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Article(id=1318978538301150123, tenantId=1146029695717560320, journalId=1263187385517883426, issueId=1318978537852359595, articleNumber=null, orderNo=null, doi=10.14062/j.issn.0454-5648.20230172, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1679241600000, receivedDateStr=2023-03-20, revisedDate=1683993600000, revisedDateStr=2023-05-14, acceptedDate=null, acceptedDateStr=null, onlineDate=1792398588967, onlineDateStr=2026-10-19, pubDate=1697731200000, pubDateStr=2023-10-20, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792398588967, onlineIssueDateStr=2026-10-19, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792398588967, creator=13701087609, updateTime=1792398588967, updator=13701087609, issue=Issue{id=1318978537852359595, tenantId=1146029695717560320, journalId=1263187385517883426, year='2023', volume='51', issue='10', pageStart='2517', pageEnd='2738', issueExtLink='null', onlineDate='null', pubDate='1697731200000', pubDateStr='2023-10-20', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1792398588860, creator='13701087609', updateTime=1792399337892, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1318981679578993157, tenantId=1146029695717560320, journalId=1263187385517883426, issueId=1318978537852359595, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1318981679578993158, tenantId=1146029695717560320, journalId=1263187385517883426, issueId=1318978537852359595, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=2566, endPage=2578, ext={EN=ArticleExt(id=1318978538515059628, articleId=1318978538301150123, tenantId=1146029695717560320, journalId=1263187385517883426, language=EN, title=Dual-Ions Substituted Hydroxyapatite Materials and Their Application in Hard Tissue Engineering, columnId=1321891276216193845, journalTitle=Journal of the Chinese Ceramic Society, columnName=Special Issue on Inorganic Bioactive Materials—Review, runingTitle=null, highlight=null, articleAbstract=

Hydroxyapatite (HA) is the main inorganic constituent of human hard tissue. It can effectively accelerate the repair process of hard tissue defects due to its high bioactivity and biocompatibility. Ion doping is an effective approach to enhance the bioactivity of HA materials. On this basis, dual-ion substitution can make HA materials have a higher simulation to nature bone in composition and some functional features (i.e., antitumor ability, antibacterial activity, pro-angiogenetic capacity, immunoregulatory and medical imaging capability). Dual-ion substitution greatly extends the applications of HA materials in bone tissue engineering. This review summarized the synthesis methods and their principles of dual-ion substituted HA (DIHA) materials, represented the applications of DIHA materials in hard tissue engineering, and finally proposed the future development direction of DIHA materials.

, authors=Zhenyu ZHONG1, 2, 3, Jun XU1, 2, 3, Zeyu SUN1, 2, 3, Yibo FAN1, 2, 3, Yingying DU1, 2, 3, Shengmin ZHANG1, 2, 3, authorsList=Zhenyu ZHONG, Jun XU, Zeyu SUN, Yibo FAN, Yingying DU, Shengmin ZHANG, authorCompany=null, correspAuthors=Yingying DU, Shengmin ZHANG, authorNote=

ZHONG Zhenyu (1991-), male, Doctoral candidate. E-mail:

, correspAuthorsNote=
ZHANG Shengmin (1962-), male, Ph.D., Professor; E-mail:
DU Yingying (1989-), female, Ph.D., Associate Professor.
, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1318978538720580525, articleId=1318978538301150123, tenantId=1146029695717560320, journalId=1263187385517883426, language=CN, title=双离子掺杂羟基磷灰石材料及其在硬组织工程中的应用, columnId=1321891276379771702, journalTitle=硅酸盐学报, columnName=无机生物活性材料专题—综合评述, runingTitle=null, highlight=null, articleAbstract=

羟基磷灰石（HA）是人体硬组织的主要无机组分，具有良好的生物活性及生物相容性，能够有效促进硬组织缺损的修复再生。研究表明：单一离子掺杂是一种有效提升HA材料生物活性的途径。而双离子掺杂不仅可实现对天然骨成分上的进一步仿生，还可以协同赋予HA材料更多功能特性，例如抗肿瘤、抗菌、促血管生成、免疫调节、医学成像等，拓展了HA材料在骨组织工程中的应用。对双离子掺杂HA材料的制备方法及原理进行了总结，并综述了双离子掺杂HA材料在硬组织工程中的潜在应用，最后对双离子掺杂HA材料的未来研究重点提出了建议和展望。

, authors=钟振宇1, 2, 3, 徐军1, 2, 3, 孙泽宇1, 2, 3, 范奕波1, 2, 3, 杜莹莹1, 2, 3, 张胜民1, 2, 3, authorsList=钟振宇, 徐军, 孙泽宇, 范奕波, 杜莹莹, 张胜民, authorCompany=null, correspAuthors=杜莹莹, 张胜民, authorNote=

