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Article(id=1319236756319351294, tenantId=1146029695717560320, journalId=1263187385517883426, issueId=1319236705027207343, articleNumber=null, orderNo=null, doi=10.14062/j.issn.0454-5648.20220086, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1643126400000, receivedDateStr=2022-01-26, revisedDate=1648051200000, revisedDateStr=2022-03-24, acceptedDate=null, acceptedDateStr=null, onlineDate=1792460152907, onlineDateStr=2026-10-20, pubDate=1666195200000, pubDateStr=2022-10-20, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792460152907, onlineIssueDateStr=2026-10-20, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792460152907, creator=13701087609, updateTime=1792460152907, updator=13701087609, issue=Issue{id=1319236705027207343, tenantId=1146029695717560320, journalId=1263187385517883426, year='2022', volume='50', issue='10', pageStart='2579', pageEnd='2808', issueExtLink='null', onlineDate='null', pubDate='1666195200000', pubDateStr='2022-10-20', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1792460140711, creator='13701087609', updateTime=1792460672919, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1319238937323884737, tenantId=1146029695717560320, journalId=1263187385517883426, issueId=1319236705027207343, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1319238937323884738, tenantId=1146029695717560320, journalId=1263187385517883426, issueId=1319236705027207343, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=2746, endPage=2753, ext={EN=ArticleExt(id=1319236756789113343, articleId=1319236756319351294, tenantId=1146029695717560320, journalId=1263187385517883426, language=EN, title=Preparation and Drug Loading Properties of Montmorillonite Microspheres, columnId=1321898015569331178, journalTitle=Journal of the Chinese Ceramic Society, columnName=Advanced Founctional Geomaterials—Research Articles, runingTitle=null, highlight=null, articleAbstract=

Aiming at the challenge of how oral drug delivery systems protect drug molecules from environmental influences in human body, a pH value-sensitive sodium alginate-montmorillonite composite microsphere (MMT/SA) was synthesized by an emulsification gel method, which was used to load anticancer drug doxorubicin hydrochloride (DOX), and overcome the biochemical barrier of gastrointestinal tract while protecting drug molecules. The effect of raw material (MMT pretreatment and content) on the morphology of microspheres was investigated, and the size of microspheres with a uniform distribution was controlled to be 20 μm. The drug loading rate of DOX/MMT/SA is 14.7%, indicating different drug release effects in simulated gastric juice and artificial intestinal juice. The cumulative release rate of DOX/MMT/SA in simulated gastric juice (i.e., 31.7%) is greater than that in artificial gastric juice (i.e., 15.8%), and it has a killing effect on the cancer cells.

, authors=Jing ZHAI1, 2, 3, Juan LIAO5, Ying CHEN1, 2, 3, Aidong TANG1, 2, 3, 4, Huaming YANG1, 2, 3, 5, authorsList=Jing ZHAI, Juan LIAO, Ying CHEN, Aidong TANG, Huaming YANG, authorCompany=null, correspAuthors=Ying CHEN, Aidong TANG, Huaming YANG, authorNote=

ZHAI Jing (1997-), female, Master candidate. E-mail:

, correspAuthorsNote=
CHEN Ying (1994-), female, Ph.D., Associate Professor. E-mail:
TANG Aidong (1968-), female, Ph. D., Professor;
YANG Huaming (1968-), male, Ph. D., Professor.
, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1319236757221126656, articleId=1319236756319351294, tenantId=1146029695717560320, journalId=1263187385517883426, language=CN, title=蒙脱石微球的可控制备及其载药性能, columnId=1321898015758074859, journalTitle=硅酸盐学报, columnName=高性能矿物功能材料专题—研究论文, runingTitle=null, highlight=null, articleAbstract=

针对口服给药体系如何保护药物分子免受人体内环境影响这一挑战，采用乳化凝胶法设计合成了一种pH值敏感性的海藻酸钠（SA）-蒙脱石（MMT）复合微球MMT/SA，用以负载抗癌药物盐酸阿霉素（DOX），在保护药物分子的同时克服了胃肠道的生物化学屏障。探索了MMT处理工艺和合成配比的不同对微球形貌的影响，最终控制微球尺寸在20 μm以内，且分布均一。复合载药微球DOX/MMT/SA的载药率为14.7%，在模拟人工胃液和人工肠液环境中表现出不同的药物缓释效果，在模拟人工肠液中的累计释放率（31.7%）明显高于在人工胃液中的释放率（15.8%），且对人结肠癌细胞有明显的杀伤效果。

