Article(id=1322943391985697312, tenantId=1146029695717560320, journalId=1263187385517883426, issueId=1322942545734546372, articleNumber=null, orderNo=null, doi=10.14062/j.issn.0454-5648.20200572, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1596297600000, receivedDateStr=2020-08-02, revisedDate=1597593600000, revisedDateStr=2020-08-17, acceptedDate=null, acceptedDateStr=null, onlineDate=1793343883749, onlineDateStr=2026-10-30, pubDate=1618848000000, pubDateStr=2021-04-20, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793343883749, onlineIssueDateStr=2026-10-30, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793343883749, creator=13701087609, updateTime=1793343883749, updator=13701087609, issue=Issue{id=1322942545734546372, tenantId=1146029695717560320, journalId=1263187385517883426, year='2021', volume='49', issue='4', pageStart='605', pageEnd='806', issueExtLink='null', onlineDate='null', pubDate='1618848000000', pubDateStr='2021-04-20', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1793343681986, creator='13701087609', updateTime=1793345524324, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322950273110508350, tenantId=1146029695717560320, journalId=1263187385517883426, issueId=1322942545734546372, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322950273110508351, tenantId=1146029695717560320, journalId=1263187385517883426, issueId=1322942545734546372, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=608, endPage=617, ext={EN=ArticleExt(id=1322943394879767074, articleId=1322943391985697312, tenantId=1146029695717560320, journalId=1263187385517883426, language=EN, title=Performance of Lattice Structure Scaffold Prepared via Digital Light Processing Manufacture by DLP Technology, columnId=null, journalTitle=Journal of the Chinese Ceramic Society, columnName=null, runingTitle=null, highlight=null, articleAbstract=

Bone defects caused by trauma, bone tumor resection, traffic accidents, etc. increase the demand for bone scaffolds and additive manufacturing technology is gradually being widely used in the preparation of bone scaffolds. Three lattice-structured hydroxyapatite (Ca10(PO4)6OH2), HA ceramic green body such as Diamond structure, Rhombic dodecahedron structure and Octet truss structure were manufactured by Digital Light Processing technology and then successfully sintered three kinds of lattice structure HA ceramic scaffolds with a porosity of 70%, and the minimum pore size after sintering is about 200-300 μm. After being sintered at 1 300℃, the HA ceramic is partially decomposed into β-Ca3(PO4)2, and the ceramic grains are tightly bound. Mechanical strength simulation matches actual results, the average compressive strength of the Octet truss structure is the largest, which is 3.16 MPa. In vitro cell experiments showed that the surface of the HA ceramic bone scaffold is beneficial to the spread and adhesion of bone mesenchymal stem cells (rBMSCs), and the HA ceramic prepared by DLP has good biocompatibility. Therefore high-precision lattice structure HA ceramic bone scaffold fabricated by DLP technology is expected to be widely used in bone tissue engineering.

, authors=Shuaibin HUA1, 2, Hao ZHU3, Jiamin WU1, 2, Zhe ZHAI1, 2, Shuang CHEN1, 2, Kai LIU4, Lijin CHENG1, 2, Jun XIAO3, Yusheng SHI1, 2, authorsList=Shuaibin HUA, Hao ZHU, Jiamin WU, Zhe ZHAI, Shuang CHEN, Kai LIU, Lijin CHENG, Jun XIAO, Yusheng SHI, authorCompany=null, correspAuthors=Jiamin WU, authorNote=

HUA Shuaibin (1998-), male, Master candidate. E-mail:

, correspAuthorsNote=
WU Jiamin (1984-), male, associate Professor. E-mail:
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由创伤、骨肿瘤切除、交通事故等原因引起的骨缺损使骨支架的需求增加。增材制造技术在制造个性化复杂结构骨支架方面具有突出优势。采用数字光处理(DLP)技术成形出金刚石结构、菱形十二面体结构和八角桁架结构3种点阵结构的羟基磷灰石[Ca10(PO4)6OH2,HA]陶瓷素坯,进而成功烧结出孔隙率为70%的3种点阵结构HA陶瓷支架,烧结后孔径最小为200~300 μm。结果表明,1300℃烧结后的HA陶瓷部分分解为了β-磷酸三钙,且陶瓷晶粒之间结合致密。力学强度模拟与实际结果相符,八角桁架点阵结构的平均抗压强度最大,为3.16 MPa。经体外细胞实验表明,HA陶瓷骨支架表面有利于骨间充质干细胞(rBMSCs)良好的铺展粘附,DLP制备的HA陶瓷具有良好的生物相容性。DLP技术成形高精度点阵结构HA陶瓷骨支架在骨组织工程中有望得到广泛的应用。

