硅酸盐学报

3D打印制备羟基磷灰石-镁黄长石分级螺旋结构骨支架

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化帅斌 ¹^,² , 彭畅 ¹^,²^,³ , 程立金 ⁴ , 吴甲民 ¹^,²^,³ , 张笑妍 ⁵ , 王秀梅 ⁶ , 史玉升 ¹^,²

硅酸盐学报 | 研究论文 2025,53(9): 2706-2717

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硅酸盐学报 |研究论文 2025 , 53 (9) : 2706 -2717

3D打印制备羟基磷灰石-镁黄长石分级螺旋结构骨支架

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化帅斌¹^,², 彭畅¹^,²^,³, 程立金⁴, 吴甲民¹^,²^,³, 张笑妍⁵, 王秀梅⁶, 史玉升¹^,²

作者信息

^1．华中科技大学材料科学与工程学院，材料成形与模具技术全国重点实验室，武汉 430074

^2．增材制造陶瓷材料教育部工程研究中心，武汉 430074

^3．华中科技大学温州先进制造研究院，浙江温州 325035

^4．河北工业大学先进装备研究院，天津 300401

^5．北京科技大学先进材料技术研究院北京 100083

^6．清华大学，新型陶瓷材料全国重点实验室，北京 100084

通讯作者:

吴甲民（1984—），男，博士，教授。

作者简介:

化帅斌（1998—），男，博士研究生。

3D Printing of Hierarchical Gyroid Hydroxyapatite-Akermanite Scaffolds with Improved Compressive Strength

Shuaibin HUA¹^,², Chang PENG¹^,²^,³, Lijin CHENG⁴, Jiamin WU¹^,²^,³, Xiaoyan ZHANG⁵, Xiumei WANG⁶, Yusheng SHI¹^,²

Affiliations

^1.State Key Laboratory of Materials Processing and Die & Mould Technology, School of Materials Science and Engineering, Huazhong University of Science and Technology, Wuhan, 430074, China

^2.Engineering Research Center of Ceramic Materials for Additive Manufacturing, Ministry of Education, Wuhan, 430074, China

^3.Wenzhou Advanced Manufacturing Institute of HUST, Wenzhou, Zhejiang, 325035, China

^4.School of Mechanical Engineering, Hebei University of Technology, Tianjin 300401, China

^5.Institute for Advanced Materials and Technology, University of Science and Technology Beijing, Beijing, 100083, China

^6.State Key Laboratory of New Ceramic Materials, Tsinghua University, Beijing 100084, China

Corresponding Author:

WU Jiamin (1984-), male, Ph., D, Professor. E-mail: jiaminwu@hust.edu.cn

HUA Shuaibin (1998-), male, Doctorial Candidate. E-mail: 459912636@qq.com

出版时间: 2025-09-20 doi: 10.14062/j.issn.0454-5648.20240621

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摘要

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性能良好的松质骨种植体需要同时具备高孔隙率和良好的机械性能，但这很难通过均一的结构来实现。采用数字光处理技术打印了一系列径向内孔隙率为50%、外孔隙率为70%的分层状羟基磷灰石-镁黄长石支架，用以模拟松质骨结构和性能。随着过渡直径的增大，弹性模量增大，骨支架的抗压强度提升。当过渡直径达到支架直径的75%时，抗压强度超过2 MPa。在降解过程中，镁黄长石释放出的离子和微孔的存在使G75支架在第一天的降解率较快（5.73%），这使得支架的抗压强度略有下降。随着浸泡时间的持续增加，降解速度减慢，14 d时由于磷灰石的沉积，支架的重量和抗压强度上升。最后，精确制备了具有松质骨几何形状的分层陀螺支架，其最大载荷比均匀结构高8倍。

关键词

生物陶瓷 / 分级结构 / 抗压强度 / 生物活性 / 数字光处理

Abstract

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Introduction

It is necessary for an ideal bioceramic scaffold to have a suitable structure. The structure can affect the mechanical properties of the scaffold (i.e., elastic modulus and compressive strength) and the biological properties of the scaffold (i.e., degradability and cell growth rate). Lattice structure is a kind of periodic porous structure, which has some advantages of light weight and high strength, and is widely used in the preparation of bioceramic scaffolders. For the structure of the scaffold, high porosity and large pore size are important for bone growth, bone integration and promoting good mechanical interlocking between neighboring bones and the scaffold. However, scaffolds with a high porosity often lack mechanical strength. In addition, different parts of the bone have different structural requirements. In this paper, scaffolds with a non-uniform structure or a hierarchical structure were designed, with loose and porous exterior to facilitate cell adhesion, osteogenic differentiation and vascularization as well as relatively dense interior to provide sufficient mechanical support for bone repair.