, authors=翟婧1, 2, 3, 廖娟5, 陈莹1, 2, 3, 唐爱东1, 2, 3, 4, 杨华明1, 2, 3, 5, authorsList=翟婧, 廖娟, 陈莹, 唐爱东, 杨华明, authorCompany=null, correspAuthors=陈莹, 唐爱东, 杨华明, authorNote=

翟婧（1997—），女，硕士研究生。

, correspAuthorsNote=
陈莹（1994—），女，博士，副教授；
唐爱东（1968—），女，博士，教授；
杨华明（1968—），男，博士，教授。
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2.Faculty of Materials Science and Chemistry, China University of Geosciences, Wuhan 430074, China
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ZHAI Jing (1997-), female, Master candidate. E-mail:

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ZHAI Jing (1997-), female, Master candidate. E-mail:

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翟婧（1997—），女，硕士研究生。

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翟婧（1997—），女，硕士研究生。

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2.Faculty of Materials Science and Chemistry, China University of Geosciences, Wuhan 430074, China
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2.Faculty of Materials Science and Chemistry, China University of Geosciences, Wuhan 430074, China
3.Key Laboratory of Functional Geomaterials in China Nonmetallic Minerals Industry, China University of Geosciences, Wuhan 430074, China
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蒙脱石微球的可控制备及其载药性能
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翟婧 1, 2, 3 , 廖娟 5 , 陈莹 1, 2, 3 , 唐爱东 1, 2, 3, 4 , 杨华明 1, 2, 3, 5
硅酸盐学报 | 高性能矿物功能材料专题—研究论文 2022,50(10): 2746-2753
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硅酸盐学报 |高性能矿物功能材料专题—研究论文 2022 , 50 (10) : 2746 -2753
蒙脱石微球的可控制备及其载药性能
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2.Faculty of Materials Science and Chemistry, China University of Geosciences, Wuhan 430074, China
3.Key Laboratory of Functional Geomaterials in China Nonmetallic Minerals Industry, China University of Geosciences, Wuhan 430074, China
5.Hunan Key Laboratory for Mineral Materials and Application, School of Minerals Processing and Bioengineering, Central South University, Changsha 410083, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322507059422151172, tenantId=1146029695717560320, journalId=1263187385517883426, articleId=1319236756319351294, authorId=1322507058964972030, language=CN, stringName=杨华明, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, 2, 3, 5, address=1．中国地质大学（武汉）纳米矿物材料及应用教育部工程研究中心，武汉 430074
2．中国地质大学（武汉）材料与化学学院，武汉 430074
3．中国非金属矿行业矿物功能材料重点实验室，武汉 430074
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翟婧1, 2, 3 , 廖娟5, 陈莹1, 2, 3 , 唐爱东1, 2, 3, 4 , 杨华明1, 2, 3, 5
作者信息
  • 1．中国地质大学（武汉）纳米矿物材料及应用教育部工程研究中心，武汉 430074
  • 2．中国地质大学（武汉）材料与化学学院，武汉 430074
  • 3．中国非金属矿行业矿物功能材料重点实验室，武汉 430074
  • 4．中南大学化学化工学院，长沙 410083
  • 5．中南大学资源加工与生物工程学院，长沙 410083
通讯作者:
陈莹（1994—），女，博士，副教授；
唐爱东（1968—），女，博士，教授；
杨华明（1968—），男，博士，教授。
作者简介:

翟婧（1997—），女，硕士研究生。

Preparation and Drug Loading Properties of Montmorillonite Microspheres
Jing ZHAI1, 2, 3 , Juan LIAO5, Ying CHEN1, 2, 3 , Aidong TANG1, 2, 3, 4 , Huaming YANG1, 2, 3, 5
Affiliations
  • 1.Engineering Research Center of Nano-Geomaterials of Ministry of Education, China University of Geosciences, Wuhan 430074, China
  • 2.Faculty of Materials Science and Chemistry, China University of Geosciences, Wuhan 430074, China
  • 3.Key Laboratory of Functional Geomaterials in China Nonmetallic Minerals Industry, China University of Geosciences, Wuhan 430074, China
  • 4.College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China
  • 5.Hunan Key Laboratory for Mineral Materials and Application, School of Minerals Processing and Bioengineering, Central South University, Changsha 410083, China
    • Corresponding Author:
    CHEN Ying (1994-), female, Ph.D., Associate Professor. E-mail:
    TANG Aidong (1968-), female, Ph. D., Professor;
    YANG Huaming (1968-), male, Ph. D., Professor.