, authors=化帅斌1, 2, 朱皓3, 吴甲民1, 2, 翟哲1, 2, 陈双1, 2, 刘凯4, 程立金1, 2, 肖骏3, 史玉升1, 2, authorsList=化帅斌, 朱皓, 吴甲民, 翟哲, 陈双, 刘凯, 程立金, 肖骏, 史玉升, authorCompany=null, correspAuthors=吴甲民, authorNote=

化帅斌(1998—),男,硕士生。

化帅斌,华中科技大学材料学院硕士研究生,研究方向为可降解复合陶瓷骨支架的光固化成形及性能研究。所在课题组研究为陶瓷增材制造技术及其应用。其中研究领域涉及结构陶瓷、生物陶瓷及功能陶瓷的光固化、激光选区融化和激光选区烧结成形等。

吴甲民,华中科技大学材料科学与工程学院副教授、博士生导师,湖北省青年科技晨光计划、武汉市青年科技朝阳计划、武汉东湖新技术开发区“3551光谷人才计划”、华中科技大学材料学院“青年优材计划”入选者。现任增材制造陶瓷材料教育部工程研究中心副主任、中国机械工程学会增材制造分会团体标准材料与工艺工作组召集人、中国机械工程学会高级会员、中国医疗器械行业协会3D打印医疗器械专业委员会专家等职务。担任SCI期刊Journal of Advanced Ceramics编委,《材料工程》《航空材料学报》青年编委,国家自然科学基金和Czech Science Foundation函评专家。主要从事陶瓷增材制造技术及其应用方面的研究工作,主持国家重点研发计划项目课题、国家自然科学基金面上项目、国家自然科学基金青年科学基金项目等科研项目20余项,获中国硅酸盐学会特种陶瓷分会2020年度特种陶瓷优秀青年奖、3D打印医疗器械团体标准制定“杰出贡献专家”、材料成形与模具技术国家重点实验室2018年度重大进展奖(排1)、2019年度华中科技大学重大学术进展奖(排2)等奖励。近年来,发表学术论文70余篇,申请了46项国家发明专利(已授权21项),参与出版专著4部。作为标准指导专家参与制定《3D打印个性化牙种植体团体标准》,多次参与组织国内外大型会议,并多次受邀在国内外大型会议和科研院所做大会报告和邀请报告。

, correspAuthorsNote=
吴甲民(1984—),男,副教授。
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化帅斌,华中科技大学材料学院硕士研究生,研究方向为可降解复合陶瓷骨支架的光固化成形及性能研究。所在课题组研究为陶瓷增材制造技术及其应用。其中研究领域涉及结构陶瓷、生物陶瓷及功能陶瓷的光固化、激光选区融化和激光选区烧结成形等。

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化帅斌,华中科技大学材料学院硕士研究生,研究方向为可降解复合陶瓷骨支架的光固化成形及性能研究。所在课题组研究为陶瓷增材制造技术及其应用。其中研究领域涉及结构陶瓷、生物陶瓷及功能陶瓷的光固化、激光选区融化和激光选区烧结成形等。

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吴甲民,华中科技大学材料科学与工程学院副教授、博士生导师,湖北省青年科技晨光计划、武汉市青年科技朝阳计划、武汉东湖新技术开发区“3551光谷人才计划”、华中科技大学材料学院“青年优材计划”入选者。现任增材制造陶瓷材料教育部工程研究中心副主任、中国机械工程学会增材制造分会团体标准材料与工艺工作组召集人、中国机械工程学会高级会员、中国医疗器械行业协会3D打印医疗器械专业委员会专家等职务。担任SCI期刊Journal of Advanced Ceramics编委,《材料工程》《航空材料学报》青年编委,国家自然科学基金和Czech Science Foundation函评专家。主要从事陶瓷增材制造技术及其应用方面的研究工作,主持国家重点研发计划项目课题、国家自然科学基金面上项目、国家自然科学基金青年科学基金项目等科研项目20余项,获中国硅酸盐学会特种陶瓷分会2020年度特种陶瓷优秀青年奖、3D打印医疗器械团体标准制定“杰出贡献专家”、材料成形与模具技术国家重点实验室2018年度重大进展奖(排1)、2019年度华中科技大学重大学术进展奖(排2)等奖励。近年来,发表学术论文70余篇,申请了46项国家发明专利(已授权21项),参与出版专著4部。作为标准指导专家参与制定《3D打印个性化牙种植体团体标准》,多次参与组织国内外大型会议,并多次受邀在国内外大型会议和科研院所做大会报告和邀请报告。

