Article(id=1157002945280693081, tenantId=1146029695717560320, journalId=1146032081894723586, issueId=1157002942403404561, articleNumber=null, orderNo=null, doi=10.3981/j.issn.2097-0781.2024.04.006, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=research-article, receivedDate=1728921600000, receivedDateStr=2024-10-15, revisedDate=1730217600000, revisedDateStr=2024-10-30, acceptedDate=null, acceptedDateStr=null, onlineDate=1753780598230, onlineDateStr=2025-07-29, pubDate=1734624000000, pubDateStr=2024-12-20, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1734969600000, onlineIssueDateStr=2024-12-24, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1753780598230, creator=13701087609, updateTime=1774072649288, updator=sys-migrate, issue=Issue{id=1157002942403404561, tenantId=1146029695717560320, journalId=1146032081894723586, year='2024', volume='3', issue='4', pageStart='4', pageEnd='152', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=1, createTime=1753780597544, creator=13701087609, updateTime=1774072620698, updator=sys-migrate, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1157003380037079397, tenantId=1146029695717560320, journalId=1146032081894723586, issueId=1157002942403404561, language=EN, specialIssueTitle=Science and Technology Foresight, coverIllustrator=, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1157003380037079398, tenantId=1146029695717560320, journalId=1146032081894723586, issueId=1157002942403404561, language=CN, specialIssueTitle=氢能技术与发展战略专刊, coverIllustrator=, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=69, endPage=78, ext={EN=ArticleExt(id=1157002945951781724, articleId=1157002945280693081, tenantId=1146029695717560320, journalId=1146032081894723586, language=EN, title=Research Progress, Trends, and Suggestion in Hydrogen Medicine, columnId=1149656489310208610, journalTitle=Science and Technology Foresight, columnName=Review and Commentary, runingTitle=null, highlight=null, articleAbstract=

Hydrogen, the universe’s most elementary element, plays a crucial role in cosmic genesis and the evolution of life. In recent times, the field of hydrogen medicine has experienced rapid advancements, revealing novel trends and challenges. This review delineated significant milestone events in the evolution of hydrogen medicine and sorted out the general trend of its development. It evaluated the present state and emerging trends of hydrogen medicine in terms of therapeutic effects, molecular mechanisms, research domains, and models. The review also provides recommendations for addressing current challenges in hydrogen medicine.

, correspAuthors=Xuejun SUN, authorNote=null, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, authorCompany=null, fund=null, authors=null, authorsList=Hongtao LU, Xuejun SUN), CN=ArticleExt(id=1157002990151356531, articleId=1157002945280693081, tenantId=1146029695717560320, journalId=1146032081894723586, language=CN, title=氢医学研究现状、趋势与发展建议, columnId=1148708266483446458, journalTitle=前瞻科技, columnName=综述与述评, runingTitle=null, highlight=null, articleAbstract=

氢作为自然界中最简单的元素，无论是在宇宙的起源还是在生命的进化过程中，都扮演着至关重要的角色。近年来，氢医学领域迅速崛起，展现出新的发展趋势，同时也遭遇了诸多挑战。文章通过回顾氢医学发展历程中的关键事件，梳理其发展的总体趋势。从氢医学的效应证据、分子机制、研究范围与模式等方面总结现状及研判趋势，并针对氢医学目前所面临的挑战提出相应的发展建议。

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卢宏涛，讲师。主要从事氢医学与代谢性疾病研究。入选全军医学科技青年培育计划、上海市扬帆计划。主持各类科研与人才项目5项。出版专著3部，发表论文10余篇。电子信箱：hongtao_lu1990@163.com。

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卢宏涛，讲师。主要从事氢医学与代谢性疾病研究。入选全军医学科技青年培育计划、上海市扬帆计划。主持各类科研与人才项目5项。出版专著3部，发表论文10余篇。电子信箱：hongtao_lu1990@163.com。

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孙学军，教授，博士研究生导师。上海交通大学氢科学中心兼职教授。中国医疗保健国际交流促进会常务理事，中国医疗保健国际交流促进会氢分子生物医学分会主任委员，中国健康促进基金会氢分子生物医学发展专项基金副理事长和专家委员会主席。主要从事气体生物学研究。主持国家自然科学基金项目3项。出版专著3部，发表论文260余篇。电子信箱：sunxjk@hotmail.com。

"}, bioImg=2VB7KvK3jFNEpgCQtWgVQQ==, bioContent=

孙学军，教授，博士研究生导师。上海交通大学氢科学中心兼职教授。中国医疗保健国际交流促进会常务理事，中国医疗保健国际交流促进会氢分子生物医学分会主任委员，中国健康促进基金会氢分子生物医学发展专项基金副理事长和专家委员会主席。主要从事气体生物学研究。主持国家自然科学基金项目3项。出版专著3部，发表论文260余篇。电子信箱：sunxjk@hotmail.com。

