硅酸盐学报

凹凸棒石在生物医学领域中的应用研究进展

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孙伟 ¹ , 王申金 ¹ , 刘小溪 ¹ , 张晨阳 ¹ , 王嵘 ¹ , 韩明君 ¹ , 肖扬 ² , 阳燕 ³ , 刘威 ⁴

硅酸盐学报 | 综合评述 2024,52(1): 359-370

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硅酸盐学报 |综合评述 2024 , 52 (1) : 359 -370

凹凸棒石在生物医学领域中的应用研究进展

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孙伟¹, 王申金¹, 刘小溪¹, 张晨阳¹, 王嵘¹, 韩明君¹, 肖扬², 阳燕³, 刘威⁴

作者信息

^1．中南大学资源加工与生物工程学院，长沙 410083

^2．中南大学，国家代谢性疾病临床医学研究中心，糖尿病免疫学教育部重点实验室，湘雅二医院代谢内分泌科，长沙 410011

^3．中南大学湘雅口腔医学院，长沙 410000

^4．中南大学，湘雅二医院普外科，长沙 410011

通讯作者:

张晨阳（1986—），男，博士，教授。

作者简介:

孙伟（1973—），男，博士，教授。

Research Progress on Application of Attapulgite in Biomedicine

Wei SUN¹, Shenjin WANG¹, Xiaoxi LIU¹, Chenyang ZHANG¹, Rong WANG¹, Mingjun HAN¹, Yang XIAO², Yan YANG³, Wei LIU⁴

Affiliations

^1.School of Resource Processing and Bioengineering, Central South University, Changsha 410083, China

^2.National Clinical Medical Research Center for Metabolic Diseases, Central South University, Key Laboratory of Diabetes Immunology, Ministry of Education, Department of Metabolism and Endocrinology, Xiangya Second Hospital, Changsha 410011, China

^3.Xiangya School of Stomatology, Central South University, Changsha 410000, China

^4.General Surgery Department, Xiangya Second Hospital, Central South University, Changsha 410011, China

Corresponding Author:

ZHANG Chenyang (1986-), male, Ph.D., Professor. E-mail: zhangchenyang@csu.edu.cn

SUN Wei (1973-), male, Ph.D., Professor. E-mail: sunmenghu@126.com

出版时间: 2024-01-20 doi: 10.14062/j.issn.0454-5648.20230419

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摘要

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凹凸棒石是一种具有2∶1型链层状结构的硅酸盐黏土矿物，针棒状的晶体长度约为0.5~5.0 μm，是一种不可再生的天然纳米材料。凹凸棒石特殊的结构赋予了它优异的吸附性，胶体性等性质。凹凸棒石作为绿色的天然矿物材料，具有良好的生物相容性，并且储量丰富，价格低廉，所以在生物医药领域有着广泛的应用潜力。本文综述了凹凸棒石在生物抗菌、药物输送、骨组织工程、伤口敷料等方面的应用研究进展，并对其未来的应用前景进行了展望。本文对于凹凸棒石的生物医学应用研究具有重要的参考价值。

关键词

凹凸棒石 / 硅酸盐矿物 / 纳米材料 / 生物医药 / 复合材料

Abstract

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Attapulgite is a rod like silicate clay minerals with a 2∶1 type chain layered nanostructure, and the length of rod crystal is 0.5-5.0 μm. It is a non-renewable natural nanomaterial. The layered crystal structure of the attapulgite chain endows it with special physical and chemical properties, including adsorption, colloidal, and cation exchange properties. Attapulgite is widely used in agriculture, environmental protection, chemical industry, and other fields due to its superior properties. The breakthrough in key common technologies for the dissociation of crystal beams in palygorskite rods enables the expansion of palygorskite from conventional applications to high-tech applications. Attapulgite as a non-toxic natural mineral material has good biocompatibility, abundant reserves, and low price. It has an enormous application potential in the field of high value-added biopharmaceuticals. This review summarized recent research work on the application, the structure and properties of attapulgite.

The first part summarized the research progress of the application of attapulgite in the field of biological antibacterial, elaborated on the possible antibacterial mechanisms of attapulgite composite antibacterial materials, compared the preparation methods and antibacterial properties of different attapulgite based composite antibacterial materials, and gave that one of the research hotspots for attapulgite based composite antibacterial materials is to explore a simple and green preparation method.

The second part summarized the application of attapulgite in the field of feed additives, represented the preparation of three different attapulgite based feed additives and their respective advantages and disadvantages, and pointed out that the relevant products are used in production practice, and listed some typical production process diagrams of the products.