钟振宇（1991—），男，博士研究生。

, correspAuthorsNote=
张胜民（1962—），男，博士，教授；
杜莹莹（1989—），女，博士，副教授。
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双离子掺杂羟基磷灰石材料及其在硬组织工程中的应用
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钟振宇 1, 2, 3 , 徐军 1, 2, 3 , 孙泽宇 1, 2, 3 , 范奕波 1, 2, 3 , 杜莹莹 1, 2, 3 , 张胜民 1, 2, 3
硅酸盐学报 | 无机生物活性材料专题—综合评述 2023,51(10): 2566-2578
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硅酸盐学报 |无机生物活性材料专题—综合评述 2023 , 51 (10) : 2566 -2578
双离子掺杂羟基磷灰石材料及其在硬组织工程中的应用
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钟振宇1, 2, 3 , 徐军1, 2, 3, 孙泽宇1, 2, 3, 范奕波1, 2, 3, 杜莹莹1, 2, 3 , 张胜民1, 2, 3
作者信息
  • 1．华中科技大学先进生物材料与组织工程研究中心，武汉 430074
  • 2．华中科技大学医疗器械监管科学研究院，武汉 430074
  • 3．国家药品监督管理局医疗器械监管科学研究基地，武汉 430074
通讯作者:
张胜民（1962—），男，博士，教授；
杜莹莹（1989—），女，博士，副教授。
作者简介:

钟振宇（1991—），男，博士研究生。

Dual-Ions Substituted Hydroxyapatite Materials and Their Application in Hard Tissue Engineering
Zhenyu ZHONG1, 2, 3 , Jun XU1, 2, 3, Zeyu SUN1, 2, 3, Yibo FAN1, 2, 3, Yingying DU1, 2, 3 , Shengmin ZHANG1, 2, 3
Affiliations
  • 1.Advanced Biomaterials and Tissue Engineering Center, Huazhong University of Science and Technology, Wuhan 430074, China
  • 2.Institute of Regulatory Science for Medical Devices, Huazhong University of Science and Technology, Wuhan 430074, China
  • 3.NMPA Research Base of Regulatory Science for Medical Devices, Wuhan 430074, China
    • Corresponding Author:
    ZHANG Shengmin (1962-), male, Ph.D., Professor; E-mail:
    DU Yingying (1989-), female, Ph.D., Associate Professor.

    ZHONG Zhenyu (1991-), male, Doctoral candidate. E-mail:

出版时间: 2023-10-20 doi: 10.14062/j.issn.0454-5648.20230172
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羟基磷灰石（HA）是人体硬组织的主要无机组分，具有良好的生物活性及生物相容性，能够有效促进硬组织缺损的修复再生。研究表明：单一离子掺杂是一种有效提升HA材料生物活性的途径。而双离子掺杂不仅可实现对天然骨成分上的进一步仿生，还可以协同赋予HA材料更多功能特性，例如抗肿瘤、抗菌、促血管生成、免疫调节、医学成像等，拓展了HA材料在骨组织工程中的应用。对双离子掺杂HA材料的制备方法及原理进行了总结，并综述了双离子掺杂HA材料在硬组织工程中的潜在应用，最后对双离子掺杂HA材料的未来研究重点提出了建议和展望。

双离子掺杂  /  羟基磷灰石  /  硬组织工程  /  微量元素

Hydroxyapatite (HA) is the main inorganic constituent of human hard tissue. It can effectively accelerate the repair process of hard tissue defects due to its high bioactivity and biocompatibility. Ion doping is an effective approach to enhance the bioactivity of HA materials. On this basis, dual-ion substitution can make HA materials have a higher simulation to nature bone in composition and some functional features (i.e., antitumor ability, antibacterial activity, pro-angiogenetic capacity, immunoregulatory and medical imaging capability). Dual-ion substitution greatly extends the applications of HA materials in bone tissue engineering. This review summarized the synthesis methods and their principles of dual-ion substituted HA (DIHA) materials, represented the applications of DIHA materials in hard tissue engineering, and finally proposed the future development direction of DIHA materials.

dual-ion substitution  /  hydroxyapatite  /  hard tissue engineering  /  trace element
钟振宇, 徐军, 孙泽宇, 范奕波, 杜莹莹, 张胜民. 双离子掺杂羟基磷灰石材料及其在硬组织工程中的应用. 硅酸盐学报, 2023 , 51 (10) : 2566 -2578 . DOI: 10.14062/j.issn.0454-5648.20230172
Zhenyu ZHONG, Jun XU, Zeyu SUN, Yibo FAN, Yingying DU, Shengmin ZHANG. Dual-Ions Substituted Hydroxyapatite Materials and Their Application in Hard Tissue Engineering[J]. Journal of the Chinese Ceramic Society, 2023 , 51 (10) : 2566 -2578 . DOI: 10.14062/j.issn.0454-5648.20230172
基金
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  • 国家重点研发计划项目(2022YFC2405701)
  • 国家自然科学基金(82130061; 32171331; 31870960)
  • 中国科协青年人才托举工程(YESS20200077)
  • 湖北省自然科学基金(2021CFB609)
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doi: 10.14062/j.issn.0454-5648.20230172
  • 接收时间：2023-03-20
  • 首发时间：2026-10-19
  • 出版时间：2023-10-20
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  • 收稿日期：2023-03-20
  • 修回日期：2023-05-14
基金
国家重点研发计划项目(2022YFC2405701)
国家自然科学基金(82130061; 32171331; 31870960)
中国科协青年人才托举工程(YESS20200077)
湖北省自然科学基金(2021CFB609)
作者信息
    1．华中科技大学先进生物材料与组织工程研究中心，武汉 430074
    2．华中科技大学医疗器械监管科学研究院，武汉 430074
    3．国家药品监督管理局医疗器械监管科学研究基地，武汉 430074

通讯作者:

张胜民（1962—），男，博士，教授；
杜莹莹（1989—），女，博士，副教授。
参考文献
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https://castjournals.cast.org.cn/joweb/gsyxb/CN/10.14062/j.issn.0454-5648.20230172
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2种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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