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Marked aggression of the tumors was found, leading to the possibility that hyperbaric hydrogen therapy might also prove to be of significance in the treatment of other types of cancer.), Reference(id=1242113989203792753, tenantId=1146029695717560320, journalId=1146032081894723586, articleId=1157002945280693081, doi=10.1038/nm1577, pmid=17486089, pmcid=null, year=2007, volume=13, issue=6, pageStart=688, pageEnd=694, url=null, language=null, rfNumber=[10], rfOrder=10, authorNames=Ohsawa I, Ishikawa M, Takahashi K, journalName=Nature Medicine, refType=null, unstructuredReference=Ohsawa I, Ishikawa M, Takahashi K, et al. Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals[J]. 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The inhalation of H(2) gas markedly suppressed brain injury by buffering the effects of oxidative stress. Thus H(2) can be used as an effective antioxidant therapy; owing to its ability to rapidly diffuse across membranes, it can reach and react with cytotoxic ROS and thus protect against oxidative damage.), Reference(id=1242113989262513010, tenantId=1146029695717560320, journalId=1146032081894723586, articleId=1157002945280693081, doi=10.1016/j.brainres.2008.11.048, pmid=19063869, pmcid=null, year=2009, volume=1256, issue=null, pageStart=129, pageEnd=137, url=null, language=null, rfNumber=[11], rfOrder=11, authorNames=Cai J M, Kang Z M, Liu K, journalName=Brain Research, refType=null, unstructuredReference=Cai J M, Kang Z M, Liu K, et al. Neuroprotective effects of hydrogen saline in neonatal hypoxia-ischemia rat model[J]. Brain Research, 2009, 1256: 129-137., articleTitle=Neuroprotective effects of hydrogen saline in neonatal hypoxia-ischemia rat model, refAbstract=Cerebral hypoxia-ischemia (HI) represents a major cause of brain damage in the term newborn. This study aimed to examine the short and long-term neuroprotective effect of hydrogen saline (H(2) saline) using an established neonatal HI rat pup model. Seven-day-old rat pups were subjected to left common carotid artery ligation and then 90 min hypoxia (8% oxygen at 37 degrees C). H(2) saturated saline was administered by peritoneal injection (5 ml/kg) immediately and again at 8 h after HI insult. At 24 h after HI, the pups were decapitated and brain morphological injury was assessed by 2,3,5-triphenyltetrazolium chloride (TTC), Nissl, and TUNEL staining. Acute cell death, inflammation and oxidative stress were evaluated at 24 h by studying caspase-3 activity, MDA measurement as well as Iba-1 immunochemistry in the brain. At 5 weeks after HI, spontaneous activity test and Morris water maze test were conducted. We observed that H(2) saline treatment reduced the caspase activity, MDA, Iba-1 levels, the infarct ratio, and improved the long-term neurological and neurobehavioral functions. H(2) saline has potentials in the clinical treatment of HI and other ischemia-related cerebral diseases.), Reference(id=1242113989321233267, tenantId=1146029695717560320, journalId=1146032081894723586, articleId=1157002945280693081, doi=10.1194/jlr.M036640, pmid=23610159, pmcid=null, year=2013, volume=54, issue=7, pageStart=1884, pageEnd=1893, url=null, language=null, rfNumber=[12], rfOrder=12, authorNames=Song G H, Li M, Sang H, journalName=Journal of Lipid Research, refType=null, unstructuredReference=Song G H, Li M, Sang H, et al. Hydrogen-rich water decreases serum LDL-cholesterol levels and improves HDL function in patients with potential metabolic syndrome[J]. Journal of Lipid Research, 2013, 54(7): 1884-1893., articleTitle=Hydrogen-rich water decreases serum LDL-cholesterol levels and improves HDL function in patients with potential metabolic syndrome, refAbstract=We have found that hydrogen (dihydrogen; H2) has beneficial lipid-lowering effects in high-fat diet-fed Syrian golden hamsters. The objective of this study was to characterize the effects of H2-rich water (0.9-1.0 l/day) on the content, composition, and biological activities of serum lipoproteins on 20 patients with potential metabolic syndrome. Serum analysis showed that consumption of H2-rich water for 10 weeks resulted in decreased serum total-cholesterol (TC) and LDL-cholesterol (LDL-C) levels. Western blot analysis revealed a marked decrease of apolipoprotein (apo)B100 and apoE in serum. In addition, we found H2 significantly improved HDL functionality assessed in four independent ways, namely, i) protection against LDL oxidation, ii) inhibition of tumor necrosis factor (TNF)-α-induced monocyte adhesion to endothelial cells, iii) stimulation of cholesterol efflux from macrophage foam cells, and iv) protection of endothelial cells from TNF-α-induced apoptosis. Further, we found consumption of H2-rich water resulted in an increase in antioxidant enzyme superoxide dismutase and a decrease in thiobarbituric acid-reactive substances in whole serum and LDL. In conclusion, supplementation with H2-rich water seems to decrease serum LDL-C and apoB levels, improve dyslipidemia-injured HDL functions, and reduce oxidative stress, and it may have a beneficial role in prevention of potential metabolic syndrome.), Reference(id=1242113989400925044, tenantId=1146029695717560320, journalId=1146032081894723586, articleId=1157002945280693081, doi=null, pmid=null, pmcid=null, year=2018, volume=9, issue=1, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[13], rfOrder=13, authorNames=Zhao P H, Jin Z K, Chen Q, journalName=Nature Communications, refType=null, unstructuredReference=Zhao P H, Jin Z K, Chen Q, et al. Local generation of hydrogen for enhanced photothermal therapy[J]. Nature Communications, 2018, 9(1), doi: 10.1038/s41467-018-06630-2., articleTitle=Local generation of hydrogen for enhanced photothermal therapy, refAbstract=null), Reference(id=1242113989501588341, tenantId=1146029695717560320, journalId=1146032081894723586, articleId=1157002945280693081, doi=null, pmid=null, pmcid=null, year=2021, volume=22, issue=1, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[14], rfOrder=14, authorNames=Zheng Z G, Sun W Z, Hu J Y, journalName=Respiratory Research, refType=null, unstructuredReference=Zheng Z G, Sun W Z, Hu J Y, et al. Hydrogen/oxygen therapy for the treatment of an acute exacerbation of chronic obstructive pulmonary disease: Results of a multicenter, randomized, double-blind, parallel-group controlled trial[J]. Respiratory Research, 2021, 22(1), doi: 10.1186/s12931-021-01740-w., articleTitle=Hydrogen/oxygen therapy for the treatment of an acute exacerbation of chronic obstructive pulmonary disease: Results of a multicenter, randomized, double-blind, parallel-group controlled trial, refAbstract=null), Reference(id=1242113989589668726, tenantId=1146029695717560320, journalId=1146032081894723586, articleId=1157002945280693081, doi=null, pmid=null, pmcid=null, year=2024, volume=187, issue=12, pageStart=2952, pageEnd=2968, url=null, language=null, rfNumber=[15], rfOrder=15, authorNames=McCurry M D, D’Agostino G D, Walsh J T, journalName=Cell, refType=null, unstructuredReference=McCurry M D, D’Agostino G D, Walsh J T, et al. Gut bacteria convert glucocorticoids into progestins in the presence of hydrogen gas[J]. Cell, 2024, 187(12): 2952-2968.e13., articleTitle=Gut bacteria convert glucocorticoids into progestins in the presence of hydrogen gas, refAbstract=null), Reference(id=1242113989644194679, tenantId=1146029695717560320, journalId=1146032081894723586, articleId=1157002945280693081, doi=10.19586/j.2095-2341.2022.0028, pmid=null, pmcid=null, year=2022, volume=12, issue=3, pageStart=332, pageEnd=343, url=null, language=null, rfNumber=[16], rfOrder=16, authorNames=王濛, 仪杨, 孙梦婷, journalName=生物技术进展, refType=null, unstructuredReference=王濛, 仪杨, 孙梦婷, 等. 富氢水和富氢生理盐水生物医学研究进展: 动物实验[J]. 生物技术进展, 2022, 12(3): 332-343., articleTitle=富氢水和富氢生理盐水生物医学研究进展: 动物实验, refAbstract=自2007年发现吸氢可有效保护脑缺血再灌注损伤以来，氢气的生物学作用被陆续发现。富氢水或富氢生理盐水作为主要的氢气干预方式已广泛应用于基础医学和临床研究中，并且已被证实对多种疾病有很好的预防和治疗作用。