The third part represented the application of palygorskite in drug carriers. Attapulgite based drug carriers are mainly in the form of hydrogels and nanofibers. At present, there is no research on the application of attapulgite based drug carriers in vivo. The main reason is that the safety of palygorskite in vivo is unknown, and it is also stable, making it difficult to enter the blood and urinary circulation system as a drug carrier. However, the prepared attapulgite sustained-release tablets can be discharged through the digestive system and have great application prospects.

The fourth part represented the application of attapulgite in composite scaffold materials. Although attapulgite based composite scaffold materials have a good osteogenic induction in vitro, their osteogenic induction in vivo is still unclear, and the mechanism of osteogenic induction in vitro is still unclear.

The fifth part summarized the application of attapulgite in wound healing. Attapulgite based wound dressings have a good usability. Mixed dimensional attapulgite seems to have better usage effects and is expected to become a novel generation of hemostatic materials.

Summary and prospects

1) In the future, it is necessary to accelerate the technological research on the full dispersion of attapulgite single crystals. Also, there is still a room for progress in the surface modification technology of attapulgite based composite antibacterial materials. The more attention should be paid to green and simple physical modification technologies, which can improve the production efficiency, and reduce the environmental pollution and costs. 2) Further research should be conducted on the application of palygorskite as a drug carrier on the body surface and digestive system, and pathways and methods suitable should be found to enable palygorskite to undergo harmless degradation in the blood and urinary systems. 3) It is necessary to accelerate the research on surface modification technologies of palygorskite, and make palygorskite based wound dressings into a form similar to gauze, which can to some extent reduce the risk of its entry into the blood system. 4) The practical application of attapulgite in the field of biomedicine is still relatively limited. In the future, we should accelerate the clinical research of attapulgite in the field of biomedicine, while still expanding the research of attapulgite in the field of biomedicine practice. For instance, we could use attapulgite to adsorb the metabolite of cholesterol-bile acid-to treat hypertension and hyperlipidemia. The adsorption of palygorskite is used to regulate the intestinal flora and interfere with the occurrence of type 2 diabetes. It is possible for the treatment of tumors to utilize the stability and biocompatibility of attapulgite to prepare high-performance drug loaded microspheres for embolization. The antibacterial and biocompatibility of attapulgite are also utilized to prepare alternative products for orthopedics and dentistry.

This review provided a reference for the application research of attapulgite in the field of biomedicine.

Key words

attapulgite / silicate minerals / nano materials / biopharmaceuticals / composite materials

引用本文

孙伟, 王申金, 刘小溪, 张晨阳, 王嵘, 韩明君, 肖扬, 阳燕, 刘威. 凹凸棒石在生物医学领域中的应用研究进展. 硅酸盐学报, 2024 , 52 (1) : 359 -370 . DOI: 10.14062/j.issn.0454-5648.20230419

Wei SUN, Shenjin WANG, Xiaoxi LIU, Chenyang ZHANG, Rong WANG, Mingjun HAN, Yang XIAO, Yan YANG, Wei LIU. Research Progress on Application of Attapulgite in Biomedicine[J]. Journal of the Chinese Ceramic Society, 2024 , 52 (1) : 359 -370 . DOI: 10.14062/j.issn.0454-5648.20230419

基金

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2023年中南大学创新驱动计划(2023CXQD002)
国家自然科学基金青年项目(82301063)
南京南欣医药技术研究院横向(738010434)
长沙市科技计划（杰出创新青年培养计划）(kq2106016)

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2024年第52卷第1期

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文章信息

doi: 10.14062/j.issn.0454-5648.20230419

接收时间：2023-06-18
首发时间：2026-10-22
出版时间：2024-01-20

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出版历史

收稿日期：2023-06-18
修回日期：2023-07-03

基金

2023年中南大学创新驱动计划(2023CXQD002)

国家自然科学基金青年项目(82301063)

南京南欣医药技术研究院横向(738010434)

长沙市科技计划（杰出创新青年培养计划）(kq2106016)

作者信息

^1．中南大学资源加工与生物工程学院，长沙 410083

^2．中南大学，国家代谢性疾病临床医学研究中心，糖尿病免疫学教育部重点实验室，湘雅二医院代谢内分泌科，长沙 410011

^3．中南大学湘雅口腔医学院，长沙 410000

^4．中南大学，湘雅二医院普外科，长沙 410011

通讯作者:

张晨阳（1986—），男，博士，教授。

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https://castjournals.cast.org.cn/joweb/gsyxb/CN/10.14062/j.issn.0454-5648.20230419

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2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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