1291416913693474840, year='2026', volume='36', issue='6', pageStart='1', pageEnd='144', issueExtLink='null', onlineDate='null', pubDate='1774800000000', pubDateStr='2026-03-30', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=1, specialIssue=null, createTime=1785907550854, creator='ztmeta', updateTime=1786331902788, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1293533012289941791, tenantId=1146029695717560320, journalId=1291416913693474840, issueId=1291753151179280707, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1293533012289941792, tenantId=1146029695717560320, journalId=1291416913693474840, issueId=1291753151179280707, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=114, endPage=121, ext={EN=ArticleExt(id=1291753231013663384, articleId=1291753227238789782, tenantId=1146029695717560320, journalId=1291416913693474840, language=EN, title=Research progress on the mechanism of exercise in improving the comorbidity of inflammatory pain and depression, columnId=1292760404241969391, journalTitle=Chinese Journal of Comparative Medicine, columnName=Research Progress, runingTitle=null, highlight=null, articleAbstract=

Inflammatory pain and depression are clinically common disorders with a high comorbidity rate. They mutually exacerbate their pathological processes and severely reduce the quality of life of patients. The pathogenesis of the comorbidity of inflammatory pain and depression is highly complex, posing significant challenges for clinical diagnosis and treatment. Recent studies have revealed that sustained activation of neuroinflammation is a central pathological link in the comorbidity of inflammatory pain and depression. As a non-pharmacological intervention, exercise can effectively improve both pain and depressive symptoms in patients with comorbidity. However, its specific mechanisms of action remain incompletely elucidated. This article summarizes recent research advances on the effects of exercise in inhibiting central inflammation, modulating the balance of microglial M1/M2 polarization, regulating neuronal excitatory-inhibitory homeostasis, and promoting hippocampal neurogenesis. It systematically reviews the molecular and neural mechanisms by which exercise modulates neuroinflammation to treat the comorbidity of inflammatory pain and depression, with the aim of providing a theoretical basis and practical guidance for clinical exercise therapy.

, authors=Xiaoxue ZHANG¹, Hongru LI², Meidan ZHAO¹, Xiao HAN¹, Jian ZHANG^{1, *}, Tianyi ZHAO^{3, *}, authorsList=Xiaoxue ZHANG, Hongru LI, Meidan ZHAO, Xiao HAN, Jian ZHANG, Tianyi ZHAO, authorCompany=null, correspAuthors=Jian ZHANG, Tianyi ZHAO, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291753230933971607, articleId=1291753227238789782, tenantId=1146029695717560320, journalId=1291416913693474840, language=CN, title=运动改善炎性痛与抑郁共病作用机制的研究进展, columnId=1292760404409741552, journalTitle=中国比较医学杂志, columnName=研究进展, runingTitle=null, highlight=null, articleAbstract=

炎性痛与抑郁症是临床常见疾病，二者具有高共病率，且能够相互加剧彼此病程，严重降低患者生活质量。炎性痛与抑郁共病的发病机制极为复杂，为临床诊疗带来严峻挑战。近年研究发现，神经炎症的持续激活是炎性痛与抑郁共病的核心病理环节。运动作为一种非药物手段，可有效改善共病患者的疼痛和抑郁症状，然而其具体的作用机制尚未完全明确。本文对运动在抑制中枢炎症水平、调节小胶质细胞M1/M2极化平衡、调控神经元兴奋-抑制稳态以及促进海马神经发生方面的最新研究进行总结，系统综述运动调节神经炎症治疗炎性痛与抑郁共病的分子及神经机制，以期为临床运动治疗提供新的理论基础和实践参考。

, authors=张小雪¹, 李泓儒², 赵美丹¹, 韩校¹, 张健^{1, *}, 赵天易^{3, *}, authorsList=张小雪, 李泓儒, 赵美丹, 韩校, 张健, 赵天易, authorCompany=null, correspAuthors=张健, 赵天易, authorNote=, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=iaJRVBz0dVhWoucj3j4Tag==, magXml=j0VVoQhGc0UPEOiaxkmJWQ==, pdfUrl=https://oss.bj-dx-dzqywjd-hlw-icp.inspurcloudoss.com:6063/cast-journal-prod/2041779779935346689/excel/pdfs/78f2a6e5dfd74ebfa3e5d4b57b5e774a.pdf?response-content-disposition=attachment%3B%20filename%3D%22202606011.pdf%22&X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Date=20260805T010730Z&X-Amz-SignedHeaders=host&X-Amz-Expires=604800&X-Amz-Credential=NjRlNmUzOGMtM2Y3OC00MDQ3LThkMmYtN2JkODRmYmI3MTgw%2F20260805%2Fbj-dx-dzqywjd-hlw-icp%2Fs3%2Faws4_request&X-Amz-Signature=6d81c449ff02f35c455f61e7151a78656498e24bc62836e79bd46fa5a119e3f1, pdf=z/VKZnw63UakTiQjs+ee2Q==, pdfFileSize=2904379, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=OP5ZiFZqo8tupY84VeNuxQ==, mapNumber=null, fund=null)}, authors=[Author(id=1292760417168810997, tenantId=1146029695717560320, journalId=1291416913693474840, articleId=1291753227238789782, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=15518318060@163.com, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1292760417248502775, tenantId=1146029695717560320, journalId=1291416913693474840, articleId=1291753227238789782, authorId=1292760417168810997, language=EN, stringName=Xiaoxue ZHANG, firstName=Xiaoxue, middleName=null, lastName=ZHANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=^1.School of Medical Technology, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1292760417311417336, tenantId=1146029695717560320, journalId=1291416913693474840, articleId=1291753227238789782, authorId=1292760417168810997, language=CN, stringName=张小雪, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=^1．天津中医药大学医学技术学院，天津　301617, bio={"content":"

张小雪（2001—），女，在读硕士研究生，研究方向：慢性疼痛与抑郁症康复的机制研究。E-mail：15518318060@163.com

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张小雪（2001—），女，在读硕士研究生，研究方向：慢性疼痛与抑郁症康复的机制研究。E-mail：15518318060@163.com

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