Article(id=1318978542109569797, tenantId=1146029695717560320, journalId=1263187385517883426, issueId=1318978537852359595, articleNumber=null, orderNo=null, doi=10.14062/j.issn.0454-5648.20230084, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1676908800000, receivedDateStr=2023-02-21, revisedDate=1680105600000, revisedDateStr=2023-03-30, acceptedDate=null, acceptedDateStr=null, onlineDate=1792398589874, onlineDateStr=2026-10-19, pubDate=1697731200000, pubDateStr=2023-10-20, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792398589874, onlineIssueDateStr=2026-10-19, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792398589874, creator=13701087609, updateTime=1792398589874, updator=13701087609, issue=Issue{id=1318978537852359595, tenantId=1146029695717560320, journalId=1263187385517883426, year='2023', volume='51', issue='10', pageStart='2517', pageEnd='2738', issueExtLink='null', onlineDate='null', pubDate='1697731200000', pubDateStr='2023-10-20', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1792398588860, creator='13701087609', updateTime=1792399337892, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1318981679578993157, tenantId=1146029695717560320, journalId=1263187385517883426, issueId=1318978537852359595, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1318981679578993158, tenantId=1146029695717560320, journalId=1263187385517883426, issueId=1318978537852359595, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=2579, endPage=2593, ext={EN=ArticleExt(id=1318978542298313478, articleId=1318978542109569797, tenantId=1146029695717560320, journalId=1263187385517883426, language=EN, title=Morphology and Biological Function of Calcium Phosphate Regulated by Elemental Doping, columnId=1321891276216193845, journalTitle=Journal of the Chinese Ceramic Society, columnName=Special Issue on Inorganic Bioactive Materials—Review, runingTitle=null, highlight=null, articleAbstract=

The inorganic composition of natural bone tissue is mainly calcium phosphate and consists of a variety of other elements necessary to maintain life activities to ensure the normal growth and development of bone tissue. In the preparation of calcium phosphate biomaterials, elemental doping can effectively regulate the morphology of calcium phosphate and have antibacterial properties, immune regulation, angiogenesis, osteoinduction and other biological functions. This review represented the regulatory effects of single-doping or co-doping of Mg, Zn, Sr, Cu, Ag, Co, Ag, Mn, and rare earth elements as well as Se, Si, and F in a variety of calcium phosphate on the structural morphology and biological function of materials. In addition, the future research work of calcium phosphate biomaterials was also proposed to provide a reference for the future research of novel scaffolds in tissue engineering.

, authors=Dongbiao CHANG1, 2, Zhenfan BAI1, 2, Hao HUANG1, 2, Anchun YANG1, 2, Siyu LI1, 2, Jie WENG1, authorsList=Dongbiao CHANG, Zhenfan BAI, Hao HUANG, Anchun YANG, Siyu LI, Jie WENG, authorCompany=null, correspAuthors=Jie WENG, authorNote=

CHANG Dongbiao (1999-), male, Doctoral candidate. E-mail:

, correspAuthorsNote=
WENG Jie (1962-), male, Ph.D., Professor. E-mail:
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天然骨组织无机成分以磷酸钙为主,也含有多种维持生命活动所必需的其他元素,以保障骨组织正常生长发育。在磷酸钙生物材料制备中,元素掺杂能够有效调控磷酸钙形貌,并赋予其抗菌性、免疫调控、血管生成和骨诱导性等多种生物学功能。本文重点综述Mg、Zn、Sr、Cu、Ag、Co、Mn、稀土元素等金属元素和Se、Si、F等非金属元素单掺杂或共掺杂对多种磷酸钙形貌和生物学功能的调控效应,最后对磷酸钙生物材料的未来研究提出展望,以期为新型组织工程支架的研究提供参考。

, authors=常栋彪1, 2, 白朕凡1, 2, 黄浩1, 2, 杨安春1, 2, 李思雨1, 2, 翁杰1, authorsList=常栋彪, 白朕凡, 黄浩, 杨安春, 李思雨, 翁杰, authorCompany=null, correspAuthors=翁杰, authorNote=

常栋彪(1999—),男,博士研究生。

, correspAuthorsNote=
翁杰(1962—),男,博士,教授。
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元素掺杂调控磷酸钙形貌及其生物学功能效应
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常栋彪 1, 2 , 白朕凡 1, 2 , 黄浩 1, 2 , 杨安春 1, 2 , 李思雨 1, 2 , 翁杰 1
硅酸盐学报 | 无机生物活性材料专题—综合评述 2023,51(10): 2579-2593
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硅酸盐学报 |无机生物活性材料专题—综合评述 2023 , 51 (10) : 2579 -2593
元素掺杂调控磷酸钙形貌及其生物学功能效应
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常栋彪(1999—),男,博士研究生。

