Article(id=1320359630216212999, tenantId=1146029695717560320, journalId=1146123346816638986, issueId=1320359610872087453, articleNumber=null, orderNo=null, doi=10.13426/j.cnki.yky.2023.03.10, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1679846400000, receivedDateStr=2023-03-27, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1792727866939, onlineDateStr=2026-10-23, pubDate=1692460800000, pubDateStr=2023-08-20, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792727866939, onlineIssueDateStr=2026-10-23, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792727866939, creator=13701087609, updateTime=1792727866939, updator=13701087609, issue=Issue{id=1320359610872087453, tenantId=1146029695717560320, journalId=1146123346816638986, year='2023', volume='42', issue='3', pageStart='1', pageEnd='106', issueExtLink='null', onlineDate='null', pubDate='1692460800000', pubDateStr='2023-08-20', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1792727862327, creator='13701087609', updateTime=1792751623992, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1320459274581553767, tenantId=1146029695717560320, journalId=1146123346816638986, issueId=1320359610872087453, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1320459274581553768, tenantId=1146029695717560320, journalId=1146123346816638986, issueId=1320359610872087453, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=63, endPage=68, ext={EN=ArticleExt(id=1320359630417539592, articleId=1320359630216212999, tenantId=1146029695717560320, journalId=1146123346816638986, language=EN, title=Study on Extraction Performance of Polymyxin E with D152 Resin, columnId=1175805041752556213, journalTitle=Uranium Mining and Metallurgy, columnName=MINING AND HYDROMETALLURGY, runingTitle=null, highlight=null, articleAbstract=

Polymyxin E is produced by fermentation of Bacillus polymyxa. It was usually purified by ion exchange. The extraction indexes of polymyxin E by D152 (weak acid cation resin) was studied, and the adsorption capacity, elution rate and yield of polymyxin E were obtained by matching D152 resin with the existing process equipment. The adsorption capacity of D152 resin can reach 6.8×10⁶ U/mL (wet resin), and the total yield is ≥98.0% under the pH of polymyxin E filtrate in 6.0~7.0, the chromatotiter in 3.0×10⁵ U/mL, the adsorption velocity of 1.0 BV/h and sulfuric acid elution velocity of 1.0~1.5 BV/h under the chromatotiter was adsorbed by three columns in series. After 6 months of continuous operation, D152 resin has stable performance.

, authors=Zhenzhong ZHAO, Haichao LI, authorsList=Zhenzhong ZHAO, Haichao LI, authorCompany=null, correspAuthors=Haichao LI, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1320359631885545993, articleId=1320359630216212999, tenantId=1146029695717560320, journalId=1146123346816638986, language=CN, title=D152树脂对多粘菌素E的提取性能研究, columnId=1175805041991631542, journalTitle=铀矿冶, columnName=开采·选冶, runingTitle=null, highlight=null, articleAbstract=

多粘菌素E由多粘类芽孢杆菌发酵产生，主要采用离子交换法进行提纯。研究了D152阳离子交换树脂提取多粘菌素E的各项指标，并将D152树脂与现有工艺设备进行匹配，得到了提取过程中吸附量、洗脱速率、收率等指标。多粘菌素E过滤液pH为6.0～7.0，色谱效价30万U/mL，采用3柱串联吸附工艺，在吸附流速1.0 BV/h、硫酸洗脱流速1.0～1.5 BV/h条件下，D152树脂吸附量可达680万U/mL（湿树脂），总收率≥98.0%。连续运行6个月，D152树脂性能稳定。

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赵振中（1982-），男，河北保定人，学士，工程师，主要研究方向为微生物制药提取。

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赵振中（1982-），男，河北保定人，学士，工程师，主要研究方向为微生物制药提取。

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