以往关于富氢水或富氢生理盐水的研究多是针对其医学效应的介绍，通过介绍富氢水或富氢生理盐水干预后体内氢浓度的变化情况、对正常生理功能的影响、对疾病的保护作用以及对肠道菌群的影响，并对不同动物实验中富氢水或富氢生理盐水的氢气浓度、干预介入时间点、干预时长以及每次干预剂量进行阐述，以期为氢分子基础研究提供一定的理论依据。), Reference(id=1242113989770023800, tenantId=1146029695717560320, journalId=1146032081894723586, articleId=1157002945280693081, doi=null, pmid=null, pmcid=null, year=2022, volume=12, issue=3, pageStart=332, pageEnd=343, url=null, language=null, rfNumber=[16], rfOrder=17, authorNames=Wang M, Yi Y, Sun M T, journalName=Current Biotechnology, refType=null, unstructuredReference=Wang M, Yi Y, Sun M T, et al. Biomedical research progress of hydrogen-rich water and hydrogen-rich saline: Animal experiment[J]. Current Biotechnology, 2022, 12(3): 332-343. (in Chinese), articleTitle=Biomedical research progress of hydrogen-rich water and hydrogen-rich saline: Animal experiment, refAbstract=null), Reference(id=1242113989832938361, tenantId=1146029695717560320, journalId=1146032081894723586, articleId=1157002945280693081, doi=null, pmid=null, pmcid=null, year=2022, volume=19, issue=4, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[17], rfOrder=18, authorNames=Botek M, Krejčí J, Valenta M, journalName=International Journal of Environmental Research and Public Health, refType=null, unstructuredReference=Botek M, Krejčí J, Valenta M, et al. Molecular hydrogen positively affects physical and respiratory function in acute post-COVID-19 patients: A new perspective in rehabilitation[J]. International Journal of Environmental Research and Public Health, 2022, 19(4), doi: 10.3390/ijerph19041992., articleTitle=Molecular hydrogen positively affects physical and respiratory function in acute post-COVID-19 patients: A new perspective in rehabilitation, refAbstract=null), Reference(id=1242113989900047226, tenantId=1146029695717560320, journalId=1146032081894723586, articleId=1157002945280693081, doi=null, pmid=null, pmcid=null, year=2018, volume=8, issue=4, pageStart=135, pageEnd=143, url=null, language=null, rfNumber=[18], rfOrder=19, authorNames=Sha J B, Zhang S S, Lu Y M, journalName=Medical Gas Research, refType=null, unstructuredReference=Sha J B, Zhang S S, Lu Y M, et al. Effects of the long-term consumption of hydrogen-rich water on the antioxidant activity and the gut flora in female juvenile soccer players from Suzhou, China[J]. Medical Gas Research, 2018, 8(4): 135-143., articleTitle=Effects of the long-term consumption of hydrogen-rich water on the antioxidant activity and the gut flora in female juvenile soccer players from Suzhou, China, refAbstract=null), Reference(id=1242113989958767483, tenantId=1146029695717560320, journalId=1146032081894723586, articleId=1157002945280693081, doi=10.1016/j.ejphar.2015.04.051, pmid=25962664, pmcid=null, year=2015, volume=762, issue=null, pageStart=96, pageEnd=101, url=null, language=null, rfNumber=[19], rfOrder=20, authorNames=Tamasawa A, Mochizuki K, Hariya N, journalName=European Journal of Pharmacology, refType=null, unstructuredReference=Tamasawa A, Mochizuki K, Hariya N, et al. Hydrogen gas production is associated with reduced interleukin-1β mRNA in peripheral blood after a single dose of acarbose in Japanese type 2 diabetic patients[J]. European Journal of Pharmacology, 2015, 762: 96-101., articleTitle=Hydrogen gas production is associated with reduced interleukin-1β mRNA in peripheral blood after a single dose of acarbose in Japanese type 2 diabetic patients, refAbstract=Acarbose, an α-glucosidase inhibitor, leads to the production of hydrogen gas, which reduces oxidative stress. In this study, we examined the effects of a single dose of acarbose immediately before a test meal on postprandial hydrogen gas in breath and peripheral blood interleukin (IL)-1β mRNA expression in Japanese type 2 diabetic patients. Sixteen Japanese patients (14 men, 2 women) participated in this study. The mean±standard deviation age, hemoglobin A1c and body mass index were 52.1±15.4 years, 10.2±2.0%, and 27.7±8.0kg/m(2), respectively. The patients were admitted into our hospital for 2 days and underwent test meals at breakfast without (day 1) or with acarbose (day 2). We performed continuous glucose monitoring and measured hydrogen gas levels in breath, and peripheral blood IL-1β mRNA levels before (0min) and after the test meal (hydrogen gas: 60, 120, 180, and 300min; IL-1β: 180min). The induction of hydrogen gas production and the reduction in peripheral blood IL-1β mRNA after the test meal were not significant between days 1 (without acarbose) and 2 (with acarbose). However, the changes in total hydrogen gas production from day 1 to day 2 were closely and inversely associated with the changes in peripheral blood IL-1β mRNA levels. Our results suggest that an increase in hydrogen gas production is inversely associated with a reduction of the peripheral blood IL-1β mRNA level after a single dose of acarbose in Japanese type 2 diabetic patients. Copyright © 2015 Elsevier B.V. All rights reserved.), Reference(id=1242113990025876348, tenantId=1146029695717560320, journalId=1146032081894723586, articleId=1157002945280693081, doi=10.1111/hdi.12112, pmid=24274030, pmcid=null, year=2014, volume=18, issue=2, pageStart=459, pageEnd=466, url=null, language=null, rfNumber=[20], rfOrder=21, authorNames=Terawaki H, Zhu W J, Matsuyama Y, journalName=Hemodialysis International, refType=null, unstructuredReference=Terawaki H, Zhu W J, Matsuyama Y, et al. Effect of a hydrogen (H₂)-enriched solution on the albumin redox of hemodialysis patients[J]. Hemodialysis International, 2014, 18(2): 459-466., articleTitle=Effect of a hydrogen (H₂)-enriched solution on the albumin redox of hemodialysis patients, refAbstract=Elevated oxidative stress (OS) is associated with severe cardiovascular disease and premature death among patients treated with hemodialysis (HD). Oxidative stress is enhanced by contact between blood and dialysis membranes during HD sessions. This study aimed to clarify whether hydrogen (H2), which is a known antioxidant, is capable of suppressing increased OS induced during HD sessions. Eight patients on regular HD treatment were studied. Two HD sessions were performed in a cross-over design trial using standard and hydrogen-enriched solutions (mean of 50 p.p.b. H2; H2-HD). Blood samples were obtained from the inlet and outlet of the dialyzer during HD to determine changes in plasma levels of glutathione, hydrogen peroxide, and albumin redox state as a marker of OS. Comparison of inlet and outlet blood revealed significant decreases in total glutathione and reduced glutathione, as well as significant increases in hydrogen peroxide in both HD treatments. However, the mean proportion of reversibly oxidized albumin in outlet serum was significantly lower than that in inlet serum following the H2-HD session, whereas no significant changes were found in the standard solution session, suggesting that "intra-dialyzer" OS is reduced by H2 -HD. In conclusion, the application of H2-enriched solutions could ameliorate OS during HD.© 2013 International Society for Hemodialysis.), Reference(id=1242113990097179517, tenantId=1146029695717560320, journalId=1146032081894723586, articleId=1157002945280693081, doi=null, pmid=null, pmcid=null, year=2017, volume=12, issue=9, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[21], rfOrder=22, authorNames=Nakayama M, Itami N, Suzuki H, journalName=PLoS One, refType=null, unstructuredReference=Nakayama M, Itami N, Suzuki H, et al. Possible clinical effects of molecular hydrogen (H₂) delivery during hemodialysis in chronic dialysis patients: Interim analysis in a 12 month observation[J]. PLoS One, 2017, 12(9), doi: 10.1371/journal.pone.0184535., articleTitle=Possible clinical effects of molecular hydrogen (H₂) delivery during hemodialysis in chronic dialysis patients: Interim analysis in a 12 month observation, refAbstract=null), Reference(id=1242113990168482686, tenantId=1146029695717560320, journalId=1146032081894723586, articleId=1157002945280693081, doi=null, pmid=null, pmcid=null, year=2018, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[22], rfOrder=23, authorNames=Nakayama M, Itami N, Suzuki H, journalName=Scientific Reports, refType=null, unstructuredReference=Nakayama M, Itami N, Suzuki H, et