Article(id=1244321216186663728, tenantId=1146029695717560320, journalId=1244284848500682798, issueId=1244321215637209904, articleNumber=null, orderNo=null, doi=10.16156/j.1004-7220.2025.05.019, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1740499200000, receivedDateStr=2025-02-26, revisedDate=1742745600000, revisedDateStr=2025-03-24, acceptedDate=null, acceptedDateStr=null, onlineDate=1774598896308, onlineDateStr=2026-03-27, pubDate=1759248000000, pubDateStr=2025-10-01, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1774598896308, onlineIssueDateStr=2026-03-27, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1774598896308, creator=13701087609, updateTime=1774598896308, updator=13701087609, issue=Issue{id=1244321215637209904, tenantId=1146029695717560320, journalId=1244284848500682798, year='2025', volume='40', issue='5', pageStart='1079', pageEnd='1366', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=1, specialIssue=null, createTime=1774598896178, creator=13701087609, updateTime=1774599509568, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1244323788452639476, tenantId=1146029695717560320, journalId=1244284848500682798, issueId=1244321215637209904, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1244323788452639477, tenantId=1146029695717560320, journalId=1244284848500682798, issueId=1244321215637209904, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=1222, endPage=1229, ext={EN=ArticleExt(id=1244321216471876404, articleId=1244321216186663728, tenantId=1146029695717560320, journalId=1244284848500682798, language=EN, title=Prediction of Blood Flow Field in Artery Stenosis Based on Hard Boundary-Constrained Physics-Informed Neural Network, columnId=1244321216404767539, journalTitle=Journal of Medical Biomechanics, columnName=Original Articles, runingTitle=null, highlight=null, articleAbstract=
Objective To address the limitations of conventional physics-informed neural network (PINN) in handling hemodynamic boundary constraints, an improved hard boundary-constrained PINN (HBC-PINN) framework was proposed to achieve precise prediction of blood flow fields within stenotic arteries.
Methods An idealized stenosed vessel geometry model was established and computational fluid dynamic simulation was performed to obtain a validation dataset. Appropriate boundary dependent trial functions were designed according to the hard constraint method to embed the flow boundary conditions into the network output. Thus, an HBC-PINN model with the hard boundary constraint method was constructed to predict the velocity field and pressure field of stenosed blood flow. Meanwhile, an original PINN model with the soft constraint method was also built for comparison. By evaluating the accuracy of the two models on the validation dataset, the capability of the HBC-PINN model to simulate hemodynamics without using any labeled data for training was verified.
Results The effectiveness of the HBC-PINN method in predicting hemodynamic parameters in stenosed blood flow tasks was validated. The relative L2 errors of the flow velocity and pressure predicted by the HBC-PINN in two different stenosis scenarios were both lower than 0.5%, representing an improvement of over 48.8% in accuracy compared to the original PINN model. Additionally, the prediction accuracy of the transverse velocity also increased by more than 35.4%.
Conclusions Implementing hard constraints on boundary conditions in the PINN modeling process can effectively improve the prediction accuracy of hemodynamic parameters and the efficiency of model solving.
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目的 针对传统物理信息神经网络(physics-informed neural network,PINN)在处理血流边界条件约束时的局限性,提出一种基于硬边界约束物理信息神经网络(hard boundary-constrained physics-informed neural network,HBC-PINN)的改进方法,实现对狭窄动脉血管内血液流场的精确预测。
方法 首先建立理想化狭窄血管几何模型并进行计算流体动力学模拟以获得验证数据集。根据硬约束方法设计合适的边界相关试函数以将流动边界条件嵌入网络输出中,从而构建采用硬边界约束方法的HBC-PINN模型预测狭窄血流的速度场和压力场。同时还构建了采用软约束方法的原始PINN模型作为对比,通过评估两种模型在验证数据集上的准确性,验证不使用任何标记数据训练下HBC-PINN模型模拟血流动力学的能力。
结果 确定了HBC-PINN方法在狭窄血流动力学参数预测任务中的有效性。两种不同狭窄情况下HBC-PINN预测的流向速度和压力的相对L2误差均低于0.5%,相比原始PINN模型精度提升了48.8%以上,垂向速度的预测精度同样提升了超过35.4%。