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吴甲民,华中科技大学材料科学与工程学院副教授、博士生导师,湖北省青年科技晨光计划、武汉市青年科技朝阳计划、武汉东湖新技术开发区“3551光谷人才计划”、华中科技大学材料学院“青年优材计划”入选者。现任增材制造陶瓷材料教育部工程研究中心副主任、中国机械工程学会增材制造分会团体标准材料与工艺工作组召集人、中国机械工程学会高级会员、中国医疗器械行业协会3D打印医疗器械专业委员会专家等职务。担任SCI期刊Journal of Advanced Ceramics编委,《材料工程》《航空材料学报》青年编委,国家自然科学基金和Czech Science Foundation函评专家。主要从事陶瓷增材制造技术及其应用方面的研究工作,主持国家重点研发计划项目课题、国家自然科学基金面上项目、国家自然科学基金青年科学基金项目等科研项目20余项,获中国硅酸盐学会特种陶瓷分会2020年度特种陶瓷优秀青年奖、3D打印医疗器械团体标准制定“杰出贡献专家”、材料成形与模具技术国家重点实验室2018年度重大进展奖(排1)、2019年度华中科技大学重大学术进展奖(排2)等奖励。近年来,发表学术论文70余篇,申请了46项国家发明专利(已授权21项),参与出版专著4部。作为标准指导专家参与制定《3D打印个性化牙种植体团体标准》,多次参与组织国内外大型会议,并多次受邀在国内外大型会议和科研院所做大会报告和邀请报告。

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点阵结构羟基磷灰石支架的数字光处理制备及性能
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化帅斌 1, 2 , 朱皓 3 , 吴甲民 1, 2 , 翟哲 1, 2 , 陈双 1, 2 , 刘凯 4 , 程立金 1, 2 , 肖骏 3 , 史玉升 1, 2
硅酸盐学报 | 2021,49(4): 608-617
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硅酸盐学报 | 2021 , 49 (4) : 608 -617
点阵结构羟基磷灰石支架的数字光处理制备及性能
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化帅斌,华中科技大学材料学院硕士研究生,研究方向为可降解复合陶瓷骨支架的光固化成形及性能研究。所在课题组研究为陶瓷增材制造技术及其应用。其中研究领域涉及结构陶瓷、生物陶瓷及功能陶瓷的光固化、激光选区融化和激光选区烧结成形等。

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化帅斌,华中科技大学材料学院硕士研究生,研究方向为可降解复合陶瓷骨支架的光固化成形及性能研究。所在课题组研究为陶瓷增材制造技术及其应用。其中研究领域涉及结构陶瓷、生物陶瓷及功能陶瓷的光固化、激光选区融化和激光选区烧结成形等。

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吴甲民,华中科技大学材料科学与工程学院副教授、博士生导师,湖北省青年科技晨光计划、武汉市青年科技朝阳计划、武汉东湖新技术开发区“3551光谷人才计划”、华中科技大学材料学院“青年优材计划”入选者。现任增材制造陶瓷材料教育部工程研究中心副主任、中国机械工程学会增材制造分会团体标准材料与工艺工作组召集人、中国机械工程学会高级会员、中国医疗器械行业协会3D打印医疗器械专业委员会专家等职务。担任SCI期刊Journal of Advanced Ceramics编委,《材料工程》《航空材料学报》青年编委,国家自然科学基金和Czech Science Foundation函评专家。主要从事陶瓷增材制造技术及其应用方面的研究工作,主持国家重点研发计划项目课题、国家自然科学基金面上项目、国家自然科学基金青年科学基金项目等科研项目20余项,获中国硅酸盐学会特种陶瓷分会2020年度特种陶瓷优秀青年奖、3D打印医疗器械团体标准制定“杰出贡献专家”、材料成形与模具技术国家重点实验室2018年度重大进展奖(排1)、2019年度华中科技大学重大学术进展奖(排2)等奖励。近年来,发表学术论文70余篇,申请了46项国家发明专利(已授权21项),参与出版专著4部。作为标准指导专家参与制定《3D打印个性化牙种植体团体标准》,多次参与组织国内外大型会议,并多次受邀在国内外大型会议和科研院所做大会报告和邀请报告。

