Article(id=1244321221534401461, tenantId=1146029695717560320, journalId=1244284848500682798, issueId=1244321215637209904, articleNumber=null, orderNo=null, doi=10.16156/j.1004-7220.2025.05.009, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1755100800000, receivedDateStr=2025-08-14, revisedDate=1757174400000, revisedDateStr=2025-09-07, acceptedDate=null, acceptedDateStr=null, onlineDate=1774598897583, onlineDateStr=2026-03-27, pubDate=1759248000000, pubDateStr=2025-10-01, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1774598897583, onlineIssueDateStr=2026-03-27, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1774598897583, creator=13701087609, updateTime=1774598897583, updator=13701087609, issue=Issue{id=1244321215637209904, tenantId=1146029695717560320, journalId=1244284848500682798, year='2025', volume='40', issue='5', pageStart='1079', pageEnd='1366', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=1, specialIssue=null, createTime=1774598896178, creator=13701087609, updateTime=1774599509568, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1244323788452639476, tenantId=1146029695717560320, journalId=1244284848500682798, issueId=1244321215637209904, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1244323788452639477, tenantId=1146029695717560320, journalId=1244284848500682798, issueId=1244321215637209904, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=1150, endPage=1156, ext={EN=ArticleExt(id=1244321222046106578, articleId=1244321221534401461, tenantId=1146029695717560320, journalId=1244284848500682798, language=EN, title=Effects of Inclined Axial Compressive Force and Flexion Moment on Lumbosacral Shear Stiffness: An
in vitro Biomechanical Study, columnId=1244321216404767539, journalTitle=Journal of Medical Biomechanics, columnName=Original Articles, runingTitle=null, highlight=null, articleAbstract=
Objective To investigate the effects of inclined axial compressive force and flexion moment on the anterior and posterior shear stiffness of the lumbosacral segment.
Methods Six fresh-frozen human cadaveric L5-S1 segments were tested under intact and two progressively impaired structural conditions: intact, a 4-mm bilateral facet joint gap, and anterior discectomy with nucleus pulposus removal plus circumferential release of the inner annular fibers (disc injury). A 300 N axial compressive force was applied either vertically downward or with a 10° or 20° anterior inclination through the disc's shear center. Anterior (0 N to 250 N) and posterior (-50 N to 0 N) shear tests were conducted using a material testing machine. These tests were repeated under a 5 N·m flexion moment. The relative motion between L5 and S1 was measured using a three-dimensional motion capture system.
Results In the intact state, the inclination of the axial compressive force did not significantly alter anterior or posterior shear stiffness. However, the application of a flexion moment increased anterior shear stiffness by 49.3%. Progressive structural damage resulted in incremental increases in anteroposterior shear translation and corresponding reductions in stiffness. Notably, under combined loading with axial compression and flexion moment, anterior stiffness decreased from 939 N/mm (intact) to 224 N/mm (disc injury), while posterior stiffness decreased from 572 N/mm to 217 N/mm. Within the low-load range, no significant differences in shear stiffness were observed across any structural conditions, regardless of axial force inclination or combined with a flexion moment.
Conclusions This study supports the clinical view that retro-inclination of the pelvis serves as a compensatory mechanism to enhance segmental shear stability. However, this compensatory capacity gradually diminishes and ultimately fails as spinal degeneration progresses.