结论 在PINN建模过程中实施边界条件硬约束可以有效提高对血流动力学参数的预测精度和模型求解效率。
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作者贡献声明:
桑建兵负责文章设计和论文修改;向华鑫负责模型计算、数据整理;所有作者讨论并共同撰写论文。
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147(8): 04021043., articleTitle=Physics-informed deep learning for computational elastodynamics without labeled data, refAbstract=null)], funds=[Fund(id=1244321239712515035, tenantId=1146029695717560320, journalId=1244284848500682798, articleId=1244321216186663728, awardId=A2020202015, language=CN, fundingSource=河北省自然科学基金项目(A2020202015), fundOrder=null, country=null), Fund(id=1244321239821566940, tenantId=1146029695717560320, journalId=1244284848500682798, articleId=1244321216186663728, awardId=12102123, language=CN, fundingSource=国家自然科学基金项目(12102123), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1244321233815323320, tenantId=1146029695717560320, journalId=1244284848500682798, articleId=1244321216186663728, xref=null, ext=[AuthorCompanyExt(id=1244321233832100539, tenantId=1146029695717560320, journalId=1244284848500682798, articleId=1244321216186663728, companyId=1244321233815323320, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=School of Mechanical Engineering, Hebei University of Technology, Tianjin 300401, China), AuthorCompanyExt(id=1244321233853072063, tenantId=1146029695717560320, journalId=1244284848500682798, articleId=1244321216186663728, companyId=1244321233815323320, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=河北工业大学 机械工程学院,天津 300401)])], figs=[ArticleFig(id=1244321237858632598, tenantId=1146029695717560320, journalId=1244284848500682798, articleId=1244321216186663728, language=EN, label=Fig. 1, caption=
General structure of flow field prediction model based on PINN, figureFileSmall=0BR4ijCa2wrGM8ttax9kWg==, figureFileBig=T6EgUNhw6McX7PAYVSliOQ==, tableContent=null), ArticleFig(id=1244321237997044635, tenantId=1146029695717560320, journalId=1244284848500682798, articleId=1244321216186663728, language=CN, label=图1, caption=
基于PINN的流场预测模型一般结构, figureFileSmall=0BR4ijCa2wrGM8ttax9kWg==, figureFileBig=T6EgUNhw6McX7PAYVSliOQ==, tableContent=null), ArticleFig(id=1244321238210954149, tenantId=1146029695717560320, journalId=1244284848500682798, articleId=1244321216186663728, language=EN, label=Fig. 2, caption=
HBC-PINN framework, figureFileSmall=mD75G1vpehBLeC8HvSZyeA==, figureFileBig=3wDDtufExRoiMWAaKMwEfg==, tableContent=null), ArticleFig(id=1244321238311617445, tenantId=1146029695717560320, journalId=1244284848500682798, articleId=1244321216186663728, language=CN, label=图2, caption=
HBC-PINN框架, figureFileSmall=mD75G1vpehBLeC8HvSZyeA==, figureFileBig=3wDDtufExRoiMWAaKMwEfg==, tableContent=null), ArticleFig(id=1244321238399697835, tenantId=1146029695717560320, journalId=1244284848500682798, articleId=1244321216186663728, language=EN, label=Fig. 3, caption=
Grid independence verification and local schematic diagram for calculation of grid (a) Pressure distribution curves calculated under different grid sizes, (b) Narrow area calculation grid, figureFileSmall=4K6MgsTwj7WBtFJrAr+/bg==, figureFileBig=YL23lGVD/AzBnQV8Pnbw4g==, tableContent=null), ArticleFig(id=1244321238496166830, tenantId=1146029695717560320, journalId=1244284848500682798, articleId=1244321216186663728, language=CN, label=图3, caption=
网格无关性验证及计算网格局部示意图, figureFileSmall=4K6MgsTwj7WBtFJrAr+/bg==, figureFileBig=YL23lGVD/AzBnQV8Pnbw4g==, tableContent=null), ArticleFig(id=1244321238559081391, tenantId=1146029695717560320, journalId=1244284848500682798, articleId=1244321216186663728, language=EN, label=Fig. 4, caption=
Comparison of predicted and simulated values for different models under narrow parameter A=12 (a) Contours of the blood flow velocity field and pressure field, (b) Contours of the absolute error, figureFileSmall=Z0D4pGVoTcO1PTYodyTuvg==, figureFileBig=iolMO6ERsuCAsNoIzFZiTQ==, tableContent=null), ArticleFig(id=1244321238668133300, tenantId=1146029695717560320, journalId=1244284848500682798, articleId=1244321216186663728, language=CN, label=图4, caption=
