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In recent years, borosilicate bioactive glass (BBG) is widely studied due to its osteoinductive activities. However, the ions accumulated in the extracts can induce cytotoxicity and hemolysis when evaluating the biological properties of the degradable materials using the extracts of the materials. In this paper, the BBGs were prepared at different ratios of B₂O₃ (0B, 1.5B, and 3.0B samples), and bone cements were fabricated by mixing the BBGs with 30% (in mass fraction) citric acid. The cytotoxic and osteogenic effects of the bone cements extracts were evaluated using human bone marrow mesenchymal stem cells (hBMSCs), and the bone healing effects of the bone cements were evaluated using a rat femoral defect model, respectively. The results show that the extracts of bone cement formed at a greatest ratio of B₂O₃ in the bioactive glass can induce a maximum inhibitive effect on the proliferation and osteogenesis of hBMSCs in vitro. However, the degradation and bone healing effect of the bone cement increase directly with the ratio of B₂O₃ in BBG upon transplantation. Also, there is a huge discrepancy with the in vivo and in vitro evaluation systems for the biodegradable biomaterials. Understanding the mechanisms of the different biological effects of BBG in vitro and in vivo will provide some guidance for the design of a more effective borate-containing bioactive materials and the construction of a better evaluation system for bioactive materials in vitro, thus facilitating the clinical applications of BBG.

, authors=Tingli CHEN¹, Ping DU¹, Xian LI¹, Kun SU¹, Shuaijie LI¹, Xu CUI¹, Haobo PAN^{1, 2}, authorsList=Tingli CHEN, Ping DU, Xian LI, Kun SU, Shuaijie LI, Xu CUI, Haobo PAN, authorCompany=null, correspAuthors=Haobo PAN, authorNote=, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1318978539458773377, articleId=1318978539022565759, tenantId=1146029695717560320, journalId=1263187385517883426, language=CN, title=硼硅酸盐生物活性玻璃体内外成骨效应对比分析, columnId=1321891267257160444, journalTitle=硅酸盐学报, columnName=无机生物活性材料专题—研究论文, runingTitle=null, highlight=null, articleAbstract=

针对硼硅酸盐生物活性玻璃（BBG）临床应用的瓶颈问题，对比不同硼硅比（样品0B、样品1.5B、样品3B）生物活性玻璃与30%（质量分数）柠檬酸混合形成的骨水泥浸提液在体外对人骨髓间充质干细胞（hBMSCs）增殖活性与成骨分化的影响，及该骨水泥体内移植后对大鼠股骨缺损的修复效果。结果表明：骨水泥的降解速率随生物玻璃中B元素含量的增加而增快，同时其浸提液在体外对hBMSCs增殖活性与成骨分化的抑制效果更明显；然而，含最高浓度B的骨水泥（样品3B）在体内诱导更多新骨生成，展示出更好的骨修复性能。基于BBG在体内外生物学效应的显著性差异，本工作为硼基生物活性材料特性的优化设计及其体外有效性评价体系的构建提出了思考和建议。

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CHEN Tingli (1998-), female, Master candidate. E-mail: tl.chen@siat.ac.cn

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陈亭利（1998—），女，硕士研究生。

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陈亭利（1998—），女，硕士研究生。

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