, correspAuthors=Linghong ZHOU, Qingan ZHU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, authorCompany=null, fund=null, authors=null, authorsList=Zhiping HUANG, Jianying ZHENG, Jiachen YANG, Junhao LIU, Junyu LIN, Xiuhua WU, Linghong ZHOU, Qingan ZHU), CN=ArticleExt(id=1244321224814346328, articleId=1244321221534401461, tenantId=1146029695717560320, journalId=1244284848500682798, language=CN, title=轴向压缩载荷倾斜和前屈力矩对腰骶椎剪切刚度影响的离体生物力学研究, columnId=1244321216576734006, journalTitle=医用生物力学, columnName=论著, runingTitle=null, highlight=null, articleAbstract=
目的 探讨轴向压缩载荷倾斜和前屈力矩对腰骶椎前、后剪切刚度的影响。
方法 采用6例新鲜尸体腰骶椎标本(L5~S1)进行实验,分别模拟腰骶椎完整、双侧小关节4 mm间隙、前路切开纤维环摘除髓核及离断内层纤维环(椎间盘损伤)3种状态,施加垂直于L5~S1椎间盘300 N轴向压缩载荷,以及前下倾斜10°或20°压缩载荷300 N,通过材料试验机对L5~S1进行前、后方向剪切试验(前:0~250 N/后:-50~0 N)。在5 N·m前屈力矩作用下,重复以上剪切试验。使用三维运动测量系统测量L5与S1之间相对运动。
结果 对于腰骶椎完整状态,轴向压缩载荷的前倾并不显著改变节段的前或后剪切刚度,但施加前屈力矩后前剪切刚度平均增加了49.3%。随着结构依次切除,腰骶节段的前或后剪切位移逐级增加,剪切刚度依次降低,尤其是小关节间隙切除合并髓核摘除后,在轴向压缩载荷复合前屈力矩作用下,前剪切刚度由完整状态的939 N/mm显著减小到224 N/mm,后剪切刚度也由完整状态的572 N/mm减小为217 N/mm。在低载荷区间,在轴向压缩载荷前倾或复合前屈力矩作用下,不同结构状态前、后剪切刚度之间的差异均没有显著性。
结论 研究结果支持了临床上腰骶椎前凸降低、骨盆后倾可适度维持节段剪切稳定性的观点,但是随着脊柱退变的进展,这种代偿能力可能会逐渐下降甚至失效。
, correspAuthors=周凌宏, 朱青安, authorNote=null, correspAuthorsNote=
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作者贡献声明:
黄志平负责实验设计与执行、数据处理、结果分析及论文撰写;郑健颖负责研究讨论、实验执行;杨佳晨负责实验执行、数据分析、论文构思;刘俊豪和林俊育负责数据统计、论文修改;吴秀华负责沟通协调;周凌宏和朱青安负责研究设计、实验指导、论文修改。
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1.School of Biomedical Engineering, Southern Medical University, Guangzhou 510515, China
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2.南方医科大学南方医院 脊柱骨科,广州 510515)])], figs=[ArticleFig(id=1244321231030305347, tenantId=1146029695717560320, journalId=1244284848500682798, articleId=1244321221534401461, language=EN, label=Fig. 1, caption=
Lumbosacral joint anterior-posterior shear test platform, figureFileSmall=FqbNj8iZncw7gp6soTJi1g==, figureFileBig=3MRQJj+qtkiWVTirLo88mQ==, tableContent=null), ArticleFig(id=1244321231135162956, tenantId=1146029695717560320, journalId=1244284848500682798, articleId=1244321221534401461, language=CN, label=图1, caption=
腰骶椎前后剪切测试平台注:X、Y、Z分别为腰骶椎冠状轴、垂直轴、矢状轴。
, figureFileSmall=FqbNj8iZncw7gp6soTJi1g==, figureFileBig=3MRQJj+qtkiWVTirLo88mQ==, tableContent=null), ArticleFig(id=1244321231424569963, tenantId=1146029695717560320, journalId=1244284848500682798, articleId=1244321221534401461, language=EN, label=Fig. 2, caption=
Comparison of anterior-posterior shear translation of the lumbosacral joint under different conditions (a) Anterior and posterior (AP) shear force-translation curves under vertical axial compression for the lumbosacral joint, (b) Total AP, anterior, posterior shear translation under axial compressive force alone, (c) Total AP, anterior, posterior shear translation under axial compressive force combined with a 5 N·m flexion moment, figureFileSmall=avzwZ4dN304vjWoBNtWwgA==, figureFileBig=uO0GPKQnGeZ92nHM7zfEMg==, tableContent=null), ArticleFig(id=1244321231533621874, tenantId=1146029695717560320, journalId=1244284848500682798, articleId=1244321221534401461, language=CN, label=图2, caption=
