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D-Pantolactone serves as a pivotal chiral intermediate in the synthesis of D-pantothenic acid (vitamin B₅) and its derivative compounds. Given the escalating global demand for D-pantolactone, the development of efficient and environmentally benign production routes has emerged as a critical research focus. Enzymatic synthesis of D-pantolactone stands out as a highly promising approach, distinguished by its green and eco-friendly attributes, and has become the predominant method in industrial production. This comprehensive review delves into the recent advancements in the enzymatic synthesis of D-pantolactone. It meticulously examines the enzymatic properties, expression, and directed evolution of D-pantolactone hydrolase under different experimental conditions. Additionally, it explores the latest progress in the asymmetric reduction of keto-pantolactone. By comparing the merits of various synthesis methods, this review offers valuable insights and guidance for the future design of production strategies for D-pantolactone and its derivatives.

, authors=Rui WANG^{1, 2}, Jing-jing SUN¹, Wei WANG¹, Cheng-cheng JIANG¹, Chao-fan WANG^{1, 2}, Jian-hua HAO^{1, *}, authorsList=Rui WANG, Jing-jing SUN, Wei WANG, Cheng-cheng JIANG, Chao-fan WANG, Jian-hua HAO, authorCompany=null, correspAuthors=Jian-hua HAO, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1315696345831289707, articleId=1315696345420247913, tenantId=1146029695717560320, journalId=1315121759093096577, language=CN, title=D-泛解酸内酯及其酶法合成的研究进展, columnId=1315696198753825373, journalTitle=微生物学杂志, columnName=专题论述, runingTitle=null, highlight=null, articleAbstract=

D-泛解酸内酯（D-pantolactone,D-PL）是一种重要的手性中间体，主要用于合成D-泛酸即维生素B₅及其衍生物。目前，全球对于D-泛解酸内酯的需求量仍在不断上升，因此开发高效、环保的生产路线具有重要意义。酶法合成D-泛解酸内酯被认为是一条具有广阔生产前景的合成路线，具有绿色、环保等特点，也是目前工业生产的主要方法。本文综述近年来酶法合成D-泛解酸内酯的研究进展，讨论了不同反应条件下D-泛解酸内酯水解酶（D-lactono hydrolase,D-Lac）的酶学性质、表达与定向进化，以及不对称还原酮基泛解酸内酯的研究进展，比较了化学法、直接发酵法与生物酶法的优势，为后续设计生产D-泛解酸内酯及其衍生物的方法提供参考。

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王睿　男，硕士研究生。研究方向为海洋产物资源与酶工程。E-mail: 1174975949@qq.com

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王睿　男，硕士研究生。研究方向为海洋产物资源与酶工程。E-mail: 1174975949@qq.com

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