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吴甲民,华中科技大学材料科学与工程学院副教授、博士生导师,湖北省青年科技晨光计划、武汉市青年科技朝阳计划、武汉东湖新技术开发区“3551光谷人才计划”、华中科技大学材料学院“青年优材计划”入选者。现任增材制造陶瓷材料教育部工程研究中心副主任、中国机械工程学会增材制造分会团体标准材料与工艺工作组召集人、中国机械工程学会高级会员、中国医疗器械行业协会3D打印医疗器械专业委员会专家等职务。担任SCI期刊Journal of Advanced Ceramics编委,《材料工程》《航空材料学报》青年编委,国家自然科学基金和Czech Science Foundation函评专家。主要从事陶瓷增材制造技术及其应用方面的研究工作,主持国家重点研发计划项目课题、国家自然科学基金面上项目、国家自然科学基金青年科学基金项目等科研项目20余项,获中国硅酸盐学会特种陶瓷分会2020年度特种陶瓷优秀青年奖、3D打印医疗器械团体标准制定“杰出贡献专家”、材料成形与模具技术国家重点实验室2018年度重大进展奖(排1)、2019年度华中科技大学重大学术进展奖(排2)等奖励。近年来,发表学术论文70余篇,申请了46项国家发明专利(已授权21项),参与出版专著4部。作为标准指导专家参与制定《3D打印个性化牙种植体团体标准》,多次参与组织国内外大型会议,并多次受邀在国内外大型会议和科研院所做大会报告和邀请报告。

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化帅斌1, 2 , 朱皓3, 吴甲民1, 2 , 翟哲1, 2, 陈双1, 2, 刘凯4, 程立金1, 2, 肖骏3, 史玉升1, 2
作者信息
  • 1.华中科技大学材料科学与工程学院,材料成形与模具技术国家重点实验室,武汉 430074
  • 2.增材制造陶瓷材料教育部工程研究中心,武汉 430074
  • 3.华中科技大学同济医学院同济医院骨科,武汉 430030
  • 4.武汉理工大学材料科学与工程学院,武汉 430070
通讯作者:
吴甲民(1984—),男,副教授。
作者简介:

化帅斌(1998—),男,硕士生。

化帅斌,华中科技大学材料学院硕士研究生,研究方向为可降解复合陶瓷骨支架的光固化成形及性能研究。所在课题组研究为陶瓷增材制造技术及其应用。其中研究领域涉及结构陶瓷、生物陶瓷及功能陶瓷的光固化、激光选区融化和激光选区烧结成形等。

吴甲民,华中科技大学材料科学与工程学院副教授、博士生导师,湖北省青年科技晨光计划、武汉市青年科技朝阳计划、武汉东湖新技术开发区“3551光谷人才计划”、华中科技大学材料学院“青年优材计划”入选者。现任增材制造陶瓷材料教育部工程研究中心副主任、中国机械工程学会增材制造分会团体标准材料与工艺工作组召集人、中国机械工程学会高级会员、中国医疗器械行业协会3D打印医疗器械专业委员会专家等职务。担任SCI期刊Journal of Advanced Ceramics编委,《材料工程》《航空材料学报》青年编委,国家自然科学基金和Czech Science Foundation函评专家。主要从事陶瓷增材制造技术及其应用方面的研究工作,主持国家重点研发计划项目课题、国家自然科学基金面上项目、国家自然科学基金青年科学基金项目等科研项目20余项,获中国硅酸盐学会特种陶瓷分会2020年度特种陶瓷优秀青年奖、3D打印医疗器械团体标准制定“杰出贡献专家”、材料成形与模具技术国家重点实验室2018年度重大进展奖(排1)、2019年度华中科技大学重大学术进展奖(排2)等奖励。近年来,发表学术论文70余篇,申请了46项国家发明专利(已授权21项),参与出版专著4部。作为标准指导专家参与制定《3D打印个性化牙种植体团体标准》,多次参与组织国内外大型会议,并多次受邀在国内外大型会议和科研院所做大会报告和邀请报告。

Performance of Lattice Structure Scaffold Prepared via Digital Light Processing Manufacture by DLP Technology
Shuaibin HUA1, 2 , Hao ZHU3, Jiamin WU1, 2 , Zhe ZHAI1, 2, Shuang CHEN1, 2, Kai LIU4, Lijin CHENG1, 2, Jun XIAO3, Yusheng SHI1, 2
Affiliations
  • 1.State Key Laboratory of Materials Processing and Die & Mould Technology, School of Materials Science and Engineering, Huazhong University of Science and Technology, Wuhan 430074, China
  • 2.Engineering Research Center of Ceramic Materials for Additive Manufacturing, Ministry of Education, Wuhan 430074, China
  • 3.Department of Orthopedic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan 430030, China
  • 4.School of Materials Science and Engineering, Wuhan University of Technology, Wuhan 430070 , China
  • Corresponding Author:
    WU Jiamin (1984-), male, associate Professor. E-mail:

    HUA Shuaibin (1998-), male, Master candidate. E-mail:

出版时间: 2021-04-20 doi: 10.14062/j.issn.0454-5648.20200572
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由创伤、骨肿瘤切除、交通事故等原因引起的骨缺损使骨支架的需求增加。增材制造技术在制造个性化复杂结构骨支架方面具有突出优势。采用数字光处理(DLP)技术成形出金刚石结构、菱形十二面体结构和八角桁架结构3种点阵结构的羟基磷灰石[Ca10(PO4)6OH2,HA]陶瓷素坯,进而成功烧结出孔隙率为70%的3种点阵结构HA陶瓷支架,烧结后孔径最小为200~300 μm。结果表明,1300℃烧结后的HA陶瓷部分分解为了β-磷酸三钙,且陶瓷晶粒之间结合致密。力学强度模拟与实际结果相符,八角桁架点阵结构的平均抗压强度最大,为3.16 MPa。经体外细胞实验表明,HA陶瓷骨支架表面有利于骨间充质干细胞(rBMSCs)良好的铺展粘附,DLP制备的HA陶瓷具有良好的生物相容性。DLP技术成形高精度点阵结构HA陶瓷骨支架在骨组织工程中有望得到广泛的应用。

数字光处理  /  阻聚剂  /  增材制造  /  羟基磷灰石支架  /  点阵结构  /  生物相容性

Bone defects caused by trauma, bone tumor resection, traffic accidents, etc. increase the demand for bone scaffolds and additive manufacturing technology is gradually being widely used in the preparation of bone scaffolds. Three lattice-structured hydroxyapatite (Ca10(PO4)6OH2), HA ceramic green body such as Diamond structure, Rhombic dodecahedron structure and Octet truss structure were manufactured by Digital Light Processing technology and then successfully sintered three kinds of lattice structure HA ceramic scaffolds with a porosity of 70%, and the minimum pore size after sintering is about 200-300 μm. After being sintered at 1 300℃, the HA ceramic is partially decomposed into β-Ca3(PO4)2, and the ceramic grains are tightly bound. Mechanical strength simulation matches actual results, the average compressive strength of the Octet truss structure is the largest, which is 3.16 MPa. In vitro cell experiments showed that the surface of the HA ceramic bone scaffold is beneficial to the spread and adhesion of bone mesenchymal stem cells (rBMSCs), and the HA ceramic prepared by DLP has good biocompatibility. Therefore high-precision lattice structure HA ceramic bone scaffold fabricated by DLP technology is expected to be widely used in bone tissue engineering.

digital light processing  /  photoinhibitor  /  additive manufacturing hydroxyapatite scaffolds  /  lattice structure  /  biological evaluations
化帅斌, 朱皓, 吴甲民, 翟哲, 陈双, 刘凯, 程立金, 肖骏, 史玉升. 点阵结构羟基磷灰石支架的数字光处理制备及性能. 硅酸盐学报, 2021 , 49 (4) : 608 -617 . DOI: 10.14062/j.issn.0454-5648.20200572
Shuaibin HUA, Hao ZHU, Jiamin WU, Zhe ZHAI, Shuang CHEN, Kai LIU, Lijin CHENG, Jun XIAO, Yusheng SHI. Performance of Lattice Structure Scaffold Prepared via Digital Light Processing Manufacture by DLP Technology[J]. Journal of the Chinese Ceramic Society, 2021 , 49 (4) : 608 -617 . DOI: 10.14062/j.issn.0454-5648.20200572
  • 国家重点研发计划项目课题(2018YFB1105503)
  • 湖北省技术创新专项重大项目(2019AAA002)
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2021年第49卷第4期
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doi: 10.14062/j.issn.0454-5648.20200572
  • 接收时间:2020-08-02
  • 首发时间:2026-10-30
  • 出版时间:2021-04-20
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  • 收稿日期:2020-08-02
  • 修回日期:2020-08-17
基金
国家重点研发计划项目课题(2018YFB1105503)
湖北省技术创新专项重大项目(2019AAA002)
作者信息
    1.华中科技大学材料科学与工程学院,材料成形与模具技术国家重点实验室,武汉 430074
    2.增材制造陶瓷材料教育部工程研究中心,武汉 430074
    3.华中科技大学同济医学院同济医院骨科,武汉 430030
    4.武汉理工大学材料科学与工程学院,武汉 430070

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吴甲民(1984—),男,副教授。
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2种不同金属材料的力学参数
科
Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)
属
Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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