al. Novel haemodialysis (HD) treatment employing molecular hydrogen (H₂)-enriched dialysis solution improves prognosis of chronic dialysis patients: A prospective observational study[J]. Scientific Reports, 2018, 8, doi: 10.1038/s41598-17-18537-x., articleTitle=Novel haemodialysis (HD) treatment employing molecular hydrogen (H₂)-enriched dialysis solution improves prognosis of chronic dialysis patients: A prospective observational study, refAbstract=null), Reference(id=1242113990235591551, tenantId=1146029695717560320, journalId=1146032081894723586, articleId=1157002945280693081, doi=10.1038/s41573-021-00233-1, pmid=34194012, pmcid=null, year=2021, volume=20, issue=9, pageStart=689, pageEnd=709, url=null, language=null, rfNumber=[23], rfOrder=24, authorNames=Forman H J, Zhang H Q, journalName=Nature Reviews Drug Discovery, refType=null, unstructuredReference=Forman H J, Zhang H Q. Targeting oxidative stress in disease: Promise and limitations of antioxidant therapy[J]. Nature Reviews Drug Discovery, 2021, 20(9): 689-709., articleTitle=Targeting oxidative stress in disease: Promise and limitations of antioxidant therapy, refAbstract=Oxidative stress is a component of many diseases, including atherosclerosis, chronic obstructive pulmonary disease, Alzheimer disease and cancer. Although numerous small molecules evaluated as antioxidants have exhibited therapeutic potential in preclinical studies, clinical trial results have been disappointing. A greater understanding of the mechanisms through which antioxidants act and where and when they are effective may provide a rational approach that leads to greater pharmacological success. Here, we review the relationships between oxidative stress, redox signalling and disease, the mechanisms through which oxidative stress can contribute to pathology, how antioxidant defences work, what limits their effectiveness and how antioxidant defences can be increased through physiological signalling, dietary components and potential pharmaceutical intervention.), Reference(id=1242113990311089025, tenantId=1146029695717560320, journalId=1146032081894723586, articleId=1157002945280693081, doi=null, pmid=null, pmcid=null, year=2020, volume=9, issue=9, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[24], rfOrder=25, authorNames=Sies H, journalName=Antioxidants, refType=null, unstructuredReference=Sies H. Oxidative stress: Concept and some practical aspects[J]. Antioxidants, 2020, 9(9), doi: 10.3390/antiox 9090852., articleTitle=Oxidative stress: Concept and some practical aspects, refAbstract=null), Reference(id=1242113990374003586, tenantId=1146029695717560320, journalId=1146032081894723586, articleId=1157002945280693081, doi=10.1007/s10863-019-09814-7, pmid=31768722, pmcid=null, year=2019, volume=51, issue=6, pageStart=393, pageEnd=402, url=null, language=null, rfNumber=[25], rfOrder=26, authorNames=Li L T, Liu T T, Liu L, journalName=Journal of Bioenergetics and Biomembranes, refType=null, unstructuredReference=Li L T, Liu T T, Liu L, et al. Effect of hydrogen-rich water on the Nrf2/ARE signaling pathway in rats with myocardial ischemia-reperfusion injury[J]. Journal of Bioenergetics and Biomembranes, 2019, 51(6): 393-402., articleTitle=Effect of hydrogen-rich water on the Nrf2/ARE signaling pathway in rats with myocardial ischemia-reperfusion injury, refAbstract=The effects of hydrogen-rich water on oxidative stress via the Nrf2/ARE signaling pathway were studied in rats with myocardial ischemia-reperfusion injury (MIRI). Sixty rats were randomly divided into a hydrogen-rich water group and a control group, with 30 rats in each group. The two groups were randomly divided into three groups: pre-ischemic period, ischemic period and reperfusion period. After the heart was removed, it was fixed in a Langendorff device and perfused with an oxygen-balanced 37 °C perfusate. The control group was perfused with Kreb's-Ringers (K-R) solution, and the hydrogen-rich water group was perfused with K-R solution + hydrogen-rich water. The levels of mRNA and protein of Nrf2, NQO1, HO-1 and SOD-1 in cardiomyocytes were detected by RT-qPCR, immunohistochemistry (IHC) and Western blot analysis. SOD activity and MDA content were determined. Hydrogen-rich water increased the activation of the Nrf2/ARE signaling pathway, and the levels of mRNA and protein Nrf2, NQO1, HO-1 and SOD-1 were significantly increased (P < 0.05) in the ischemia-reperfusion period compared with the ischemic period. In the control group, the levels of mRNA and protein of Nrf2, NQO1, HO-1 and SOD-1 were significantly decreased (P < 0.05) in the ischemia-reperfusion period compared with the ischemic period. Compared with the ischemic period, the ischemia-reperfusion phase showed significantly increased SOD activity and significantly decreased MDA content in the hydrogen-rich water group, while SOD activity was significantly decreased, and MDA content was significantly increased in the control group (P < 0.05). Hydrogen-rich water can activate the Nrf2/ARE signaling pathway, alleviate ischemia-reperfusion injury in isolated rat hearts and reduce the oxidative stress level of myocardial tissue.), Reference(id=1242113990436918147, tenantId=1146029695717560320, journalId=1146032081894723586, articleId=1157002945280693081, doi=null, pmid=null, pmcid=null, year=2020, volume=34, issue=5, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[26], rfOrder=27, authorNames=Lu Y, Li C F, Ping N N, journalName=Journal of Biochemical and Molecular Toxicology, refType=null, unstructuredReference=Lu Y, Li C F, Ping N N, et al. Hydrogen-rich water alleviates cyclosporine A-induced nephrotoxicity via the Keap1/Nrf2 signaling pathway[J]. Journal of Biochemical and Molecular Toxicology, 2020, 34(5), doi: 10.1002/jbt.22467., articleTitle=Hydrogen-rich water alleviates cyclosporine A-induced nephrotoxicity via the Keap1/Nrf2 signaling pathway, refAbstract=null), Reference(id=1242113990512415620, tenantId=1146029695717560320, journalId=1146032081894723586, articleId=1157002945280693081, doi=null, pmid=null, pmcid=null, year=1981, volume=5, issue=2, pageStart=259, pageEnd=264, url=null, language=null, rfNumber=[27], rfOrder=28, authorNames=Katz R J, Roth K A, Schmaltz K, journalName=Neuroscience & Biobehavioral Reviews, refType=null, unstructuredReference=Katz R J, Roth K A, Schmaltz K. Amphetamine and tranylcypromine in an animal model of depression: Pharmacological specificity of the reversal effect[J]. Neuroscience & Biobehavioral Reviews, 1981, 5(2): 259-264., articleTitle=Amphetamine and tranylcypromine in an animal model of depression: Pharmacological specificity of the reversal effect, refAbstract=null), Reference(id=1242113990583718789, tenantId=1146029695717560320, journalId=1146032081894723586, articleId=1157002945280693081, doi=null, pmid=null, pmcid=null, year=2022, volume=19, issue=1, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[28], rfOrder=29, authorNames=Yin H L, Feng Y J, Duan Y, journalName=Journal of Inflammation, refType=null, unstructuredReference=Yin H L, Feng Y J, Duan Y, et al. Hydrogen gas alleviates lipopolysaccharide-induced acute lung injury and inflammatory response in mice[J]. Journal of Inflammation, 2022, 19(1), doi: 10.1186/s12950-022-00314-x., articleTitle=Hydrogen gas alleviates lipopolysaccharide-induced acute lung injury and inflammatory response in mice, refAbstract=null), Reference(id=1242113990655021958, tenantId=1146029695717560320, journalId=1146032081894723586, articleId=1157002945280693081, doi=null, pmid=null, pmcid=null, year=2024, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[29], rfOrder=30, authorNames=Xu L Y, Guo W H, Dai J Y, journalName=International Immunopharmacology, refType=null, unstructuredReference=Xu L Y, Guo W H, Dai J Y, et al. Hydrogen gas alleviates acute ethanol-induced hepatotoxicity in mice via modulating TLR4/9 innate immune signaling and pyroptosis[J]. International Immunopharmacology, 2024, 127, doi: 10.1016/j.intimp.2023.111399., articleTitle=Hydrogen gas alleviates acute ethanol-induced hepatotoxicity in mice via modulating TLR4/9 