不同状态下腰骶椎前、后剪切位移比较注:状态1、2、3分别为完整、小关节4 mm间隙、椎间盘损伤状态;与完整状态相比,**P<0.01,*P<0.05(下同)。
, figureFileSmall=avzwZ4dN304vjWoBNtWwgA==, figureFileBig=uO0GPKQnGeZ92nHM7zfEMg==, tableContent=null), ArticleFig(id=1244321231651062395, tenantId=1146029695717560320, journalId=1244284848500682798, articleId=1244321221534401461, language=EN, label=Fig. 3, caption=
Comparison of anterior shear stiffness under axial compressive force alone with axial compressive force combined with a 5 N·m flexion moment (a) Under intact condition, (b) Under 4 mm facet-joint gap condition, (c) Under disc injury condition, figureFileSmall=a7MtRtTgGYJNO9WaTu52XQ==, figureFileBig=RXlAmgsZJJW+4x3eOfY1eQ==, tableContent=null), ArticleFig(id=1244321231751725698, tenantId=1146029695717560320, journalId=1244284848500682798, articleId=1244321221534401461, language=CN, label=图3, caption=
腰骶椎在轴向压缩载荷或复合5 N·m前屈力矩作用下前剪切刚度比较, figureFileSmall=a7MtRtTgGYJNO9WaTu52XQ==, figureFileBig=RXlAmgsZJJW+4x3eOfY1eQ==, tableContent=null), ArticleFig(id=1244321231860777611, tenantId=1146029695717560320, journalId=1244284848500682798, articleId=1244321221534401461, language=EN, label=Fig. 4, caption=
Comparison between anterior and posterior shear stiffness under each conditions in low-load region (a) Under axial compressive force alone, (b) Under axial compressive force combined with a 5 N·m flexion moment, figureFileSmall=ruskqjVwJD8n0LgB3zLPiA==, figureFileBig=tK35jYFoVqq6E6PYlvdJhA==, tableContent=null), ArticleFig(id=1244321231969829522, tenantId=1146029695717560320, journalId=1244284848500682798, articleId=1244321221534401461, language=CN, label=图4, caption=
低剪切载荷区间腰骶椎各结构状态前剪切刚度和后剪切刚度比较, figureFileSmall=ruskqjVwJD8n0LgB3zLPiA==, figureFileBig=tK35jYFoVqq6E6PYlvdJhA==, tableContent=null), ArticleFig(id=1244321233500750493, tenantId=1146029695717560320, journalId=1244284848500682798, articleId=1244321221534401461, language=EN, label=Tab. 1, caption=
Anterior shear stiffness
, figureFileSmall=null, figureFileBig=null, tableContent=
| 倾斜角/(°) | 轴向压缩载荷作用下 | N·m前屈力矩作用下轴向压缩载荷复合5 |
|---|
| 状态1 | 状态2 | 状态3 | 状态1 | 状态2 | 状态3 |
|---|
| 0 | 502±178 | 363±206 | 229±131 | 1033±1094 | 357±172 | 189±64 |
| 10 | 721±733 | 406±254 | 225±196 | 924±650 | 314±202 | 223±93 |
| 20 | 665±655 | 316±157 | 167±65 | 861±563 | 377±191 | 261±115 |
| 平均刚度 | 629±512 | 362±198 | 207±134 | 939±718 | 349±177 | 224±88 |
| 平均变化/% | 100 | 58 | 33 | 100 | 37 | 24 |
), ArticleFig(id=1244321233626579625, tenantId=1146029695717560320, journalId=1244284848500682798, articleId=1244321221534401461, language=CN, label=表1, caption=
前剪切刚度(n=6)
, figureFileSmall=null, figureFileBig=null, tableContent=
| 倾斜角/(°) | 轴向压缩载荷作用下 | N·m前屈力矩作用下轴向压缩载荷复合5 |
|---|
| 状态1 | 状态2 | 状态3 | 状态1 | 状态2 | 状态3 |
|---|
| 0 | 502±178 | 363±206 | 229±131 | 1033±1094 | 357±172 | 189±64 |
| 10 | 721±733 | 406±254 | 225±196 | 924±650 | 314±202 | 223±93 |
| 20 | 665±655 | 316±157 | 167±65 | 861±563 | 377±191 | 261±115 |
| 平均刚度 | 629±512 | 362±198 | 207±134 | 939±718 | 349±177 | 224±88 |
| 平均变化/% | 100 | 58 | 33 | 100 | 37 | 24 |
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