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Article(id=1318978552205263352, tenantId=1146029695717560320, journalId=1263187385517883426, issueId=1318978537852359595, articleNumber=null, orderNo=null, doi=10.14062/j.issn.0454-5648.20230200, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1680192000000, receivedDateStr=2023-03-31, revisedDate=1686240000000, revisedDateStr=2023-06-09, acceptedDate=null, acceptedDateStr=null, onlineDate=1792398592282, onlineDateStr=2026-10-19, pubDate=1697731200000, pubDateStr=2023-10-20, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792398592282, onlineIssueDateStr=2026-10-19, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792398592282, creator=13701087609, updateTime=1792398592282, updator=13701087609, issue=Issue{id=1318978537852359595, tenantId=1146029695717560320, journalId=1263187385517883426, year='2023', volume='51', issue='10', pageStart='2517', pageEnd='2738', issueExtLink='null', onlineDate='null', pubDate='1697731200000', pubDateStr='2023-10-20', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1792398588860, creator='13701087609', updateTime=1792399337892, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1318981679578993157, tenantId=1146029695717560320, journalId=1263187385517883426, issueId=1318978537852359595, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1318981679578993158, tenantId=1146029695717560320, journalId=1263187385517883426, issueId=1318978537852359595, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=2553, endPage=2565, ext={EN=ArticleExt(id=1318978552419172857, articleId=1318978552205263352, tenantId=1146029695717560320, journalId=1263187385517883426, language=EN, title=Preparation and Applications of Micro-Nano Bioactive Glass, columnId=1321891276216193845, journalTitle=Journal of the Chinese Ceramic Society, columnName=Special Issue on Inorganic Bioactive Materials—Review, runingTitle=null, highlight=null, articleAbstract=

Micro-nano bioactive glass (MNBG) has a good biological activity and is widely used in tissue engineering. In recent years, a variety of metal ions are incorporated into the network structure of materials during the preparation of MNBG, thereby endowing MNBG with various physicochemical and biological functional properties. However, the exact mechanism of interaction between the ion release products of MNBG and human cells is not fully clarified. This review represented the preparation methods and processes of MNBG and the application of its lysates in bone and tooth and other hard tissue repair, skin tissue repair, cancer treatment and cell imaging. This review could provide a reference for the further development of MNBGs applied to the biomedical field.

, authors=Zhengyu YANG1, 2, 3, Fujian ZHAO4, Chang DU1, 2, 3, Xiaofeng CHEN1, 2, 3, authorsList=Zhengyu YANG, Fujian ZHAO, Chang DU, Xiaofeng CHEN, authorCompany=null, correspAuthors=Xiaofeng CHEN, authorNote=

YANG Zhenyu (1997-), male, Doctoral candidate. E-mail:

, correspAuthorsNote=
CHEN Xiaofeng (1956-), male, Ph.D., Professor. E-mail:
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微纳米生物活性玻璃（MNBG）已被证明具有良好的生物活性，在骨、齿及皮肤创面修复及组织工程领域受到高度关注。在近些年的研究中，多种金属离子在MNBG的制备过程中被掺入材料的网络结构中，从而赋予MNBG各种理化及生物学功能特性。然而，MNBG的离子释放产物与人体细胞之间相互作用的确切机制尚不完全清楚，这促使国内外研究者对离子掺杂的MNBG进行了较深入的研究。本文综述了有关MNBG的制备方法和工艺流程及其溶解产物在骨、齿等硬组织修复，皮肤组织修复，癌症治疗及细胞成像等方面的应用。为进一步开发应用于生物医学领域的新型MNBG提供参考。

, authors=杨峥宇1, 2, 3, 赵夫健4, 杜昶1, 2, 3, 陈晓峰1, 2, 3, authorsList=杨峥宇, 赵夫健, 杜昶, 陈晓峰, authorCompany=null, correspAuthors=陈晓峰, authorNote=

杨峥宇（1997—），男，博士研究生。

, correspAuthorsNote=
陈晓峰（1956—），男，博士，教授。
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YANG Zhenyu (1997-), male, Doctoral candidate. E-mail:

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杨峥宇（1997—），男，博士研究生。

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微纳米生物活性玻璃的制备与应用
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杨峥宇 1, 2, 3 , 赵夫健 4 , 杜昶 1, 2, 3 , 陈晓峰 1, 2, 3
硅酸盐学报 | 无机生物活性材料专题—综合评述 2023,51(10): 2553-2565
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硅酸盐学报 |无机生物活性材料专题—综合评述 2023 , 51 (10) : 2553 -2565
微纳米生物活性玻璃的制备与应用
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杨峥宇（1997—），男，博士研究生。