innate immune signaling and pyroptosis, refAbstract=null), Reference(id=1242113992123028359, tenantId=1146029695717560320, journalId=1146032081894723586, articleId=1157002945280693081, doi=10.1016/j.jss.2021.01.022, pmid=33639371, pmcid=null, year=2021, volume=263, issue=null, pageStart=63, pageEnd=70, url=null, language=null, rfNumber=[30], rfOrder=31, authorNames=Matsuura H, Matsumoto H, Okuzaki D, journalName=Journal of Surgical Research, refType=null, unstructuredReference=Matsuura H, Matsumoto H, Okuzaki D, et al. Hydrogen gas therapy attenuates inflammatory pathway signaling in septic mice[J]. Journal of Surgical Research, 2021, 263: 63-70., articleTitle=Hydrogen gas therapy attenuates inflammatory pathway signaling in septic mice, refAbstract=Molecular hydrogen (H) has been used in clinical cases. However, there are few studies of H therapy to treat sepsis, and anti-inflammatory mechanisms of H are mostly unknown. We aimed to confirm effects of H therapy on sepsis and reveal its therapeutic mechanism via RNA sequencing in multiple organs in septic mice.Nine-week-old C57BL/6 male mice underwent cecal ligation and puncture (CLP) or sham procedure. Subsequently, the CLP model received immediate ± continuous inhalation of 7% H. Mice were observed for a week to assess survival rates. Serum inflammatory cytokines were evaluated at 24 h after CLP procedure. Liver, intestine, and lungs in CLP mice receiving 24-h ± H therapy were assessed by RNA sequencing. Data were analyzed with Ingenuity Pathways Analysis (QIAGEN Inc).Seven-day survival rate in septic mice was significantly improved in the H inhalation group compared with that in the control group (75% versus 40%, P < 0.05). H treatment attenuated serum interleukin-6 and tumor necrosis factor-α levels at 24 h after CLP, and blood glucose levels were maintained in the H-treated group. In RNA sequencing, canonical pathway analysis revealed inactivity of various inflammatory signaling pathways, for example, acute phase response signaling and STAT3 pathways, in the liver and intestine in the CLP model after 24-h H inhalation. We detected significantly decreased expressions of upstream regulator genes such as the CD14 antigen gene in the liver and various cytokine receptor genes in the intestine and lungs in the H-treated group.These findings may contribute to clarifying the mechanism of action of H therapy in sepsis.Copyright © 2021 Elsevier Inc. All rights reserved.), Reference(id=1242113992219497353, tenantId=1146029695717560320, journalId=1146032081894723586, articleId=1157002945280693081, doi=null, pmid=null, pmcid=null, year=2022, volume=9, issue=10, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[31], rfOrder=32, authorNames=Yao X X, Chen D Y, Zhao B, journalName=Advanced Science, refType=null, unstructuredReference=Yao X X, Chen D Y, Zhao B, et al. Acid-degradable hydrogen-generating metal-organic framework for overcoming cancer resistance/metastasis and off-target side effects[J]. Advanced Science, 2022, 9(10), doi: 10.1002/advs.202101965., articleTitle=Acid-degradable hydrogen-generating metal-organic framework for overcoming cancer resistance/metastasis and off-target side effects, refAbstract=null), Reference(id=1242113992282411914, tenantId=1146029695717560320, journalId=1146032081894723586, articleId=1157002945280693081, doi=null, pmid=null, pmcid=null, year=2023, volume=158, issue=12, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[32], rfOrder=33, authorNames=Turan H T, Boittier E, Meuwly M, journalName=The Journal of Chemical Physics, refType=null, unstructuredReference=Turan H T, Boittier E, Meuwly M. Interaction at a distance: Xenon migration in Mb[J]. The Journal of Chemical Physics, 2023, 158(12), doi: 10.1063/5.0124502., articleTitle=Interaction at a distance: Xenon migration in Mb, refAbstract=null), Reference(id=1242113992353715083, tenantId=1146029695717560320, journalId=1146032081894723586, articleId=1157002945280693081, doi=null, pmid=null, pmcid=null, year=2022, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[33], rfOrder=34, authorNames=Bulut M, Çelebi S Y, Ceylan M M, journalName=Food Chemistry, refType=null, unstructuredReference=Bulut M, Çelebi S Y, Ceylan M M, et al. Hydrogen-rich water can reduce the formation of biogenic amines in butter[J]. Food Chemistry, 2022, 384, doi: 10.1016/j.foodchem.2022.132613., articleTitle=Hydrogen-rich water can reduce the formation of biogenic amines in butter, refAbstract=null), Reference(id=1242113992420823948, tenantId=1146029695717560320, journalId=1146032081894723586, articleId=1157002945280693081, doi=null, pmid=null, pmcid=null, year=2024, volume=35, issue=2, pageStart=203, pageEnd=219, url=null, language=null, rfNumber=[34], rfOrder=35, authorNames=Alwazeer D, journalName=Phytochemical Analysis, refType=null, unstructuredReference=Alwazeer D. Hydrogen-rich solvent method in phytochemical extraction: Potential mechanisms and perspectives[J]. Phytochemical Analysis, 2024, 35(2): 203-219., articleTitle=Hydrogen-rich solvent method in phytochemical extraction: Potential mechanisms and perspectives, refAbstract=null), Reference(id=1242113992483738509, tenantId=1146029695717560320, journalId=1146032081894723586, articleId=1157002945280693081, doi=null, pmid=null, pmcid=null, year=2015, volume=100, issue=7, pageStart=2724, pageEnd=2733, url=null, language=null, rfNumber=[35], rfOrder=36, authorNames=Song G H, Lin Q Q, Zhao H, journalName=The Journal of Clinical Endocrinology and Metabolism, refType=null, unstructuredReference=Song G H, Lin Q Q, Zhao H, et al. Hydrogen activates ATP-binding cassette transporter A1-dependent efflux ex vivo and improves high-density lipoprotein function in patients with hypercholesterolemia: A double-blinded, randomized, and placebo-controlled trial[J]. The Journal of Clinical Endocrinology and Metabolism, 2015, 100(7): 2724-2733., articleTitle=Hydrogen activates ATP-binding cassette transporter A1-dependent efflux ex vivo and improves high-density lipoprotein function in patients with hypercholesterolemia: A double-blinded, randomized, and placebo-controlled trial, refAbstract=null), Reference(id=1242113992550847374, tenantId=1146029695717560320, journalId=1146032081894723586, articleId=1157002945280693081, doi=null, pmid=null, pmcid=null, year=2014, volume=392, issue=1/2, pageStart=117, pageEnd=124, url=null, language=null, rfNumber=[36], rfOrder=37, authorNames=Xin H G, Zhang B B, Wu Z Q, journalName=Molecular and Cellular Biochemistry, refType=null, unstructuredReference=Xin H G, Zhang B B, Wu Z Q, et al. Consumption of hydrogen-rich water alleviates renal injury in spontaneous hypertensive rats[J]. Molecular and Cellular Biochemistry, 2014, 392(1/2): 117-124., articleTitle=Consumption of hydrogen-rich water alleviates renal injury in spontaneous hypertensive rats, refAbstract=null), Reference(id=1242113992617956239, tenantId=1146029695717560320, journalId=1146032081894723586, articleId=1157002945280693081, doi=null, pmid=null, pmcid=null, year=2022, volume=37, issue=1, pageStart=103, pageEnd=108, url=null, language=null, rfNumber=[37], rfOrder=38, authorNames=王金璞, 史红颜, 赵敬国, journalName=山东师范大学学报(自然科学版), refType=null, unstructuredReference=王金璞, 史红颜, 赵敬国. 氢气在运动医学领域应用的研究进展[J]. 