Methods

In this work, composite ceramics scaffolds with 10% akermanite content were prepared by DLP technology. The scaffold had a high porosity outside to promote the growth of bone tissue, and a low porosity inside to withstand external forces. The compressive strength, fracture form, in-vitro degradation performance and bioactivity of graded bioceramic scaffolds were investigated. The models of scaffolds were imported into the DLP printer with a 405 nm light. The samples were printed with the intensity of 8 mJ/cm² and a layer thickness of 50 µm. Finally, the ceramic samples were sintered at 1100 ℃. The degradability of the hierarchical gyroid bioceramic scaffolds was evaluated through immersion in Tris-HCl solution and SBF solution at a ratio of 200 mL/g. The bioactivity of bioceramic was obtained via immersing them in SBF solution for two weeks. The concentrations of calcium, phosphate, silicon, and magnesium ions in the soaking solution were determined by an inductively coupled plasma optical emission spectrometer.

Results and discussion

In this work, a hierarchical Gyroid structure HA-AK10 scaffold (sintered at 1100 ℃) with a radial internal porosity of 50% and an external porosity of 70% is prepared, and the influence of structural form on the compressive strength and degradation performance of the scaffold is investigated. The biological activity of the bioceramics in vitro is also verified. The mechanical simulation results show that the stress distribution corresponds to the porosity distribution of the structure, and the low porosity is larger and the overall stress concentration phenomenon does not appear. After soaking in SBF solution, Si—OH is firstly formed on the surface of bioceramics, and then silicon gel layer is produced due to the presence of calcium and silicon ions. The silicon gel layer is dissociated into negatively charged groups under alkaline environment secondary adsorption of calcium ions and phosphate ions, forming amorphous calcium phosphate, and finally amorphous calcium phosphate crystals and adsorption of carbonate ions, forming carbonate hydroxyapatite. This indicates that the composite bioceramics have a good biological activity in-vitro and can provide a good environment for the growth of bone cells. A hierarchical Gyroid ceramic scaffold with a bone geometry is prepared via applying the hierarchical structure to the bone contour scaffold. The maximum load capacity of the hierarchical Gyroid ceramic scaffold is 8 times that of the uniform structure.

Conclusions

The hierarchical structure scaffold designed had good overall compressive performance, good degradation performance, and still maintained a good mechanical stability during degradation. In addition, in-vitro biological experimental results showed that the surface graded composite scaffold could have a good in-vitro biological activity and provide a good environment for bone cells. Compared to the heterosexual structure, the graded scaffold had greater mechanical properties.

Key words

bioceramic scaffolds / hierarchical gyroid structure / compressive strength / bioactivity / digital light processing

引用本文

化帅斌, 彭畅, 程立金, 吴甲民, 张笑妍, 王秀梅, 史玉升. 3D打印制备羟基磷灰石-镁黄长石分级螺旋结构骨支架. 硅酸盐学报, 2025 , 53 (9) : 2706 -2717 . DOI: 10.14062/j.issn.0454-5648.20240621

Shuaibin HUA, Chang PENG, Lijin CHENG, Jiamin WU, Xiaoyan ZHANG, Xiumei WANG, Yusheng SHI. 3D Printing of Hierarchical Gyroid Hydroxyapatite-Akermanite Scaffolds with Improved Compressive Strength[J]. Journal of the Chinese Ceramic Society, 2025 , 53 (9) : 2706 -2717 . DOI: 10.14062/j.issn.0454-5648.20240621

基金

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温州市基础科学研究项目(G20240008)
北京自然科学基金(L212020)
清华大学新型陶瓷与精细加工国家重点实验室开放课题(KF202301)
中央高校基本科研基金(2024JCYJ068; 15882024XCZX002)

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2025年第53卷第9期

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文章信息

doi: 10.14062/j.issn.0454-5648.20240621

接收时间：2024-09-24
首发时间：2026-10-21
出版时间：2025-09-20

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出版历史

收稿日期：2024-09-24
修回日期：2024-11-11

基金

温州市基础科学研究项目(G20240008)

北京自然科学基金(L212020)

清华大学新型陶瓷与精细加工国家重点实验室开放课题(KF202301)

中央高校基本科研基金(2024JCYJ068; 15882024XCZX002)

作者信息

^1．华中科技大学材料科学与工程学院，材料成形与模具技术全国重点实验室，武汉 430074

^2．增材制造陶瓷材料教育部工程研究中心，武汉 430074

^3．华中科技大学温州先进制造研究院，浙江温州 325035

^4．河北工业大学先进装备研究院，天津 300401

^5．北京科技大学先进材料技术研究院北京 100083

^6．清华大学，新型陶瓷材料全国重点实验室，北京 100084

通讯作者:

吴甲民（1984—），男，博士，教授。

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https://castjournals.cast.org.cn/joweb/gsyxb/CN/10.14062/j.issn.0454-5648.20240621

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2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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