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Article(id=1318978547587334605, tenantId=1146029695717560320, journalId=1263187385517883426, issueId=1318978537852359595, articleNumber=null, orderNo=null, doi=10.14062/j.issn.0454-5648.20230212, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1680278400000, receivedDateStr=2023-04-01, revisedDate=1681660800000, revisedDateStr=2023-04-17, acceptedDate=null, acceptedDateStr=null, onlineDate=1792398591180, onlineDateStr=2026-10-19, pubDate=1697731200000, pubDateStr=2023-10-20, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792398591180, onlineIssueDateStr=2026-10-19, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792398591180, creator=13701087609, updateTime=1792398591180, updator=13701087609, issue=Issue{id=1318978537852359595, tenantId=1146029695717560320, journalId=1263187385517883426, year='2023', volume='51', issue='10', pageStart='2517', pageEnd='2738', issueExtLink='null', onlineDate='null', pubDate='1697731200000', pubDateStr='2023-10-20', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1792398588860, creator='13701087609', updateTime=1792399337892, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1318981679578993157, tenantId=1146029695717560320, journalId=1263187385517883426, issueId=1318978537852359595, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1318981679578993158, tenantId=1146029695717560320, journalId=1263187385517883426, issueId=1318978537852359595, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=2536, endPage=2543, ext={EN=ArticleExt(id=1318978547830604238, articleId=1318978547587334605, tenantId=1146029695717560320, journalId=1263187385517883426, language=EN, title=Effect of Micro-Nano Bioactive Glass Content in Gelatin Based Composite Hydrogel on Its Mineralization and Degradation In Vitro, columnId=1321891267076805371, journalTitle=Journal of the Chinese Ceramic Society, columnName=Special Issue on Inorganic Bioactive Materials—Research Articles, runingTitle=null, highlight=null, articleAbstract=

In recent years, the composite hydrogels composed of micro-nano bioactive glass (MNBG) and gelatin are widely used in tissue regeneration. However, the relationship between hydrogels and MNBG in terms of mineralization and degradation is still unclear. In this paper, gelatin based composite hydrogels with different concentrations of MNBG were prepared, and the effect of MNBG on the mineralization and degradation properties of composite hydrogel was investigated by in vitro experiments. The results show that the composite hydrogel does not affect the bioactive ion release of MNBG, and the formation of negative curvature interface by a high concentration of MNBG aggregates is a necessary condition for composite hydrogels to mineralize. In addition, increasing the concentration of MNBG and quickly mineralizing to form hydroxyapatite layer can effectively reduce the degradation rate of gelatin based composite hydrogel.

, authors=Zhen YANG1, Cong LIU2, Xiaofeng CHEN2, Lei YANG1, authorsList=Zhen YANG, Cong LIU, Xiaofeng CHEN, Lei YANG, authorCompany=null, correspAuthors=Xiaofeng CHEN, Lei YANG, authorNote=

YANG Zhen (1993-), male, Ph.D. E-mail:

, correspAuthorsNote=
CHEN Xiaofeng (1956-), male, Ph.D., Professor. E-mail:
YANG Lei (1982-), male, Ph.D., Professor.
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近年来，基于明胶和微纳米生物活性玻璃（MNBG）的复合水凝胶被广泛用于组织再生领域，然而MNBG对水凝胶矿化和降解性能的调控规律尚不明确。通过制备不同MNBG含量的明胶基复合水凝胶，探究了MNBG含量对复合水凝胶体外矿化及降解性能的影响。结果表明：复合水凝胶体系不影响MNBG的生物活性离子释放，而表层高含量MNBG团聚体形成负曲率接触界面则是复合水凝胶发生体外矿化的必要条件；此外，提高MNBG的含量和快速矿化形成羟基磷灰石层均能够有效降低明胶基复合水凝胶的降解速率。

, authors=杨振1, 刘聪2, 陈晓峰2, 杨磊1, authorsList=杨振, 刘聪, 陈晓峰, 杨磊, authorCompany=null, correspAuthors=陈晓峰, 杨磊, authorNote=

杨振（1993—），男，博士。

, correspAuthorsNote=
陈晓峰（1970—），男，博士，教授。
杨磊（1982—），男，博士，教授。
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YANG Zhen (1993-), male, Ph.D. E-mail:

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YANG Zhen (1993-), male, Ph.D. E-mail:

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杨振（1993—），男，博士。

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杨振（1993—），男，博士。

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明胶基复合水凝胶中微纳米生物活性玻璃含量对其体外矿化及降解性能的影响
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杨振 1 , 刘聪 2 , 陈晓峰 2 , 杨磊 1
硅酸盐学报 | 无机生物活性材料专题—研究论文 2023,51(10): 2536-2543
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硅酸盐学报 |无机生物活性材料专题—研究论文 2023 , 51 (10) : 2536 -2543
明胶基复合水凝胶中微纳米生物活性玻璃含量对其体外矿化及降解性能的影响
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杨振1 , 刘聪2, 陈晓峰2 , 杨磊1
作者信息
  • 1．河北工业大学材料科学与工程学院，天津 300131
  • 2．华南理工大学材料科学与工程学院，广州 510641
通讯作者:
陈晓峰（1970—），男，博士，教授。
杨磊（1982—），男，博士，教授。
作者简介:

杨振（1993—），男，博士。

Effect of Micro-Nano Bioactive Glass Content in Gelatin Based Composite Hydrogel on Its Mineralization and Degradation In Vitro
Zhen YANG1 , Cong LIU2, Xiaofeng CHEN2 , Lei YANG1
Affiliations
  • 1.School of Materials Science and Engineering, Hebei University of Technology, Tianjin 300131, China
  • 2.School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China
    • Corresponding Author:
    CHEN Xiaofeng (1956-), male, Ph.D., Professor. E-mail:
    YANG Lei (1982-), male, Ph.D., Professor.

    YANG Zhen (1993-), male, Ph.D. E-mail:

出版时间: 2023-10-20 doi: 10.14062/j.issn.0454-5648.20230212
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近年来，基于明胶和微纳米生物活性玻璃（MNBG）的复合水凝胶被广泛用于组织再生领域，然而MNBG对水凝胶矿化和降解性能的调控规律尚不明确。通过制备不同MNBG含量的明胶基复合水凝胶，探究了MNBG含量对复合水凝胶体外矿化及降解性能的影响。结果表明：复合水凝胶体系不影响MNBG的生物活性离子释放，而表层高含量MNBG团聚体形成负曲率接触界面则是复合水凝胶发生体外矿化的必要条件；此外，提高MNBG的含量和快速矿化形成羟基磷灰石层均能够有效降低明胶基复合水凝胶的降解速率。

微纳米生物活性玻璃  /  复合水凝胶  /  体外矿化  /  降解

In recent years, the composite hydrogels composed of micro-nano bioactive glass (MNBG) and gelatin are widely used in tissue regeneration. However, the relationship between hydrogels and MNBG in terms of mineralization and degradation is still unclear. In this paper, gelatin based composite hydrogels with different concentrations of MNBG were prepared, and the effect of MNBG on the mineralization and degradation properties of composite hydrogel was investigated by in vitro experiments. The results show that the composite hydrogel does not affect the bioactive ion release of MNBG, and the formation of negative curvature interface by a high concentration of MNBG aggregates is a necessary condition for composite hydrogels to mineralize. In addition, increasing the concentration of MNBG and quickly mineralizing to form hydroxyapatite layer can effectively reduce the degradation rate of gelatin based composite hydrogel.

micro-nano bioactive glass  /  composite hydrogel  /  in vitro mineralization  /  degradation
杨振, 刘聪, 陈晓峰, 杨磊. 明胶基复合水凝胶中微纳米生物活性玻璃含量对其体外矿化及降解性能的影响. 硅酸盐学报, 2023 , 51 (10) : 2536 -2543 . DOI: 10.14062/j.issn.0454-5648.20230212
Zhen YANG, Cong LIU, Xiaofeng CHEN, Lei YANG. Effect of Micro-Nano Bioactive Glass Content in Gelatin Based Composite Hydrogel on Its Mineralization and Degradation In Vitro[J]. Journal of the Chinese Ceramic Society, 2023 , 51 (10) : 2536 -2543 . DOI: 10.14062/j.issn.0454-5648.20230212
基金
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  • 国家自然科学基金杰出青年基金(82025025)
  • “十三五”国家重点研发计划项目课题(2020YFC1107401)
  • 河北省全职引进高端人才项目(2020HBQZYC012)
  • 河北省自然基金创新研究群体项目(H2022202007)
  • 云南省杨磊专家工作站(202205AF150025)
  • 天津市多元投入基金项目重点项目(S21DYZD5171)
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2023年第51卷第10期
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doi: 10.14062/j.issn.0454-5648.20230212
  • 接收时间：2023-04-01
  • 首发时间：2026-10-19
  • 出版时间：2023-10-20
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  • 收稿日期：2023-04-01
  • 修回日期：2023-04-17
基金
国家自然科学基金杰出青年基金(82025025)
“十三五”国家重点研发计划项目课题(2020YFC1107401)
河北省全职引进高端人才项目(2020HBQZYC012)
河北省自然基金创新研究群体项目(H2022202007)
云南省杨磊专家工作站(202205AF150025)
天津市多元投入基金项目重点项目(S21DYZD5171)
作者信息
    1．河北工业大学材料科学与工程学院，天津 300131
    2．华南理工大学材料科学与工程学院，广州 510641

通讯作者:

陈晓峰（1970—），男，博士，教授。
杨磊（1982—），男，博士，教授。
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https://castjournals.cast.org.cn/joweb/gsyxb/CN/10.14062/j.issn.0454-5648.20230212
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2种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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