山东师范大学学报(自然科学版), 2022, 37(1): 103-108., articleTitle=氢气在运动医学领域应用的研究进展, refAbstract=null), Reference(id=1242113992689259408, tenantId=1146029695717560320, journalId=1146032081894723586, articleId=1157002945280693081, doi=null, pmid=null, pmcid=null, year=2022, volume=37, issue=1, pageStart=103, pageEnd=108, url=null, language=null, rfNumber=[37], rfOrder=39, authorNames=Wang J P, Shi H Y, Zhao J G, journalName=Journal of Shandong Normal University (Natural Science), refType=null, unstructuredReference=Wang J P, Shi H Y, Zhao J G. Research progress of hydrogen application in sports medicine[J]. Journal of Shandong Normal University (Natural Science), 2022, 37(1): 103-108. (in Chinese), articleTitle=Research progress of hydrogen application in sports medicine, refAbstract=null), Reference(id=1242113992752173969, tenantId=1146029695717560320, journalId=1146032081894723586, articleId=1157002945280693081, doi=10.4103/2045-9912.222448, pmid=29497485, pmcid=null, year=2017, volume=7, issue=4, pageStart=247, pageEnd=255, url=null, language=null, rfNumber=[38], rfOrder=40, authorNames=Mizuno K, Sasaki A T, Ebisu K, journalName=Medical Gas Research, refType=null, unstructuredReference=Mizuno K, Sasaki A T, Ebisu K, et al. Hydrogen-rich water for improvements of mood, anxiety, and autonomic nerve function in daily life[J]. Medical Gas Research, 2017, 7(4): 247-255., articleTitle=Hydrogen-rich water for improvements of mood, anxiety, and autonomic nerve function in daily life, refAbstract=Health and a vibrant life are sought by everyone. To improve quality of life (QOL), maintain a healthy state, and prevent various diseases, evaluations of the effects of potentially QOL-increasing factors are important. Chronic oxidative stress and inflammation cause deteriorations in central nervous system function, leading to low QOL. In healthy individuals, aging, job stress, and cognitive load over several hours also induce increases in oxidative stress, suggesting that preventing the accumulation of oxidative stress caused by daily stress and daily work contributes to maintaining QOL and ameliorating the effects of aging. Hydrogen has anti-oxidant activity and can prevent inflammation, and may thus contribute to improve QOL. The present study aimed to investigate the effects of drinking hydrogen-rich water (HRW) on the QOL of adult volunteers using psychophysiological tests, including questionnaires and tests of autonomic nerve function and cognitive function. In this double-blinded, placebo-controlled study with a two-way crossover design, 26 volunteers (13 females, 13 males; mean age, 34.4 ± 9.9 years) were randomized to either a group administered oral HRW (600 mL/d) or placebo water (PLW, 600 mL/d) for 4 weeks. Change ratios (post-treatment/pre-treatment) for K6 score and sympathetic nerve activity during the resting state were significantly lower after HRW administration than after PLW administration. These results suggest that HRW may reinforce QOL through effects that increase central nervous system functions involving mood, anxiety, and autonomic nerve function.), Reference(id=1242113992823477138, tenantId=1146029695717560320, journalId=1146032081894723586, articleId=1157002945280693081, doi=null, pmid=null, pmcid=null, year=2024, volume=46, issue=1, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[39], rfOrder=41, authorNames=Si Y C, Liu L L, Zhang Y Y, journalName=Renal Failure, refType=null, unstructuredReference=Si Y C, Liu L L, Zhang Y Y, et al. Magnesium hydride protects against acetaminophen-induced acute kidney injury by inhibiting TXNIP/NLRP3/nf-κb pathway[J]. Renal Failure, 2024, 46(1), doi: 10.1080/0886022X.2024.2330629., articleTitle=Magnesium hydride protects against acetaminophen-induced acute kidney injury by inhibiting TXNIP/NLRP3/nf-κb pathway, refAbstract=null), Reference(id=1242113992886391699, tenantId=1146029695717560320, journalId=1146032081894723586, articleId=1157002945280693081, doi=null, pmid=null, pmcid=null, year=2023, volume=12, issue=2, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[40], rfOrder=42, authorNames=Gong F, Yang N L, Xu J C, journalName=Advanced Healthcare Materials, refType=null, unstructuredReference=Gong F, Yang N L, Xu J C, et al. Calcium hydride-based dressing to promote wound healing[J]. Advanced Healthcare Materials, 2023, 12(2), doi: 10.1002/adhm.202201771., articleTitle=Calcium hydride-based dressing to promote wound healing, refAbstract=null), Reference(id=1242113992945111956, tenantId=1146029695717560320, journalId=1146032081894723586, articleId=1157002945280693081, doi=null, pmid=null, pmcid=null, year=2022, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[41], rfOrder=43, authorNames=Johnsen H M, Filtvedt W, Hiorth M, journalName=International Journal of Pharmaceutics, refType=null, unstructuredReference=Johnsen H M, Filtvedt W, Hiorth M, et al. Silicon nanoparticles for oral administration of molecular hydrogen[J]. International Journal of Pharmaceutics, 2022, 629, doi: 10.1016/j.ijpharm.2022.122371., articleTitle=Silicon nanoparticles for oral administration of molecular hydrogen, refAbstract=null), Reference(id=1242113993016415125, tenantId=1146029695717560320, journalId=1146032081894723586, articleId=1157002945280693081, doi=10.4103/2045-9912.330692, pmid=34854419, pmcid=null, year=2022, volume=12, issue=3, pageStart=91, pageEnd=99, url=null, language=null, rfNumber=[42], rfOrder=44, authorNames=Tanaka Y, Xiao L, Miwa N, journalName=Medical Gas Research, refType=null, unstructuredReference=Tanaka Y, Xiao L, Miwa N. Hydrogen-rich bath with nano-sized bubbles improves antioxidant capacity based on oxygen radical absorbing and inflammation levels in human serum[J]. Medical Gas Research, 2022, 12(3): 91-99., articleTitle=Hydrogen-rich bath with nano-sized bubbles improves antioxidant capacity based on oxygen radical absorbing and inflammation levels in human serum, refAbstract=This study compared the effects of hydrogen-water (HW) bath on the oxygen radical absorption-based antioxidant capacity and the inflammatory indicator, C-reactive protein (CRP), in serum between healthy volunteers and inflammatory/collagen disease-patients. The HW bath apparatus supplied nano-bubbles with a diameter of 110 ± 10 nm and 338-682 μg/L of dissolved hydrogen after 120 minutes electrolysis, and nano-bubbles increased to 9.91 × 10/mL along with the increase of correlative dissolved hydrogen. Ten-minute HW bath increased the oxygen radical absorption-based antioxidant capacity to 110.9 ± 9.2% at post-bathing 120 minutes, although unaltered with 10-minute normal water bath at 40°C in healthy subjects. The CRP level was repressed to 70.2 ± 12.1% at 120 minutes after HW bath, although rather increased for normal water bath. In the patients with connective tissue diseases, the CRP level was repressed to 3-24% upon 9 days to 4 months of HW bathing. In another six patients with diverse autoimmune-related diseases, upon daily HW bathing as long as 2-25 months, the pre-bathing CRP level of 5.31 mg/dL decreased to 0.24 mg/dL being within the standard-range, with relief of visible inflammatory symptoms for some cases. Thus, the HW bath with high-density nano-bubbles has beneficial effects on serum antioxidant capacity, inflammation, and the skin appearance. The study was approved by the Committee of Ethics, Japanese Center of Anti-Aging Medical Sciences (Authorization No. H-15-03-2, on January 15, 2019), which was a non-profitable organization officially authenticated by the Hiroshima Prefecture Government of Japan.), Reference(id=1242113993096106902, tenantId=1146029695717560320, journalId=1146032081894723586, articleId=1157002945280693081, doi=10.19586/j.2095-2341.2023.0005, pmid=null, pmcid=null, year=2023, volume=13, issue=3, pageStart=366, pageEnd=374, url=null, language=null, rfNumber=[43], rfOrder=45, authorNames=马晨, 宋怡菲, 仪杨, journalName=生物技术进展, refType=null, unstructuredReference=马晨, 宋怡菲, 仪杨, 等. 氢气与线粒体作用关系的研究进展[J]. 生物技术进展, 2023, 13(3): 366-374., articleTitle=氢气与线粒体作用关系的研究进展, refAbstract=氢气是一种无色无味的惰性气体，随着氢分子医学的发展，研究人员发现氢气对多种疾病都有很好的预防和治疗效果，但有关氢干预治疗性效应的作用机制及其具体靶点尚不明确，这些问题都等待着人们深入探索。研究发现，氢气的抗氧化、抗凋亡、调节代谢等都与线粒体有关，同时线粒体还与氢化酶和氢化酶体具有一定程度的同源性，这些发现为氢分子作用机制的研究奠定了基础。对目前已知的与线粒体相关的氢分子作用机制进行了总结，讨论了氢代谢与线粒体之间的关系，以期为后续研究氢分子生物学效应的作用机制提供参考。), Reference(id=1242113993163215767, tenantId=1146029695717560320, journalId=1146032081894723586, articleId=1157002945280693081, doi=10.19586/j.2095-2341.2023.0005, pmid=null, pmcid=null, year=2023, volume=13, issue=3, pageStart=366, pageEnd=374, url=null, language=null, rfNumber=[43], rfOrder=46, authorNames=Ma C, Song Y F, Yi Y, journalName=Current Biotechnology, refType=null, unstructuredReference=Ma C, Song Y F, Yi Y, et al. Research progress on the relationship between hydrogen and mitochondria[J]. Current Biotechnology, 2023, 13(3): 366-374. (in Chinese), articleTitle=Research progress on the relationship between hydrogen and mitochondria, refAbstract=