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常栋彪(1999—),男,博士研究生。

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常栋彪1, 2 , 白朕凡1, 2, 黄浩1, 2, 杨安春1, 2, 李思雨1, 2, 翁杰1
作者信息
  • 1.西南交通大学医学院(生物医学工程研究院),成都 610031
  • 2.西南交通大学材料科学与工程学院,材料先进技术教育部重点实验室,成都 610031
通讯作者:
翁杰(1962—),男,博士,教授。
作者简介:

常栋彪(1999—),男,博士研究生。

Morphology and Biological Function of Calcium Phosphate Regulated by Elemental Doping
Dongbiao CHANG1, 2 , Zhenfan BAI1, 2, Hao HUANG1, 2, Anchun YANG1, 2, Siyu LI1, 2, Jie WENG1
Affiliations
  • 1.College of Medicine, Institute of Biomedical Engineering, Southwest Jiaotong University, Chengdu 610031, China
  • 2.Key Laboratory of Advanced Technologies of Materials Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China
  • Corresponding Author:
    WENG Jie (1962-), male, Ph.D., Professor. E-mail:

    CHANG Dongbiao (1999-), male, Doctoral candidate. E-mail:

出版时间: 2023-10-20 doi: 10.14062/j.issn.0454-5648.20230084
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天然骨组织无机成分以磷酸钙为主,也含有多种维持生命活动所必需的其他元素,以保障骨组织正常生长发育。在磷酸钙生物材料制备中,元素掺杂能够有效调控磷酸钙形貌,并赋予其抗菌性、免疫调控、血管生成和骨诱导性等多种生物学功能。本文重点综述Mg、Zn、Sr、Cu、Ag、Co、Mn、稀土元素等金属元素和Se、Si、F等非金属元素单掺杂或共掺杂对多种磷酸钙形貌和生物学功能的调控效应,最后对磷酸钙生物材料的未来研究提出展望,以期为新型组织工程支架的研究提供参考。

磷酸钙  /  元素掺杂  /  形貌  /  生物学功能

The inorganic composition of natural bone tissue is mainly calcium phosphate and consists of a variety of other elements necessary to maintain life activities to ensure the normal growth and development of bone tissue. In the preparation of calcium phosphate biomaterials, elemental doping can effectively regulate the morphology of calcium phosphate and have antibacterial properties, immune regulation, angiogenesis, osteoinduction and other biological functions. This review represented the regulatory effects of single-doping or co-doping of Mg, Zn, Sr, Cu, Ag, Co, Ag, Mn, and rare earth elements as well as Se, Si, and F in a variety of calcium phosphate on the structural morphology and biological function of materials. In addition, the future research work of calcium phosphate biomaterials was also proposed to provide a reference for the future research of novel scaffolds in tissue engineering.

calcium phosphate  /  elemental doping  /  morphology  /  biological function
常栋彪, 白朕凡, 黄浩, 杨安春, 李思雨, 翁杰. 元素掺杂调控磷酸钙形貌及其生物学功能效应. 硅酸盐学报, 2023 , 51 (10) : 2579 -2593 . DOI: 10.14062/j.issn.0454-5648.20230084
Dongbiao CHANG, Zhenfan BAI, Hao HUANG, Anchun YANG, Siyu LI, Jie WENG. Morphology and Biological Function of Calcium Phosphate Regulated by Elemental Doping[J]. Journal of the Chinese Ceramic Society, 2023 , 51 (10) : 2579 -2593 . DOI: 10.14062/j.issn.0454-5648.20230084
  • 国家自然科学基金面上项目(52071277; 22172120)
  • 四川省科技计划项目(2022YFSY0044)
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doi: 10.14062/j.issn.0454-5648.20230084
  • 接收时间:2023-02-21
  • 首发时间:2026-10-19
  • 出版时间:2023-10-20
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  • 收稿日期:2023-02-21
  • 修回日期:2023-03-30
基金
国家自然科学基金面上项目(52071277; 22172120)
四川省科技计划项目(2022YFSY0044)
作者信息
    1.西南交通大学医学院(生物医学工程研究院),成都 610031
    2.西南交通大学材料科学与工程学院,材料先进技术教育部重点实验室,成都 610031

通讯作者:

翁杰(1962—),男,博士,教授。
参考文献
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https://castjournals.cast.org.cn/joweb/gsyxb/CN/10.14062/j.issn.0454-5648.20230084
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2种不同金属材料的力学参数
科
Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)
属
Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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