狭窄参数A=12时不同模型预测值与模拟值对比, figureFileSmall=Z0D4pGVoTcO1PTYodyTuvg==, figureFileBig=iolMO6ERsuCAsNoIzFZiTQ==, tableContent=null), ArticleFig(id=1244321238756213688, tenantId=1146029695717560320, journalId=1244284848500682798, articleId=1244321216186663728, language=EN, label=Fig. 5, caption=
Convergence history for the loss functions of two models during training (a) A=6, (b) A=12, figureFileSmall=CpLPWU6AGeg4OOZQxtLEhw==, figureFileBig=QKbxXR5fbAUTWUml49o22A==, tableContent=null), ArticleFig(id=1244321238869459900, tenantId=1146029695717560320, journalId=1244284848500682798, articleId=1244321216186663728, language=CN, label=图5, caption=
训练期间两种模型损失函数的收敛历史, figureFileSmall=CpLPWU6AGeg4OOZQxtLEhw==, figureFileBig=QKbxXR5fbAUTWUml49o22A==, tableContent=null), ArticleFig(id=1244321238986900416, tenantId=1146029695717560320, journalId=1244284848500682798, articleId=1244321216186663728, language=EN, label=Fig. 6, caption=
Comparison of HBC-PINN model prediction results under different working conditions (a) Vertical velocity distribution along the centerline of blood vessels, (b) Relative L2 error of flow field solutions under different viscosities, (c) Pressure distribution along the centerline of blood vessels, (d) Relative L2 error of flow field solutions under different inlet velocities, figureFileSmall=3KwduHX1qY6xsG9sUtw4Uw==, figureFileBig=HUpkd3dh+Izwp/wsuOKZ3A==, tableContent=null), ArticleFig(id=1244321239108535239, tenantId=1146029695717560320, journalId=1244284848500682798, articleId=1244321216186663728, language=CN, label=图6, caption=
不同工况下HBC-PINN模型预测结果对比, figureFileSmall=3KwduHX1qY6xsG9sUtw4Uw==, figureFileBig=HUpkd3dh+Izwp/wsuOKZ3A==, tableContent=null), ArticleFig(id=1244321239234364360, tenantId=1146029695717560320, journalId=1244284848500682798, articleId=1244321216186663728, language=EN, label=Tab. 1, caption=
Comparison of prediction results between PINN model and HBC-PINN model
, figureFileSmall=null, figureFileBig=null, tableContent=
| 参数 | HBC-PINN | PINN |
|---|
| A | 6 | 12 | 6 | 12 |
| εu/% | 0.22 | 0.5 | 0.43 | 1.71 |
| εv/% | 2.54 | 3.1 | 4.63 | 4.8 |
| εp/% | 0.24 | 0.33 | 1.57 | 3.16 |
| 训练时间/s | 492.1 | 504.5 | 665.4 | 671.6 |
), ArticleFig(id=1244321239360193483, tenantId=1146029695717560320, journalId=1244284848500682798, articleId=1244321216186663728, language=CN, label=表1, caption=
PINN模型与HBC-PINN模型预测结果对比
, figureFileSmall=null, figureFileBig=null, tableContent=
| 参数 | HBC-PINN | PINN |
|---|
| A | 6 | 12 | 6 | 12 |
| εu/% | 0.22 | 0.5 | 0.43 | 1.71 |
| εv/% | 2.54 | 3.1 | 4.63 | 4.8 |
| εp/% | 0.24 | 0.33 | 1.57 | 3.16 |
| 训练时间/s | 492.1 | 504.5 | 665.4 | 671.6 |
), ArticleFig(id=1244321239460856783, tenantId=1146029695717560320, journalId=1244284848500682798, articleId=1244321216186663728, language=EN, label=Tab. 2, caption=
Comparison of the relative L2 error of predicted flow field variables under different working conditions
, figureFileSmall=null, figureFileBig=null, tableContent=
| 参数 | 黏度/(mPa·s-1) | 入口速度/(mm·s-1) |
|---|
| 3.2 | 3.5 | 3.8 | 4.1 | 150 | 175 | 200 | 225 |
|---|
| εu | 0.59±0.09 | 0.50±0.10 | 0.76±0.06 | 0.65±0.11 | 0.52±0.11 | 0.50±0.10 | 0.42±0.04 | 0.53±0.08 |
| εv | 3.47±0.21 | 3.10±0.49 | 3.99±0.33 | 3.31±0.75 | 2.97±0.41 | 3.10±0.49 | 2.50±0.12 | 2.93±0.72 |
| εp | 0.36±0.05 | 0.33±0.02 | 0.29±0.01 | 0.37±0.06 | 0.28±0.05 | 0.33±0.02 | 0.30±0.01 | 0.33±0.06 |
), ArticleFig(id=1244321239561520084, tenantId=1146029695717560320, journalId=1244284848500682798, articleId=1244321216186663728, language=CN, label=表2, caption=
不同工况下预测的流场变量相对L2误差对比
, figureFileSmall=null, figureFileBig=null, tableContent=
| 参数 | 黏度/(mPa·s-1) | 入口速度/(mm·s-1) |
|---|
| 3.2 | 3.5 | 3.8 | 4.1 | 150 | 175 | 200 | 225 |
|---|
| εu | 0.59±0.09 | 0.50±0.10 | 0.76±0.06 | 0.65±0.11 | 0.52±0.11 | 0.50±0.10 | 0.42±0.04 | 0.53±0.08 |
| εv | 3.47±0.21 | 3.10±0.49 | 3.99±0.33 | 3.31±0.75 | 2.97±0.41 | 3.10±0.49 | 2.50±0.12 | 2.93±0.72 |
| εp | 0.36±0.05 | 0.33±0.02 | 0.29±0.01 | 0.37±0.06 | 0.28±0.05 | 0.33±0.02 | 0.30±0.01 | 0.33±0.06 |
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