Hydrogen is a colorless and tasteless inert gas. With the development of hydrogen molecular medicine， researchers have found that hydrogen has a good preventive and therapeutic effect on a variety of diseases， but the mechanism and specific targets of hydrogen intervention for therapeutic effect are not clear. It has been found that the antioxidant， anti apoptotic， metabolic regulation and other effect of hydrogen are related to mitochondria， and mitochondria also has a certain degree of homology with hydrogenase and hydrogenosome. These foundings have laid the foundation for the research on the mechanism of hydrogen. In this review， we summarized the currently known mechanisms of hydrogen related to mitochondria， and discussed the relationship between hydrogen metabolism and mitochondria， in order to provide reference for the subsequent research on the mechanism of molecular biological effects of hydrogen.

), Reference(id=1242113993230324632, tenantId=1146029695717560320, journalId=1146032081894723586, articleId=1157002945280693081, doi=null, pmid=null, pmcid=null, year=2022, volume=13, issue=1, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[44], rfOrder=47, authorNames=Chen S Q, Zhu Y X, Xu Q Q, journalName=Nature Communications, refType=null, unstructuredReference=Chen S Q, Zhu Y X, Xu Q Q, et al. Photocatalytic glucose depletion and hydrogen generation for diabetic wound healing[J]. Nature Communications, 2022, 13(1), doi: 10.1038/s41467-022-33475-7., articleTitle=Photocatalytic glucose depletion and hydrogen generation for diabetic wound healing, refAbstract=null), Reference(id=1242113993293239193, tenantId=1146029695717560320, journalId=1146032081894723586, articleId=1157002945280693081, doi=S0142-9612(19)30057-2, pmid=30703744, pmcid=null, year=2019, volume=197, issue=null, pageStart=393, pageEnd=404, url=null, language=null, rfNumber=[45], rfOrder=48, authorNames=Zhang L, Zhao P H, Yue C P, journalName=Biomaterials, refType=null, unstructuredReference=Zhang L, Zhao P H, Yue C P, et al. Sustained release of bioactive hydrogen by Pd hydride nanoparticles overcomes Alzheimer’s disease[J]. Biomaterials, 2019, 197: 393-404., articleTitle=Sustained release of bioactive hydrogen by Pd hydride nanoparticles overcomes Alzheimer’s disease, refAbstract=Oxidative stress-induced mitochondrial dysfunction plays an important role in the pathogenesis of Alzheimer's disease (AD). Hydrogen molecule, a special antioxidant, can selectively scavenge highly cytotoxic reactive oxygen species such as ·OH, exhibiting a potential to treat AD by reducing oxidative stress. However, there is no effective route to realize the continuous and efficient accumulation of administrated hydrogen in AD brain owing to its low solubility. Here, we develop the small-sized Pd hydride (PdH) nanoparticles for high payload of hydrogen and in situ sustained hydrogen release in AD brain. By virtue of the catalytic hydrogenation effect of Pd, the released hydrogen from PdH nanoparticles exhibits high bio-reductivity in favor of effectively scavenging cytotoxic ·OH in a self-catalysis way. Bio-reductive hydrogen is able to recover mitochondrial dysfunction, inhibit Aβ generation and aggregation, block synaptic and neuronal apoptosis and promote neuronal energy metabolism by eliminating oxidative stress and activating the anti-oxidative pathway, consequently ameliorating the cognitive impairment in AD mice. The proposed hydrogen-releasing nanomedicine strategy would open a new window for the treatment of AD.Copyright © 2019 Elsevier Ltd. All rights reserved.), Reference(id=1242113993372930970, tenantId=1146029695717560320, journalId=1146032081894723586, articleId=1157002945280693081, doi=null, pmid=null, pmcid=null, year=2019, volume=40, issue=6, pageStart=586, pageEnd=589, url=null, language=null, rfNumber=[46], rfOrder=49, authorNames=李超富, 高云姝, 周洲, journalName=解放军医学院学报, refType=null, unstructuredReference=李超富, 高云姝, 周洲, 等. 富氢水协同金复康口服液阻断硫代乙酰胺诱发大鼠胆管癌上皮癌变的实验研究[J]. 解放军医学院学报, 2019, 40(6): 586-589, 604., articleTitle=富氢水协同金复康口服液阻断硫代乙酰胺诱发大鼠胆管癌上皮癌变的实验研究, refAbstract=null), Reference(id=1242113993435845531, tenantId=1146029695717560320, journalId=1146032081894723586, articleId=1157002945280693081, doi=null, pmid=null, pmcid=null, year=2019, volume=40, issue=6, pageStart=586, pageEnd=589, url=null, language=null, rfNumber=[46], rfOrder=50, authorNames=Li C F, Gao Y S, Zhou Z, journalName=Academic Journal of Chinese PLA Medical School, refType=null, unstructuredReference=Li C F, Gao Y S, Zhou Z, et al. Synergistic effect of hydrogen-rich water and Jinfukang oral liquid in prevention of cholangiocarcinoma in rats induced by thioacetamide[J]. Academic Journal of Chinese PLA Medical School, 2019, 40(6): 586-589, 604. (in Chinese), articleTitle=Synergistic effect of hydrogen-rich water and Jinfukang oral liquid in prevention of cholangiocarcinoma in rats induced by thioacetamide, refAbstract=null), Reference(id=1242113993528120220, tenantId=1146029695717560320, journalId=1146032081894723586, articleId=1157002945280693081, doi=null, pmid=null, pmcid=null, year=2024, volume=17, issue=4, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[47], rfOrder=51, authorNames=Artamonov M Y, LeBaron T W, Pyatakovich F A, journalName=Pharmaceuticals, refType=null, unstructuredReference=Artamonov M Y, LeBaron T W, Pyatakovich F A, et al. Mesenchymal stem cell priming: Potential benefits of administration of molecular hydrogen[J]. Pharmaceuticals, 2024, 17(4), doi: 10.3390/ph17040469., articleTitle=Mesenchymal stem cell priming: Potential benefits of administration of molecular hydrogen, refAbstract=null), Reference(id=1242113993624589213, tenantId=1146029695717560320, journalId=1146032081894723586, articleId=1157002945280693081, doi=null, pmid=null, pmcid=null, year=2022, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[48], rfOrder=52, authorNames=Kong X F, Lu T Y, Lu Y Y, journalName=Frontiers in Medicine, refType=null, unstructuredReference=Kong X F, Lu T Y, Lu Y Y, et al. Effect of hydrogen inhalation therapy on hearing loss of patients with nasopharyngeal carcinoma after radiotherapy[J]. Frontiers in Medicine, 2022, 9, doi: 10.3389/fmed.2022.828370., articleTitle=Effect of hydrogen inhalation therapy on hearing loss of patients with nasopharyngeal carcinoma after radiotherapy, refAbstract=null), Reference(id=1242113993691698078, tenantId=1146029695717560320, journalId=1146032081894723586, articleId=1157002945280693081, doi=null, pmid=null, pmcid=null, year=2015, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[49], rfOrder=53, authorNames=Runtuwene J, Amitani H, Amitani M, journalName=Peer J, refType=null, unstructuredReference=Runtuwene J, Amitani H, Amitani M, et al. Hydrogen-water enhances 5-fluorouracil-induced inhibition of colon cancer[J]. Peer J, 2015, 3, doi: 10.7717/peerj.859., articleTitle=Hydrogen-water enhances 5-fluorouracil-induced inhibition of colon cancer, refAbstract=null)], funds=[Fund(id=1242113988327183206, tenantId=1146029695717560320, journalId=1146032081894723586, articleId=1157002945280693081, awardId=21QNPY035, language=CN, fundingSource=军队医学科技青年培养项目(21QNPY035), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1242113985382781772, tenantId=1146029695717560320, journalId=1146032081894723586, articleId=1157002945280693081, xref=null, ext=[AuthorCompanyExt(id=1242113985391170381, tenantId=1146029695717560320, journalId=1146032081894723586, articleId=1157002945280693081, companyId=1242113985382781772, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Naval Medicine, Naval Medical University, Shanghai 200433, China), AuthorCompanyExt(id=1242113985399558990, tenantId=1146029695717560320, journalId=1146032081894723586, articleId=1157002945280693081, companyId=1242113985382781772, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=海军军医大学海军医学系，上海 200433)])], figs=[ArticleFig(id=1242113988121662308, tenantId=1146029695717560320, journalId=1146032081894723586, articleId=1157002945280693081, language=EN, label=Table 1, caption=

