Article(id=1319232611462001044, tenantId=1146029695717560320, journalId=1263187385517883426, issueId=1319232566922695375, articleNumber=null, orderNo=null, doi=10.14062/j.issn.0454-5648.20210888, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1634227200000, receivedDateStr=2021-10-15, revisedDate=1638720000000, revisedDateStr=2021-12-06, acceptedDate=null, acceptedDateStr=null, onlineDate=1792459164728, onlineDateStr=2026-10-20, pubDate=1658246400000, pubDateStr=2022-07-20, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792459164728, onlineIssueDateStr=2026-10-20, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792459164728, creator=13701087609, updateTime=1792459164728, updator=13701087609, issue=Issue{id=1319232566922695375, tenantId=1146029695717560320, journalId=1263187385517883426, year='2022', volume='50', issue='7', pageStart='1775', pageEnd='2066', issueExtLink='null', onlineDate='null', pubDate='1658246400000', pubDateStr='2022-07-20', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1792459154109, creator='13701087609', updateTime=1792460038980, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1319236278420357264, tenantId=1146029695717560320, journalId=1263187385517883426, issueId=1319232566922695375, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1319236278420357265, tenantId=1146029695717560320, journalId=1263187385517883426, issueId=1319232566922695375, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1964, endPage=1971, ext={EN=ArticleExt(id=1319232611654939029, articleId=1319232611462001044, tenantId=1146029695717560320, journalId=1263187385517883426, language=EN, title=Osteogenic Activity of Mg-Containing Mesoporous Bioactive Glass/Hardystonite Composite Scaffold, columnId=1263922769897599102, journalTitle=Journal of the Chinese Ceramic Society, columnName=Research Articles, runingTitle=null, highlight=null, articleAbstract=

The osteogenic activity and mechanical properties of the bone repair scaffold are important for its clinical application. Mg-M/HT porous composite scaffold was prepared with hardystonite (Ca₂ZnSi₂O₇, HT) with good mechanical properties as a matrix and Mg-doped biodegradable mesoporous bioactive glass (MBG) as a coating. The effect of Mg doping on the microstructure and osteogenic activity of the M/HT composite scaffold was investigated. The microstructures of the composite scaffolds were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM) and Fourier transform infrared spectroscopy (FTIR). The osteogenic activity of the scaffolds was investigated with human bone marrow mesenchymal stem cells (hBMSCs). The results show that Mg doping can reduce the mesoporous order of MBG to a certain extent, but Mg-M/HT composite scaffold still has a uniform and ordered pore structure. Compared with M/HT scaffold, Mg-M/HT scaffold has higher intracellular focal adhesion proteins and integrins, as well as alkaline phosphatase, calcium nodules and osteocalcin expression, indicating that Mg doping can promote the osteoblast activity of M/HT scaffold. Mg-M/HT scaffold has a potential application in the field of bone tissue repair.

, authors=Zhen MA^{1, 2}, Wei SUN², Dandan YE^{1, 2}, Xiaobing ZHAO¹, Guocheng WANG², authorsList=Zhen MA, Wei SUN, Dandan YE, Xiaobing ZHAO, Guocheng WANG, authorCompany=null, correspAuthors=Xiaobing ZHAO, authorNote=, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1319232611969511830, articleId=1319232611462001044, tenantId=1146029695717560320, journalId=1263187385517883426, language=CN, title=含镁介孔生物活性玻璃/锌黄长石复合支架的成骨活性, columnId=1263922770220560512, journalTitle=硅酸盐学报, columnName=研究论文, runingTitle=null, highlight=null, articleAbstract=

骨修复支架的成骨活性和力学性能对其使用效果至关重要。以具有良好力学性能的锌黄长石（Ca₂ZnSi₂O₇, HT）为基体，以Mg掺杂的生物可降解介孔生物活性玻璃（MBG）为涂层，制备Mg-M/HT多孔复合支架。研究Mg掺杂对复合支架微观结构和成骨活性的影响。利用X射线衍射仪、透射电子显微镜和Fourier变换红外吸收光谱仪等手段对复合支架的物化性能进行表征。利用人骨髓间充质干细胞（hBMSCs）考察Mg掺杂对支架成骨活性的影响。结果表明：Mg掺杂虽然一定程度上降低了MBG的介孔有序度，但Mg-M/HT复合支架仍具有均匀有序的孔道结构。与MBG改性的HT生物支架（M/HT）相比，Mg-M/HT支架具有更高的细胞内黏着斑蛋白和整合素以及碱性磷酸酶、钙结节和骨钙素的表达量，表明Mg掺杂可促进M/HT支架的成骨细胞活性，在骨组织修复领域具有较好的应用潜力。

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