    ZHAI Jing (1997-), female, Master candidate. E-mail:

出版时间: 2022-10-20 doi: 10.14062/j.issn.0454-5648.20220086
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针对口服给药体系如何保护药物分子免受人体内环境影响这一挑战，采用乳化凝胶法设计合成了一种pH值敏感性的海藻酸钠（SA）-蒙脱石（MMT）复合微球MMT/SA，用以负载抗癌药物盐酸阿霉素（DOX），在保护药物分子的同时克服了胃肠道的生物化学屏障。探索了MMT处理工艺和合成配比的不同对微球形貌的影响，最终控制微球尺寸在20 μm以内，且分布均一。复合载药微球DOX/MMT/SA的载药率为14.7%，在模拟人工胃液和人工肠液环境中表现出不同的药物缓释效果，在模拟人工肠液中的累计释放率（31.7%）明显高于在人工胃液中的释放率（15.8%），且对人结肠癌细胞有明显的杀伤效果。

蒙脱石  /  口服载药体系  /  化疗  /  pH值敏感性

Aiming at the challenge of how oral drug delivery systems protect drug molecules from environmental influences in human body, a pH value-sensitive sodium alginate-montmorillonite composite microsphere (MMT/SA) was synthesized by an emulsification gel method, which was used to load anticancer drug doxorubicin hydrochloride (DOX), and overcome the biochemical barrier of gastrointestinal tract while protecting drug molecules. The effect of raw material (MMT pretreatment and content) on the morphology of microspheres was investigated, and the size of microspheres with a uniform distribution was controlled to be 20 μm. The drug loading rate of DOX/MMT/SA is 14.7%, indicating different drug release effects in simulated gastric juice and artificial intestinal juice. The cumulative release rate of DOX/MMT/SA in simulated gastric juice (i.e., 31.7%) is greater than that in artificial gastric juice (i.e., 15.8%), and it has a killing effect on the cancer cells.

montmorillonite  /  oral delivery system  /  chemotherapy  /  pH value sensitivity
翟婧, 廖娟, 陈莹, 唐爱东, 杨华明. 蒙脱石微球的可控制备及其载药性能. 硅酸盐学报, 2022 , 50 (10) : 2746 -2753 . DOI: 10.14062/j.issn.0454-5648.20220086
Jing ZHAI, Juan LIAO, Ying CHEN, Aidong TANG, Huaming YANG. Preparation and Drug Loading Properties of Montmorillonite Microspheres[J]. Journal of the Chinese Ceramic Society, 2022 , 50 (10) : 2746 -2753 . DOI: 10.14062/j.issn.0454-5648.20220086
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  • 中央高校基本科研业务费专项基金资助项目
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doi: 10.14062/j.issn.0454-5648.20220086
  • 接收时间：2022-01-26
  • 首发时间：2026-10-20
  • 出版时间：2022-10-20
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  • 收稿日期：2022-01-26
  • 修回日期：2022-03-24
基金
中央高校基本科研业务费专项基金资助项目
作者信息
    1．中国地质大学（武汉）纳米矿物材料及应用教育部工程研究中心，武汉 430074
    2．中国地质大学（武汉）材料与化学学院，武汉 430074
    3．中国非金属矿行业矿物功能材料重点实验室，武汉 430074
    4．中南大学化学化工学院，长沙 410083
    5．中南大学资源加工与生物工程学院，长沙 410083

通讯作者:

陈莹（1994—），女，博士，副教授；
唐爱东（1968—），女，博士，教授；
杨华明（1968—），男，博士，教授。
参考文献
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https://castjournals.cast.org.cn/joweb/gsyxb/CN/10.14062/j.issn.0454-5648.20220086
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2种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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