Milestone events in evolution of hydrogen medicine

, figureFileSmall=null, figureFileBig=null, tableContent=

时间	代表性工作	研究团队	贡献
1941年	氢气应用于大深度饱和潜水[6]	Case和Haldane	证实了氢气的生物安全性
1975年	高压氢气治疗小鼠皮肤鳞状细胞癌[9]	Dole等	发现氢气具有治疗疾病的作用
2007年	低浓度氢气通过选择性清除羟自由基改善大鼠脑缺血再灌注后的脑损伤[10]	太田成男等	提出氢气的选择性抗氧化作用，开启了现代氢医学研究热潮
2008年	富氢生理盐水对脑缺血再灌注后的神经保护作用[11]	孙学军等	国内首个氢医学研究，引领并带动国内氢医学发展
2013年	富氢水改善血脂的临床试验[12]	秦树存等	国内首次双盲对照试验
2018年	利用纳米钯材料的氢热协同效应治疗肿瘤[13]	何前军等	开启了氢医学和材料领域的交叉研究
2020年	氢氧雾化吸入设备获批三类医疗器械	相关企业	标志着氢医学正式进入临床应用
2021年	多中心随机对照试验研究证明氢氧混合气能够改善慢性阻塞性肺疾病急性加重期症状[14]	钟南山等	氢气医学迈入高水平临床研究
2024年	氢气可作为肠道菌群甾体激素21去羟化酶的底物[15]	Devlin等	为氢气参与机体生化反应提供了直接证据

), ArticleFig(id=1242113988201354085, tenantId=1146029695717560320, journalId=1146032081894723586, articleId=1157002945280693081, language=CN, label=表1, caption=

氢医学发展中的代表性工作

, figureFileSmall=null, figureFileBig=null, tableContent=

时间	代表性工作	研究团队	贡献
1941年	氢气应用于大深度饱和潜水[6]	Case和Haldane	证实了氢气的生物安全性
1975年	高压氢气治疗小鼠皮肤鳞状细胞癌[9]	Dole等	发现氢气具有治疗疾病的作用
2007年	低浓度氢气通过选择性清除羟自由基改善大鼠脑缺血再灌注后的脑损伤[10]	太田成男等	提出氢气的选择性抗氧化作用，开启了现代氢医学研究热潮
2008年	富氢生理盐水对脑缺血再灌注后的神经保护作用[11]	孙学军等	国内首个氢医学研究，引领并带动国内氢医学发展
2013年	富氢水改善血脂的临床试验[12]	秦树存等	国内首次双盲对照试验
2018年	利用纳米钯材料的氢热协同效应治疗肿瘤[13]	何前军等	开启了氢医学和材料领域的交叉研究
2020年	氢氧雾化吸入设备获批三类医疗器械	相关企业	标志着氢医学正式进入临床应用
2021年	多中心随机对照试验研究证明氢氧混合气能够改善慢性阻塞性肺疾病急性加重期症状[14]	钟南山等	氢气医学迈入高水平临床研究
2024年	氢气可作为肠道菌群甾体激素21去羟化酶的底物[15]	Devlin等	为氢气参与机体生化反应提供了直接证据

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