Article(id=1291753245333017375, tenantId=1146029695717560320, journalId=1291416913693474840, issueId=1291753151179280707, articleNumber=PA20260408_aB8KjoQo, orderNo=null, doi=10.3969/j.issn.1671-7856.2026.06.001, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1755100800000, receivedDateStr=2025-08-14, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785907573302, onlineDateStr=2026-08-05, pubDate=1774800000000, pubDateStr=2026-03-30, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785907573302, onlineIssueDateStr=2026-08-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785907573302, creator=admin, updateTime=1785907573302, updator=admin, issue=Issue{id=1291753151179280707, tenantId=1146029695717560320, journalId=1291416913693474840, year='2026', volume='36', issue='6', pageStart='1', pageEnd='144', issueExtLink='null', onlineDate='null', pubDate='1774800000000', pubDateStr='2026-03-30', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=1, specialIssue=null, createTime=1785907550854, creator='ztmeta', updateTime=1786331902788, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1293533012289941791, tenantId=1146029695717560320, journalId=1291416913693474840, issueId=1291753151179280707, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1293533012289941792, tenantId=1146029695717560320, journalId=1291416913693474840, issueId=1291753151179280707, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1, endPage=10, ext={EN=ArticleExt(id=1291753249833505569, articleId=1291753245333017375, tenantId=1146029695717560320, journalId=1291416913693474840, language=EN, title=Effect and mechanism of Shizao decoction on inducing apoptosis in breast cancer transplants in nude mice, columnId=1292760394137887571, journalTitle=Chinese Journal of Comparative Medicine, columnName=Reseaech Reports, runingTitle=null, highlight=null, articleAbstract=
Objective To investigate the effect and underlying mechanism of Shizao decoction (SZD) on inducing apoptosis in breast cancer transplants in nude mice.
Methods SKBR3 cells were cultured and transplanted into nude mice to construct tumor models. SZD was applied by continuous intragastric administration for 4 weeks and its effects on tumor growth were observed. After administration, the mice were killed and the transplanted tumor tissues were separated. Lactate dehydrogenase (LDH) levels in tumor tissues were detected using an LDH kit. Morphological changes in transplanted tumor tissues were observed by Hoechst33342-propidium iodide staining, reactive oxygen species (ROS) were evaluated by 2′,7′-dichlorodihydrofluorescein diacetate staining, and mitochondrial membrane potential was evaluated by JC-1 assay. Caspase3, Caspase8, and Caspase9 activities in the transplanted tumor cells were detected by enzyme-linked immunosorbent assay. Fas and Fas ligand (FasL) protein expression were detected by Western blot. Caspase3, Caspase8, Caspase9, Fas, and FasL gene expression were detected by quantitative polymerase chain reaction.
Results Compared with the model group, SZD significantly increased LDH production (P<0.05, P<0.01) by transplanted breast cancer cells in nude mice, induced apoptosis, increased the ROS content (P<0.05) and mitochondrial depolarization (P<0.05, P <0.01), increased the gene expression and enzyme activities of Caspase3, Caspase8, and Caspase9 (P<0.05, P<0.01), and increased the gene/protein expression of Fas and FasL (P<0.05, P<0.01).
Conclusions SZD can induce apoptosis in transplanted breast tumors, possibly via the apoptotic caspase and Fas/FasL pathways tumor.
, authors=Liwei MA
1, Zhe CHEN
2, Xu LI
1, Jicheng LIU
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目的 探讨十枣汤诱导乳腺癌裸鼠移植瘤细胞凋亡的作用及相关的分子机制。
方法 培养乳腺癌SKBR3细胞并构建其裸鼠移植瘤模型；连续灌胃给药4周，观察小鼠肿瘤生长抑制情况；给药结束后处死裸鼠分离移植瘤组织，通过乳酸脱氢酶（LDH）试剂盒检测移植瘤组织细胞的LDH生成量；Hoechst33342-PI染色观察移植瘤组织细胞的形态学变化；DCFH-DA染色评估组织细胞活性氧（ROS）含量变化；JC-1染色评估细胞线粒体膜电位变化；ELISA法检测肿瘤组织细胞中Caspase3、Caspase8、Caspase9酶活性表达；Western blot法检测Fas、FasL蛋白表达变化；qPCR法检测Caspase3、Caspase8、Caspase9、Fas、FasL基因表达变化。结果与模型组比较，十枣汤干预后能使移植瘤组织细胞的LDH生成量增加（P<0.05，P<0.01），组织细胞呈现典型的凋亡形态学特征，ROS含量显著增加（P<0.05），线粒体去极化程度变化显著（P<0.05，P<0.01），Caspase3、Caspase8、Caspase9基因/酶活性表达增高（P<0.05，P<0.01），Fas、FasL蛋白/基因表达增高（P<0.05，P<0.01）。
结论 十枣汤能诱导乳腺癌移植瘤组织细胞的凋亡，Caspase途径及Fas/FasL途径介导了对乳腺癌组织细胞凋亡的调控。
, authors=马立威
1, 陈哲
2, 李旭
1, 刘吉成
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马立威（1987—），男，博士，副研究员，研究方向：天然药物抗肿瘤研究。E-mail: maliwei@qmu.edu.cn
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马立威（1987—），男，博士，副研究员，研究方向：天然药物抗肿瘤研究。E-mail: maliwei@qmu.edu.cn
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