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杨峥宇1, 2, 3 , 赵夫健4, 杜昶1, 2, 3, 陈晓峰1, 2, 3
作者信息
  • 1．华南理工大学材料科学与工程学院生物材料系，广州 510641
  • 2．国家人体组织功能重建工程技术研究中心，广州 510641
  • 3．生物医用材料与工程教育部重点实验室，广州 510641
  • 4．南方医科大学口腔医院，广州 510641
通讯作者:
陈晓峰（1956—），男，博士，教授。
作者简介:

杨峥宇（1997—），男，博士研究生。

Preparation and Applications of Micro-Nano Bioactive Glass
Zhengyu YANG1, 2, 3 , Fujian ZHAO4, Chang DU1, 2, 3, Xiaofeng CHEN1, 2, 3
Affiliations
  • 1.Department of Biomaterials, School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China
  • 2.National Engineering Research Center for Tissue Restoration and Reconstruction, Guangzhou 510006, China
  • 3.Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education, South China University of Technology, Guangzhou 510006, China
  • 4.Stomatological Hospital, Southern Medical University, Guangzhou 510280, China
    • Corresponding Author:
    CHEN Xiaofeng (1956-), male, Ph.D., Professor. E-mail:

    YANG Zhenyu (1997-), male, Doctoral candidate. E-mail:

出版时间: 2023-10-20 doi: 10.14062/j.issn.0454-5648.20230200
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微纳米生物活性玻璃（MNBG）已被证明具有良好的生物活性，在骨、齿及皮肤创面修复及组织工程领域受到高度关注。在近些年的研究中，多种金属离子在MNBG的制备过程中被掺入材料的网络结构中，从而赋予MNBG各种理化及生物学功能特性。然而，MNBG的离子释放产物与人体细胞之间相互作用的确切机制尚不完全清楚，这促使国内外研究者对离子掺杂的MNBG进行了较深入的研究。本文综述了有关MNBG的制备方法和工艺流程及其溶解产物在骨、齿等硬组织修复，皮肤组织修复，癌症治疗及细胞成像等方面的应用。为进一步开发应用于生物医学领域的新型MNBG提供参考。

微纳米生物活性玻璃  /  离子掺杂  /  生物活性  /  组织工程

Micro-nano bioactive glass (MNBG) has a good biological activity and is widely used in tissue engineering. In recent years, a variety of metal ions are incorporated into the network structure of materials during the preparation of MNBG, thereby endowing MNBG with various physicochemical and biological functional properties. However, the exact mechanism of interaction between the ion release products of MNBG and human cells is not fully clarified. This review represented the preparation methods and processes of MNBG and the application of its lysates in bone and tooth and other hard tissue repair, skin tissue repair, cancer treatment and cell imaging. This review could provide a reference for the further development of MNBGs applied to the biomedical field.

micro-nano bioactive glass  /  ionic doping  /  biological activity  /  tissue engineering
杨峥宇, 赵夫健, 杜昶, 陈晓峰. 微纳米生物活性玻璃的制备与应用. 硅酸盐学报, 2023 , 51 (10) : 2553 -2565 . DOI: 10.14062/j.issn.0454-5648.20230200
Zhengyu YANG, Fujian ZHAO, Chang DU, Xiaofeng CHEN. Preparation and Applications of Micro-Nano Bioactive Glass[J]. Journal of the Chinese Ceramic Society, 2023 , 51 (10) : 2553 -2565 . DOI: 10.14062/j.issn.0454-5648.20230200
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  • 国家自然科学基金(32000933; 32171311; U1501245; 51672088)
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2023年第51卷第10期
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doi: 10.14062/j.issn.0454-5648.20230200
  • 接收时间：2023-03-31
  • 首发时间：2026-10-19
  • 出版时间：2023-10-20
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  • 收稿日期：2023-03-31
  • 修回日期：2023-06-09
基金
国家自然科学基金(32000933; 32171311; U1501245; 51672088)
作者信息
    1．华南理工大学材料科学与工程学院生物材料系，广州 510641
    2．国家人体组织功能重建工程技术研究中心，广州 510641
    3．生物医用材料与工程教育部重点实验室，广州 510641
    4．南方医科大学口腔医院，广州 510641

通讯作者:

陈晓峰（1956—），男，博士，教授。
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https://castjournals.cast.org.cn/joweb/gsyxb/CN/10.14062/j.issn.0454-5648.20230200
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2种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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